IP Indian Journal of Immunology and Respiratory Medicine最新文献_第9页

The coexistence of bronchial asthma in patients with bronchiectasis: A cross sectional study 支气管扩张患者共存支气管哮喘的横断面研究

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.006

N. Sudhakar

{"title":"The coexistence of bronchial asthma in patients with bronchiectasis: A cross sectional study","authors":"N. Sudhakar","doi":"10.18231/j.ijirm.2022.006","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.006","url":null,"abstract":"To determine the co-existence of bronchial asthma in patients of bronchiectasis, and to compare the clinico-radiological profile between patients having only bronchiectasis and both bronchiectasis and bronchial asthma.: 67 patients who presented as Bronchiectasis (Clinical and radiological) to Respiratory Medicine Department at VIMS & RC, Bangalore from January 2020 to June 2021, were subjected to baseline investigations and spirometry/PEFR after informed consent. Statistical analysis was performed using SPSS 22 version software.The clinical and radiological profile were compared between the group having only bronchiectasis and those with bronchiectasis and asthma.Out of the 67 study patients, 55(82.08%) had only bronchiectasis and 12(17.91%) had bronchiectasis with bronchial asthma. In the bronchiectasis only group, majority of the patients were male 40(72.72%) and in the in bronchiectasis with bronchial asthma group majority of the patients were female 7(58.33%) which was statistically significant (P value <0.05). Patients with bronchiectasis and coexisting asthma had statistically significant increased symptoms of breathlessness, wheeze, running nose, sneezing, itching (P value <0.05). Similarly exposure to dust, fumes, pets was found to be more common in bronchiectasis with bronchial asthma group (P value >0.05). The mean age for onset of symptoms was found to be lower in the bronchiectasis with bronchial asthma group. Patients in the bronchiectasis with bronchial asthma group had a lower mean FEV1 value. Hyperinflation on chest radiograph was found to be 10.90% in bronchiectasis group, and 8.33 % in bronchiectasis with bronchial asthma group. Bilateral bronchiectasis on CT thorax was common in both groups. 17.91% of bronchiectasis patients had coexisting bronchial asthma. Hence, a proper diagnosis can reduce the burden of patients suffering from more frequent exacerbations, with better optimized treatment options.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"111 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89398314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on the safety profile and clinical outcomes in patients using tulobuterol transdermal patch as an add on therapy in stable chronic obstructive pulmonary disease 稳定期慢性阻塞性肺疾病患者使用妥布特罗透皮贴剂作为辅助治疗的安全性和临床结果研究

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.005

R. R., B. Thomas, A. Rafad, Jerin James, Mekha Monsi Chenthiyethu, Ruben Thomas Lal

{"title":"A study on the safety profile and clinical outcomes in patients using tulobuterol transdermal patch as an add on therapy in stable chronic obstructive pulmonary disease","authors":"R. R., B. Thomas, A. Rafad, Jerin James, Mekha Monsi Chenthiyethu, Ruben Thomas Lal","doi":"10.18231/j.ijirm.2022.005","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.005","url":null,"abstract":"Tulobuterol Transdermal Drug Delivery (TTD) may be beneficial in COPD management. We aimed to study the effect of adding TTD to Triple Inhalation therapy (TI). Participants on TTD and TI (TTD-TI cohort) and, TI only (TI cohort) were identified at the out-patient pharmacy counter. There was no loss to follow-up from 35 participants each enrolled in the cohorts. They were assessed with Modified British Medical Research Council questionnaire (modified Medical Research Council), COPD Control Questionnaire (CCQ) and COPD Assessment Test (CAT). The latter two were repeated at the end of six months. The change in score were compared with Mann-Whitney-U test. Mean age of participants in years was 63.4 and 65.7; 31% and 20% were females and rest were males in TTD-TI and TI cohorts respectively. All of them had modified Medical Research Council grade 2 or above. CCQ and CAT scores were comparable at baseline. Change in both CCQ and CAT scores were statistically significant between the cohorts (p<0.001). Median (minimum, maximum) change in CCQ score were -0.6(-2.8, 0) in TTD-TI cohort and 0.3(-2 to 1.2) in TI cohort. Median (minimum, maximum) change in CAT score were -4(-16, -2) in TTD-TI cohort and 2(-7 to 7) in TI cohort. All of the participants in TTD-TI cohort and, 5(14.3%) and 7(20%) participants improved in TI cohort by CCQ and CAT score respectively. There would be a subjective improvement with addition of tulobuterol transdermal patch on to triple inhalation therapy for older persons with COPD.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86482203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stealth omicron-A new substrain in an ongoing pandemic of COVID-19 隐形组粒——正在进行的COVID-19大流行中的新亚株

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.002

S. Yadav

引用次数: 3

Bilastine - Novel anti histamine drug for allergic rhinitis Bilastine——治疗变应性鼻炎的新型抗组胺药

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.003

A. Trailokya, Soumen Roy

引用次数: 0

Therapeutic drug monitoring: The future of tuberculosis management 治疗药物监测:结核病管理的未来

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.001

Gyanshankar P. Mishra

引用次数: 0

Successful management of cytokine storm induced acute respiratory distress syndrome secondary to H1N1 influenza with itolizumab: A case series 伊托单抗成功治疗细胞因子风暴诱导的H1N1流感继发急性呼吸窘迫综合征:一个病例系列

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.010

Deepak Siddavaram

{"title":"Successful management of cytokine storm induced acute respiratory distress syndrome secondary to H1N1 influenza with itolizumab: A case series","authors":"Deepak Siddavaram","doi":"10.18231/j.ijirm.2022.010","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.010","url":null,"abstract":"Critically ill patients often have a dysregulated immune response to the underlying insult leading to varied clinical features and end-organ dysfunction. One of the dysregulated immune responses termed ‘cytokine storm (CS)’ secondary to SARS-COV-2 during the recent COVID-19 pandemic was responsible for unacceptably high morbidity and mortality across the world. Cytokine storm is not unique to just COVID-19 but can also occur due to certain other viruses like H1N1 influenza. This phenomenon accelerated not only our understanding of the underlying pathophysiology and the role of the immune system in critically ill patients but also strengthened the concept of the possible need for an immunomodulator incorporated with standard therapy for treating Acute Respiratory Distress Syndrome(ARDS). Itolizumab, a reformulated anti-CD-6 humanized monoclonal antibody, downregulates the synthesis of proinflammatory cytokines leading to reduced interferon-γ (IFNγ), interleukin (IL-6), and tumour necrosis factor-α (TNFα) levels, along with reduced T-cell infiltration at the inflammatory site. Its usage in the management of CS in non-COVID 19 ARDS seems to be an appealing therapeutic approach given its mechanism of action. The current cases highlight an underlying possible hyperimmune response secondary to H1N1 in two patients who were successfully managed using Itolizumab along with standard treatment of ARDS.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73739561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation and psychometric properties of the Gujarati version post-COVID functional status scale 古吉拉特版covid - 19后功能状态量表的翻译和心理测量特性

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.004

K. Thakkar, C. Verma, Aditi Parekh

{"title":"Translation and psychometric properties of the Gujarati version post-COVID functional status scale","authors":"K. Thakkar, C. Verma, Aditi Parekh","doi":"10.18231/j.ijirm.2022.004","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.004","url":null,"abstract":"The ‘Post COVID Functional Status Scale’ (PCFS) is an ordinal scale concentrating on the functional limitations to view the variety of post-COVID 19 outcomes and to measure the consequence of the infection other than death The adapted version of the PCFS Scale will be useful in tracking the post COVID functional status in the individuals who can comprehend the scale better in the Gujarati language. This study was carried out in a post-COVID-19 patient population at a government tertiary care hospital. The study was carried out according to the guidelines given by the American Association of Orthopaedic Surgeons. The methodology consisted of 3 Phases. Forward and backward translation, expert committee review, and usability testing on the participants who were asked to fill out the Gujarati version of the PCFS scale twice in Phase 1, 2, and 3 respectively.30 participants, both males, and females participated in the study. Cronbach’s α was used to calculate the internal consistency of the scale. The ICC was 0.99, which interprets as a very high correlation and stability of the scale.The Cronbach’s alpha was calculated for a population of 30 participants. On test 1 the value for Cronbach’s Alpha (ɑ1) was 0.821 and on the second test, the value was (ɑ2) 0.866. A linguistically and practically identical Gujarati PCFS Scale was formulated after a careful and systematic process, which offers a viable and trustworthy method for assessing the functionality of post-COVID-19 patients. ","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90981232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A young adult with multisystem inflammatory syndrome (MIS-A) following COVID-19 infection: A case report 1例青年人在COVID-19感染后出现多系统炎症综合征(misa): 1例报告

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.008

Subhajit Sen, Suresh Ramasubban, Chadrashish Chakravarty, Lawni Goswami, Debasis Rout, A. Mohapatra

{"title":"A young adult with multisystem inflammatory syndrome (MIS-A) following COVID-19 infection: A case report","authors":"Subhajit Sen, Suresh Ramasubban, Chadrashish Chakravarty, Lawni Goswami, Debasis Rout, A. Mohapatra","doi":"10.18231/j.ijirm.2022.008","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.008","url":null,"abstract":"Recent reports have described a secondary Multi system Inﬂammatory Syndrome in adult (MIS-A)and its temporal association with COVID-19 infection. Here, we report the case of a 25-year-old male who presented with shock and multi organ failure. Three-week prior to present admission he developed an Influenza like illness, secondary to SARS-CoV2 infection as detected by a reverse-transcription polymerase chain reaction (RT-PCR). Three weeks later, patient had recurrence of fever associated with throat pain, neck swelling, and a rash followed by shock and multiorgan failure. Laboratory work revealed elevated inflammatory markers. His throat swab for SARS-CoV-2 by RT-PCR was negative and SARS-CoV-2 IgG antibody was reactive.In view of presentation like multi-inflammatory syndrome in children (MIS-C) a probable diagnosis of MIS-A was made. He was successfully treated with intravenous Immunoglobulin and pulse dose Methylprednisolone. This case highlights the need to remain vigilant for multisystem inﬂammatory syndromes in the COVID-19 affected patients.[","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83234902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare cause of subcutaneous emphysema with pneumomediastinum and pneumoperitoneum in a young adult: Paraquat poisoning 青年人皮下肺气肿合并纵隔气肿和气腹的罕见病因:百草枯中毒

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2022-04-15 DOI: 10.18231/j.ijirm.2022.009

P. Upadhya, S. C., A. Moorthy, B. N, M. R., J. B

引用次数: 0

An unusual case of hemoptysis secondary to Abernethy malformation type II and hepatopulmonary syndrome, pulmonary arterial hypertension 咯血继发于阿伯内蒂畸形II型和肝肺综合征肺动脉高压的罕见病例

IP Indian Journal of Immunology and Respiratory Medicine Pub Date : 2021-12-15 DOI: 10.18231/j.ijirm.2021.051

Ramakrishna Rachakonda, Shaik Umar Pasha, Shaik Abdul Waseem, Nagarjuna Reddy Sunkara, Seenu Ayyakannu

引用次数: 0