Japanese circulation journal最新文献_第6页

Serial assessment of left and right ventricular filling in patients with congestive heart failure. 充血性心力衰竭患者左、右心室充盈的系列评价。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.803

T. Ohta, S. Nakatani, S. Izumi, S. Nagata, S. Beppu, K. Miyatake

{"title":"Serial assessment of left and right ventricular filling in patients with congestive heart failure.","authors":"T. Ohta, S. Nakatani, S. Izumi, S. Nagata, S. Beppu, K. Miyatake","doi":"10.1253/JCJ.65.803","DOIUrl":"https://doi.org/10.1253/JCJ.65.803","url":null,"abstract":"Serial changes in the diastolic filling of both ventricles were studied using Doppler echocardiography in 19 patients with congestive heart failure from the acute to the convalescent stage. During the acute stage, left ventricular early filling velocity (E) was high (88 +/- 17 cm/s) and atrial filling velocity (A) was low (44 +/- 23 cm/s), whereas the right ventricular E was depressed (17 +/- 8 cm/s) and A was enhanced (40 +/- 9 cm/s). As the condition improved, left ventricular E decreased (43 +/- 11 cm/s, p < 0.01) and A increased (59 +/- 24 cm/s, p < 0.01) along with a decrease in the left ventricular and atrial dimensions. In contrast to the changes in left ventricular filling, right ventricular E increased (31 +/- 10 cm/s, p < 0.01) and A decreased (32 +/- 5 cm/s, p < 0.05). There are opposite directional changes in left and right ventricular filling with clinical improvement from the acute to the convalescent stage of congestive heart failure, which suggest that the changes are related to improvement of the hemodynamic conditions of both ventricles. The changes in the right ventricular filling pattern was likely to be related to changes in right ventricular afterload, ventricular interaction and external constraint rather than a change in right ventricular filling pressure.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"49 1","pages":"803-7"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90036431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Microvascular angina in a patient with aortic stenosis. 主动脉狭窄患者的微血管性心绞痛1例。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.839

R. Kawamoto, T. Imamura, K. Kawabata, H. Date, T. Ishikawa, M. Maeno, T. Nagoshi, Y. Fujiura, A. Matsuyama, T. Matsuo, Y. Koiwaya, T. Eto

引用次数: 11

Renin-angiotensin system is involved in the mechanism of increased serum asymmetric dimethylarginine in essential hypertension. 肾素-血管紧张素系统参与了原发性高血压患者血清不对称二甲基精氨酸升高的机制。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.775

Akira Ito, K. Egashira, T. Narishige, Kouhei Muramatsu, Akira Takeshita

{"title":"Renin-angiotensin system is involved in the mechanism of increased serum asymmetric dimethylarginine in essential hypertension.","authors":"Akira Ito, K. Egashira, T. Narishige, Kouhei Muramatsu, Akira Takeshita","doi":"10.1253/JCJ.65.775","DOIUrl":"https://doi.org/10.1253/JCJ.65.775","url":null,"abstract":"Endothelium-dependent/nitric oxide (NO)-mediated vasodilation is impaired in hypertensive individuals. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, is synthesized by many types of cells including vascular endothelial cells. The serum level of ADMA is elevated in patients with essential hypertension, but the mechanism for this increase is unknown. Therefore, the present study examined whether the renin-angiotensin system (RAS) is involved. Patients with essential hypertension [systolic blood pressure (BP) > 160 mmHg and/or diastolic BP > 95 mmHg] were randomized to an angiotensin-converting enzyme (ACE) inhibitor treatment group (perindopril, 4mg/day for 4 weeks, n = 7), an angiotensin II type 1 (AT1) receptor antagonist treatment group (losartan, 50 mg/day for 4 weeks, n = 7) or a beta-blocker treatment group (bisoprolol, 5 mg/day for 4 weeks, n = 7). Before and after the treatment, BP, serum concentration of ADMA and plasma concentration of von Willebrand factor (vWF, a biological marker of endothelial injury) were measured. Perindopril, losartan and bisoprolol decreased BP to a similar extent, and either perindopril or losartan, but not bisoprolol, significantly decreased serum ADMA and plasma vWF. These findings suggest that the RAS may contribute to the mechanism of increased serum ADMA as well as to the endothelial injury observed in hypertensive patients. The vasculoprotective actions of ACE inhibitors or AT1 receptor antagonists may be explained at least in part by amelioration of the endothelial injury through a decrease in the serum ADMA concentration.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"2012 1","pages":"775-8"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87858404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 117

Role of nitric oxide in regulation of coronary blood flow in response to increased metabolic demand in dogs with pacing-induced heart failure. 在起搏性心力衰竭犬代谢需求增加时，一氧化氮在调节冠状动脉血流中的作用

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.827

H. Tada, K. Egashira, M. Yamamoto, M. Usui, Y. Arai, Y. Katsuda, H. Shimokawa, A. Takeshita

{"title":"Role of nitric oxide in regulation of coronary blood flow in response to increased metabolic demand in dogs with pacing-induced heart failure.","authors":"H. Tada, K. Egashira, M. Yamamoto, M. Usui, Y. Arai, Y. Katsuda, H. Shimokawa, A. Takeshita","doi":"10.1253/JCJ.65.827","DOIUrl":"https://doi.org/10.1253/JCJ.65.827","url":null,"abstract":"The role of endothelium-derived nitric oxide (NO) in the metabolic control of coronary blood flow (CBF) in heart failure (HF) is poorly understood, so the present study investigated the effects of inhibitors of NO synthesis on the response of CBF to changes in myocardial oxygen consumption (MVO2) in dogs with HF produced by rapid ventricular pacing and in control dogs. The CBF, MVO2, and other hemodynamic parameters were measured in anesthetized animals. Before infusion of Nomega-nitro-L-arginine methyl ester (L-NAME), the increases in CBF and MVO2 during pacing tachycardia were not significantly different between the control and HF dogs. Intracoronary infusion of L-NAME did not alter the responses of CBF or MVO2 to pacing tachycardia in the control dogs, but in the HF dogs, it reduced the CBF response to pacing tachycardia without altering the tachycardia-induced changes in MVO2. Intracoronary infusion of L-arginine reversed the effect of L-NAME. These results suggest that in HF dogs NO contributes to the regulation of CBF in response to an increased metabolic demand.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"18 1","pages":"827-33"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79950166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effects of smoking on myocardial injury in patients with conservatively treated acute myocardial infarction: a study with resting 123I-15-iodophenyl 3-methyl pentadecanoic acid/201Tl myocardial single photon emission computed tomography. 吸烟对保守治疗急性心肌梗死患者心肌损伤的影响:静息123i -15-碘苯基3-甲基五酸/201Tl心肌单光子发射计算机断层扫描研究

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/jcj.65.769

H. Yamagishi, K. Akioka, N. Shirai, M. Yoshiyama, M. Teragaki, K. Takeuchi, J. Yoshikawa, H. Ochi

{"title":"Effects of smoking on myocardial injury in patients with conservatively treated acute myocardial infarction: a study with resting 123I-15-iodophenyl 3-methyl pentadecanoic acid/201Tl myocardial single photon emission computed tomography.","authors":"H. Yamagishi, K. Akioka, N. Shirai, M. Yoshiyama, M. Teragaki, K. Takeuchi, J. Yoshikawa, H. Ochi","doi":"10.1253/jcj.65.769","DOIUrl":"https://doi.org/10.1253/jcj.65.769","url":null,"abstract":"Many reports have demonstrated that smokers who have suffered an acute myocardial infarction (AMI) have a better prognosis than nonsmokers. The present study investigated the effects of current smoking on myocardial injury with resting 123I-15-iodophenyl 3-methyl pentadecanoic acid (BMIPP)/201Tl myocardial single photon emission computed tomography in 103 patients with conservatively treated AMI. The left ventricular myocardium was divided into 9 segments and BMIPP and 201Tl defects were scored using a 5-point grading system (0 = normal and 4 = no uptake). The sum of the defect scores was defined as the total defect score. There was no significant difference in either the baseline severity of the coronary artery disease or the total defect scores for BMIPP and 201Tl between the current smoker and nonsmoker groups. The difference between the total defect scores for BMIPP and 201Tl tended to be larger in the current smoker group than in the nonsmoker group (2.0 +/- 1.9 vs 1.3 +/- 1.6, p = 0.056). Forty-one (53%) of 77 patients in the current smoker group exhibited a BMIPP/201Tl mismatch, whereas only 8 (31%) of 26 patients in the nonsmoker group did (p = 0.047). In conclusion, current smokers had more likelihood of salvageable myocardium in areas at risk, as demonstrated by BMIPP/201Tl mismatch, in AMI than nonsmokers.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"13 1","pages":"769-74"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88319581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart. 心肌游离脂肪酸利用异常随着高血压心脏形态改变而恶化。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.783

Hiroyuki Nakayama, T. Morozumi, S. Nanto, T. Shimonagata, T. Ohara, Yuzuru Takano, Jun-ichi Kotani, Tetsuya Watanabe, Masashi Fujita, Mayu Nishio, Hideo Kusuoka, Masatsugu Hori, Seiki Nagata

{"title":"Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart.","authors":"Hiroyuki Nakayama, T. Morozumi, S. Nanto, T. Shimonagata, T. Ohara, Yuzuru Takano, Jun-ichi Kotani, Tetsuya Watanabe, Masashi Fujita, Mayu Nishio, Hideo Kusuoka, Masatsugu Hori, Seiki Nagata","doi":"10.1253/JCJ.65.783","DOIUrl":"https://doi.org/10.1253/JCJ.65.783","url":null,"abstract":"The left ventricle's morphological adaptation to high blood pressure is classified into 4 patterns based on mass and wall thickness. The geometric changes caused by maladaptation to pressure overload possibly relate to progression of contractile dysfunction with abnormal energy metabolism. The present study assessed whether the geometric adaptation of the left ventricle (LV) to high blood pressure relates to changes in myocardial energy metabolism, especially free fatty acid (FFA) utilization. Thirty-five patients with essential hypertension underwent echocardiography and dual isotopes myocardial scintigraphy using iodine-123 labeled 15-p-iodophenyl-3-(R,S)-methylpentadecanoic acid (BMIPP, an analogue of a FFA) and thallium-201 (Tl-201). Systolic (endocardial fractional shortening; %FS) and diastolic indices (the ratio of early to atrial filling waves; E/A) of LV function were also assessed. Quantitative myocardial BMIPP uptake was evaluated by the BMIPP/TI-201 myocardial uptake ratio (B/T). The subjects were divided into 4 groups based on LV mass and wall thickness: (1) concentric hypertrophy (CH), (2) eccentric hypertrophy (EH), (3) concentric remodeling (CR), and (4) normal geometry (N). The %FS was lower in the EH group than in the other groups. The mitral E/A ratio in the CH group was lowest. B/T was significantly decreased in the EH group compared with the N group (p < 0.05). B/T correlated with the mitral E/A ratio significantly (p < 0.05, r = 0.42), whereas there was no relationship between %FS and B/T. These results indicate that the geometric changes occurring in hypertensive hearts strongly correlate with alternations in cardiac function and with abnormal myocardial FFA metabolism, and that the latter is associated with diastolic abnormality, but not with systolic function.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"162 1","pages":"783-7"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76985623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Left atrial appendage dysfunction in chronic nonvalvular atrial fibrillation is significantly associated with an elevated level of brain natriuretic peptide and a prothrombotic state. 慢性非瓣膜性房颤左心耳功能障碍与脑利钠肽水平升高和血栓前状态显著相关。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.788

Y. Igarashi, K. Kashimura, Y. Makiyama, T. Sato, K. Ojima, Y. Aizawa

{"title":"Left atrial appendage dysfunction in chronic nonvalvular atrial fibrillation is significantly associated with an elevated level of brain natriuretic peptide and a prothrombotic state.","authors":"Y. Igarashi, K. Kashimura, Y. Makiyama, T. Sato, K. Ojima, Y. Aizawa","doi":"10.1253/JCJ.65.788","DOIUrl":"https://doi.org/10.1253/JCJ.65.788","url":null,"abstract":"The study tested the hypothesis that left atrial appendage (LAA) dysfunction in nonvalvular atrial fibrillation (NVAF) correlates with a prothrombotic state, and investigated whether the plasma natriuretic peptides are marker of LAA dysfunction in NVAF. Sixty-seven patients underwent transthoracic and transesophageal echocardiography. The left ventricular fractional shortening, left atrial diameter (LAD), LAA flow velocity and the grade of spontaneous echo contrast (SEC) were determined. The plasma concentrations of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), D-dimer, and thrombin-antithrombin III complex (TAT) were measured. The patients were divided into 2 groups according to LAA flow velocity: group I (LAA velocity <20 cm/s) and group II (LAA velocity > or = 20cm/s). The SEC score, D-dimer, TAT, BNP and LAD were significantly increased in group I. Based on simple linear regression analysis, SEC score (r=-0.638), LAD (r=-0.493), D-dimer (r = -0.485), BNP (r = -0.463), TAT (r = -0.455) and age (r = -0.314) were inversely correlated with LAA flow velocity. Multivariate analysis showed that SEC score (p = 0.0014) and plasma BNP level (p=0.0075) were independent negative predictors for LAA flow velocity. In conclusion, LAA dysfunction is associated with a prothrombotic state, and the plasma BNP concentration may serve as a determinant of LAA function in NVAF.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"28 1","pages":"788-92"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74102966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Relation of QT-interval variability to ventricular arrhythmias during percutaneous transluminal coronary angioplasty. 经皮冠状动脉腔内成形术中qt间期变异性与室性心律失常的关系。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.779

A. Kajiyama, D. Saito, T. Murakami, T. Shiraki, T. Oka, M. Doi, T. Masaka, K. Tanemoto, T. Tsuji

{"title":"Relation of QT-interval variability to ventricular arrhythmias during percutaneous transluminal coronary angioplasty.","authors":"A. Kajiyama, D. Saito, T. Murakami, T. Shiraki, T. Oka, M. Doi, T. Masaka, K. Tanemoto, T. Tsuji","doi":"10.1253/JCJ.65.779","DOIUrl":"https://doi.org/10.1253/JCJ.65.779","url":null,"abstract":"The present study investigated the role of the dispersion of QT interval in percutaneous transluminal coronary angioplasty (PTCA)-induced ventricular tachyarrhythmias. Patients with effort angina without a previous myocardial infarction (n = 22), who had single-vessel disease of the anterior descending coronary artery (LAD), underwent PTCA if the coronary lesion was 75% or more stenosed in segment 6 or 7 of the LAD. The standard 12-lead ECG was continuously recorded during the procedure. Averaged QTc and QTac intervals, where QTac was the interval from the beginning of QRS complex to the nadir of T wave corrected by Bazett's formula, did not change significantly during PTCA. Of the 22 patients, 7 showed ventricular arrhythmias during PTCA. The maximum difference (deltaQTc) and the standard deviation (QTcSD) of the corrected QT interval in the standard 12-lead ECG increased significantly during PTCA in the 7 patients with ventricular arrhythmias, whereas they decrreased in the 15 patients without ventricular arrhythmias. deltaQTac and QTacSD were not affected by PTCA regardless of ventricular arrhythmias, which shows that the increases in the variation of the ventricular repolarization process play a role in PTCA-induced ventricular arrhythmias.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"31 1","pages":"779-82"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87177388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Usefulness of selective myocardial contrast echocardiography in percutaneous transluminal septal myocardial ablation: a case report. 选择性心肌超声造影在经皮腔内室间隔心肌消融术中的应用:1例报告。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.842

H. Okayama, T. Sumimoto, N. Morioka, Kouzo Yamamoto, Hiroyuki Kawada

引用次数: 11

Hemielliptic proximal isovelocity surface area method modified for clinical application: more accurate quantification of mitral regurgitation in Doppler echocardiography. 改进的半椭圆近端等速表面积法用于临床应用:多普勒超声心动图中二尖瓣反流更准确的定量。

Japanese circulation journal Pub Date : 2001-08-20 DOI: 10.1253/JCJ.65.820

H. Fujii, S. Kibira, C. Izumi, T. Saito, A. Ryabikov, M. Miura

{"title":"Hemielliptic proximal isovelocity surface area method modified for clinical application: more accurate quantification of mitral regurgitation in Doppler echocardiography.","authors":"H. Fujii, S. Kibira, C. Izumi, T. Saito, A. Ryabikov, M. Miura","doi":"10.1253/JCJ.65.820","DOIUrl":"https://doi.org/10.1253/JCJ.65.820","url":null,"abstract":"The proximal isovelocity surface area (PISA) method is one of the various methods used for quantitatively estimating mitral regurgitation. The PISA shape is hemielliptic rather than hemispheric on a slit-like orifice, and the hemielliptic method is more accurate than the hemispheric method for in vitro studies. Nevertheless, the hemispheric method is used clinically because of its simplicity, whereas the hemielliptic method is difficult to approach from 3 orthogonal directions. The present study tries to establish a modified hemielliptic method for use in clinical applications. A closed-circuit, constant flow system was designed to simulate PISA, and various types of slit-like orifices were selected. Three orthogonal PISA radii were measured and flow rates were calculated using the original hemielliptic formula from the 3 orthogonal radii. Flow rates were also calculated indirectly using a linear regression formula, and PISA radii from a bird's eye approach and lateral approaches (modified hemielliptic method) were compared. Flow rates that were determined using the original hemielliptic method correlated significantly with actual flow rates (r = 0.92, p < 0.0001; y = 1.1x - 13; SEE = 13.63 ml/s). Similarly, flow rates calculated using the modified hemielliptic method correlated significantly with actual flow rates (r = 0.90, p < 0.001; y = 0.94x - 0.78; SEE = 14.13 ml/s). The study's results imply that the modified hemielliptic method can be used to accurately quantify mitral regurgitation and could be applied for clinical examinations.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"203 1","pages":"820-6"},"PeriodicalIF":0.0,"publicationDate":"2001-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79694436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4