IP Indian Journal of Immunology and Respiratory Medicine最新文献

{"title":"Cytomegalovirus and Epstein-Barr virus infections in pediatric patients of choledochal cyst","authors":"Yashwant Kumar, A. Ram, Prema Menon, R. Kanojia, A. Bhatia, R. Minz","doi":"10.18231/j.ijirm.2024.012","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.012","url":null,"abstract":"Association of viral infection with obstructive jaundice is well-known however frequency of cholangiotropic virus infection in pediatric choledochal cyst is not known. IgG and IgM antibodies against Cytomegalo virus (CMV) and Epstein Barr virus (EBV) in 48 children with choledochal cysts and 26 controls were analysed using ELISA. We found significantly higher anti-CMV IgG and IgM in patients (95.8% and 77.1%, respectively) compared to controls (73.1% and 42.3%) and a notable prevalence of anti-EBV antibodies among both groups (83.3% versus 65.4% IgG and 77.1% versus 46.1 for IgM in patients and controls respectively). Moreover, 79.2% of patients were positive for both anti-CMV and anti-EBV IgG, and 62.5% for both IgMs. This pilot study suggests that infection with CMV, EBV, or both is frequently seen in pediatric patients with CDC. Molecular screening and follow-up in a larger cohort is therefore required for further validation.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"25 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common variable immunodeficiency- A delayed diagnosis of an underdiagnosed entity in resource limited setting","authors":"S. Raina, Tanya Thakur, Korada Vivek Naidu, Bikram Shah, Manoj Thakur","doi":"10.18231/j.ijirm.2024.016","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.016","url":null,"abstract":"We report a case of common variable immunodeficiency (CVID) in a 42-year-old female who presented with history of recurrent rhinosinusitis for the last ten years. Patient had developed cough and progressive dyspnoea for last one year. Patient was admitted with community acquired pneumonia and sputum culture was positive for Pseudomonas aeruginosa. Common variable immunodeficiency was diagnosed ten years after the onset of symptoms. CVID is an underdiagnosed disorder because of the low index of suspicion, lack of awareness, poor facilities for the investigations and higher prevalence of infectious diseases in developing countries. CVID should be suspected in patients with recurrent rhinosinusitis or pneumonia and evaluation of serum immunoglobulins is advised.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"44 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A closer look -Asymptomatic cysticercosis unveiled during COPD exacerbation: A case report","authors":"Gyanshankar P. Mishra, Nirajkumar Dhakare, R. Munje, J. Atram","doi":"10.18231/j.ijirm.2024.015","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.015","url":null,"abstract":"Disseminated cysticercosis a widespread dissemination of cysticerci throughout the whole body is a rare manifestation of cysticercosis. This case report describes a unique presentation of asymptomatic and incidentally diagnosed case of disseminated cysticercosis which is rare and with very few cases being reported in India to date. This 62-year-old male presented to the emergency department with acute onset breathlessness due to an exacerbation of chronic obstructive pulmonary disease (COPD). Routine Chest radiograph revealed an incidental suspicion of disseminated cysticercosis. After treating exacerbation of COPD, he was further evaluated for cysticercosis and active infection. Following confirmation of disseminated cysticercosis, a multidisciplinary treatment approach was implemented to address both COPD and neurocysticercosis.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"11 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrolyte disruption in drug-resistant tuberculosis: Managing risks for improved treatment outcomes","authors":"Sankalp Yadav","doi":"10.18231/j.ijirm.2024.010","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.010","url":null,"abstract":"This editorial sheds light on the critical issue of electrolyte imbalance in drug-resistant tuberculosis (TB), a significant challenge exacerbated by the prolonged and intensive treatment regimens required for multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB strains. The use of second-line drugs, such as fluoroquinolones and aminoglycosides, necessary in these cases, often disrupts electrolyte homeostasis, leading to complications like hypokalemia and hypomagnesaemia. These disturbances can pose serious risks to patients, including cardiac arrhythmias and renal dysfunction. Beyond medication effects, TB itself induces systemic inflammation and metabolic alterations, further complicating electrolyte balance. Effective management necessitates vigilant monitoring of electrolyte levels throughout treatment, coupled with renal function assessments and nutritional support.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Think beyond TB lymphadenitis - Kikuchi fujimoto lymphadenitis","authors":"Aishwarya Alavandar, K. Mathivanan","doi":"10.18231/j.ijirm.2024.014","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.014","url":null,"abstract":"Kikuchi-Fujimoto disease (KFD) is an extremely unusual lymphadenopathy that typically affects females between the ages of 20 and 40, but the aetiology is still unclear. A 28-year-old female presented with right-sided cervical lymph nodes, but there was no history of fever, anorexia, or loss of appetite. Ultrasonography of the patient's neck revealed bilateral cervical lymphadenopathy. Both the acid-fast bacilli smear and GeneXpert tests returned negative results. Histopathology revealed the presence of lymphocytes and histiocytes mixed with karyorrhectic debris. Immunohistochemistry markers support the diagnosis of Kikuchi-Fujimoto lymphadenitis. This case demonstrates that early recognition of KFD reduces unnecessary evaluations and treatments and patient suffering. KFD is a self-limiting disease that requires a systematic approach for a diagnosis; once the diagnosis is made and confirmed by techniques such as immunohistochemistry, symptomatic treatment alone would suffice in the majority of cases. The commonest presentation is an acute or subacute febrile illness associated with cervical lymphadenopathy.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in tuberculosis diagnosis: Revolutionizing detection and treatment","authors":"Sankalp Yadav, Naveen Jeyaraman, Madhan Jeyaraman, G. Rawal","doi":"10.18231/j.ijirm.2024.017","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.017","url":null,"abstract":"Artificial intelligence (AI) is rapidly transforming tuberculosis (TB) diagnosis. It is addressing the longstanding challenges in accuracy, efficiency, and accessibility. Traditional diagnostic methods, while effective, often suffer from limitations such as variability in sensitivity and lengthy turnaround times. AI technologies, including machine learning and deep learning algorithms, offer innovative solutions by automating the analysis of chest X-rays, genomic data, and clinical parameters. These advancements promise improved diagnostic accuracy, expedited treatment initiation, and personalized medicine approaches. However, successful implementation requires overcoming challenges related to data quality, integration with healthcare systems, and ethical considerations. Moving forward, this paper sheds light on AI-driven TB diagnosis, which stands poised to enhance global healthcare outcomes through enhanced detection capabilities and optimized treatment strategies.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"17 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of impact of adherence to inhaled therapy and critical mistakes in inhalation technique on clinical outcomes in patients with obstructive airway diseases in India","authors":"Ajay Godse, Rakesh Gurjar, Namrata Rao, Shivanjali Gore, Ria Vijay","doi":"10.18231/j.ijirm.2024.013","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.013","url":null,"abstract":"Adherence to inhaled therapy is more relevant in respiratory diseases because, to achieve therapeutic efficacy, it is necessary that the patient adhere to the recommended therapy as well as use their inhalers correctly with appropriate inhalation technique.This was a prospective, observational study that included 126 patients >18 years of age of all genders, diagnosed with an obstructive airway disease, and prescribed inhaler medication. Adherence was assessed using the Test of Adherence to Inhalers (TAI) questionnaire, and inhaler device technique was assessed every 3 months. At the end of one year, outcome data like the number of exacerbations, the number of admissions, including critical-care admissions, the number of days of hospitalization, adverse events, and their associations were analyzed.Poor adherence to inhaled therapy was found in 40.48% of patients, with the majority of patients (69.05%) having an unwitting or ignorant pattern of non- adherence. Out of 75 patients using MDI (Metered Dose Inhaler), 34.67% had critical mistakes in technique, and out of 51 patients using Rotahaler, 23.53% had critical mistakes in technique. There was no significant relationship between level of adherence and critical mistakes with gender, BMI category, or past history of smoking. Patients with poor adherence and those with critical mistakes in inhalation technique had poor health outcomes.This study highlights the role of adherence and identifies barriers responsible for non-adherence to inhaled therapy. Identifying the behaviors responsible for non-adherence and counseling the patients on the correct inhalation technique can improve the health outcomes of chronic respiratory diseases.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"15 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological manifestations in patients with tuberculosis: prevalence and contributing factors","authors":"Surya Kant, A. Pandey, Sushma Yadav, Pranjal Tripathi","doi":"10.18231/j.ijirm.2024.011","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.011","url":null,"abstract":"Tuberculosis (TB) continues to be a major global health concern impacting millions of people each year. Beyond its outward symptoms TB can have a significant negative influence on psychological health and cause psychological anguish in those who are afflicted. The purpose of this review is to recapitulate the frequency and contributing variables of psychological discomfort in TB patients. Previous studies show varying prevalence rates of psychological distress which frequently manifests as stress, worry, and depression. Numerous factors such as sociodemographic characteristics the severity of the disease the treatment plan, stigma, and social support. these factors can alter gene expression patterns, epigenetic modifications, and immune responses linked to higher psychological distress. Psychological factors like stress, anxiety, and depression can influence gene metabolism in TB patients through various mechanisms. These factors impacting TB susceptibility, disease progression, and treatment outcomes. To effectively address the mental health needs of TB patients, it is imperative to comprehend the prevalence and factors of psychological distress in tb population. Promote the holistic well-being of TB patients, it is imperative that mental health treatments be integrated into TB care in conjunction with initiatives to lessen stigma and enhance social support.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Yes! We can end TB’ the theme of the world tuberculosis day 2024: A commitment to fight the oldest known infectious disease from the world","authors":"Sankalp Yadav","doi":"10.18231/j.ijirm.2024.009","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.009","url":null,"abstract":"Tuberculosis is a constant issue related to public health. The disease is highly infectious, and about one-fourth of the global population is presumed to be infected. The efforts for tuberculosis control are in full swing, especially in the endemic countries. The World Tuberculosis Day was celebrated on March 24, 2024; however, the theme of the last year, i.e., 'Yes! We can end TB', was continued for 2024. The theme justifies the commitment of stakeholders and policymakers to a sustained effort to eliminate tuberculosis.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"349 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study on clinical profile, severity, microbiology, and outcome of patients with ventilator associated infective complications admitted in intensive care unit of a tertiary care hospital","authors":"Subhajit Sen, Suresh Ramasubban","doi":"10.18231/j.ijirm.2024.004","DOIUrl":"https://doi.org/10.18231/j.ijirm.2024.004","url":null,"abstract":": Mechanical ventilation epitomizes intensive care medicine. Ventilator‑associated complications are mainly Ventilator associated respiratory infections (VARI); These are a major cause of concern in the intensive care units (ICUs) worldwide, especially in developing countries. VARI includes patients with ventilator‑associated tracheobronchitis (VAT) and ventilator‑associated pneumonia (VAP).The clinical profile, severity, microbiology, and outcomes of such infections is not well described in Eastern India. The primary objective of the study was to study the risk factors, severity scoring, microbiological profile and 28 days outcome of patients admitted in intensive care unit of our hospital.Secondary objective of our study was to find out any correlation between risk factors, severity scoring, microbiological profile, and outcome of patients with VAT and VAP admitted in intensive care unit of our hospital.: This was a prospective observational study done in the ICU of a tertiary care centre in eastern India. A total 50 patients of clinically, microbiologically and/or radiologically diagnosed case of VAP and VAT were included in the study. A structured data collection proforma was prepared and data collection was done. Raw data was tabulated and analysed: 66% of our patients were male, Smoking was the commonest addiction(24%), VARI developed early with 17% on Day 3, 72% developed VARI within 5 days of ventilation. 16% had history of recent admission, Diabetes and hypertension were the commonest comorbidities. 58% of the patients developed VAP, the median SOFA score in VAP was 6 also similar in VAT. Patients with neurological diseases had the maximum number of VAT and VAP. Klebsiella pneumoniae was the commonest organism causing VAT (42%) while Acinetobacter Baumanii was commonest to cause VAP (44%). 51% of VAP patients were on volume control mode, while it was 52% of VAT patients. Most isolates are MDR pathogens with intermediate sensitivity to Polymyxin being most common (66%) 1 isolate was pan resistant. Mortality was 58% for VAP and 19% in VAT. Both Klebsiella and Acinetobacter accounts for 41% death in VAP group, in VAT group Klebsiella was commonest however no statistical significance with other organism.: Gram negative bacteria were the predominant cause of VAT and VAP, Acinetobacter and Klebsiella are the commonest organisms. Most Isolates are MDR with intermediate sensitivity to Polymyxins. Median SOFA scores were the same in both. Mortality was high in VAP group. Volume control mode was predominant mode of ventilation, Neurological causes was predominant cause that leads to ventilation and subsequent VARI.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"24 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}