JACC. Clinical electrophysiology最新文献

{"title":"PVI With CF-Sensing Large-Tip Focal PFA Catheter With 3D Mapping for Paroxysmal AF","authors":"Mattias Duytschaever MD ,&nbsp;Massimo Grimaldi MD ,&nbsp;Tom De Potter MD, PhD ,&nbsp;Atul Verma MD ,&nbsp;Laurent Macle MD ,&nbsp;Josef Kautzner MD ,&nbsp;Dominik Linz MD, PhD ,&nbsp;Ante Anic MD ,&nbsp;Hugo Van Herendael MD ,&nbsp;Gediminas Rackauskas MD ,&nbsp;Petr Neuzil MD ,&nbsp;Julian Chun MD ,&nbsp;Boris Schmidt MD ,&nbsp;Sebastien Knecht MD ,&nbsp;Alexandre Almorad MD ,&nbsp;Benjamin Berte MD ,&nbsp;Vivek Y. Reddy MD ,&nbsp;Johan Vijgen MD","doi":"10.1016/j.jacep.2025.04.008","DOIUrl":"10.1016/j.jacep.2025.04.008","url":null,"abstract":"<div><h3>Background</h3><div>Omny-IRE (A Study For Treatment of Paroxysmal Atrial Fibrillation [PAF] With the OMNYPULSE Catheter and the TRUPULSE Generator) evaluated safety and effectiveness of a novel large-tip focal, multielectrode, contact force–sensing, pulsed field ablation catheter with electroanatomic mapping integration.</div></div><div><h3>Objectives</h3><div>This study sought to assess 3-month safety and effectiveness of the platform for treating symptomatic paroxysmal atrial fibrillation.</div></div><div><h3>Methods</h3><div>Pulmonary vein isolation (PVI) was performed using the OMNYPULSE Platform. Primary effectiveness was adenosine/isoproterenol-proof entrance block. Primary safety was occurrence of primary adverse events. Prespecified patient subsets underwent systematic brain imaging, esophageal endoscopy, cardiac computed tomography/magnetic resonance angiogram, and mandatory 3-month remapping for PVI durability assessment.</div></div><div><h3>Results</h3><div>Of 188 patients enrolled, 136 were included in the per-protocol analysis. Primary effectiveness was 100% (136 of 136). Median (Q1-Q3) procedure, left atrial dwell, total ablation, and total fluoroscopy times were 105.5 (91.0-124.0), 70.0 (56.0-81.5), 46.9 (37.1-58.8), and 5.0 (3.1-9.8) minutes, respectively. The primary adverse event rate was 3.0% (4 of 135 patients with 3-month follow-up; 3 major vascular access complications, 1 pericarditis). Brain imaging (n = 30) revealed 1 patient (3.3%) with an asymptomatic silent cerebral event at discharge, which resolved at 1 month without neurological change. No esophageal injury was observed. Computed tomography/magnetic resonance angiogram imaging (n = 24) showed no incidences of pulmonary vein narrowing &gt;70%. During remapping, PVI was durable in 84.5% (98 of 116) of veins and 62.1% (18 of 29) of patients. With an optimized workflow, PVI durability improved to 89.3% (75 of 84) and 71.4% (15 of 21) of veins and patients, respectively.</div></div><div><h3>Conclusions</h3><div>The force-sensing, large-focal pulsed field ablation catheter with 3-dimensional electroanatomic mapping integration showed 100% acute success with a promising safety profile for treating paroxysmal atrial fibrillation. Prespecified remapping showed good PVI durability. (A Study For Treatment of Paroxysmal Atrial Fibrillation [PAF] With the OMNYPULSE Catheter and the TRUPULSE Generator; <span><span>NCT05971693</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1769-1782"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEMESIS-PFA","authors":"Dhanunjaya Lakkireddy MD ,&nbsp;Aashish Katapadi MD ,&nbsp;Jalaj Garg MD ,&nbsp;Eli Herink BS ,&nbsp;Michael Klotz BS ,&nbsp;Jagruth Ganta BS ,&nbsp;Aanya Kabra BS ,&nbsp;Rajesh Kabra MD ,&nbsp;Naga Venkata Pothineni MD ,&nbsp;Douglas Darden MD ,&nbsp;Rangarao Tummala MD ,&nbsp;Scott Koerber MD ,&nbsp;Rakesh Gopinathannair MD ,&nbsp;Sudharani Bommana PhD ,&nbsp;Donita Atkins BSN ,&nbsp;Rahul Chaudhary MD ,&nbsp;Mackenzie Mbai MD ,&nbsp;Venkat Tholakanahalli MD ,&nbsp;Sanghamitra Mohanty MD ,&nbsp;Luigi DiBiase MD ,&nbsp;Andrea Natale MD","doi":"10.1016/j.jacep.2025.04.017","DOIUrl":"10.1016/j.jacep.2025.04.017","url":null,"abstract":"<div><h3>Background</h3><div>Early evidence showed reduced complications with pulsed field ablation (PFA), but non-target tissue collateral damage created by electroporation effects is poorly understood and may significantly differ between systems.</div></div><div><h3>Objectives</h3><div>In this study, the authors evaluated the collateral effects of PFA.</div></div><div><h3>Methods</h3><div><span><span>NEMESIS-PFA is a multicenter, observational registry of patients who underwent AF ablation from March 2024 onwards with any approved PFA systems—either a circular </span>multielectrode array<span>, spherical, pentaspline, or variable loop catheter—or radiofrequency ablation (RFA). We assessed procedural characteristics, biomarkers for </span></span>myocardial injury<span>, hemolytic anemia<span>, and renal function, and left atrial function in select patients.</span></span></div></div><div><h3>Results</h3><div><span>A total of 871 patients, aged 68.9 ± 10.9 years and male (70.8%), with paroxysmal atrial fibrillation (59.4%), and CHA</span>₂DS₂<span>VASC of 3.3 ± 1.3 were included. Of these, 87.1% (n = 773) underwent PFA with a pentaspline (70.9%), circular multielectrode (14.1%), spherical (12.4%), and variable loop (2.3%) catheter. Significant postprocedural change in certain biomarkers such as troponin (13,551.0 vs 127.5 ng/dL; </span><em>P</em><span> &lt; 0.001), lactate dehydrogenase (107.5 vs 26.5 IU/L; </span><em>P</em><span> &lt; 0.001), and haptoglobin (−102.0 vs −33.5 mg/dL; </span><em>P</em><span><span> &lt; 0.001) were detected following the PFA procedures compared with RFA, and the change was dose-dependent. There were also significant differences in biomarkers across PFA systems. Lastly, there was a significant change in left atrial </span>ejection fraction (−20.0% vs. −5.0%, </span><em>P</em> &lt; 0.001) in PFA vs RFA.</div></div><div><h3>Conclusions</h3><div>Current PFA technologies are associated with worse troponin leak, hemolysis, and renal dysfunction than RFA. As PFA becomes mainstream, future studies appraising these effects and understanding the short term and long-term implications are needed.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1747-1756"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature Ventricular Complexes After Ablation for Paroxysmal Atrial Fibrillation and Recurrent Atrial Arrhythmias","authors":"William Whang MD ,&nbsp;Marwan Bahu MD ,&nbsp;David Newton MD ,&nbsp;Christopher F. Liu MD ,&nbsp;William H. Sauer MD ,&nbsp;Sandeep Goyal MD ,&nbsp;Vivek Iyer MD ,&nbsp;Devi Nair MD ,&nbsp;Luigi Di Biase MD, PhD ,&nbsp;Jose Osorio MD ,&nbsp;Moussa Mansour MD ,&nbsp;Hugh Calkins MD ,&nbsp;Oussama Wazni MD ,&nbsp;Andrea Natale MD ,&nbsp;Vivek Y. Reddy MD ,&nbsp;admIRE trial investigators","doi":"10.1016/j.jacep.2025.03.035","DOIUrl":"10.1016/j.jacep.2025.03.035","url":null,"abstract":"<div><h3>Background</h3><div>Premature ventricular complexes (PVCs) have been reported to independently predict incident atrial fibrillation in the general population. The prognostic importance of PVCs after catheter ablation for paroxysmal atrial fibrillation (PAF) is unknown.</div></div><div><h3>Objectives</h3><div>In patients undergoing catheter ablation for PAF, we assessed whether postablation PVCs influence the risk for recurrence.</div></div><div><h3>Methods</h3><div>We analyzed data from admIRE (Assessment of Safety and Effectiveness in Treatment Management of Atrial Fibrillation With the Biosense-Webster Irreversible Electroporation Ablation System; <span><span>NCT05293639</span><svg><path></path></svg></span>), a multicenter single-arm Food and Drug Administration trial of PAF patients undergoing pulsed field ablation with a variable-loop catheter. Transtelephonic monitoring ≥60 seconds was collected weekly during months 1 to 5, monthly during months 6 to 12, and for symptomatic events, and PVCs were assessed by a core lab. Logistic regression models of the relationship between early postablation PVCs (days 1-180) and postblanking (days 91-365) recurrence of atrial arrhythmia were fitted.</div></div><div><h3>Results</h3><div>Among 361 patients from admIRE, 135 (37.5%) patients had postablation PVCs noted prior to day 180. In the multivariable model, as compared with patients without postablation PVCs, those with PVCs had double the risk of atrial arrhythmia recurrence (OR: 2.1; 95% CI: 1.2-3.5; <em>P =</em> 0.006). An additional analysis in a second study that used very high-power, short-duration radiofrequency ablation for PAF demonstrated in a smaller cohort (N = 261), early PVCs were again associated with higher risk of recurrence (OR: 2.3; 95% CI: 1.2-4.6; <em>P =</em> 0.015).</div></div><div><h3>Conclusions</h3><div>Patients with PVCs in the first 6 months after catheter ablation for PAF are at higher risk for recurrent atrial arrhythmia. Whether PVCs themselves trigger atrial arrhythmias, or common underlying mechanisms trigger both, remains uncertain.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1738-1746"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes and Burdens to Return-to-Play for Phenotype Negative Athletes With a Genetic Heart Disease","authors":"Katherine A. Martinez BS ,&nbsp;J. Martijn Bos MD, PhD ,&nbsp;Kathryn E. Tobert BA ,&nbsp;John R. Giudicessi MD, PhD ,&nbsp;Michael J. Ackerman MD, PhD","doi":"10.1016/j.jacep.2025.03.013","DOIUrl":"10.1016/j.jacep.2025.03.013","url":null,"abstract":"<div><h3>Background</h3><div>Over the past decade, the care of athletes with a genetic<span><span> heart disease<span> (GHD) has shifted. Guidelines surrounding return-to-play (RTP) for athletes who are genotype positive but phenotype negative (G+/P−) remain variable and their management challenging. Recommendations depend on diagnosis, ranging from RTP with monitoring [hypertrophic cardiomyopathy (HCM), and </span></span>long QT syndrome (LQTS)] to automatic disqualification [catecholaminergic polymorphic ventricular tachycardia (CPVT), and arrhythmogenic cardiomyopathy (ACM)].</span></div></div><div><h3>Objectives</h3><div>This study sought to examine the prevalence, management, and outcomes of athletes with G+/P− GHD using a retrospective cohort of all self-identified athletes considered G+/P− treated in Mayo Clinic's Windland Smith Rice Genetic Heart Rhythm Clinic between July 2000 and November 2023.</div></div><div><h3>Methods</h3><div>There were 274 G+/P− athletes [119 females (43%); mean age at diagnosis 15 ± 12 years; median follow up 32 months] participating in sports at all levels. Diagnoses included LQTS (231; 84%), CPVT (19; 7%), ACM (15; 6%), or HCM (9; 3%). Treatments initiated after our first evaluation, but required for RTP approval, included pharmacologic therapy (187; 68%), left cardiac sympathetic denervation<span> (11; 4%), or an implantable cardioverter defibrillator (6; 2%).</span></div></div><div><h3>Results</h3><div>For 76 athletes (27%), an intentional non-therapy strategy was implemented. One in five athletes (53; 19%) specifically sought RTP approval following disqualification elsewhere.</div></div><div><h3>Conclusions</h3><div>Despite possessing a GHD-associated variant, a GHD-associated cardiac event or death has not occurred in over 1,300 combined years of follow-up. RTP for most G+/P− athletes is safe. Restricting such athletes based solely on a positive genetic test result should be viewed as genetic discrimination.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1708-1717"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Mechanical Insights Into Left Bundle Branch Pacing and Left Ventricular Septal Pacing","authors":"Matteo Bertini MD, PhD ,&nbsp;Francesco Vitali MD, PhD ,&nbsp;Michele Malagù MD ,&nbsp;Giorgia Azzolini MD ,&nbsp;Stefano Clò MD ,&nbsp;Luca Canovi MD ,&nbsp;Jacopo Farina MD ,&nbsp;Nicola Bianchi MD ,&nbsp;Martina De Raffele MD ,&nbsp;Chiara Bianchi MD ,&nbsp;Marco De Pietri MD ,&nbsp;Gabriele Guidi Colombi MD ,&nbsp;Marco Micillo MD ,&nbsp;Angelo Melpignano MD ,&nbsp;Rita Pavasini MD ,&nbsp;Cristina Balla MD, PhD ,&nbsp;Gabriele Guardigli MD ,&nbsp;Pugazhendhi Vijayaraman MD ,&nbsp;Marco Zuin MD, MS, PhD","doi":"10.1016/j.jacep.2025.03.037","DOIUrl":"10.1016/j.jacep.2025.03.037","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between left ventricular (LV) mechanical efficiency and various modalities of left bundle branch area pacing (LBBAP) is not well understood.</div></div><div><h3>Objectives</h3><div>The goal of this study was to evaluate the correlation between 2 different modalities of LBBAP, including left bundle branch pacing (LBBP) and LV septal pacing (LVSP) and myocardial work (MW), during spontaneous rhythm and LBBAP in patients with normal or moderately reduced LV ejection fraction.</div></div><div><h3>Methods</h3><div>Patients were retrieved from the TREEBEARD (Evaluation of Contemporary Cardiac Stimulation in Clinical Practice: Left, Biventricular, Right, and Conduction System Pacing; <span><span>NCT06324682</span><svg><path></path></svg></span>) prospective study and categorized into 2 groups based on whether they received LBBP or LVSP. MW was assessed using metrics such as global work index, global constructive work, global wasted work, and global work efficiency.</div></div><div><h3>Results</h3><div>Overall, 155 patients were included in the study (mean age 73.3 ± 14.3 years; 74.8% male), with 102 in the LBBP group and 53 in the LVSP group. In the LBBP group, all MW indices displayed a strong correlation between values recorded during spontaneous rhythm and LBBP. Conversely, the LVSP group exhibited moderate correlations for global work index (<em>r</em> = 0.535; <em>P</em> = 0.004), global constructive work (<em>r</em> = 0.587; <em>P</em> = 0.009), and global work efficiency (<em>r</em> = 0.503; <em>P</em> = 0.01). Global wasted work did not show a statistically significant correlation (<em>r</em> = 0.641; <em>P</em> = 0.13).</div></div><div><h3>Conclusions</h3><div>In patients with preserved or moderately reduced LV ejection fraction, LBBP exhibited LV mechanical efficiency comparable to that of spontaneous LV activation. Conversely, LVSP is a valuable option, but LV mechanics is impaired, showing a reduced GWE of the left ventricle. (Evaluation of Contemporary Cardiac Stimulation in Clinical Practice: Left, Biventricular, Right, and Conduction System Pacing [TREEBEARD]; <span><span>NCT06324682</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1852-1861"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transiently Organized Polymorphic VT in Repaired Tetralogy of Fallot","authors":"John Triedman MD","doi":"10.1016/j.jacep.2025.06.027","DOIUrl":"10.1016/j.jacep.2025.06.027","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1817-1819"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Septal Perforation During Left Bundle Branch Pacing","authors":"Shunmuga Sundaram Ponnusamy MD, DM, CEPS ,&nbsp;Pugazhendhi Vijayaraman MD","doi":"10.1016/j.jacep.2025.03.040","DOIUrl":"10.1016/j.jacep.2025.03.040","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1880-1881"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Side Lobe Artifacts Mimicking False Micro-Perforations","authors":"Emine Özpak MD ,&nbsp;Thomas Van Overmeiren MD ,&nbsp;Frank Timmermans MD, PhD ,&nbsp;Haran Burri MD, PhD ,&nbsp;Jan De Pooter MD, PhD","doi":"10.1016/j.jacep.2025.04.033","DOIUrl":"10.1016/j.jacep.2025.04.033","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1883-1884"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irrigation of Pulsed Field Ablation Electrodes Mitigates Joule Heating and the Heat Stacking Phenomena","authors":"William H. Sauer MD,&nbsp;Daniel Campos-Villarreal MD,&nbsp;Nathaniel A. Steiger MD","doi":"10.1016/j.jacep.2025.04.018","DOIUrl":"10.1016/j.jacep.2025.04.018","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1866-1868"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Transvenous Lead Extraction in Patients With Fungemia","authors":"Jingwen Huang MD,&nbsp;Neal K. Bhatia MD,&nbsp;Mikhael F. El-Chami MD,&nbsp;Faisal M. Merchant MD,&nbsp;Vardhmaan Jain MD","doi":"10.1016/j.jacep.2025.05.003","DOIUrl":"10.1016/j.jacep.2025.05.003","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 8","pages":"Pages 1874-1876"},"PeriodicalIF":7.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}