Iranian Journal of Radiation Research最新文献_第4页

Development of radiolabeled dextran coated iron oxide nanoparticles with 111-In and its biodistribution studies 放射性标记右旋糖酐包被的111In氧化铁纳米粒子的研制及其生物分布研究

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.539

S. M. Anijdan, Amir Gholami, A. Lahooti

{"title":"Development of radiolabeled dextran coated iron oxide nanoparticles with 111-In and its biodistribution studies","authors":"S. M. Anijdan, Amir Gholami, A. Lahooti","doi":"10.18869/ACADPUB.IJRR.18.3.539","DOIUrl":"https://doi.org/10.18869/ACADPUB.IJRR.18.3.539","url":null,"abstract":"Background: The main aim of this study is to radiolabel dextran coated iron oxide nanoparticles (NPs) (with 80 nm hydrodynamic size) with the Indium-111 and evaluation their biodistribution after intravenous injection normal mice. Materials and Method: The chelator Diethylenetriamine Pentaacetic Acid (DTPA) dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method at a ratio of 1:5 (NPs:DTPA) molar ratio. The reaction was purified with magnetic assorting columns (MACs) using high gradient magnetic field following incubation. Then the radiochemical purity of the radiolabeled NPs were determined using RTLC method. The magnetic properties of nanoparticles were measured by a 1.5 tesla clinical human MRI. Results: The NPs showed high super paramagnetic properties whereas their r2/r1 was 17.6. The RTLC showed that the purity of compound was above 99% after purification and the compound has shown a good in-vitro stability until 6 hours in the presence of human serum. The biodistribution of In-DTPA-NPs in mice demonstrated high uptake in the reticuloendothelial system (RES) and the blood clearance was so fast. Conclusion: Due to magnificent uptakes of this radiotracer in the liver and spleen, its stability and their fast clearance from other tissues, especially in blood, it is suggested that this radiotracer would be suitable for RES theranostics purposes.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"539-547"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45869343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Demonstration of bystander response in high dose technique of grid using theoretical calculation by linear quadratic model along with experimental investigations 用线性二次模型的理论计算和实验研究证明了高剂量电网技术中的旁观者反应

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.495

F. Pakniyat, S. Gholami, H. Nedaie, H. Mozdarani, A. Mahmoudzadeh, M. Salimi

{"title":"Demonstration of bystander response in high dose technique of grid using theoretical calculation by linear quadratic model along with experimental investigations","authors":"F. Pakniyat, S. Gholami, H. Nedaie, H. Mozdarani, A. Mahmoudzadeh, M. Salimi","doi":"10.18869/ACADPUB.IJRR.18.3.495","DOIUrl":"https://doi.org/10.18869/ACADPUB.IJRR.18.3.495","url":null,"abstract":"Background: The Linear Quadratic (LQ) equation as the most common formula in radiotherapy has a debatable accuracy in modeling high-dose effects. The purpose of this study was to demonstrate bystander response of the Grid treatment in SCC cell line, based on both theoretical calculations and experimental investigations. Materials and methods: The linear quadratic model was used to calculate the equivalent uniform dose (EUD) of a Grid-field with the 10 Gy maximum doses. According to the EUD definition, the identical tumor survival fraction (SF) was expected to obtain from both Grid and openfield single fraction. After observing the difference, the clonogenic and apoptosis assays were exerted to investigate bystander response via medium transfer strategy which was performed from 10Gy-irradiated donors to 1.5Gyirradiated recipients. Results: The EUD was equal to 4 Gy and the SF of 4 Gy EUD and 10 Gy Grid-field were 0.1 ± 0.02 and 0.051 ± 0.008, respectively. These findings contradicted the theoretical expectations of their survivals equality. Moreover, the bystander clonogenic cells death enhanced approximately by 2.91 times (statistically significant); highlighting the bystander response role. The apoptotic findings illustrated that the bystander cells experienced an approximately 10% increase and the apoptotic rate confirmed the clonogenic survival result which was less in the EUD than the Grid-field. Conclusion: Since the SF of the Grid-field was less than the EUD, it revealed the Grid therapeutic advantages plus bystander response manifestation; that was ignored in the LQ equation and may not be demonstrated by sheer theoretical calculations of the modulated-field.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"495-504"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43073525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Patient radiation dosimetry during interventional cardiac procedures 心脏介入手术中的患者辐射剂量测定

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.511

F. Omidvar, F. Bouzarjomehri, F. Falahati, M. Zare

{"title":"Patient radiation dosimetry during interventional cardiac procedures","authors":"F. Omidvar, F. Bouzarjomehri, F. Falahati, M. Zare","doi":"10.18869/ACADPUB.IJRR.18.3.511","DOIUrl":"https://doi.org/10.18869/ACADPUB.IJRR.18.3.511","url":null,"abstract":"Background: Cardiac catheterization plays an essential role in the evaluation of suspected heart failure patients. This work aimed to determine the mean effective dose of patients undergoing catheterization tests and to estimate the associated radiation risk of malignancy. Material and Methods: Measurements were performed during 65 coronary angiographies (CA), 70 coronary angioplasties (PTCA) 27, radio fluoroscopy (RF) ablations and 25 electro physiologies procedures in a dedicated laboratory. The procedures were undertaken with the Siemens and General Electric X-ray equipment. A dose area product (DAP) meter was also used. The DAP values and fluoroscopy times were recorded for each patient. Results: The mean DAP values and patient effective doses were 19.53 Gy.cm and 1.71 mSv for CA, 49.74 Gy.cm2 and 4.57 mSv for PTCA, 153.34 Gy.cm and 16.38 mSv for ablations and 14.88 Gy.cm and 1.65 mSv for electrophysiology, respectively. The patient radiation risk was estimated at 13, 1.3, 1.3, 3.6 fatal cancer per 10000 procedures of ablations, electrophysiology, CA and PTCA cases, respectively. Conclusion: Results showed that the radiation risk due to RF cardiac ablation is higher than the other complication procedures so, efforts should be made to minimize patient radiation risk from RF ablation procedures. Also we found no clear correlation between cardiologist level of experience and reduced level of patient’s dose.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"511-519"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42869113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Brainstem schwannoma: A case report and review of clinical and imaging features 脑干神经鞘瘤1例报告及临床和影像学特征回顾

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.605

Xiao Liang, W. Shi, Xin Wang, Jiang-bo Qin, Le Wang, Xiao-feng Wu, Hui Zhang, Yan Tan

{"title":"Brainstem schwannoma: A case report and review of clinical and imaging features","authors":"Xiao Liang, W. Shi, Xin Wang, Jiang-bo Qin, Le Wang, Xiao-feng Wu, Hui Zhang, Yan Tan","doi":"10.18869/ACADPUB.IJRR.18.3.605","DOIUrl":"https://doi.org/10.18869/ACADPUB.IJRR.18.3.605","url":null,"abstract":"Background: Intracerebral schwannoma is an extremely rare disease, accounting for fewer than 1% of intracranial schwannomas. The most common site for this type of schwannoma is the cerebral hemisphere, especially the frontal and temporal lobes; brainstem schwannoma is infrequent. Case Description: Here, we report a 51-year-old man with a monthlong history of blurred vision and weakness in his left lower limb. Magnetic resonance imaging showed a heterogeneous cystic tumor with a solid nodule arising from the brainstem. The patient underwent a craniotomy with complete resection of the tumor, which was confirmed to be a brainstem schwannoma by histopathological examination. We also performed a literature review of the 19 reported cases of brainstem schwannoma. Conclusions: Brainstem schwannomas predominated in children and young adults (60% of cases occurred in patients ≤ 30 years of age), and were more common in females (65%). Most of these schwannomas exhibited heterogeneous intensity, containing cystic (78%) and solid-enhanced components. The vast majority of reported cases (94.9%) followed a benign course, with an improved prognosis following tumor resection.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"605-610"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46353301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Complication analysis of breast cancer patients after mastectomy with immediate autologous breast reconstruction and adjuvant radiotherapy 乳腺癌癌症患者乳房切除术后即刻自体乳房重建及辅助放疗并发症分析

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.389

Soo Jung Lee, Y. Kwak, E. Park, S. Lee, S. Sung, B. Choi

引用次数: 0

Effect of lung inhomogeneity on dose distribution during radiotherapy of patient with lung cancer 肺不均匀性对癌症放疗剂量分布的影响

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.579

M. Zabihzadeh, Z. Ghahremani, S. Hoseini, H. Shahbazian, M. H. Ghahfarokhi

{"title":"Effect of lung inhomogeneity on dose distribution during radiotherapy of patient with lung cancer","authors":"M. Zabihzadeh, Z. Ghahremani, S. Hoseini, H. Shahbazian, M. H. Ghahfarokhi","doi":"10.18869/ACADPUB.IJRR.18.3.579","DOIUrl":"https://doi.org/10.18869/ACADPUB.IJRR.18.3.579","url":null,"abstract":"Background: Presence of inhomogeneities such as lung tissue with low density can perturbs the dose distribution in the path of therapeutic photon beam and causes undesired cold or hot spots. The aim of this study was to investigate the effect of lung tissue inhomogeneities on dose distribution in thorax irradiation. Materials and Methods: The Monte Carlo simulation (MC) code of EGSnrc-based BEAMnrc was used to calculate dose distribution for 6 MVSiemens Primus linear accelerator (Linac) in a homogenous phantom. Dose perturbation and inhomogeneity corrected factors (ICFs) were calculated due to implementation of lung tissue depended to the lung density and field size. Results: The maximum increased dose in lung tissue with lung density of 0.5 and 0.25gr/cm was 15.9%, 16.2%, 15.6%, 23.8 %, 24.8% and 25.0% for 6 × 6, 10 × 10 and 20 × 20 cm field sizes, respectively. The maximum ICF for these field sizes was 1.16 and 1.25 for lung density of 0.5 and 0.25gr/cm, respectively. The maximum dose reduction in lung tissue with density of 0.25 and 0.5gr/cm was 19.5% and 4.2 %, and the related ICF was estimated 0.84 and 0.95, respectively. Conclusion: Involvement of lung tissue in the path of irradiation perturbs the dose distribution which is dependent to the lung density and field size. The ICFs resulted from our MC model could be useful to accurately calculate the dose distribution in radiotherapy of lung abnormalities.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"579-586"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49252314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dosimetric comparison of conventional and field-in-field techniques in early-stage breast cancer radiotherapy 早期乳腺癌放疗常规与现场放射技术的剂量学比较

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.487

S. Hosseini, M. Momennezhad, S. Naseri

引用次数: 0

Clinical outcome of stereotactic body radiotherapy for localized prostate cancer: long-term results 立体定向放射治疗局限性前列腺癌的临床效果:远期效果

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.381

H. Kim, Jung-Sub Lee, W. Kim

引用次数: 0

Effects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation 肾上腺素和ramp2对全身辐射小鼠肺部的影响

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI: 10.18869/ACADPUB.IJRR.18.3.571

M. K. Ozbilgin, G. Z. Karaman, S. Gencur, E. Gumustepe, C. Kurtman

{"title":"Effects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation","authors":"M. K. Ozbilgin, G. Z. Karaman, S. Gencur, E. Gumustepe, C. Kurtman","doi":"10.18869/ACADPUB.IJRR.18.3.571","DOIUrl":"https://doi.org/10.18869/ACADPUB.IJRR.18.3.571","url":null,"abstract":"Background: Adrenomedullin (AM) and its receptor, receptor activitymodifying protein (RAMP) 2 have pleiotropic regulatory functions in normal tissue and cancer tissue. AM is produced and secreted both numerous stromal cells and tumor cells. This study aims to investigate a possible role of AM and RAMP2 in the radiation exposure in the normal lung tissue. Materials and Methods: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice were subjected to a 500 cGy single-dose radiation exposure in the total body radiation device and lung tissues were collected. 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. Results: The general histology and the immunohistochemistry of the tissue samples prepared with antiAM, anti– RAMP2, and monoclonal antibodies were investigated, yielding a statistically significant increase for AM on day 3 and for RAMP2 on day 1 after radiation exposure. Conclusion: The observed increase of AM and RAMP2 concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"571-578"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46325189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why can COVID-19 fatality in space be significantly higher than on Earth? 为什么太空中的新冠肺炎致死率会显著高于地球？

Iranian Journal of Radiation Research Pub Date : 2020-07-01 DOI: 10.18869/ACADPUB.IJRR.18.3.421

J. Welsh, J. Bevelacqua, H. Mozdarani, S. Mortazavi, S. Mortazavi

{"title":"Why can COVID-19 fatality in space be significantly higher than on Earth?","authors":"J. Welsh, J. Bevelacqua, H. Mozdarani, S. Mortazavi, S. Mortazavi","doi":"10.18869/ACADPUB.IJRR.18.3.421","DOIUrl":"https://doi.org/10.18869/ACADPUB.IJRR.18.3.421","url":null,"abstract":"Astronauts are exposed to a wide variety of stressors ranging from radiation and microgravity to persistent fluids shifts, circadian shifts and the psychological stress of prolonged isolation and confinement. On deep space missions, beyond the range of the Earth's magnetosphere, ionizing radiation may increase oxidative stress and DNA damage, immune system dysregulation and alter the effectiveness of the cellular defense mechanisms. By reviewing the health problems reported by astronauts participated in previous space missions, it is evident that viral infections are not rare in space. Recent reports suggest that COVID-19 can last for a long time in communities. Although NASA implements countermeasures designed to limit crew illness during space missions such as a pre-flight quarantine, it is not clear whether an outbreak can be prevented. Currently, it is not likely that astronauts could get a viral infection, but the consequences of potential lifethreatening viral diseases such as COVID-19 should be better characterized. In this paper we discuss why COVID-19 fatality in space might be significantly higher than on the Earth. The reasons for such an increased risk include 1) uselessness of social distancing due to microgravity 2) immune system dysregulation 3) possibly higher mutation rates of RNA viruses such as the novel coronavirus (SARS-CoV-2) 4) existence of strong selective pressure and 5) decreased maximum oxygen uptake. Given these considerations, the combined effects of microgravity, space radiation (and possibly other major space stressors) on the immune system of astronauts exposed to SARS-CoV-2 and possible interactions of the virus, space stressors and host should be carefully investigated.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"421-426"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47500648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8