IP Indian Journal of Immunology and Respiratory Medicine最新文献

{"title":"A curious case of exploding cannonball","authors":"Dharm Prakash Dwivedi, S. C., Muniza Bai, Mithradevi Sekar","doi":"10.18231/j.ijirm.2022.021","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.021","url":null,"abstract":"Pulmonary cavitary lesions with pneumothorax are very common in chest imaging and usually pose diagnostic challenge to clinicians Pneumothorax with a cavitary lesion is a rare occurrence in primary and metastatic lung cancer. A 40-year-old male presented with cough with whitish expectoration, right loin pain, loss of weight and appetite for 3 months and difficulty in breathing for 2 days. Chest x-ray was suggestive of right-side pneumothorax with bilateral nodular opacities in all zones. Contrast-enhanced computed tomography (CECT) thorax and abdomen revealed a non-homogenous large mass in the right kidney with hydronephrotic changes with cavitary lesions in bilateral lungs. Urine cytology was suggestive of urothelial carcinoma. Thus, a diagnosis of urothelial cancer with cavitating metastasis leading to secondary spontaneous pneumothorax was made. Herein, we aim to highlight that cavitating metastasis should be considered in a case of pneumothorax with bilateral lung nodules.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82496081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular systems processes and cellular mechanisms-causing to itching tingling and aching in atopic dermatitis skin conditions and repercussions for innovative therapeutics","authors":"V. R. Raju","doi":"10.18231/j.ijirm.2022.015","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.015","url":null,"abstract":": Atopic dermatitis (AD) is a prolonged seditious, rabble rousing, and inflammatory—provocative skin disease. The subjects (i.e., patients) by means of atopic-dermatitis suffer incendiary lesions linked through extreme itching plus discomfort, and that is leading to sleep disorder (and also rarely apnea), weak mental and psychological health and also quality-of-life (QoL). : This study discusses the molecular systems processes/mechanisms causing to itching, tingling and irritation plus aching signs in atopic-dermatitis and examine the existing clinical, medical-advancement of therapies for mild-to-acute atopic-dermatitis. : The molecular pathology of AD contains abnormal immune, protected stimulation including substantial crisscross-talk amongst the skin and safe and neural cells/neuronal cells. Exogenous and endogenous triggers modulate stimulus of mediators including cytokine/chemokine expression/release by the skin and immune cells, which causes inflammation, skin barrier disruption, activation and growth of sensory neurons, itching and paining. These complex interactions among cell types are mediated primarily by cytokines, but also involve chemokines, neurotransmitters, lipids, proteases, antimicrobial peptides, and agonists of ion channels or various G protein–coupled receptors. : Patients with atopic dermatitis have a cytokine profile characterized by abnormal levels of interleukins 4,12,13,18,22,31 and 33; thymic stromal lymphopoietin; and interferon gamma. Cytokine receptors mainly signal through the Janus kinase/signal transducer and activator of transcription pathways. Among emerging novel therapeutics, several Janus kinase inhibitors are being developed for topical or (general nut systemic) systematic treatment of mild to acute AD tis as of their ability to regulate-cytokine countenance then make available. Janus-kinase hampers take the lead to variations in genetic representation which has positive impacts on provincial and general (universal) cytokine-release, and possibly additional intermediaries, so well regulating molecular-cellular-mechanisms accountable for irritation, itching, tingling followed by agony in AD. : This study explored the skin disorder in which the skin develops pink, inflamed plus wound.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85891852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine-lipoarabinomannan-might fill the gap in delayed diagnosis of life-threatening tuberculosis","authors":"S. Kant, Ankit Kumar, V. Niranjan, D. Bajaj, L. Devi","doi":"10.18231/j.ijirm.2022.014","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.014","url":null,"abstract":"Mycobacterium tuberculosis bacilli is a causative organism for tuberculosis disease. The lungs are the most commonly affected organ with this infection but it can infect any vital organ of the body. The person with signs and symptoms of tuberculosis disease was identified with detection of acid-fast bacilli in the biological specimen and with rapid molecular testing. However, the limiting factor for the early tuberculosis (Tb) diagnosis is the running cost of the diagnostic test. It is the common reason preventing the advancement of diagnostic laboratories in low and middle-income countries. The person and community both suffered from this diagnostic delay. This delay causes significant morbidity and mortality in the patient. An alternate test and an alternate sample that can be easily obtained would be beneficial to prevent these diagnostic delay issues. Lipoarabinomannan (LAM) antigen detection in the urine sample is one such promising diagnostic test. Mycobacterium tuberculosis’s inner layer is made up of glycolipids. LAM is derived from phosphatidylinositol. LAM is a heat-stable amphiphilic cell wall component. It is the precursor of phosphatidyl-inositol-mannosidase and lipomannan. An extra mannose cap is a characteristic feature of a virulent strain of Mycobacterium. LAM has immunogenic and immunomodulatory properties. It is a promising diagnostic test because it is simple to do, the assay can be performed at the patient’s bedside and takes a while to perform. This assay sensitivity varies from 56% to 85% and it has greater than 88% specificity. In HIV seropositive patients, use of LAM assay can reduce 8-week mortality. LAM detection is also a very good assay for the detection of tuberculosis in renal failure and disseminated tuberculosis patients.Lipoarabinomannan detection in the urine is a possible test that can prevent delay in diagnosis. This is a promising test because it's easy to perform, the test can be done with a card test besides the patient's bed. It can be used in HIV seropositive patients and various other forms of extra pulmonary tuberculosis. It can be a very useful test for diagnosing a critically ill patient who is not able to produce a target sample.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79684869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effectiveness of bacteriophage in the treatment of pneumonia caused by NDM-4 producing in a mouse model","authors":"Vinodkumar C.S, S. H, Chirag Arun Kumar, S. Kalasuramath, B. Prasad, Jayasimha V.L, R. Nachimuthu, P. Manohar","doi":"10.18231/j.ijirm.2022.019","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.019","url":null,"abstract":"Exploration for an alternative to antibiotics to treat bacterial diseases is becoming more important due to the emergence of antibiotic resistance. Bacteriophage or phage has been used for the treatment of superficial infections. In this study, phage isolated from the environment was used as a therapeutic agent against NDM-producing causing respiratory disease in an experimental mouse model. The isolated phage was found to belong to the family based on morphology. For experiments, five groups of mice were used including infection-free, phage-only, bacteria-infected, and the other two groups infected with and treated either with an antibiotic, levofloxacin (50 mg/kg, twice a day intraperitoneally) or phage (3×10 PFU/mL). All the animals were observed for 72 hours for mortality, and the surviving mice were killed for analysis. In the infected group, pneumonia was developed after 48 hours, and 8/10 animals were dead after 72 hours. When pneumonia infected mice were treated with an antibiotic, levofloxacin all the animals survived but showed the signs of pneumonia, and there was up to 6 log CFU/g±0.82 reduction in the bacterial count. In phage treated group, all the animals survived at the end of 72 hours and all the animals were healthy with no signs of pneumonia. The experiment showed new insights into the biology of the broad host range of phage, demonstrating that phage has prospects for the treatment of pneumonia caused by the NDM-producing .","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86019656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of induced sputum eosinophil, absolute eosinophil count and serum immunoglobulin E level in assessment of the clinical severity in bronchial asthma","authors":"K. Patel, Varun Patel, Payal Gogdani","doi":"10.18231/j.ijirm.2022.016","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.016","url":null,"abstract":"The study was done with the aim to determine the relationship between the severity of asthma in patient and the level of serum immunoglobulin E, peripheral eosinophil count and nature of sputum.Current research was conducted at the Department of Respiratory Medicine, GAIMS, Bhuj, India over one year. All subjects of Bronchial asthma distinct by Genetic Information Nondiscrimination Act (GINA) guidelines of age 17-61 year were registered. Severity of asthma was assessed by clinical features and by Forced expiratory volume in the first second (FEV1 in spirometry. Following evaluating the sternness of bronchial asthma all subjects undergo sputum examination for sputum eosinophil counts, blood sampling for absolute eosinophil counts and serum IgE levels. Elevated sputum eosinophil count (>3) was significantly elevated in additional subjects with severe persistent asthma even though extra than half of them had normal sputum eosinophil. An important association amid peripheral eosinophil count, sputum eosinophil count, and serum IgE with severe persistent asthma. Mean sputum eosinophil% augments considerably according to severity, demonstrates though affirmative association which was statistically important.The use of inexpensive and easy method with evaluation of AEC, sputum eosinophil count and evaluation of serum IgE level showed a straight measurement of inflammation of airway and allergic etiology of illness.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81468528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of CD4 count response in HIV subjects with antiretroviral treatment protocol","authors":"K. Patel, Varun Patel, Simran Samnani","doi":"10.18231/j.ijirm.2022.017","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.017","url":null,"abstract":"The present study was undertaken to evaluate the CD4 count responses in subjects who are on long term first line antiretroviral treatment (ART).A total of 200 People Living with HIV/AIDS (PLHIV), on first line ART for five years seen in the ART centre were included in the study. Patients were interviewed and details entered as per the proforma. Proforma included various details such as serial CD4 counts and Opportunistic infection pre and post ART.Mean CD4 count pre ART was 171.32 ± 65.23 per mm and one year after ART was 374.56 ± 159.12. There was significant rise in CD4 count one year after the initiation of ART (p = 0.000) The mean CD4 count at the time of collection of data was 545.23 ± 259.11 as compared to mean CD4 count pre ART of 171.32 ± 65.23 per mm. The rise was significant.National AIDS Control. OrganizationNACO) suggested first line regimens outcome in vigorous immunologic response that is continued over a mean period of over six years in a majority (84%) of the subjects and consequence in significant decline in opportunistic infections.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79047266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical course of critically ill non-COVID 19 ARDS patients using Itolizumab versus conventional treatment: A case series","authors":"M. Rajendran","doi":"10.18231/j.ijirm.2022.022","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.022","url":null,"abstract":"We tracked the inflammatory mediators and blood gases ratios to evaluate the progress of treatment with Itolizumab administered in 5 critically ill patients against other therapeutic options in COVID 19 negative patients admitted to the ICU with ARDS. All patients had PaO2/FiO2 ratio <200>25mm Hg, while inflammatory markers such as D-Dimer value of > 0.21 g/L and IL-6 values >150 up to 1250 pg/ml at the time of admission. Radiological images were evaluated for improvement, patients requiring ventilator support were intubated and when the patient’s PaO2 was within normal range, they were extubated. The prognostic indicators were measured till clinical outcomes in patients were met in all 10 patients of which 5 received Itolizumab on day 2 of hospitalization. All prognostic indicators showed a decline in inflammatory markers, proportionate improvement in PaO2/FiO2 values, and a reduction in PaCo2 values. All patients treated with Itolizumab were recovered and discharged, while one patient died and did not receive Itolizumab.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75549295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of herbal handwash gel containing Andrographis paniculata alcoholic extract","authors":"K. Mishra, Amit Kumar, Aakash Gupta, Sunil Singh, A. Sahu, P. Kashyap, S. Mishra","doi":"10.18231/j.ijirm.2022.018","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.018","url":null,"abstract":"Nowadays, herbs used worldwide due to its medicinal and pharmaceutical potentials. Herbs are also used to prevent human beings from variety of diseases. In the current study, alcoholic extract of which is commonly known as green chiretta used in the development of handwash (herbal). Traditionally, green chiretta was used and known for their different pharmacological action. Alcoholic extract of loaded herbal hand wash prepared by using Carbopol-934 as gelling agent, TEA (triehanolamine) as neutralizer and sodium lauryl sulfoacetate (SLSA) as surfactant. Antibacterial activity of herbal handwash gel evaluated by cup plate method. Sthaphylococcus aureus, Escherihia coli and Bacillus subtilis are used to assess the potential of gel against microorganisms. It shows good potential action against Bacillus subtilis. Physicochemical characterization of herbal handwash gel was performed by morphological study such as odor, color, pH, foam height, consistency and retention as per chemical standards. The developed herbal hand wash formulation showed no side effects and outcomes are in the limits.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90779072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let us save our environment","authors":"S. Kant","doi":"10.18231/j.ijirm.2022.011","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.011","url":null,"abstract":"","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74516525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleomorphic sarcoma of the chest wall: A case report","authors":"Sonali Parida, Srinibash Sahoo","doi":"10.18231/j.ijirm.2022.007","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.007","url":null,"abstract":"Primary pleomorphic liposarcoma of the chest wall is a rare entity. Most of the reported cases of the chest wall liposarcomas are low grade, well differentiated with mediastinal extension. Majority of these develop from a subcutaneous lipoma. Complete surgical resection is the preferred treatment modality. The benefit of adjuvant radiotherapy or chemoradiotherapy for these tumors is a subject of debate. We report, an unusual case of high grade primary pleomorphic subtype of liposarcoma in a 50-year-old male presenting with a painful swelling in the anterior thoracic wall extending into the pleura but without any mediastinal involvement or distant metastasis.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74539452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}