Iranian Biomedical Journal最新文献

{"title":"Development of Experimental Platforms to Assess Helicobacter pylori HopQ Interaction with Host CEACAM Molecules.","authors":"Nazanin Shans, Maryam Esmaeili, Kimia Abraheh, Niloofar Asadi Hanjani, Maedeh Farrokhi, Negar Sardarpour, Yeganeh Talebkhan, Fatemeh Kazemi-Lomedasht, Esmat Mirabzadeh, Marjan Mohammadi","doi":"10.61186/ibj.5029","DOIUrl":"10.61186/ibj.5029","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori is an extracellular bacterium responsible for various gastrointestinal diseases, such as peptic ulcers and gastric cancer. It uses multiple mechanisms to colonize the harsh, acidic environment of the stomach and establish its pathogenic processes, mostly through CagA translocation. While cell surface integrin molecules were previously believed to be the main mediators anchoring H. pylori and facilitating this process, recent studies highlight the critical role of the interaction between the bacterial adhesin Helicobacter pylori outer membrane protein Q (HopQ) and host carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in CagA translocation and subsequent pathogenic signaling.</p><p><strong>Methods: </strong>Recombinant proteins, including HopQ, HopQ-GFP (green fluorescent protein), HopQ-HRP (horseradish peroxidase), and recombinant N-terminal domain of human CEACAM1 (C1ND), were produced via gene cloning, expression, and purification techniques. Ligand-receptor interactions were evaluated using FACS analysis along with antigen- and cell-based ELISA assays.</p><p><strong>Results: </strong>In this study, we have developed antigen and cell-based platforms using recombinant fusion proteins (HopQ-GFP and HopQ-HRP) that effectively interact with recombinant C1ND, as well as various CEACAM molecules expressed on gastric cell lines (MKN45 and AGS).</p><p><strong>Conclusion: </strong>These assay platforms enable detailed investigation of the HopQ-CEACAM interaction and supports high-throughput screening of inhibitors, facilitating the identification of potential drugs or vaccine candidates targeting H. pylori infection.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 3","pages":"138-148"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Peptides and Bioactive Peptides on Acute Kidney Injury: A Review Study.","authors":"Zeynab Mohamadi Yarijani, Houshang Najafi","doi":"10.61186/ibj.5000","DOIUrl":"10.61186/ibj.5000","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is the sudden loss of kidney function that occurs within hours or days, resulting in the accumulation of waste materials in the blood and disruption of fluid balance. AKI is prevalent among hospitalized patients, especially the elderly in the intensive care units. Inflammation, oxidative stress, and apoptosis are typical physiological responses following AKI. Peptides, especially bioactive peptides, exhibit various properties, including immunomodulatory and antihypertensive effects, and functions against diabetes, obesity, and cancer. In recent years, much attention has been drawn to the application of peptides and bioactive peptides in pharmaceuticals, particularly for their potential use, alone or in combination, in the treatment of AKI. Given the critical role of inflammation, oxidative stress, and apoptosis pathways in AKI, along with the anti-inflammatory, anti-apoptotic, and antioxidant effects of peptides, this study was designed to review the effects and underlying mechanisms of peptides in AKI.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 3","pages":"90-103"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Potential of Streptomyces-Derived Metabolites Against Fluconazole-Resistant Oral Candida albicans: In vitro Evaluation and Mechanistic Insights.","authors":"Mahtab Karami-Feli, Zahra Jahanshiri, Akram Sadeghi","doi":"10.61186/ibj.4937","DOIUrl":"10.61186/ibj.4937","url":null,"abstract":"<p><strong>Background: </strong>Oropharyngeal candidiasis, primarily caused by Candida albicans, is the most common opportunistic fungal infection in patients with head and neck cancer. The increasing emergence of fluconazole (FLZ) resistance has led to higher morbidity and mortality rates. Streptomyces, a genus of Actinomycetes, produces bioactive molecules with antimicrobial effects. This study investigated the antifungal potential of S. monomycini strain 615 against FLZ-resistant C. albicans clinical isolates in vitro.</p><p><strong>Methods: </strong>S. monomycini strain 615 was cultured, and an aqueous crud extract containing its metabolites was prepared. The effects of extract were tested on five FLZ-resistant C. albicans isolates. Key pathogenic factors such as protease activity, biofilm formation, and gene expressions related to virulence (SAP1, SAP2, HWP1, and ERG11) and azole resistance (ERG11) were evaluated. Cytotoxicity of the extract (1.8-0.0008 µg/ml) was assessed on KYSE-30 esophageal epithelial cells using the MTT assay.</p><p><strong>Results: </strong>Strain 615 showed strong antifungal activity with minimum inhibitory concentration (MIC) values of 0.0008-0.0035 µg/ml and minimum fungicidal concentration (MFC) values of 0.0017-0.0035 µg/ml after 48 hours. The extract significantly reduced ergosterol content by 31.81%, completely inhibited phospholipase and proteinase activities at 0.0035 µg/ml and suppressed biofilm formation at 0.0035-0.0140 µg/ml. Expression of all tested virulence genes decreased except for ERG11, indicating a possible mechanism to overcome azole resistance. The highest extract concentration caused 76.7% cytotoxicity in KYSE-30 cells after 72 hours.</p><p><strong>Conclusion: </strong>S. monomycini strain 615 could serve as an alternative or adjunct therapy for FLZ-resistant oropharyngeal candidiasis in head and neck cancer patients, warranting further research to confirm safety and efficacy.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":" ","pages":"126-137"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering of the Caspase-3 Gene in Recombinant CHO Cells Caused More Apoptosis Resistance and enhanced Recombinant Protein Production Than the BAX Gene.","authors":"Amirabbas Rahimi, Morteza Karimipoor, Reza Mahdian, Atefeh Alipour, Saadi Hosseini, Marzieh Mohammadi, Hooman Kaghazian, Hosein Shahsavarani, Mohammad Ali Shokrgozar","doi":"10.61186/ibj.4934","DOIUrl":"10.61186/ibj.4934","url":null,"abstract":"<p><strong>Background: </strong>BAX and caspase-3 are essential genes in the apoptotic pathway of cells, promoting the apoptotic cascade through different mechanisms. Inhibition of these genes can increase the longevity of cells in cell culture. This study aimed to compare the effects of clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9 (CRISPR-Cas9)-mediated knockdown of BAX and caspase-3 genes on apoptosis inhibition, cell lifespan, and erythropoietin (EPO) production in CHO cell lines.</p><p><strong>Methods: </strong>The BAX and caspase-3 gene expression was evaluated in the recombinant Chinese hamster ovary (rCHO) cell lines producing EPO using the CRISPR-Cas9 method. Their anti-apoptotic effects and the level of EPO expression were also compared. In addition, oleuropein (OP) as an apoptosis inducer, was introduced to the manipulated cell line to assess the stability and viability of the manipulated cell lines.</p><p><strong>Results: </strong>The rCHO cells with the manipulated BAX gene exhibited a higher cell density than those with the manipulated caspase-3 gene (152% vs. 142%). Despite the increased cell density in the cells with the BAX gene manipulation, EPO production was higher in the cells with the manipulated caspase-3 gene (1.58-fold increase in the BAX-manipulated cells compared to a 1.70-fold increase in the caspase-3-manipulated cells).</p><p><strong>Conclusion: </strong>Our observations suggest that the downregulation of the BAX and caspase-3 genes using the CRISPR method, inhibits apoptosis and enhances the yield of recombinant EPO, even in the presence of an apoptosis inducer. Additionally, reduction of caspase-3 expression was proved to be more effective than BAX in extending the lifespan of cells and producing heterologous recombinant proteins.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 3","pages":"149-158"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifaceted Cooperation Between WNT and PI3K Signaling Axis through the Long Noncoding RNA SNHG16 and TCF7 in de novo Acute Lymphoblastic Leukemia Patients.","authors":"Mohadeseh Khani, Atbin Latifi, Mohammad Sayyadi","doi":"10.61186/ibj.5031","DOIUrl":"10.61186/ibj.5031","url":null,"abstract":"<p><strong>Background: </strong>Acute lymphoblastic leukemia (ALL) is the most prevalent form of acute leukemia in children, arising from the known and unknown factors. This complexity has limited advancements in patient recovery. Recently, long noncoding RNAs lncRNA (lncRNA) molecules have emerged as significant but not fully understood players in leukemia research. Studies have indicated that c-Myc can stimulate and enhance gene expression through multiple pathways, particularly by activating the PI3K and WNT pathways. The present study investigated the expression levels of lncRNAs involved in the upstream regulation of the PI3K/WNT pathways in patients diagnosed with ALL.</p><p><strong>Methods: </strong>This case-control cross-sectional study was conducted using RNA from blood samples. The study examined 36 patients with ALL and 36 healthy controls. The expression levels of SNHG16 and TCF7 lncRNAs and their target genes were determined using qRT-PCR.</p><p><strong>Results: </strong>The expression of Akt, β-catenin and c-Myc genes in the patient group showed a significant increase compared to the control group \u0000(p < 0.05). The expression levels of SNHG16 and TCF7 were significantly elevated in ALL patients compared to the control group (p < 0.05). Furthermore, a significant positive correlation was observed between the expression levels of these two lncRNAs in the patient group (p < 0.05).</p><p><strong>Conclusion: </strong>Our findings demonstrate that SNHG16 and TCF7 lncRNA may act as crucial regulators of the Akt and β-catenin in ALL, which in turn influence c-Myc expression levels in affected individuals. Further research is needed to better understand the molecular mechanisms underlying ALL, potentially leading to improved treatment and monitoring strategies for patients.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 3","pages":"104-113"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atorvastatin-Loaded Carboxymethyl Cellulose-Gelatin Hydrogel: A Synergistic Strategy for Enhanced Wound Healing and Skin Tissue Regeneration.","authors":"Seyed Reza Mousavi, Mojtaba Rashidi, Azam Khedri, Maryam Kouchak, Majid Salehi, Sepehr Zamani, Ghorban Mohammadzadeh","doi":"10.61186/ibj.5043","DOIUrl":"10.61186/ibj.5043","url":null,"abstract":"<p><strong>Background: </strong>Skin tissue engineering is an innovative alternative to traditional methods for addressing skin injuries. This study aimed to synthesize a hydrogel consisting of carboxymethyl cellulose (CMC) and gelatin (Gel) containing atorvastatin (ATR) with the potential to accelerate tissue regeneration and wound healing in an animal model.</p><p><strong>Methods: </strong>Five unique formulations of hydrogel with different concentrations of ATR (0.1%, 0.5%, 1%, and 2% w/v) were synthesized using CMC-Gel. The structural characteristics of the hydrogels were assessed using SEM and FTIR spectroscopy. Additional evaluations carried out included swelling behavior, degradability, ATR release, compatibility, hemolytic activity, and the viability of NIH/3T3 fibroblast cells. The therapeutic effectiveness of these hydrogels in enhancing wound healing was investigated in an animal model by making a full-thickness skin incision in Wistar rats.</p><p><strong>Results: </strong>The synthesized CMC-Gel scaffolds had a porous structure with interconnected pores measuring 103 ± 8.74 μm and the ability to enhance cell migration. The MTT analysis showed a concentration-dependent relationship between ATR and cell proliferation, among which, the desirable concentration was 0.1% w/v. Furthermore, increased ATR concentrations were associated with decreased dressing capacity for hemostasis and coagulation. In vivo studies revealed that all the hydrogel-treated groups significantly outperformed the control group in promoting wound closure rates. Remarkably, the CMC-Gel-ATR 0.1% group exhibited the highest rates of wound closure, re-epithelialization, and angiogenesis.</p><p><strong>Conclusion: </strong>Our results suggest the CMC-Gel-ATR as a desirable wound dressing for clinical application due to its unique physicochemical properties and comprehensive biocompatibility in in vitro and in vivo investigations.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 3","pages":"114-125"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migration Pattern and Tissue Tropism of Toxascaris leonina (Linstow, 1902) Larvae: An in vivo Evaluation.","authors":"Mohammad Sardari, Alireza Nourian, Farzad Parsa, Salman Zafari, Heshmatollah Taherkhani, Amir Hossein Maghsood, Mohammad Matini, Seyed Mousa Motevali Haghi, Mohammad Fallah","doi":"10.61186/ibj.4998","DOIUrl":"10.61186/ibj.4998","url":null,"abstract":"<p><strong>Background: </strong>: The role of Toxascaris leonina in visceral larva migrans is controversial. This study aimed to investigate the migratory behavior of T. leonina larvae across different organs in mice.</p><p><strong>Methods: </strong>Six-week-old Swiss albino mice (n = 26) were randomly allocated into six experimental groups and one control group. Each mouse in the experimental groups was orally inoculated with 1,000 embryonated T. leonina eggs. The animals were euthanized at 2, 5, 10, 15, 20 and 30 dpi (days post-infection). Tissue samples were examined for larval presence and associated pathological changes using digestive and histopathological methods. The squash method was used for brain tissue analysis.</p><p><strong>Results: </strong>T. leonina larvae were recovered from the small intestinal wall, lungs, liver, and striated muscles. No larvae were detected in the kidneys, heart, spleen, and brain using digestive or squash methods. Histological examination revealed granulomatous reactions, inflammatory cell accumulation, and larval presence in the isolated tissues. Larval concentration in the striated muscles increased over time, demonstrating the potential of Swiss albino mice to serve as paratenic hosts in toxocariasis.</p><p><strong>Conclusion: </strong>Our study exhibits that Swiss albino mice are susceptible to T. leonina infection, with larvae localizing primarily in the small intestinal wall, liver, lungs, and striated muscles.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 3","pages":"167-172"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy of Oncolytic Newcastle Virus and Lenalidomide Enhanced Cytotoxicity in Prostate Cancer Cells","authors":"Mahdie Jafari, Shahriyar Abdoli, Majid Asgari, Masoud Moghaddam Pour, Mohammad Ali Shokrgozar, Zahra Sharifzadeh","doi":"10.61186/ibj.4367","DOIUrl":"https://doi.org/10.61186/ibj.4367","url":null,"abstract":"<p><strong>Background: </strong>Despite existing treatments, advanced solid tumors, such as prostate cancer (PCa), require the development of novel anticancer therapies. Oncolytic viruses (OVs) present a potential treatment option for solid tumors. Newcastle disease virus (NDV) is one of the most promising OVs that can replicate within and destroys human cancer cells. This study aimed to evaluate the cytotoxic and apoptotic effects of the NDV strain on human PCa cells in vitro. Additionally, We examined a novel treatment for PCa by combining Lenalidomide (Len) with NDV.</p><p><strong>Methods: </strong>NDV strains La Sota, B1, and I2 were tested for cytotoxicity against several cell lines. A safety assessment was conducted in primary cells using peripheral blood mononuclear cells (PBMCs). Also, apoptosis induction was measured using annexin V/7AAD staining. Finally, the cytotoxic effects of NDV alone and in combination with Len, were assessed using MTT.</p><p><strong>Results: </strong>The NDV showed cytotoxic effects on tumor cell lines and induced apoptosis in infected prostate cells compared to control cells. The NDV La Sota strain exhibited significant oncolytic capacity, reducing the viability of LNCaP and DU145 cells to less than 40% at specific concentrations, while showing no cytotoxic effects on primary PBMCs. Also, NDV induced apoptosis in the prostate cell line by 60%. Furthermore, Len enhanced the cytotoxicity of PCa cells when combined with NDV.</p><p><strong>Conclusion: </strong>Our study confirms the efficacy of oncolytic NDV treatment for PCa, particularly utilizing the La Sota strain. When combined with Len, NDV indicates an enhanced effectiveness in destroying tumor cells. These findings suggest a prospective treatment approach that needs more preclinical and clinical studies to improve outcomes in PCa treatment.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 1 & 2","pages":"9-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Pattern Study of miR-200a and XIAP Gene in the Non-small Cell Lung Cancer Patients’ Blood","authors":"Tara Fereydouni, Seyed Jalal Zargar, Sharareh Seifi, Mojgan Sheikhpour","doi":"10.61186/ibj.4354","DOIUrl":"https://doi.org/10.61186/ibj.4354","url":null,"abstract":"<p><strong>Background: </strong>In non-small cell lung cancer (NSCLC), miR-200a plays a significant role in apoptosis. One of the genes involved in this pathway is XIAP, which has been shown anti-apoptotic activity. Research has indicated a significant association between miR-200a and the XIAP gene in this pathway. The present study investigated the expression profiles of miR-200a and the XIAP gene in NSCLC patients compared to normal individuals, as well as cancer cells compared to normal and apoptosis-inducing conditions.</p><p><strong>Methods: </strong>In this study, 40 blood specimens were collected from NSCLC patients and 40 from healthy individuals. After isolating plasma and peripheral blood mononuclear cells from these samples, we analyzed the miR-200a and XIAP gene expression levels using real-time PCR. Subsequently, normal and lung cancer cells were treated with paclitaxel as a model of apoptosis. The antiproliferative effects and induction of apoptosis were then evaluated using the MTT and flow cytometry assays, respectively. Finally, the expression patterns of miR-200a and the XIAP gene were investigated through a real-time PCR method.</p><p><strong>Results: </strong>Results indicated that the miR-200a expression level was lower in NSCLC patients than in healthy ones, while the expression level of XIAP gene increased in the NSCLC Patients’ blood. The MTT and flow cytometry results demonstrated a decreased proliferation and increased apoptosis rates in two lung line cells (A549 and MRC5) treated with paclitaxel. XIAP expression level also decreased in A549 cells treated with paclitaxel compared to untreated A549 cells.</p><p><strong>Conclusion: </strong>MiR-200a may be associated with the XIAP gene expression and the induction of the apoptosis pathway in NSCLC.</p>","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"29 1 & 2","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25th National and 11th International Annual Congress on Research and Technology of Iranian Medical Sciences Students, Urmia, Iran, 5-7 September, 2024","authors":"Akbar Arjamandpour, Zahra Hojjaji, Sara Moslehi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14500,"journal":{"name":"Iranian Biomedical Journal","volume":"28 7","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}