Intervirology最新文献_第9页

Havachoobe (Onosma dichroanthum Boiss) Root Extract Decreases the Hepatitis B Virus Surface Antigen Secretion in the PLC/PRF/5 Cell Line. Havachoobe（Onosma dichroanthum Boiss）根提取物可减少 PLC/PRF/5 细胞系中乙型肝炎病毒表面抗原的分泌。

IF 4.6 4区医学

Intervirology Pub Date : 2020-12-15 DOI: 10.1159/000512140

Alireza Mohebbi, Fahimeh Azadi, Mohammad Mostakhdem Hashemi, Fatemeh Sana Askari, Nazanin Razzaghi

{"title":"Havachoobe (Onosma dichroanthum Boiss) Root Extract Decreases the Hepatitis B Virus Surface Antigen Secretion in the PLC/PRF/5 Cell Line.","authors":"Alireza Mohebbi, Fahimeh Azadi, Mohammad Mostakhdem Hashemi, Fatemeh Sana Askari, Nazanin Razzaghi","doi":"10.1159/000512140","DOIUrl":"10.1159/000512140","url":null,"abstract":"Background: Many efforts are currently focused on functional treatment of the hepatitis B virus (HBV). This can be done by suppressing the secretion of HBV surface antigen (HBsAg). Scientific communities are very interested in natural products in that respect.Objective: Use of root extract of Havachoobe (Onosma dichroanthum BoissI), a Northern Iranian native medical herb, for assessment of its anti-HBsAg secretion activity.Methods: Havachoobe had been bought at a nearby apothecary store. Plant root extract was obtained using a hydroalcoholic process. Cytotoxic activity of the extract was examined on PLC/PRF/5 cells using MTT assay. ELISA has been used to measure HBsAg in the treated cell line supernatants. In addition, real-time PCR analysis was performed to evaluate the expression of HBsAg before and after treatment of Onosma in vitro.Results: The results showed very low root extract cytotoxicity at concentrations under 8 μg/mL. Tissue culture infectious dose 50 was obtained at 63.78 μg/mL. In a dose-dependent and time-dependent manner, a significantly reduced HBsAg secretion was observed at a concentration of 8 ppm at 12 h post-treatment. The real-time PCR result showed relative decreased HBsAg expression at all doses at 12 h post-treatment time.Discussion: In this study, we first reported anti-HBsAg activity on an Iranian herbal medicine. Havachoobe root extract was shown to be able to inhibit HBsAg in a dose-dependent and time-dependent manner. We find the extract exerts its inhibitory effect of HBsAg by targeting transcription of HBsAg.","PeriodicalId":14547,"journal":{"name":"Intervirology","volume":" ","pages":"1-5"},"PeriodicalIF":4.6,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38716131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Available Antiretrovirals in the Treatment and Pre-Exposure Prophylaxis of SARS-CoV-2: Quo Vadis? 现有抗逆转录病毒药物在 SARS-CoV-2 治疗和暴露前预防中的应用：何去何从？

IF 4.6 4区医学

Intervirology Pub Date : 2020-12-11 DOI: 10.1159/000512134

Miguel Alpalhão, Paulo Filipe

引用次数: 0

Association of Sex, Age, and Comorbidities with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis. 性别、年龄和合并症与COVID-19患者死亡率的关系:一项系统综述和荟萃分析

IF 4.6 4区医学

Intervirology Pub Date : 2020-12-09 DOI: 10.1159/000512592

Mohitosh Biswas, Shawonur Rahaman, Tapash Kumar Biswas, Zahirul Haque, Baharudin Ibrahim

{"title":"Association of Sex, Age, and Comorbidities with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis.","authors":"Mohitosh Biswas, Shawonur Rahaman, Tapash Kumar Biswas, Zahirul Haque, Baharudin Ibrahim","doi":"10.1159/000512592","DOIUrl":"10.1159/000512592","url":null,"abstract":"Introduction: Although severe acute respiratory syndrome coronavirus-2 infection is causing mortality in considerable proportion of coronavirus disease-2019 (COVID-19) patients, however, evidence for the association of sex, age, and comorbidities on the risk of mortality is not well-aggregated yet. It was aimed to assess the association of sex, age, and comorbidities with mortality in COVID-2019 patients.Methods: Literatures were searched using different keywords in various databases. Relative risks (RRs) were calculated by RevMan software where statistical significance was set as p < 0.05.Results: COVID-19 male patients were associated with significantly increased risk of mortality compared to females (RR 1.86: 95% confidence interval [CI] 1.67-2.07; p < 0.00001). Patients with age ≥50 years were associated with 15.4-folds significantly increased risk of mortality compared to patients with age <50 years (RR 15.44: 95% CI 13.02-18.31; p < 0.00001). Comorbidities were also associated with significantly increased risk of mortality; kidney disease (RR 4.90: 95% CI 3.04-7.88; p < 0.00001), cereborovascular disease (RR 4.78; 95% CI 3.39-6.76; p < 0.00001), cardiovascular disease (RR 3.05: 95% CI 2.20-4.25; p < 0.00001), respiratory disease (RR 2.74: 95% CI 2.04-3.67; p < 0.00001), diabetes (RR 1.97: 95% CI 1.48-2.64; p < 0.00001), hypertension (RR 1.95: 95% CI 1.58-2.40; p < 0.00001), and cancer (RR 1.89; 95% CI 1.25-2.84; p = 0.002) but not liver disease (RR 1.64: 95% CI 0.82-3.28; p= 0.16).Conclusion: Implementation of adequate protection and interventions for COVID-19 patients in general and in particular male patients with age ≥50 years having comorbidities may significantly reduce risk of mortality associated with COVID-19.","PeriodicalId":14547,"journal":{"name":"Intervirology","volume":" ","pages":"1-12"},"PeriodicalIF":4.6,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801974/pdf/int-0001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38703652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front & Back Matter 正面和背面

IF 4.6 4区医学

Intervirology Pub Date : 2020-12-01 DOI: 10.1159/000513757

J. Manuguerra, U. Liebert

引用次数: 0

Contents Vol. 63, 2020 目录2020年第63卷

IF 4.6 4区医学

Intervirology Pub Date : 2020-12-01 DOI: 10.1159/000513437

引用次数: 0

Front & Back Matter 正面和背面事项

IF 4.6 4区医学

Intervirology Pub Date : 2020-07-01 DOI: 10.1159/000510374

J. Manuguerra, Thomas Labadie

引用次数: 0

Contents 内容

IF 4.6 4区医学

Intervirology Pub Date : 2020-07-01 DOI: 10.1159/000510039

引用次数: 1

Orthomyxoviridae. Orthomyxoviridae。

IF 4.6 4区医学

Intervirology Pub Date : 2020-02-07 DOI: 10.32388/y4m0nv

W. R. Dowdle, F. M. Davenport, H. Fukumi, G. Schild, B. Tůmová, R. G. Webster, L. Y. Zakstelskaja

引用次数: 84

Bunyaviridae. 布尼亚病毒科。

IF 4.6 4区医学

Intervirology Pub Date : 2020-02-02 DOI: 10.32388/jk0m5f

D. Bishop, C. Calisher, J. Casals, M. Chumakov, S. Gaidamovich, C. Hannoun, D. K. Lvov, I. Marshall, N. Oker‐Blom, R. Pettersson, J. S. Porterfield, P. Russell, R. E. Shope, E. G. Westaway

{"title":"Bunyaviridae.","authors":"D. Bishop, C. Calisher, J. Casals, M. Chumakov, S. Gaidamovich, C. Hannoun, D. K. Lvov, I. Marshall, N. Oker‐Blom, R. Pettersson, J. S. Porterfield, P. Russell, R. E. Shope, E. G. Westaway","doi":"10.32388/jk0m5f","DOIUrl":"https://doi.org/10.32388/jk0m5f","url":null,"abstract":"The family Bunyaviridae comprises over 200 viruses (serotypes, subtypes, and varieties) that infect vertebrates and/or invertebrates. Four genera of viruses have been defined (Bunyavirus, Nairovirus, Phlebovirus, and Uukuvirus). The main characteristics of the member viruses are: (i) the virus particles are for the most part uniformly spherical, 80-110 nm in diameter, and possess a unit membrane envelope from which protrude polypeptide spikes 5-10nm long; (ii) the viruses have three helical nucleocapsids, often in the form of supercoiled circles, each consisting of a single species of single-stranded RNA, major nucleocapsid polypeptide, N, and at least in some cases minor amounts of a large polypeptide which may be a transcriptase component; (iii) the genome is composed of three species of RNA (L, large; M, medium; and S, small), organized in end-hydrogen bonded circular structures; (iv) most viruses have three major virion polypeptides (N, and two surface polypeptides, designated G1 and G2); (v) for at least some member viruses, the virions have been shown to contain an RNA-directed RNA polymerase, believed to be responsible for the synthesis of viral complementary mRNA, so that bunyaviruses are considered to be negative-stranded viruses; (vi) at least some bunyaviruses are capable of heterologous virus genome segment reassortment and can form recombinant viruses at high or low frequency; (vii) viruses appear to mature primarily at smooth membrane surfaces and accumulate in Golgi vesicles and saccules, or nearby; (viii) transovarial, venereal and/or transstadial transmission in arthropods has been shown to occur for some members of the family.","PeriodicalId":14547,"journal":{"name":"Intervirology","volume":"14 3-4 1","pages":"125-43"},"PeriodicalIF":4.6,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48056029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenoviridae. 腺病毒科。

IF 4.6 4区医学

Intervirology Pub Date : 2020-02-02 DOI: 10.32388/yoct69

E. Norrby, A. Bartha, P. Boulanger, R. Dreizin, H. Ginsberg, S. Kalter, H. Kawamura, W. Rowe, W. Russell, W. Schlesinger, R. Wigand

引用次数: 0