Japanese circulation journal最新文献_第10页

Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneous transluminal coronary angioplasty. 尼可地尔是硝酸盐和atp敏感的钾离子通道打开剂的混合物，在经皮冠状动脉腔内成形术中对人心脏缺血起预先作用。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.526

T. Yasuda, K. Hashimura, Y. Matsu-ura, Y. Kato, T. Ueda, I. Mori, Y. Kijima

{"title":"Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneous transluminal coronary angioplasty.","authors":"T. Yasuda, K. Hashimura, Y. Matsu-ura, Y. Kato, T. Ueda, I. Mori, Y. Kijima","doi":"10.1253/JCJ.65.526","DOIUrl":"https://doi.org/10.1253/JCJ.65.526","url":null,"abstract":"The human heart progressively becomes more tolerant to ischemia after repeated balloon inflations during percutaneous transluminal coronary angioplasty (PTCA). The present study investigated whether nicorandil, a hybrid between nitrate and an ATP-sensitive potassium channel opener, affects this ischemic preconditioning. Sixteen patients with stable angina pectoris caused by left anterior descending artery lesions were subjected to 2 balloon inflations of 2-min duration with a 3-min reperfusion period. Seven of these patients served as the control group and in the remaining 9 patients, nicorandil was administered intravenously (6 mg/h) throughout the PTCA procedure (nicorandil group). The lactate extraction ratio (LER) was obtained at 30 s after each ischemic event (LERpost-1 and LERpost-2) in both groups. In the control group, LERpost-1 was more negative than LERpost-2 (-185.7+/-74.2 vs -98.0+/-37.3%, p<0.01). The ratio of the sum of the ST elevation in the precordial leads during the second inflation (sumST-2, 0.94+/-0.66 mV) to that during the first inflation (sumST-1, 1.43+/-1.17 mV) was 0.72+/-0.16 in the control group, which was less than the ratio in the nicorandil group (1.06+/-0.13, p<0.01). Nicorandil abolished the difference between the 2 ischemic events (LERpost-1, -45.1+/-41.6 vs LERpost-2, -43.5+/-51.1%; sumST-1, 1.38+/-0.80 vs sumST-2, 1.46+/-0.90 mV). LER was less negative in the nicorandil group than that in the control group (LERpost-1, -45.1+/-41.6 vs -185.7+/-74.2%, p<0.01; LERpost-2, -43.5+/-51.1 vs -98.0+/-37.3%, p<0.05). Thus, nicorandil improved lactate metabolism during PTCA without significantly influencing ST-elevation. In conclusion, intravenous pre-administration of nicorandil appears to precondition the human heart during PTCA.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"19 1","pages":"526-30"},"PeriodicalIF":0.0,"publicationDate":"2001-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77733858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Using isoproterenol stress echocardiography to predict the response to carvedilol in patients with dilated cardiomyopathy. 应用异丙肾上腺素应激超声心动图预测扩张型心肌病患者对卡维地洛的反应。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.514

I. Nishi, K. Iida, S. Kawano, T. Masumi, I. Yamaguchi

{"title":"Using isoproterenol stress echocardiography to predict the response to carvedilol in patients with dilated cardiomyopathy.","authors":"I. Nishi, K. Iida, S. Kawano, T. Masumi, I. Yamaguchi","doi":"10.1253/JCJ.65.514","DOIUrl":"https://doi.org/10.1253/JCJ.65.514","url":null,"abstract":"Trials have demonstrated that carvedilol can produce hemodynamic, symptomatic, and prognostic improvements in dilated cardiomyopathy (DCM), but some DCM patients have deteriorated after carvedilol, developing congestive heart failure. The present study investigated the use of isoproterenol (ISP) stress echocardiography to select those patients with DCM who would respond to carvedilol. ISP was infused intravenously in 22 patients with DCM and they were classified into 2 groups based on the left ventricular systolic response: good response to ISP [change in fractional shortening (FS) with ISP > 0.05, n=13] and poor response to ISP (change < or = 0.05, n=9). In the good response group, FS significantly increased from 0.12+/-0.04 to 0.17+/-0.08 (mean+/-SD, p<0.05) with carvedilol, and 7 patients improved symptomatically (New York Heart Association class). However, in the poor response group, no significant difference was observed between FS at baseline and that at the end of follow-up. Moreover, only 1 patient in the poor response group improved symptomatically. ISP stress echocardiography can assist in selecting patients with DCM who will respond positively to carvedilol.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"1 1","pages":"514-8"},"PeriodicalIF":0.0,"publicationDate":"2001-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76724966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Association between job strain status and cardiovascular risk in a population of Taiwanese white-collar workers. 台湾白领人群工作压力状况与心血管风险之关系。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.509

C. Su

引用次数: 19

Evolution and stabilization of vulnerable atherosclerotic plaques. 易损性动脉粥样硬化斑块的演变和稳定。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.473

P. Libby, M. Aikawa

{"title":"Evolution and stabilization of vulnerable atherosclerotic plaques.","authors":"P. Libby, M. Aikawa","doi":"10.1253/JCJ.65.473","DOIUrl":"https://doi.org/10.1253/JCJ.65.473","url":null,"abstract":"mammals, have resident smooth muscle cells in the tunica intima underneath the endothelial monolayer, even before atherosclerotic changes begin.1,2 The thickness of the intimal layer increases progressively as humans age from fetus to child to young adult, and its complex structure probably favors the formation of atheroma. When atherogenesis begins, the artery wall becomes host to inflammatory cells, including macrophages and T lymphocytes,3 and an excess of risk factors accelerates the pathological changes in the artery. Presently, the most understood risk factor is low-density lipoprotein (LDL). Epidemiological and clinical studies suggest that elevated levels of plasma cholesterol, especially LDL particles, increase the risk of acute coronary events.4,5 Beginning with Anitschkow and Chalatow’s description in 1913 of a diet rich in cholesterol that induced atherosclerosis in rabbits, 6 a number of animal studies have linked hypercholesterolemia to atherosclerosis. 7–9 In vitro studies, however, suggested that native LDL itself does not induce vascular cell activation and foam cell formation, the features that are related to atherosclerosis. In the late 1980s, the ‘oxidized LDL’ hypothesis postulated the missing link between hypercholesterolemia and atherosclerosis;10 that is, excess LDL in the artery wall can be modified, which instigates an inflammatory response on the endothelial surface of the artery.11 Endothelial activation, in turn, causes an infiltration of macrophages, one of the hallmarks of the atherosclerotic lesion. 12–15 Macrophage-rich atheroma, which are prone to rupture and thrombus formation, result in the onset of acute coronary syndromes such as unstable angina and myocardial infarction.16–19 Recent clinical and preclinical studies have repeatedly suggested that lipid lowering can stabilize these vulnerable plaques and improve clinical outcomes.20 This review will discuss the current understanding of the biology of vascular inflammation, the pathophysiolgy of acute thrombotic complications, and the likely mechanisms responsible for the effects of lipid-lowering therapy.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"13 1","pages":"473-9"},"PeriodicalIF":0.0,"publicationDate":"2001-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91343108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Clinical significance of preheparin serum lipoprotein lipase mass in coronary vasospasm. 肝素前期血清脂蛋白脂肪酶团块在冠状动脉痉挛中的临床意义。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.539

T. Hitsumoto, K. Yoshinaga, H. Noike, M. Kanai, K. Shirai

{"title":"Clinical significance of preheparin serum lipoprotein lipase mass in coronary vasospasm.","authors":"T. Hitsumoto, K. Yoshinaga, H. Noike, M. Kanai, K. Shirai","doi":"10.1253/JCJ.65.539","DOIUrl":"https://doi.org/10.1253/JCJ.65.539","url":null,"abstract":"The present study investigated the clinical significance of preheparin serum lipoprotein lipase (LPL) mass in coronary vasospasm by examining its relationship with the acetylcholine-induced coronary artery response in patients without angiographically demonstrable atherosclerotic coronary artery disease (CAD). The subjects were 39 men who had suspected CAD and who underwent coronary angiography. Coronary vasospasm was defined as a marked luminal narrowing or total occlusion provoked by the intracoronary administration of acetylcholine. Preheparin LPL mass was lower (p<0.05) in 25 subjects in whom vasospasm was induced by the acetylcholine provocation test than in the 14 subjects with a negative response. As regards preheparin LPL mass, the subjects with multiple vessel spasm had significantly low concentrations (p<0.05) compared with single vessel spasm, although serum lipid levels were not significantly different. Multiple regression analysis revealed only preheparin LPL mass had a significant absolute t-value (2.016) among the coronary risk factors. Low preheparin LPL mass is interpreted as reflecting an impaired acetylcholine-induced coronary relaxation in coronary vasospasm and preheparin LPL mass may be useful as a marker of early stage coronary atherosclerosis that is not detectable by angiography.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"10 1","pages":"539-44"},"PeriodicalIF":0.0,"publicationDate":"2001-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77025121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Monophasic transmitral flow pattern with less increase in heart rate indicates left ventricular dysfunction. 心率增加较少的单相递质血流模式提示左心室功能不全。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.545

K. Matsukida, Y. Otsuji, S. Hamasaki, S. Yoshifuku, T. Kumanohoso, C. Fujiyama-Koriyama, A. Kisanuki, S. Minagoe, C. Tei

{"title":"Monophasic transmitral flow pattern with less increase in heart rate indicates left ventricular dysfunction.","authors":"K. Matsukida, Y. Otsuji, S. Hamasaki, S. Yoshifuku, T. Kumanohoso, C. Fujiyama-Koriyama, A. Kisanuki, S. Minagoe, C. Tei","doi":"10.1253/JCJ.65.545","DOIUrl":"https://doi.org/10.1253/JCJ.65.545","url":null,"abstract":"When heart rate (HR) increases, mitral flow can become monophasic. Prolonged isovolumic contraction and relaxation time (ICT and IRT), directly related to left ventricular (LV) function, can potentially influence the HR with monophasic mitral flow. The present study investigated the relation between HR that causes monophasic flow and LV function. During diagnostic catheterization, HR was increased using right atrial pacing by 2 beats/min every 2 min in a stepwise manner until the development of monophasic mitral flow in 17 patients with normal sinus rhythm. ICT, IRT, end-diastolic and end-systolic LV volumes, LV ejection fraction, LV peak + and -dP/dt, peak (+dP/dt)/P, and the relaxation time constant (tau) were measured by Doppler echocardiography or catheterization when monophasic mitral flow developed. The monophasic HR varied from 74 to 106 beats/min. By univariate analysis, ICT (p<0.01, r2=0.73), LV peak +dP/dt (p<0.05, r2=0.37), peak (+dP/dt)/P (p<0.01, r2=0.71), peak -dP/dt (p<0.05, r2=0.25), and tau (p<0.05, r2=0.33) had a significant correlation with monophasic HR. By multivariate analysis, prolonged ICT and reduced LV peak -dP/dt independently contributed to monophasic mitral flow with less increase in HR. Monophasic mitral flow with less increase in HR indicates impaired LV systolic and diastolic function during isovolumic contraction and relaxation.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"14 1","pages":"545-9"},"PeriodicalIF":0.0,"publicationDate":"2001-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84581373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Imbalance of cusp width and aortic regurgitation associated with aortic cusp prolapse in ventricular septal defect. 室间隔缺损患者主动脉瓣尖脱垂与瓣宽不平衡及主动脉瓣反流相关。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.500

H. Tomita, Yoshio Arakaki, Yasuo Ono, Osamu Yamada, T. Yagihara, S. Echigo

{"title":"Imbalance of cusp width and aortic regurgitation associated with aortic cusp prolapse in ventricular septal defect.","authors":"H. Tomita, Yoshio Arakaki, Yasuo Ono, Osamu Yamada, T. Yagihara, S. Echigo","doi":"10.1253/JCJ.65.500","DOIUrl":"https://doi.org/10.1253/JCJ.65.500","url":null,"abstract":"The Doppler echocardiograms of the aortic valve and associated aortic regurgitation (AR) were reviewed in 72 patients with a ventricular septal defect (VSD). Group I comprised 13 patients without any deformity of the aortic cusp for > or = 10 years, group 2 included 35 patients who did not develop AR for > or = 10 years after right coronary cusp prolapse (RCCP) was first detected, group 3 comprised 11 patients with RCCP and AR in whom the AR remained subclinical for > or = 10 years, and group 4 was 13 patients who underwent surgical treatment because of moderate to severe AR. The cusp imbalance index [width of right (R) or non- (N) coronary cusp/width of left coronary cusp (L)] was compared among the 4 groups. R/L or N/L was larger in group 4 than in groups 1-3; R/L exceeded 1.30 in all the patients in group 4, whereas it was less than 1.30 in all the atients in groups 1-3. Two patients in group 4 with non-coronary cusp prolapse had an N/L greater than 1.50. No other patients in any group had an N/L larger than 1.20. An imbalance of cusp width may predict possible progressive deterioration of AR.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"6 1","pages":"500-4"},"PeriodicalIF":0.0,"publicationDate":"2001-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85364309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Large thrombus in the ascending aorta successfully treated by thrombolysis--an unusual cause of acute massive myocardial infarction. 大血栓在升主动脉成功治疗溶栓-一个不寻常的原因急性大面积心肌梗死。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.572

H. Ito, K. Takahashi, H. Sasaki, H. Akiho, Y. Katahira, H. Saito, T. Ishibashi

引用次数: 28

Difference in thioredoxin expression in viral myocarditis in inbred strains of mice. 小鼠近交系病毒性心肌炎中硫氧还蛋白表达的差异。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.561

M. Miyamoto, C. Kishimoto, K. Shioji, H. Nakamura, S. Toyokuni, Y. Nakayama, M. Kita, J. Yodoi, S. Sasayama

引用次数: 15

Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus. 胰岛素增敏降糖药曲格列酮对非胰岛素依赖型糖尿病患者冠状动脉循环的有益影响。

Japanese circulation journal Pub Date : 2001-05-20 DOI: 10.1253/JCJ.65.487

M. Sekiya, J. Suzuki, K. Watanabe, J. Funada, T. Otani, H. Akutsu

{"title":"Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus.","authors":"M. Sekiya, J. Suzuki, K. Watanabe, J. Funada, T. Otani, H. Akutsu","doi":"10.1253/JCJ.65.487","DOIUrl":"https://doi.org/10.1253/JCJ.65.487","url":null,"abstract":"Evidence is increasing for small vessel remodeling and disturbance of endothelium-dependent vasodilation in diabetic patients. Insulin increases vascular wall thickening and produces endothelial dysfunction. Troglitazone, a new insulin-sensitizer antidiabetic agent, is considered to reduce plasma insulin level and the present study assessed its effect on the coronary circulation of the patients with non-insulin-dependent diabetes mellitus (NIDDM). Analysis of the myocardial washout rate with adenosine triphosphate-stress thallium-201 scintigraphy was used to estimate coronary circulation, and for estimation of insulin sensitivity, the homeostasis model insulin resistance index (HOMA-R) was calculated. Patients were treated with monotherapy of either troglitazone (200 mg bid, n=12) or glibenclamide (2.5 mg daily, n=12) for 3 months. Age-, sex- and risk factors-matched subjects without NIDDM were employed as a control. Fasting plasma glucose and hemoglobin A1c were similarly decreased by troglitazone or glibenclamide. Plasma insulin level (pmol/L) decreased from 66.6+/-10.8 to 39.0+/-7.2 with troglitazone, but was unchanged by glibenclamide (58.8+/-7.2 to 66.0+/-10.8). The diabetic groups had a significantly lower washout rate than controls, which was improved by troglitazone, but not by glibenclamide. In addition, the increase in washout rate correlated significantly with the decrease in HOMA-R in the troglitazone group. In conclusion, troglitazone can restore coronary circulation by improving insulin resistance in patients with NIDDM.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"52 1","pages":"487-90"},"PeriodicalIF":0.0,"publicationDate":"2001-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73461621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21