IP Indian Journal of Immunology and Respiratory Medicine最新文献

{"title":"Retrospective study of occurrence of pressure ulcers among the patients admitted in rural tertiary care hospital and their outcome","authors":"Akshaya Narayan Shetti, Ch. Chandana Chowdary, Rachita Mustilwar","doi":"10.18231/j.ijirm.2023.022","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.022","url":null,"abstract":"This retrospective study addresses the pivotal role of pressure ulcer prevention in evaluating the quality of care within critical care units. The incidence of pressure ulcers serves as a crucial indicator, impacting patient recovery and complicating treatment. In this data based retrospective study we assessed the prevalence of pressure ulcers for a duration of 6 years. In this data we included the patients from surgical, medical, respiratory and cardiac critical care units who were admitted between 01/06/16 to 01/06/22. All male and female patients aged above 18 years were included. Patients who got discharge within 48 hours were excluded. Total of 35 patients were noted to have bedsores in intensive care unit from June 2016-June 2022 admitted under both medical and surgical branches. Out of which 34.3% were in age group above 70yrs where 87.9% were male patients. Most commonly 1-2 bedsores (97.1%) were present involving mostly buttock area (82.9%) of 2-5cm size (45.7%). Most of the patients admitted under medical branch developed bedsores more often than surgical branch and appeared after admission (77.1%) with 15-30 days hospital stay (31.4%). This study has illuminated our path forward in improving patient care and preventing pressure ulcer development among patients admitted to our medical and surgical Intensive Care Units in our Rural Tertiary hospital. The findings have paved the way for targeted interventions, underlining our commitment to raising the standard of care for our critically ill patients.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135758967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hypersensitive pneumonitis specific IgG antibodies in the Indian population: A retrospective study","authors":"Alap Christy, Flavia Almeida, Madhuri Bhosle, Raj Jatale, Shibani Ramchandran","doi":"10.18231/j.ijirm.2023.019","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.019","url":null,"abstract":"Identifying the underlying antigen responsible for Hypersensitivity Pneumonitis (HP) in patients poses a significant challenge within the confines of a typical clinical environment. Our primary objective in this study was to investigate the distribution and prevalence of G antibodies among individuals diagnosed with HP, taking into account factors such as age, gender, and geographical location. A retrospective study spanning 5 years (from January 2018 to June 2023) was conducted, involving patients over the age of 18 who had undergone screening for HP. Data collected from 1087 patients was analysed, and the patients were categorized based on age, gender, location, and their antibody status. Out of the total cohort of 1087 patients, 62.47% were female, while 37.53% were male. The overall positivity rate for HP panel testing was determined to be 49.22%. Among the patients subjected to testing, 174 individuals (16.01%) tested positive for at least one specific antibody. Notably, among patients aged 18 to 30 years, Penicillium emerged as the most prevalent (48.28%), closely followed by fumigatus Fumigatus (44.83%). In contrast, for patients aged 31 to 45 years, Pigeon serum feathers exhibited the highest prevalence (39.69%). Moreover, the positivity rates varied across different regions in India. HP can be attributed to an array of agents commonly encountered in both workplace and home settings, encompassing microorganisms, animal and plant proteins, as well as organic and inorganic chemicals. Discerning the causative antigen not only holds immense value for physicians in optimizing patient treatment but also plays a pivotal role in pinpointing the source of exposure. Armed with this knowledge, physicians can provide patients with tailored advice to minimize their exposure risk, potentially leading to disease stabilization or even reversal. In summary, the successful identification of the etiologic antigen emerges as a formidable tool for enhancing the overall quality of patient care.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135759345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The collaboration of ‘Active case finding campaign’ with the 'Leprosy case detection campaign': An important step towards tuberculosis elimination","authors":"S. Yadav","doi":"10.18231/j.ijirm.2023.011","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.011","url":null,"abstract":"","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82192784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory effect of Mesenchymal stem cells: A blessing to combat cytokine storm appeared during COVID-19 infection","authors":"K. Mishra, Urvi Panwar","doi":"10.18231/j.ijirm.2023.012","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.012","url":null,"abstract":"Whilst the manufacture of a safe and potent vaccine for SARS-CoV-2 is the ultimate goal of the COVID-19 response, research is also in progress to develop novel treatments that could facilitate infected patients in the meantime. Casualty in COVID-19 patients are connected with onset of acute respiratory distress syndrome (ARDS) due to its cytokine storm phenomenon resulting in abandoned systemic inflammatory response from the release of pro-inflammatory chemokines (CCL2, CCL3, CCL5, CXCL8, CXCL9, CXCL-10) and cytokines (TNF-α, TGF-β, IFN-α, IFNγ, IL-1β, IL-6, IL-12, IL-8, IL-33). This implies immune system is not capable to turn itself off once it has generated enough of a defense against the virus. An extended cytokine storm will finally shut down breathing completely, which may lead to death. In the context of COVID19, there is a likelihood possibility of treatment of patients by transplanting Mesenchymal Stem Cells (MSCs). MSCs are known to have an immune-regulatory role and MSCs have used in patients that have been affected by the cytokine storm may fine balance the immune system in order to stop the overreaction, without switching it completely off, so that the immune system can carry on to fight the infection. In this review, we have considered the research studies which have used MSCs for the treatment of COVID-19. The cohort study is needed to approve MSCs as therapy, although many clinical trials have been registered to apply MSCs as therapy for severely affected COVID-19 patients.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90481832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levodropropizine: A promising peripherally acting antitussive agent","authors":"Amar Shirsat, A. Trailokya, S. Wankhede","doi":"10.18231/j.ijirm.2023.013","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.013","url":null,"abstract":"Cough is one of the most frequent symptom for patients to seek medical attention. Cough can be associated with many disease processes and the ultimate treatment depends on determining the etiology and diagnosis. Antitussive agents with different mechanisms of action have been developed in the past, but there are still very few medications that seem to be effective without any side effects especially related to central nervous system (CNS). Levodropropizine is an antitussive agent which acts peripherally and is a non-opioid cough medication that is in use since many years as a symptomatic therapy for cough. Levodropropizine has potent antitussive activity mainly due to peripheral effects by inhibiting the activation of vagal C-fibers. In fact, levodropropizine has been proven effective in controlling cough and is devoid of the central depressant effect. Levodropropizine oral suspension (30mg/5ml) is approved by drug approval body of India, Drug Controller General of India (DCGI) for the management non-productive cough in adults. Levodropropizine is approved in some of the European countries and in Asian countries. It is widely used in Republic of Korea for the symptomatic treatment of cough in both adults and children above 2 years of age. Levodropropizine has the utmost level of benefit in comparison with central antitussive agents namely codeine and dextromethorphan for the patients with cough due to acute and chronic bronchitis.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"54 60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80591628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on clinical and arterial blood gas parameters before and after tube thoracostomy among cases of primary and secondary spontaneous pneumothorax","authors":"Subhajit Sen, S. Kundu, S. Chatterjee","doi":"10.18231/j.ijirm.2023.014","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.014","url":null,"abstract":"Pneumothorax is a common respiratoryemergency that requires active interventions in many cases specially Tube thoracostomy. Objective of the present study is to find out changes in clinical and arterial blood gas parameters in primary and secondary pneumothorax following tube thoracostomy at different time intervals.Total 30 cases, Primary spontaneous pneumothorax (PSP) 11 and secondary spontaneous pneumothorax (SSP) 19. Clinical parameters: pulse rate, blood pressure, respiratory rates, oxygen saturation (SpO2). ABG analysis: pH, partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), AaDO2. Time interval: pre tube thoracostomy, 1hour and 24hours after thoracostomy and after tube removal. PSP was found more in young patients (mean 34.18), SSP in older patient (mean 52.68), (P=0.001). Among clinical parameters statistically significant changes were seen in pulse rate, (P<0.001) respiratory rate (P<0.001) in both groups, in both cases tachycardia and tachypnea decreased. Diastolic blood pressure in SSP group (P<0.01), SO in SSP group (P<0.05). There is an increase in mean arterial pressure from pre thoracostomy compared to in 1hr, 24hr and at removal. Which statistically significant in SSP group.In PSP group hypoxaemia was present in 54.54% patients before giving chest tube, after 1 hour of tube thoracostomy only 18.18% cases had mild hypoxaemia. In SSP group 68.42% cases presented with hypoxaemia initially, after tube removal 26.31% cases had mild hypoxaemia.No significant changes in other blood gas parameters were seen in either groups. The impact of tube thoracostomy on primary and secondary pneumothorax are mainly reflected on clinical parameters rather than blood gas parameters.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87887029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons of exacerbation among children with reactive airway disease","authors":"Anjusha Maheswari Nair, P. T, B. S","doi":"10.18231/j.ijirm.2023.016","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.016","url":null,"abstract":"Reactive airway disease has a multifactorial aetiology, where genetic liabilities and environmental exposures interact in complex ways to cause reversible airway inflammation and obstruction and acute exacerbation can be life threatening. The present study was to assess the reasons of exacerbation among children with reactive airway disease which include infection, cold climate, lunar variations, discontinuation of metered dose inhaler and allergens and irritants. The study was conducted in a tertiary care centre Thiruvananthapuram among 101 caretakers of children with reactive airway disease. A structured interview schedule was used to assess the socio demographic data, clinical data of the child and the reasons of exacerbation. Among 101 children with reactive airway disease majority of children 67.3% the reason for exacerbation was cold climate, in 16.8% infection, 21.8% activity, 8.9% lunar variation, 10.9% discontinuation of metered dose inhaler and in 28.7% other factors of exacerbation include strong odour, pets, pollen, pests, smoke, mosquito repellents and dust. The study also revealed that 72.3% are having family history of allergic diseases and 27.7% do not have any family history of allergic diseases. Of the 73 children with family history of allergic disease 79.5% were having family history of asthma, 16.4% were having allergic rhinitis and 4.1% were having allergic dermatitis. Asthma is a chronic inflammatory disease of the airways. It is one of the most common chronic diseases of childhood, affecting more than 6 million children worldwide Advances in science have led to an increased understanding of asthma and its mechanisms as well as improved treatment approaches. Proper identification and elimination of triggers can reduce the exacerbation of asthma.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90302817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionising TB treatment: Implications of the TRUNCATE-TB Trial on the Indian TB landscape","authors":"Gyanshankar P. Mishra, Jasmin Mulani","doi":"10.18231/j.ijirm.2023.010","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.010","url":null,"abstract":"","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79335567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise in chronic obstructive pulmonary disease","authors":"A. R., M. M","doi":"10.18231/j.ijirm.2023.015","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.015","url":null,"abstract":"Chronic Obstructive pulmonary disease is continuing as a major public health problem across the globe, causing significant morbidity and affecting the quality of life more commonly among the elderly. This aim of the study was to assess whether a regular, routine 20 minute walk will help improve the quality of life and symptoms in patients with COPD. Patients selected according to the inclusion and exclusion criteria and using a pretested questionnaire, were included in the study and data were collected. The questionnaire included information on basic demographic details, symptomatology, and smoking and alcohol habits. History, clinical examination, and selected investigations were done before and after a month of this exercise program. Qualitative data was analyzed using Chi-Square Test and Quantitative data using Paired T test The study population was mostly elderly males. Most of them gave history of smoking in the past and a few had biomass exposure. The most predominant symptom was dyspnea. After 2 months of regular exercise there was statistically significant change in CAT Score, mMRC score and six minute walk distance. The desaturation while doing Six minute walk test also improved after the exercise program. This study concluded that a regular physical activity can be considered as a possible alternative to pulmonary rehabilitation program for those who cannot afford the cost of consultations, transport for attending the program.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81259100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary rehabilitation care: Current perspective","authors":"Ankit Kumar, S. Kant","doi":"10.18231/j.ijirm.2023.003","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.003","url":null,"abstract":"Pulmonary rehabilitation is a program that helps individuals with chronic respiratory diseases improve their physical function, quality of life, and overall well-being. The program typically involves a combination of exercise, education, and support to help patients manage their symptoms and improve their respiratory health.Exercise is a crucial component of pulmonary rehabilitation and can help improve cardiovascular health, increase lung function, and reduce shortness of breath. Aerobic exercise, resistance exercise, and flexibility exercise are all important types of exercise used in pulmonary rehabilitation, with patients gradually increasing the intensity and duration of their workouts over time.Breathing techniques are another essential component of pulmonary rehabilitation and can help patients manage their symptoms and improve their overall respiratory function. Techniques such as diaphragmatic breathing, pursed-lip breathing, and controlled coughing can help improve oxygenation, reduce shortness of breath, and improve overall respiratory function.In addition to exercise and breathing techniques, pulmonary rehabilitation programs may also include education and support to help patients better manage their condition. This may include education on medication management, nutrition, stress management, and other topics relevant to respiratory health.Overall, pulmonary rehabilitation is a comprehensive program that can help individuals with chronic respiratory diseases improve their physical function, reduce symptoms, and improve their overall quality of life. By incorporating exercise, breathing techniques, education, and support, pulmonary rehabilitation can help patients better manage their condition and achieve optimal respiratory health.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73024465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}