Iranian Endodontic Journal最新文献

{"title":"Dissimilar Sequelae Caused by Single Dental Trauma: A Case Report with Long-Term Follow-up.","authors":"Marisa Nogueira Alencar, Tatiana Carvalho Kowaltschuk, Mariana Martins Juglair, Alexandre Kowalczuck, Everdan Carneiro, Ulisses Xavier da Silva Neto, Vânia Portela Ditzel Westphalen","doi":"10.22037/iej.v19i3.44264","DOIUrl":"10.22037/iej.v19i3.44264","url":null,"abstract":"<p><p>Immediate care and accurate diagnosis are essential for treating dental trauma. This report presents a 7-year-old boy suffered a bicycle accident with direct trauma to the mouth and extrusive luxation of teeth #11 and #21. The emergency treatment was performed within the first hour. Clinical examinations showed that both teeth exhibited 3 mm extrusion from comparing their incisal edges to their neighboring teeth, had edematous gingiva, showed grade 3 mobility and were painful to percussion. Radiographic exams showed incomplete root formation, widened periodontal spaces along their entire lengths and absence of bone or root fractures. The treatment consisted of immediate repositioning and semi-rigid splinting. After 15 days, tooth #11 exhibited no clinical signor symptom and tooth #21 was diagnosed with pulp necrosis, with an acute dentoalveolar abscess and intraoral edema. Immediate endodontic treatment was initiated (intracanal dressing with calcium hydroxide paste). At 30 days, another pulp sensibility test was performed on tooth #11, which had a negative response. In the same visit, the intracanal dressing of tooth #21 was replaced. The Ca(OH)₂ medication was replaced every 6 months until the formation of an apical barrier. The final dressing consisted of gutta-percha and Grossman's sealer and was placed two and a half years after the first dressing appointment. The extrusive luxation resulted in two different sequelae: complete root obliteration in tooth #11 and anomalous root development after the formation of an apical barrier in tooth #21. The patient received orthodontic treatment after 6 years from the initial treatment with no negative outcome. After 18 years follow-up, both teeth were stabilized with no symptom or sign. It's important to follow the evolution of every trauma case continuously because the sequelae can be unpredictable.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 3","pages":"237-241"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success of Nonsurgical Endodontically Treated Posterior Teeth with Complex Restorative/Prosthodontic Treatments: A Retrospective Study.","authors":"Mohammadreza Vatankhah, Hengameh Ashraf, Forough Jamalian, Sepehr Talebi, Alireza Akbarzadeh Baghban, Kamyar Khosravi, Nazanin Zargar","doi":"10.22037/iej.v19i4.43587","DOIUrl":"10.22037/iej.v19i4.43587","url":null,"abstract":"<p><strong>Introduction: </strong>Endodontic therapy has been regarded as a safe treatment option with highly promising results in preserving natural teeth. Numerous factors may influence the longevity of endodontically treated teeth (ETT), thus altering their success/survival rate. This study aimed to determine the survival and success rates of endodontically treated premolars and molars with different complex restorative/prosthodontic treatments.</p><p><strong>Materials and methods: </strong>A total of 190 patients with an ETT were included, who had received final coronal restoration up to 14 days after the temporary one and at least one year prior to the enrollment. The investigator evaluated the quality of endodontic filling, coronal restoration, mobility, and proximal contacts. Data were analyzed with multiple binary logistic regression and the Chi-Square test.</p><p><strong>Results: </strong>The average duration of follow-up was 28.6±11.9 months. Overall, 89.4% (170/190) of the teeth survived. The overall success rate for the investigated teeth was 70.5% (134/190). Success rates of 100% for crown, 95.7% for post and core crown (PCC), and 94.7% for amalgam build-up with post were achieved. However, the success rates were 75%, 52.5%, and 50% for amalgam build-up, composite build-up, and PCC with crown lengthening, respectively. The Chi-square test revealed that there was a significant difference between the different restorations in terms of success (<i>P</i><0.001). Multiple binary logistic regression models revealed that coronal leakage (<i>P</i>=0.048), obturation void (<i>P</i>=0.037), obturation length (<i>P</i>=0.020), mobility (<i>P</i>=0.002), type of the restoration (<i>P</i><0.001), and proximal contact (<i>P</i><0.001) were significant predictors for success. However, apical lucency, root length, marginal caries, tooth type, and post did not appear to be significant indicators of success (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>ETT with minimal mobility, exhibiting underfilled obturations without visible voids, and having received crown/PCC/amalgam build-up with a post, along with the presence of both proximal contacts, tend to exhibit a significantly high success rate.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 4","pages":"263-269"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Supplementary Cleaning Techniques for Removal of Bio-C Sealer and AH-Plus from Oval Root Canals: A Micro-CT Analysis.","authors":"Iris Nogueira Bincelli Seckler, Rina Andréa Pelegrine, Carolina Pessoa Stringheta, Ricardo Tadeu Lopes, Aline Saddock de Sá Silva, Carlos Eduardo da Silveira Bueno","doi":"10.22037/iej.v19i3.43580","DOIUrl":"10.22037/iej.v19i3.43580","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare the effectiveness of two endodontic cleaning techniques, passive ultrasonic irrigation (PUI) and the XP-endo Finisher R (XPR) system, in removing residual filling material during endodontic retreatment procedures.</p><p><strong>Materials and methods: </strong>Forty mandibular premolars with oval canals were divided into four groups based on the sealer used (AH-Plus or Bio-C Sealer) and the cleaning technique employed (PUI or XPR). To ensure uniformity of canal volume among groups, initial micro-CT scans were conducted. The canals were instrumented, filled, and then re-instrumented before undergoing either PUI or XPR cleaning techniques. Residual filling material volumes were assessed through micro-CT scans, and statistical analysis was performed using the Kruskal-Wallis and Mann-Whitney U tests.</p><p><strong>Results: </strong>Following instrumentation, there was no significant difference in residual filling material volumes between AH-Plus and Bio-C Sealer groups (1.35 mm³and 1.02 mm³, respectively; <i>P</i>>0.05). However, after supplementary cleaning techniques, XPR-cleaned specimens exhibited significantly less residual material compared to PUI-cleaned specimens (0.01 mm³ and 0.29 mm³ for Bio-C Sealer, and 0.07 mm³ and. 0.30 mm³ for AH-Plus, <i>P</i><0.05).</p><p><strong>Conclusion: </strong>The XPR system was found to be more effective than PUI in removing residual filling material from Bio-C Sealer-filled root canals. This highlights its potential as a useful supplementary cleaning technique in endodontic retreatment procedures.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 3","pages":"199-207"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Foraminal Enlargement on Periapical Healing in Necrotic Teeth: A Systematic Review.","authors":"Gustavo Oliveira Campos, Alexandre Henrique Dos Reis Prado, Isabella Figueiredo de Assis Macedo, Isabella da Costa Ferreira, Gabriela da Costa Ferreira, Francine Benetti, Isabella Faria da Cunha Peixoto, Ana Cecília Diniz Viana","doi":"10.22037/iej.v19i2.44037","DOIUrl":"https://doi.org/10.22037/iej.v19i2.44037","url":null,"abstract":"<p><strong>Introduction: </strong>Foraminal Enlargement (FE) is a cleaning performed in the apical-most region of the tooth, in order to optimize root disinfection. This systematic review evaluated the influence of FE during root canal treatment on bacterial reduction and repair of the periapical lesion.</p><p><strong>Materials and methods: </strong>Searches in PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, Scielo, Lilacs and OpenGrey were performed until January-2024. <i>Ex vivo</i> and <i>in vivo</i> studies evaluating the effects of FE in the bacterial reduction and repair of the periapical lesion were included, respectively, followed by risk of bias assessment (modified version of Joanna Briggs Institute's for <i>ex vivo</i> studies and Systematic Review Centre for Laboratory animal Experimentation's risk of bias tools for <i>in vivo</i> studies). The meta-analysis was not feasible and a qualitative summary for each outcome was provided.</p><p><strong>Results: </strong>Of 950 studies, 2 <i>in vivo</i> studies were eligible, using animal models with infected teeth. Of these two, periapical repair was evaluated with hematoxylin-eosin stain, and FE improved periapical healing. Regarding <i>ex vivo</i> studies, 3 were eligible, using extracted human teeth. The inoculations in <i>ex vivo</i> models were performed with <i>Enterococcus</i> <i>(E.) faecalis,</i> and FE reduced <i>E. faecalis</i> in the <i>ex vivo</i> models.</p><p><strong>Conclusions: </strong>Foraminal enlargement seems to increase bacterial reduction within the root canal, and provide major periapical tissue repair on the histological analysis in animal studies. However, caution is necessary when translating these results to the clinical environment.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 2","pages":"75-84"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Chronicles: A Case Report on Pink Tooth of Mummery.","authors":"Simran Kriplani, Joyeeta Mahapatra, Shweta Sedani, Anuja Ikhar, Aditya Patel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Internal tooth resorption is a subtle proceeding typically occurring in teeth with a history of trauma, chronic pulpal inflammation, or caries-related issues. It is frequently observed in anterior teeth that are more vulnerable and susceptible to injury, but can also affect posterior teeth, often due to pulp involvement in caries. This case report illustrates the handling of a resorption in the cervical third of the root. A 28-year-old female patient was referred for endodontic and esthetic treatment for her primary complaint of pink spot staining in her upper left central incisor's crown. The tooth had symptomatic apical periodontitis. Final Diagnosis was Class 4 invasive cervical resorption. This case study outlines the effective management of an extensive internal root resorption using a non-surgical approach and the application of MTA as repairing material with thermo-plascticized gutta-percha as an obturation material. The treatment resulted in the resolution of symptoms and the restoration of periapical tissues. Timely detection, addressing the underlying cause, and effective care of the invasive cervical resorption are essential for achieving a favorable treatment outcome. Obtaining positive results required a patient-centered approach, well-planned therapy, and an accurate diagnosis.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 4","pages":"291-295"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Endodontics: A Scoping Review.","authors":"Saeed Asgary","doi":"10.22037/iej.v19i2.44842","DOIUrl":"10.22037/iej.v19i2.44842","url":null,"abstract":"<p><p>Artificial intelligence (AI) is transforming the diagnostic methods and treatment approaches in the constantly evolving field of endodontics. The current review discusses the recent advancements in AI; with a specific focus on convolutional and artificial neural networks. Apparently, AI models have proved to be highly beneficial in the analysis of root canal anatomy, detecting periapical lesions in early stages as well as providing accurate working-length determination. Moreover, they seem to be effective in predicting the treatment success next to identifying various conditions e.g., dental caries, pulpal inflammation, vertical root fractures, and expression of second opinions for non-surgical root canal treatments. Furthermore, AI has demonstrated an exceptional ability to recognize landmarks and lesions in cone-beam computed tomography scans with consistently high precision rates. While AI has significantly promoted the accuracy and efficiency of endodontic procedures, it is of high importance to continue validating the reliability and practicality of AI for possible widespread integration into daily clinical practice. Additionally, ethical considerations related to patient privacy, data security, and potential bias should be carefully examined to ensure the ethical and responsible implementation of AI in endodontics.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 2","pages":"85-98"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Mandibular Molar Root Length on Success in Supplemental Intraligamentary Injection for Irreversible Pulpitis.","authors":"Marzieh Kamali, Masoud Parirokh, Hamed Manochehrifar, Nouzar Nakhaei","doi":"10.22037/iej.v19i1.42660","DOIUrl":"10.22037/iej.v19i1.42660","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the influence of root length in mandibular molars with irreversible pulpitis on the success of supplemental intraligamentary injection following an inferior alveolar nerve (IAN) block. Various factors, including anatomical location, tooth type, and anesthetic solution, may affect supplemental anesthesia success.</p><p><strong>Materials and methods: </strong>A total of 251 patients diagnosed with irreversible pulpitis in mandibular first or second molars underwent buccal infiltration anesthesia (4% articaine with 1:100,000 epinephrine) after IAN block injection (3% prilocaine and 0.03 IU/mL of felypressin). Fifty patients experiencing pain during access cavity preparation received supplemental intraligamentary injection (0.3 mL of 2% lidocaine with 1:80,000 epinephrine) at each mesial and distal line angle. The root length of treated teeth was recorded using an apex locator. Data analysis involved independent t-tests, Chi-square tests, and logistic regression.</p><p><strong>Results: </strong>Successful supplemental intraligamentary injection was observed in 21 (42%) out of 50 patients. No significant correlation was found between the mean length of mesiobuccal (<i>P</i>=0.61), mesiolingual (<i>P</i>=0.34), or distal (<i>P</i>=0.60) canals of mandibular molars and the injection's success. Logistic regression analysis, however, revealed a significant impact of mesiolingual canal length on the success rate [OR 0.09 (0.01-0.79), <i>P</i>=0.030].</p><p><strong>Conclusion: </strong>The root length of mandibular first and second molars does not significantly affect the success of supplemental intraligamentary injection.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Canal Transportation and Centering Ability of RaCe and Af f-one Systems by Cone-beam Computed Tomography: An <i>in Vitro</i> Study.","authors":"Hadi Mokhtari, Sedigheh Razi, Saeed Rahimi, Pouya Haghighat, Atefeh Abedi, Elham Behrouzpour","doi":"10.22037/iej.v19i3.41837","DOIUrl":"10.22037/iej.v19i3.41837","url":null,"abstract":"<p><strong>Introduction: </strong>Rotary systems have made significant advances to improve their root canal preparation efficacy. These instruments can properly preserve the root canal anatomy and morphology. The present <i>in vitro</i> study aimed to compare canal transportation and centering ability of RaCe and Af f-one systems using cone-beam computed tomography.</p><p><strong>Materials and methods: </strong>Thirty-six mandibular molars were included. The samples were randomly assigned to two groups (<i>n</i>=18): group 1, RaCe, and group 2, Af f-one. Canal preparation was conducted using the respective files according to the manufacturers' instructions. The cone-beam computed tomographic scanning of the samples was performed before and after preparation. The data were analyzed by using two-way ANOVA.</p><p><strong>Results: </strong>In both the RaCe and Af f-one rotary systems, canal centrality and transportation were similar at coronal, middle, and apical cross-sections. In addition, canal transportation and centrality were identical in the RaCe and Af f-one rotary files (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The two studied rotary systems did not exhibit significant differences in root canal transportation and preservation of root canal centrality in the apical, middle, and coronal thirds.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 3","pages":"193-198"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Cervical Root Resorption: A Comprehensive Review on Pathogenesis, Diagnosis, and Treatment.","authors":"Saeed Asgary, Omid Dianat","doi":"10.22037/iej.v19i1.44246","DOIUrl":"10.22037/iej.v19i1.44246","url":null,"abstract":"<p><p>Invasive cervical root resorption (ICRR) is a dental pathology, marked by unexpected destruction originating in the cervical region of the tooth. This comprehensive literature review provides a holistic view into the pathogenesis, clinical manifestation, and precise management of ICRR, aiming to guide endodontists and enhance patient care and treatment outcomes. The review delves into the potential etiology of ICRR, covering contributing factors such as trauma, orthodontic treatment, and other pertinent conditions. It outlines the clinical and radiographic indicators, underscoring the crucial role of early detection and precise diagnosis in effectively managing and halting ICRR progression. The exploration of treatment approaches is thorough, ranging from non-surgical methods like vital pulp therapy or root canal treatment to surgical interventions. This review accentuates the essential role of interdisciplinary collaboration among diverse dental specialties in enhancing ICRR management. It highlights the importance of a consolidated strategy in enhancing treatment outcomes and preserving tooth structure and function. Moreover, it investigates prevention methods, risk evaluation, and identifies prospective research pathways to address the existing knowledge gaps.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 1","pages":"2-12"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vivo</i> Evaluation of Tissue Biocompatibility of Calcium Silicate-based and Epoxy Resin-based Sealers.","authors":"George Táccio de Miranda Candeiro, Amanda Kevys Magalhães, Laissa Sousa Evangelista, Amanda Brito Santos, Larissa Bernardo Dantas, Hermano Camelo Paiva, Giulio Gavini, Paulo Goberlânio de Barros Silva","doi":"10.22037/iej.v19i4.45646","DOIUrl":"10.22037/iej.v19i4.45646","url":null,"abstract":"<p><strong>Introduction: </strong>Calcium silicate-based sealers are an alternative to be used into root canal, mainly to their biological properties. However, some biological parameters need to be determined in an <i>in vivo</i> animal research model. So, the aim of the present study was to evaluate <i>in vivo</i> the tissue biocompatibility of a calcium silicate-based sealer (EndoSequence BC Sealer) and an epoxy resin-based sealer (AH-Plus).</p><p><strong>Materials and methods: </strong>Polyethylene tubes were filled with freshly mixed sealers and implanted in connective subcutaneous tissue of 25 rats (5/euthanasia day) (<i>Rattus norvegicus albinus</i>). Empty tubes were used as controls and no tubes as sham. Histopathological (hematoxylin eosin) and histochemical (Picrosirius red) examinations were conducted at 3, 7, 15, 30 and 60 days (five rats/day) after the implantation procedure (<i>n</i>=5/group). The type/intensity of inflammation and collagenesis was analyzed statistically with Friedman or Kruskal-Wallis/Dunn tests (<i>P</i><0.05).</p><p><strong>Results: </strong>The profile of inflammation induced by AH-Plus (Median=2, Range=2-3) was significantly greater than that by Endosequence BC Sealer (Median=1, Range=1-1) during the 15-day experimentation period (<i>P</i>=0.018). After 30 days, both materials produced similar tissue reaction (<i>P</i>>0.05). AH-Plus and Endosequence BC Sealer (Median=2, Range=1-2) induced a high level of fibrosis after 60-day than control (Median=1, Range=1-1) and sham (Median=0, Range=0-0) groups (<i>P</i><0.001) of fibrosis based in type I collagen increase (<i>P</i>=0.025 and <i>P</i>=0.021, respectively). Tissue necrosis was not observed and the bioceramic sealer showed significant signs of endocytosed (Median=1, Range=1-1) material after 7 days than other groups (Median=0, Range=0-0) (<i>P</i><0.05). The calcium silicate-based sealer induced tissue repair faster than the epoxy resin-based sealer tested. However, both materials showed adequate biocompatibility and tolerance by subcutaneous tissues, with few differences in inflammatory profiles, formation of granulation tissue, and collagenesis.</p><p><strong>Conclusions: </strong>It may be concluded that calcium silicate-based sealer (EndoSequence BC Sealer) and an epoxy resin-based sealer (AH-Plus) presented suitable biocompatibility.</p>","PeriodicalId":14534,"journal":{"name":"Iranian Endodontic Journal","volume":"19 4","pages":"278-286"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}