IP Indian Journal of Immunology and Respiratory Medicine最新文献

{"title":"Macrophage death induced cellular mechanisms and some regulatory pathways of macrophage death related diseases","authors":"Malavika Bhattacharya, Debaleena Samanta","doi":"10.18231/j.ijirm.2023.026","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.026","url":null,"abstract":"In mammalian physiology the dead cells of body and cellular debris could not be digested by body’s own cellular mechanism. Macrophage is a component living inside the cell sometimes engulf the unrequired cell debris by phagocytosis and became dead by its own, this type of death inside macrophage is called ‘‘Macrophage Death’’ which has been done for our good cytosolic condition. Macrophage death is about many types those have been disclosed later and referred as ‘‘Programmed Cell Death.’’Apoptosis, Autophagy, Necrophagy all are different types of cell death associated with macrophage. When cytotoxicity of a cell condition leads to a cell destroy by its own then often it’s referred as a ‘‘Cellular Suicide’’ where cells die by itself.Macrophages death is a complicated mechanism which directly involves with ER stress, oxidative stress, lost mitochondrial functional ability, lysosomal outburst and other cell particulates dysfunctioning.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":" 65","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139621159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specifics of cystic fibrosis genetic spectrum in Georgia","authors":"Ia Khurtsilava, D. Agladze, Tsitsino Parulava, L. Margvelashvili, Oleg Kvlividze","doi":"10.18231/j.ijirm.2023.029","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.029","url":null,"abstract":"Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). F508del is the most common mutation in the world. Other mutations are rare and population specific. The study aimed to comprehensively analyze the distribution of CFTR mutations in Georgian CF patients. Knowing the prevalence and characteristics of specific mutations can be reflected in genetic counseling and management strategies. We reviewed the data of 129 CF patients, aged < 18 years, from all parts of Georgia. 91 patients with a clinically confirmed CF diagnosis were tested for CF-causing mutations (constituting 70.5% of all currently registered CF patients in the country). These patients have been analyzed for rare CFTR variants by massively parallel sequencing of the entire CFTR coding region and adjacent introns combined with the analysis of intra-CFTR rearrangements.  CFTR gene analysis revealed 29 mutations in Georgian CF patients. The most common mutation was c.1545_1546delTA (1677delTA) with a frequency of 42.7%, while the second most common mutation, W1282X, was detected in 11.2% of all CF alleles. Another 27 CFTR mutations have low frequency, including F508del (6.7% of alleles). 3 novel mutations were found (c.708dupT; CFTRdele16_17; c.3170C>G) and reported to CFTR2 database.According to the data, the distribution of CFTR mutations in the Georgian CF population differs regarding the high frequency of mutation c.1545_1546delTA (1677delTA) and the low frequency of the predominant F508del mutation. Compared to patients with F508 del and W1282X mutations, patients with 1677delTA have typical manifestations and complications; however, the frequency of growth retardation and liver damage is 3 times, and the frequency of chronic respiratory manifestations and chronic malnutrition is 2 times lower, though pancreatic insufficiency is more severe in patients with 1677delTa. CF-associated diabetes, distal intestinal obstruction syndrome, and hemoptysis were only observed in patients with the 1677delTA mutation. The mortality rate is lower compared to patients with F508del and W1282X mutations.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the diagnostic value of white blood cell profiles in H1N1 screening","authors":"Preethiraj Ballal, Abha Pandey Mahashur, Shruthi Rai P, P. Prabhudesai","doi":"10.18231/j.ijirm.2023.028","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.028","url":null,"abstract":"This research sought to evaluate the effectiveness of White Blood Cell (WBC) profiles as a screening method for promptly identifying H1N1 infection in individuals exhibiting symptoms of Influenza-like Illness (ILI) and undergoing throat swab testing for H1N1 through the RT-PCR technique. Seventy patients from a tertiary care hospital were included based on specific inclusion and exclusion criteria. Throat swab tests were conducted using RT-PCR, resulting in 35 positive and 35 negative cases for influenza A H1N1. Complete Blood Count (CBC) profiles, including total WBC counts, differential count, neutrophil to lymphocyte ratios, lymphocyte to monocyte ratios, and absolute monocyte count (AMC), were obtained for all subjects. Analysis of the obtained data revealed that increased symptoms, higher monocyte counts, and an Absolute Monocyte Count (AMC) exceeding 800 cells/mm³ were indicative of a higher likelihood of H1N1 positivity. The study suggests that utilizing WBC profiles, particularly the neutrophil to lymphocyte ratios, lymphocyte to monocyte ratios, and AMC, can serve as a valuable screening measure for the early detection of H1N1 infection. This approach may be especially beneficial in peripheral healthcare settings where the standard RT-PCR diagnostic method is time-consuming, enabling timely and appropriate intervention based on CBC results.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-mycological profile of fungal infections in a tertiary care hospital","authors":"Veenu Gupta, Monica Singh, Rajesh Mahajan, J. Chaudhary, Manisha Aggarwal","doi":"10.18231/j.ijirm.2023.027","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.027","url":null,"abstract":"The fungal infections are increasing at high rate especially in immune-compromised patients and elderly population. In high risk population, antifungal resistance is becoming a major concern. Antifungal susceptibility testing is important for appropriate management and better outcome of patients. The aim of the study was to know clinico-Mycological profile of fungal infections in admitted patients.This prospective study was carried out in a tertiary care hospital. Various samples were received from patients with suspected fungal infections. All samples were inoculated on SDA except blood & body fluids which were directly inoculated into blood culture bottles and processed in BACTEK/BacTAlert system. Fungal infections were characterized and antifungal susceptibility was done for yeast isolates with VITEK-AST panel. : Out of total 19698 patients suspected of fungal infection, fungal infection was seen in 365 patients , 100% susceptibility was seen to Fluconazole and Echinocandins. Whereas in NAC (non-albicans ), 72.5% susceptibility was seen to fluconazole and Voriconazole (82.5%). Antifungal resistance is major cause of morbidity and mortality. Prompt diagnosis and antifungal susceptibility will offer the early appropriate treatment and better clinical outcome of patient.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoma presenting as massive pleural effusion: An unusual presentation","authors":"Vikas Kumar, Shweta Anand, Praveen Kumar Dubey","doi":"10.18231/j.ijirm.2023.023","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.023","url":null,"abstract":"The mediastinum is an anatomical space between the lungs that houses the thymus, heart, large blood vessels, lymph nodes, nerves, and portions of the esophagus and trachea. It divides into anterior, middle, and posterior compartments. Mediastinal masses encompass a broad histopathological spectrum, ranging from benign to malignant. Fifty percent of mediastinal masses occur in the anterior compartment, the most common of which are thymoma, teratoma, thyroid goiter, and lymphoma. Thymoma is one of the causes of anterior mediastinal masses. The incidence of thymoma is quiet less. It is usually benign in nature. Malignant thymoma is very rare and pleural involvement is further rare. We are reporting a case of malignant thymoma presenting as massive pleural effusion.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135758802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary melioidosis misdiagnosed as pulmonary tuberculosis","authors":"Chandan Kumar Sheet, Saibal Ghosh, Subhankar Chatterjee, Biplab Chandra","doi":"10.18231/j.ijirm.2023.024","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.024","url":null,"abstract":"is a facultative Gram-negative saprophytic bacterium commonly found in soil or contaminated water causing melioidosis. Melioidosis can mimic various other disease due to its heterogenous clinical manifestations and different organ involvement. Because of its versatility it is called as “the great imitator” and remains challenging to diagnose. We report a case of melioidosis misdiagnosed and treated as pulmonary tuberculosis. A 54-year-old male non-smoker with history of diabetes admitted with persistent cough, breathlessness and hemoptysis for 5 months. Initially there was pleuritic chest pain and high-grade fever. He was treated with multiple intravenous broad-spectrum antibiotics and anti-tubercular therapy multiple times in the local hospitals based on clinical symptoms and radiological manifestation though Sputum examination for AFB and Gene xpert for Mycobacterium tuberculosis was negative. Chest radiology showed multiple thick-walled cavities with pericavitary consolidation along with patchy infiltrative opacities. BALF culture identified . The respiratory morbidity was resolved using antibiotics based on antibiotic susceptibility tests. This case study described a case of melioidosis in adult male with diabetes and engaged in farming presented with diverse and indistinct clinical manifestations that mimics many other diseases. Definitive diagnosis was made by isolation , in culture collected through bronchoscopic examination.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135758803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, radiological and microbiological profile of patients with bronchiectasis in a tertiary care center in South Kerala","authors":"Stephen Sunny, Mathew Ninan","doi":"10.18231/j.ijirm.2023.018","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.018","url":null,"abstract":"Bronchiectasis is a common but neglected chronic lung disease. There is paucity of data from Southern India regarding the clinical, radiological and microbiological profile of patients with bronchiectasis. To study the clinical profile, radiological pattern and microbiological flora in patients with bronchiectasis in a tertiary care center in South Kerala. A descriptive cross-sectional study done in 41 patients over 1 year. This study comprised 41 patients, of whom 18 were males (44%) and 23 were females (56.1 %), with a predominant population pertaining to 61-70 years (51.2%). Majority were non-smokers (65%, N=27). Most common cause was post-TB bronchiectasis (34%, N=14). Predominant symptoms were cough (73.2%, N=30) and sputum production (70.7%, N=29), predominant clinical sign was crepitation (73.1%, N=30). Majority had PFT showing obstruction (60.97%, N=25), among which 48% (N=12) had severe obstruction. Radiologically, most common CT pattern was cystic bronchiectasis (46.3%, N=19), predominantly located in lower lobes (63.4%, N=26) with bilateral involvement (65.9%, N=27). was the most frequently isolated organism (43.9%, N=18) followed by (29.3, N=12). Most of our patients were females and post TB bronchiectasis was the leading cause of bronchiectasis. Cough and sputum production were the most common symptoms. was the commonest pathogen isolated from sputum samples. Spirometry showed obstructive pattern in majority of patients and cystic bronchiectasis being most common radiological pattern.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135758801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis of the wrist joint: Unmasking an uncommon challenge","authors":"Sankalp Yadav","doi":"10.18231/j.ijirm.2023.017","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.017","url":null,"abstract":"Tuberculosis of the wrist joint: Unmasking an uncommon challenge - IJIRM- Print ISSN No: - 2581-4214 Online ISSN No:- 2581-4222 Article DOI No:- 10.18231/j.ijirm.2023.017, IP Indian Journal of Immunology and Respiratory Medicine-IP Indian J Immunol Respir Med","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135759343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial screening associated with respiratory infection and the synergistic effect of ginger and garlic tea extract conducted at assulfan herbal research center","authors":"Khalid Ibrahim Yahaya, Musbahu Abdullahi Abubakar, Muhyiddin Muhd Haruna, Musbahu Sani Abubakar","doi":"10.18231/j.ijirm.2023.021","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.021","url":null,"abstract":"Respiratory tract infection are the most common infectious diseases in human due to its common mode of transmission and leading a heavy burden to Public Health. The study was aimed to isolate the bacterial pathogens that are associated with respiratory infection and using synergistic effect to evaluate the antibacterial activity of ginger and garlic tea extract of potential isolates. The present study revealed the presence of 41 isolates of respiratory pathogens out of 200 Sample collected from sputum and swab throat. The isolation and identification of target pathogens were done using Cultural and biochemical Characterizations. 7(17.07%), 16(39.02%), 14(34.15%), 3(07.39%) and 1(02.44%) are positive of respectively. For the synergistic antibacterial effect of both methanolic and ethanolic extracts of garlic and ginger tea, all respiratory pathogens that were isolated in the present study were showed the great antibacterial effect except has highest activity of 17±0.7mm at 150mg/ml in methanolic while in ethanolic with 15±0.2 at 100mg/ml. Lowest activity was found to be 07±0.2mm at 50mg/ml for both and .","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135758800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on association of obstructive airway disease in previously treated pulmonary tuberculosis patients","authors":"Vijay Kumar K Shettar, M Sandhya, Sreelatha J, LakshmiDevi B P, Reshma Cleetus, Nandish Kumar K, Srinivasan S","doi":"10.18231/j.ijirm.2023.020","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.020","url":null,"abstract":"Pulmonary tuberculosis (TB) and obstructive airway disease are of growing concern in a developing country akin to India. A considerable number of TB patients develop post-tubercular respiratory disease. There are few Indian studies assessing the relationship between antecedents of PTB and COPD. PTB has a considerable impact on quality of life. To evaluate the prevalence of obstructive airway disease in previously treated pulmonary tuberculosis patients and to evaluate the impact of post TB obstructive airway disease on QOL using SGRQ-C. A prospective, observational cross-sectional study was conducted in a tertiary care health centre over six months, enrolling 116 study subjects who met the inclusion criteria included after acquiring Informed consent. Study subjects had been categorized primarily based on prior history of PTB. Therefore, this study involved two groups of study subjects, PTB associated COPD and COPD. Subjects were assessed for PFT through the aid of MIR Spirobank smart App and QOL using SGRQ-C scale. Of 116 patients, 19(22.6%) women and 65(77.4%) men and 5(15.6%) women and 27(84.4%) men were diagnosed as PTB associated COPD and COPD respectively. Dyspnea and cough with sputum were the most common symptoms presented by 76(94.04%) and 62(71.42%) patients respectively. The effect of airflow limitation (FEV1) was slightly increased in PTB associated COPD patients (25.65%) compared to COPD patients (26.4%) and study endpoint showed noteworthy decrease in QOL of PTB associated COPD(72%) patients compared to COPD(66.4%). PTB-associated COPD constitutes a significant proportion of COPD within clinical setting. It is an independent risk factor for OAD in extensive TB burden countries. The results indicated that early diagnosis, appropriate management and control of TB are as critical as smoking cessation for reducing OAD. Early identification of Post tubercular COPD and early initiation of treatment in these patients improve the QOL and reduces morbidity and mortality.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135759342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}