Japanese circulation journal最新文献

Th1/Th2 balance alteration in the clinical course of a patient with acute viral myocarditis. 1例急性病毒性心肌炎患者临床过程中Th1/Th2平衡的改变

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1082

K. Fuse, M. Kodama, Y. Aizawa, M. Yamaura, Y. Tanabe, K. Takahashi, K. Sakai, T. Miida, H. Oda, N. Higuma

引用次数: 22

Coronary vasomotor responses to bradykinin and acetylcholine in patients with coronary spastic angina. 缓激肽和乙酰胆碱对冠心病痉挛性心绞痛患者冠状动脉血管舒缩反应的影响。

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1052

T. Matsumoto, H. Horie, K. Minai, H. Yokohama, H. Takashima, N. Ohira, T. Tsutui, M. Takahashi, M. Kinoshita

{"title":"Coronary vasomotor responses to bradykinin and acetylcholine in patients with coronary spastic angina.","authors":"T. Matsumoto, H. Horie, K. Minai, H. Yokohama, H. Takashima, N. Ohira, T. Tsutui, M. Takahashi, M. Kinoshita","doi":"10.1253/JCJ.65.1052","DOIUrl":"https://doi.org/10.1253/JCJ.65.1052","url":null,"abstract":"It is unclear whether coronary endothelial function is linked to the pathogenesis of coronary spastic angina (CSA), so the present study examined the coronary vasomotor responses to acetylcholine (ACh) and bradykinin (BK) in 23 patients with CSA, 26 patients with CSA+coronary artery disease (CAD), and 21 control patients. Acetylcholine induced vasospasm of the left coronary artery in all of the patients with CSA, but not in any of the control patients. The changes in dilatation of the left coronary artery in response to bradykinin at doses of 0.2, 0.6 and 2.0 microg/min in the CSA group were significantly greater than those in the other 2 groups. The ratio of epicardial coronary vasodilations induced by BK to those induced by nitroglycerin did not differ among any of the groups. Bradykinin caused a similar increase in coronary blood flow in the control group and CSA group, but had less of an effect in the CSA+CAD group. In conclusion, the vasorelaxing effect of BK was preserved not only in epicardial spasm coronary arteries induced by ACh, but also in resistance coronary arteries distal to the spasm arteries in patients with CSA. The coronary vasodilation response induced by BK may not deteriorate until coronary atherosclerosis advances in patients with CSA.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"2 1","pages":"1052-6"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87576821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Vasospastic total occlusion at the left main tract in a single coronary artery. 单根冠状动脉左主干血管痉挛性全闭塞。

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1091

Y. Maejima, T. Yasu, N. Fujiwara, T. Ishida, Y. Kobayashi, M. Kuroki, N. Kubo, M. Fujii, M. Saito

引用次数: 3

Improving glucose metabolism and/or sarcoplasmic reticulum Ca2+-ATPase function is warranted for immature pressure overload hypertrophied myocardium. 改善葡萄糖代谢和/或肌浆网Ca2+- atp酶功能对未成熟的压力过载肥厚心肌是必要的。

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1064

K. Takeuchi, M. Nagashima, K. Itoh, M. Minagawa, M. Munakata, I. Ichinoseki, K. Fukui, F. McGowan, P. D. del Nido

{"title":"Improving glucose metabolism and/or sarcoplasmic reticulum Ca2+-ATPase function is warranted for immature pressure overload hypertrophied myocardium.","authors":"K. Takeuchi, M. Nagashima, K. Itoh, M. Minagawa, M. Munakata, I. Ichinoseki, K. Fukui, F. McGowan, P. D. del Nido","doi":"10.1253/JCJ.65.1064","DOIUrl":"https://doi.org/10.1253/JCJ.65.1064","url":null,"abstract":"The cellular mechanisms of abnormal calcium regulation and excitation-contraction coupling in relation to glucose metabolism in the hypertrophied heart are not well understood. The present study evaluated the myocardial mechanics of 6-7-week-old pressure overload hypertrophied rabbit hearts in response to dobutamine by (1) serial echocardiograms in vivo and (2) isolated Langendorff perfusion. Cytosolic Ca2+([Ca2+]i) and sarcoplasmic reticulum Ca2+-ATPase (SERCA2) expression were measured by fluorescence spectroscopy and Western immunoblotting, respectively. The effect of glycolytic inhibition by 2-deoxy-D-glucose +/- pyruvate was also evaluated. Both systolic and diastolic [Ca2+]i tended to be higher and diastolic calcium removal (tauCa) significantly slower in the hypertrophied heart. The myocardial response to dobutamine was blunted and dobutamine insignificantly improved tauCa. The SERCA2 protein level was higher in early hypertrophy, but was significantly reduced by 6 weeks of age, with progressive contractile failure. Inhibition of glycolysis or SERCA2 caused an increase in [Ca2+]i as well as a slower tauCa. Pyruvate completely preserved myocardial function and [Ca2+]i handling during glycolytic inhibition. It was concluded that in this model of advanced pressure overload hypertrophy, contractile failure and inotrope insensitivity are associated with increased [Ca2+]i, slower tauCa and reduced sensitivity of the contractile proteins to Ca2+. These changes occur in association with downregulation of the SERCA2, probably caused by impaired glucose metabolism.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"34 1","pages":"1064-70"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82718714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Spectral characteristics of human atrial fibrillation waves of the right atrial free wall with respect to the duration of atrial fibrillation and effect of class I antiarrhythmic drugs. 人右心房游离壁心房颤动波的频谱特征与房颤持续时间及I类抗心律失常药物的作用

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1047

A. Fujiki, H. Nagasawa, M. Sakabe, Kenji Sakurai, K. Nishida, K. Mizumaki, Hiroshi Inoue

{"title":"Spectral characteristics of human atrial fibrillation waves of the right atrial free wall with respect to the duration of atrial fibrillation and effect of class I antiarrhythmic drugs.","authors":"A. Fujiki, H. Nagasawa, M. Sakabe, Kenji Sakurai, K. Nishida, K. Mizumaki, Hiroshi Inoue","doi":"10.1253/JCJ.65.1047","DOIUrl":"https://doi.org/10.1253/JCJ.65.1047","url":null,"abstract":"The aim of this study was to use fast Fourier transform analysis to clarify the characteristics of human atrial fibrillation (AF) waves with respect to the duration of AF and the effect of class I antiarrhythmic drugs. Twenty-two patients (10 paroxysmal AF, 12 persistent AF) without organic heart disease were studied by conventional electrophysiological methods. Electrograms were recorded from the right atrial free wall during AF and spectral analysis was performed for 35s (16 consecutive 4096-ms epochs with 50% overlap) and the fibrillation cycle length (FCL) was calculated from the peak frequency. Mean FCL and SD were determined from 16-epoch data, and the temporal variability of FCL was defined as the SD of FCL. Paroxysmal AF had a longer mean FCL than persistent AF (178+/-26ms vs 139+/-16 ms, p<0.001) and AF duration had a significant inverse correlation with mean FCL (r=-0.79, p<0.001). The temporal variability of FCL was significantly greater in paroxysmal AF than in persistent AF (p<0.05) and there was a significant positive correlation between the mean FCL and the temporal variability of FCL (r=0.66, p<0.001). In 8 of 18 patients given a class I antiarrhythmic drug (cibenzoline or procainamide), AF was terminated and in those patients the mean FCLs before administration of class I drugs were significantly greater than in patients without AF termination. With respect to mean FCL before drug administration, conversion occurred in 100% of patients with FCL > or =168 ms and in 17% of those with FCL <168 ms. A longer duration of AF shortens the mean FCL, which is consistent with atrial electrical remodeling. Class I drugs prolong the mean FCL above a critical level and will terminate AF, which can be estimated from the mean FCL before drug administration.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"78 1","pages":"1047-51"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79222747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Differences in the expression of protein kinase C isoforms and its translocation after stimulation with phorbol ester between young-adult and middle-aged ventricular cardiomyocytes isolated from Fischer 344 rats. 菲舍尔344大鼠分离的青壮年和中年心室心肌细胞中蛋白激酶C同工型的表达及其易位的差异

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1071

M. Takayama, Y. Ebihara, M. Tani

{"title":"Differences in the expression of protein kinase C isoforms and its translocation after stimulation with phorbol ester between young-adult and middle-aged ventricular cardiomyocytes isolated from Fischer 344 rats.","authors":"M. Takayama, Y. Ebihara, M. Tani","doi":"10.1253/JCJ.65.1071","DOIUrl":"https://doi.org/10.1253/JCJ.65.1071","url":null,"abstract":"It is known that the tolerance against ischemia-reperfusion and the effects of preconditioning decrease in aged hearts, but the mechanisms responsible for this diminished ischemic tolerance and reduced efficacy of preconditioning remain unknown. To determine the age-related changes in these mechanisms, protein kinase C (PKC) isoform expression and its translocation by phorbol ester were analyzed because PKC is believed to be involved in preconditioning. Immunoblotting and immunostaining analysis were performed with isoform-specific PKC antibodies using cardiomyocytes isolated from young-adult (12-week-old: 12W) and middle-aged (50-week-old: 50W) Fischer 344 rats. There was significantly greater PKC-delta expression in both the cytosolic and membrane fractions of 12W cardiomyocytes than in 50W ones. Exposure of cardiomyocytes to 100 nmol/L 4-beta-phorbol 12-myristate 13-acetate (PMA) caused translocation of PKC-delta from the cytosol to the membrane in the 12W group, whereas in the 50W group, the translocation was attenuated. Immunostaining confirmed the PKC-delta translocation in the 12W cardiomyocytes. Oil pellet examination showed that the translocation of PKC-delta induced by preconditioning was associated with cell protection from ischemic injury in the 12W group only. Age-related changes in PKC isoform expression and activation in cardiomyocytes might be responsible for the reduced ischemic tolerance and less efficient preconditioning that accompanies aging.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"42 1","pages":"1071-6"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77896435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Spontaneous onset of torsade de pointes in long-QT syndrome and the role of sympathovagal imbalance. 长qt综合征自发性椎体扭转及交感迷走神经失衡的作用。

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1087

A. Fujiki, K. Nishida, K. Mizumaki, H. Nagasawa, M. Shimono, H. Inoue

{"title":"Spontaneous onset of torsade de pointes in long-QT syndrome and the role of sympathovagal imbalance.","authors":"A. Fujiki, K. Nishida, K. Mizumaki, H. Nagasawa, M. Shimono, H. Inoue","doi":"10.1253/JCJ.65.1087","DOIUrl":"https://doi.org/10.1253/JCJ.65.1087","url":null,"abstract":"The net effects of sympathetic and vagal activity on the QT interval and the mode of spontaneous onset of torsade de pointes (TdP) are still unclear in long-QT syndrome. Two patients with long-QT syndrome had syncope while undergoing Holter ECG investigation. The spontaneous onset of TdP in these patients was analyzed with respect to the relation between the RR and QT intervals. Both patients were high-school students (16- and 17-year-old boys) who had been diagnosed as long-QT syndrome and followed up without medical treatment because they had had neither a history of syncope nor arrhythmia induction by treadmill exercise tests. The first episode of syncope in both patients occurred during ordinary daily life and was not related to exercise or psychological stress. The dynamic changes between the RR and QT intervals associated with the spontaneous onset of TdP were analyzed by Holter ECG. Both patients showed sinus tachycardia followed by abrupt sinus bradycardia immediately before the onset of TdP. The enhanced rate of the adaptive response of the QT interval that occurred during the deceleration of the heart rate preceded the onset of TdP. These observations suggest that the complex situation that follows sympathovagal imbalance may have an important role in the dynamic change in the QT interval and initiation of TdP in patients with long-QT syndrome.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"20 1","pages":"1087-90"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73936166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Coronary revascularization in Japan. Part 1: survey of facilities during 1997. 日本的冠状动脉重建术。第1部分:1997年的设施调查。

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1005

M. Shihara, H. Tsutsui, M. Tsuchihashi, H. Shigematsu, S. Yamamoto, G. Koike, S. Kono, A. Takeshita

{"title":"Coronary revascularization in Japan. Part 1: survey of facilities during 1997.","authors":"M. Shihara, H. Tsutsui, M. Tsuchihashi, H. Shigematsu, S. Yamamoto, G. Koike, S. Kono, A. Takeshita","doi":"10.1253/JCJ.65.1005","DOIUrl":"https://doi.org/10.1253/JCJ.65.1005","url":null,"abstract":"Coronary artery disease is one of the major causes of morbidity and mortality in industrialized countries, including Japan. Increasing numbers of patients have been treated with percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), but there is little information in Japan concerning the use of revascularization therapy and the facilities. The Japanese Coronary Intervention Study (JCIS) Group conducted a nationwide survey on coronary revascularization procedures and facilities during 1997. A questionnaire was mailed to the presidents or designated delegates of 8,253 laboratories in 7,986 hospitals that had departments of internal medicine and/or cardiovascular medicine and to 578 facilities in 558 hospitals identified by the PCI survey as performing CABG and/or registered in the annual survey carried out by the Japanese Association for Thoracic Surgery. A total of 109,788 PCIs were performed at 1,023 laboratories, and 17,667 CABGs at 477 facilities. PCI and CABG numbers per 10(6) population were 870 and 140, respectively. The ratio of PCI to CABG was 6.2. The numbers of PCI laboratories and CABG facilities per 10(6) population were 8.1 and 3.8, respectively. The majority of PCI laboratories and CABG facilities had a small annual volume: 44% of PCI laboratories and 77% of CABG facilities had annual volumes of 50 or less. Only half of the PCI laboratories had surgical backup on-site. Despite the small volume for each facility, coronary revascularization, especially PCI, is highly utilized in Japan.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"12 1","pages":"1005-10"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87193402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Comparison of glucose-insulin-thallium-201 infusion single photon emission computed tomography (SPECT), stress-redistribution-reinjection thallium-201 SPECT and low dose dobutamine echocardiography for prediction of reversible dysfunction. 葡萄糖-胰岛素-铊-201输注单光子发射计算机断层扫描(SPECT)、应力再分布-再注射铊-201 SPECT和低剂量多巴酚丁胺超声心动图预测可逆性功能障碍的比较。

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1017

H. Sakamoto, M. Kondo, M. Motohiro, S. Usami

{"title":"Comparison of glucose-insulin-thallium-201 infusion single photon emission computed tomography (SPECT), stress-redistribution-reinjection thallium-201 SPECT and low dose dobutamine echocardiography for prediction of reversible dysfunction.","authors":"H. Sakamoto, M. Kondo, M. Motohiro, S. Usami","doi":"10.1253/JCJ.65.1017","DOIUrl":"https://doi.org/10.1253/JCJ.65.1017","url":null,"abstract":"The usefulness of glucose-insulin-thallium-201 (GI-Tl) infusion single photon emission computed tomography (SPECT) in predicting reversible dysfunction has not been evaluated, so the present study recruited 20 patients with regional ischemic dysfunction for investigation. All patients underwent GI-Tl SPECT, post-stress Tl reinjection imaging and low dose dobutamine echocardiography. The diagnostic accuracy of these 3 techniques in predicting functional recovery was evaluated by receiver operating characteristic (ROC) analysis. In segments with functional recovery, regional Tl activities of GI-Tl SPECT were significantly higher than those of reinjection imaging (p<0.05), although there were no significant differences in segments without recovery. The area under the ROC curve for GI-Tl SPECT (0.75+/-0.06) was greater than that for reinjection imaging (0.68+/-0.07). The optimal cutoff values to identify viable myocardium were considered to be 55% of peak activity for GI-Tl SPECT and 50% for reinjection imaging. At this cutoff point, the sensitivity and specificity for detection of functional recovery were, respectively, 85% and 61% for GI-Tl SPECT, and 73% and 61% for reinjection imaging. Dobutamine echocardiography had the same sensitivity (85%), but lower specificity (48%) than GI-Tl SPECT. Continuous infusion of GI-Tl solution enhances regional Tl uptake compared with conventional post-stress reinjection imaging. This study suggests that GI-Tl SPECT is superior to reinjection imaging and dobutamine echocardiography in predicting functional recovery after ischemic left ventricular dysfunction.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"116 1","pages":"1017-21"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77208182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Electrophysiological characteristics and radiofrequency ablation of focal atrial tachycardia originating from the superior vena cava. 源自上腔静脉的局灶性房性心动过速的电生理特征和射频消融。

Japanese circulation journal Pub Date : 2001-11-20 DOI: 10.1253/JCJ.65.1034

K. Chang, Y. C. Lin, J. Chen, H. Chou, J. Hung

{"title":"Electrophysiological characteristics and radiofrequency ablation of focal atrial tachycardia originating from the superior vena cava.","authors":"K. Chang, Y. C. Lin, J. Chen, H. Chou, J. Hung","doi":"10.1253/JCJ.65.1034","DOIUrl":"https://doi.org/10.1253/JCJ.65.1034","url":null,"abstract":"The initiation of focal atrial tachycardia (AT) from the superior vena cava (SVC) remains unclear. In 3 patients (2 females, 1 male; aged 57, 66 and 50 years, respectively) with focal AT arising from different parts of the SVC, the AT occurred spontaneously, rather than being induced by electrical stimulation. The cycle length of the tachycardia was highly variable, ranging between 190 and 300 ms in patient 1, 180 and 320ms in patient 2, and 200 and 300ms in patient 3. The clinical or associated arrhythmias were atrial fibrillation (AF) (patients 1, 3) and atrial flutter (AFL) (patients 2, 3). A presumed SVC potential that was earlier than the activation of all the other mapping sites was recorded during AT at the lower anterior (15-mm above the atriocaval junction), the mid-anterior (25-mm above the atriocaval junction) and the lower posterior aspect of the SVC (17-mm above the atriocaval junction. Radiofrequency (RF) ablation targeting the SVC focus with the SVC potential promptly eliminated the focal AT in all 3 patients. The coexistent typical AFL was ablated, but the AF was not. The follow-up period was 6, 6, and 3 months, respectively, for each of the patients under no antiarrhythmic medication; there has not been a recurrence of symptomatic palpitation. In conclusion, focal electrical firing in the SVC can initiate AT and this type of focal AT is always associated with AFL or AF. RF ablation guided by the presumed SVC potential is safe and highly effective in eliminating the tachycardia.","PeriodicalId":14544,"journal":{"name":"Japanese circulation journal","volume":"19 1","pages":"1034-40"},"PeriodicalIF":0.0,"publicationDate":"2001-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78810269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19