Chemistry - A European Journal最新文献_第6页

Functionalized Thorium-Based Metal-Organic Frameworks for the Photocatalytic Oxidation of 1, 5-Dihydroxynaphthalene.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-26 DOI: 10.1002/chem.202500065

Hui Zhou, Ran-Wei Zhang, Xiao-Yue Pan, Shi-Yan Ai, Zi-Wei Cui, Pengfei Wu, Qing Huang, Dan Tian

引用次数: 0

Simultaneous Construction of Axial and Central Stereogenicity by Cobalt-Catalyzed Stereoconvergent Reductive Coupling of Heterobiaryl Triflates and Aldehydes. 通过钴催化异丁烯三酸酯和醛的立体转化还原偶联同时构建轴向和中心立体性。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-26 DOI: 10.1002/chem.202500248

Chuiyi Lin, Xiang Xu, Qinglei Chong, Fanke Meng

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Asymmetric Amination of 1,2-Diol through Borrowing Hydrogen: Synthesis of Vicinal Amino α-Tertiary Alcohol.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-26 DOI: 10.1002/chem.202404152

Tariq Ali, Tahir Rahman, Shahida Perveen, Lingyun Wang, Ajmal Khan

{"title":"Asymmetric Amination of 1,2-Diol through Borrowing Hydrogen: Synthesis of Vicinal Amino α-Tertiary Alcohol.","authors":"Tariq Ali, Tahir Rahman, Shahida Perveen, Lingyun Wang, Ajmal Khan","doi":"10.1002/chem.202404152","DOIUrl":"https://doi.org/10.1002/chem.202404152","url":null,"abstract":"Methods to prepare vicinal amino alcohols are important because of their presence in biologically active compounds. Despite the development of various methods for vicinal amino alcohol synthesis, C(sp3)-rich oxygen-containing β-amine compounds continue to pose great challenge. While ring-opening reaction of epoxides with amine nucleophile is the prime method for vicinal amino alcohol preparation, epoxides are highly reactive and sometimes difficult to make, resulting in drawbacks regarding selectivity of this approach. Here, we report a catalytic enantio-convergent amination of α-tertiary 1,2-diols for the efficient access to vicinal amino α-tertiary alcohols. The racemic α-tertiary 1,2-diol substrates of different alkyl/aryl or alkyl/alkyl backbone, can be converted to chiral vicinal amino a-tertiary alcohols through diphenyl phosphate-mediated RuCl3 catalysed asymmetric borrowing hydrogen (ABH) pathway. This simple ABH reaction can be scaled up to the synthesis of chiral ligands, synthetic intermediates, and other medicinally-relevant compounds. Overall, this catalytic redox-neutral procedure broadens the scope of Ru-catalysed amination of alcohols and discloses an underexplored step- and atom-economical synthetic strategy for the synthesis of vicinal amino α-tertiary alcohols and provides a practicable alternative to the present benchmark procedures.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404152"},"PeriodicalIF":3.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive Coordination Behavior of Bisphosphanylphosphanido-Ligands toward Group 2, 11 and 12 Metal Ions.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-26 DOI: 10.1002/chem.202500406

Dennis Langgut, Clemens Bruhn, Rudolf Pietschnig

引用次数: 0

Cover Feature: Design and Synthesis of Thioglycosylated Monolignol Dual Probes for Bioimaging of Lignin Biosynthesis (Chem. Eur. J. 12/2025) 封面专题：用于木质素生物合成生物成像的硫代糖苷化单木酚双探针的设计与合成（Chem.）

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-25 DOI: 10.1002/chem.202581202

Dr. Clémence Simon, Dr. Mingxiang Zhu, Prof. Dr. Cédric Lion, Dr. Corentin Spriet, Maxence Hemry, Prof. Dr. Godfrey Neutelings, Prof. Dr. Samir Messaoudi, Prof. Dr. Christophe Biot

{"title":"Cover Feature: Design and Synthesis of Thioglycosylated Monolignol Dual Probes for Bioimaging of Lignin Biosynthesis (Chem. Eur. J. 12/2025)","authors":"Dr. Clémence Simon, Dr. Mingxiang Zhu, Prof. Dr. Cédric Lion, Dr. Corentin Spriet, Maxence Hemry, Prof. Dr. Godfrey Neutelings, Prof. Dr. Samir Messaoudi, Prof. Dr. Christophe Biot","doi":"10.1002/chem.202581202","DOIUrl":"https://doi.org/10.1002/chem.202581202","url":null,"abstract":"The Cover Feature highlights the design and synthesis of thioglycosylated monolignol probes that were developed for the biological imaging of lignin biosynthesis. These innovative probes mimic monolignol glucosides (MLGs), which are hypothesized to play a role in monolignol transport and storage, though their exact function in lignin biosynthesis remains unclear. By incorporating a thioglycosyl moiety, these probes enable selective metabolic incorporation and facilitate the tracking of lignin biosynthesis in vivo. More information can be found in the Research Article by S. Messaoudi, C. Biot and co-workers (DOI: 10.1002/chem.202404117).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>\u0000 ","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":"31 12","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/chem.202581202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twisted Amide-Mediated Synthesis and Rapid Structure-Activity Relationship Study of Medium-Sized Cyclic Peptides.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-25 DOI: 10.1002/chem.202500331

Takefumi Kuranaga, Ai Koyama, Junta Asano, Takumi Matsumoto, Hideaki Kakeya

{"title":"Twisted Amide-Mediated Synthesis and Rapid Structure-Activity Relationship Study of Medium-Sized Cyclic Peptides.","authors":"Takefumi Kuranaga, Ai Koyama, Junta Asano, Takumi Matsumoto, Hideaki Kakeya","doi":"10.1002/chem.202500331","DOIUrl":"10.1002/chem.202500331","url":null,"abstract":"Medium-sized cyclic peptides are expected to be ideal drug leads because these peptides combine the advantages, while compensating for the disadvantages, of small molecules and antibodies. Although medium-sized peptides can be produced by chemical synthesis, two major problems, namely (i) Cα-epimerization during C-terminal modification and (ii) side reactions in the cyclization, remain to be solved. These issues have hampered the synthesis of pure materials for bioassays, making it difficult to accomplish accurate structure-activity relationship (SAR) studies. Herein, we report an efficient synthesis of medium-sized cyclic peptides based on the twisted amide-mediated amidation strategy. First, a variety of linear peptides were synthesized by the \"inverse\" peptide synthesis and fragment coupling. Second, the C-terminus of the linear peptides were converted to twisted amides, which were then reacted with a variety of α-amino acyl sulfonamides, realizing the rapid C-terminal diversification of peptides. Finally, the resulting linear peptides were cyclized by the intramolecular twisted amide-mediated amidation to afford stereochemically pure cyclic peptides. Using this strategy, total synthesis of acyl-surugamide A, the stereoselective synthesis of 13 non-natural analogs, and the discovery of potent antimicrobial/antifungal peptides beyond the natural product were also achieved.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500331"},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: DiQuinoline-MonoQuinazoline: A Flat Proton Binder and its Application as a Polyaromatic Hydrocarbon Scavenger and G4 Ligand (Chem. Eur. J. 12/2025) 封面：DiQuinoline-MonoQuinazoline：一种扁平质子粘合剂及其作为多芳烃清除剂和 G4 配体的应用（《欧洲化学杂志》第 12/2025 期）

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-25 DOI: 10.1002/chem.202581201

Taiga Karimata, Wei Xu, Naoya Kumagai

引用次数: 0

Cover Feature: A Hybrid BN-Doped Nanographene with Narrow Emission Bandwidths for OLEDs (Chem. Eur. J. 12/2025)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-25 DOI: 10.1002/chem.202581204

Vyacheslav V. Diev, Yunlong Zou, Denis Kondakov, Glenn P. A. Yap

引用次数: 0

Sulfide Synthesis via A Bioinspired C-S σ-Bond Metathesis.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-25 DOI: 10.1002/chem.202500153

Youwei Xie, Hongmei Liu, Yuzhu Zheng, Ke-Lin Xian, Qi-Qi Hu, Rong-Zhen Liao

引用次数: 0

Cooperative Photoredox Catalysis Under Confinement. 限制条件下的合作光氧化催化。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-02-25 DOI: 10.1002/chem.202404699

Shweta Gaikwad, Argha Bhattacharjee, Elizabeth Elacqua

{"title":"Cooperative Photoredox Catalysis Under Confinement.","authors":"Shweta Gaikwad, Argha Bhattacharjee, Elizabeth Elacqua","doi":"10.1002/chem.202404699","DOIUrl":"https://doi.org/10.1002/chem.202404699","url":null,"abstract":"Photoredox catalysis has emerged as a potent means to conduct synthetic chemistry. Leveraging light to achieve challenging organic transformations has led to many developments, both of fundamental and industrial nature. Despite their potency, photoredox processes are inherently diffusion controlled, which can limit their ability to enable both reactivity and selectivity. Relevant to this is the idea of colocalizing cocatalysts in architectures that enable spatial proximity, promoting 'catalysis under confinement.' In this Concept review, we summarize recent designs and advancements using well-defined heterogeneous and homogeneous frameworks that enable dual photoredox catalysis, such as metal-organic frameworks, heterogeneous organic polymeric systems, and single-chain polymer nanoparticles (SCNPs). These advances generally stem from the material's inherent ability to enforce catalyst communication, typically resulting in expedient radical, electron, or energy transfer that accelerates reactivity. Whereas heterogeneous systems are comprehensively investigated, the design space arising from the modularity and versatility of a SCNP is quite large making the recyclable platform an intriguing candidate to investigate for confinement-enabled photoredox catalysis. We expect that both heterogeneous and homogeneous platforms systems detailed herein will continue to exhibit superior performance, while underscoring the importance of confinement to tackle diffusion-limited reactions.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404699"},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0