Association between Apical Periodontitis and Chronic Diseases: An Umbrella Review.

Q3 Dentistry

Iranian Endodontic Journal Pub Date : 2023-01-01 DOI:10.22037/iej.v18i3.42560

Karem Paula Pinto, Gabriella Serrão, Cláudio Malizia Alves Ferreira, Luciana Moura Sassone, Tatiana Kelly da Silva Fidalgo, Emmanuel J N L Silva

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引用次数: 0

Abstract

Introduction: To assess the methodological quality of systematic reviews (SRs) that evaluated the association between apical periodontitis (AP) and chronic diseases.

Materials and methods: A systematic search was performed in the databases PubMed, Virtual Health Library, Scopus, Cochrane Library, Embase, Web of Science and Open Grey. SRs that evaluated the association between any chronic disease and AP, and that had performed a valid risk of bias assessment were included. The AMSTAR-2 tool was used for quality assessment and each included systematic review received a final categorization as having "high", "moderate", "low", or "critically low" quality.

Results: Nine studies that met the eligibility criteria were included. The diseases investigated were cardiovascular diseases, diabetes mellitus, HIV, osteoporosis, chronic liver disease, blood disorders and autoimmune diseases. The systematic reviews included in this umbrella review showed a 'low' to 'high' quality of evidence.

Conclusion: There are substantial heterogeneity and several methodological concerns in the included studies. It was observed a positive association between diabetes mellitus and apical periodontitis with limited evidence, no association between HIV and apical periodontitis and a positive association between apical periodontitis and cardiovascular disease, blood disorders, chronic liver disease, osteoporosis and autoimmune diseases with moderate evidence.

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根尖牙周炎与慢性疾病的关系:综述。

目的:评价评价根尖牙周炎(AP)与慢性疾病之间关系的系统评价(SRs)的方法学质量。材料和方法:系统检索PubMed、Virtual Health Library、Scopus、Cochrane Library、Embase、Web of Science和Open Grey数据库。包括评估任何慢性疾病与AP之间的关联，并进行了有效的偏倚风险评估的SRs。AMSTAR-2工具用于质量评估，每个包括系统评价的最终分类为“高”、“中等”、“低”或“极低”质量。结果:9项研究符合入选标准。调查的疾病包括心血管疾病、糖尿病、艾滋病、骨质疏松症、慢性肝病、血液疾病和自身免疫性疾病。本总括性评价中包括的系统评价显示证据质量从“低”到“高”。结论:在纳入的研究中存在大量的异质性和一些方法学问题。糖尿病与根尖周炎呈正相关，证据有限;艾滋病与根尖周炎无相关性;根尖周炎与心血管疾病、血液疾病、慢性肝病、骨质疏松症和自身免疫性疾病呈正相关，证据中等。

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来源期刊

Iranian Endodontic Journal Dentistry-Dentistry (all)

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Endodontic Journal (IEJ) is an international peer-reviewed biomedical publication, the aim of which is to provide a scientific medium of communication for researchers throughout the globe. IEJ aims to publish the highest quality articles, both clinical and scientific, on all aspects of Endodontics. The journal is an official Journal of the Iranian Center for Endodontic Research (ICER) and the Iranian Association of Endodontists (IAE). The Journal welcomes articles related to the scientific or applied aspects of endodontics e.g. original researches, systematic reviews, meta-analyses, review articles, clinical trials, case series/reports, hypotheses, letters to the editor, etc. From the beginning (i.e. since 2006), the IEJ was the first open access endodontic journal in the world, which gave readers free and instant access to published articles and enabling them faster discovery of the latest endodontic research.