International Journal of Vascular Medicine最新文献_第7页

Risk and Outcome after Simultaneous Carotid Surgery and Cardiac Surgery: Single Centre Experience. 颈动脉手术和心脏手术后的风险和结果：单中心经验。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-08-16 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7205903

Theodor Tirilomis, Dieter Zenker, Tomislav Stojanovic, Stella Malliarou, Friedrich A Schoendube

{"title":"Risk and Outcome after Simultaneous Carotid Surgery and Cardiac Surgery: Single Centre Experience.","authors":"Theodor Tirilomis, Dieter Zenker, Tomislav Stojanovic, Stella Malliarou, Friedrich A Schoendube","doi":"10.1155/2018/7205903","DOIUrl":"10.1155/2018/7205903","url":null,"abstract":"Objective: Carotid artery stenosis in patients undergoing open-heart surgery may increase risk and deteriorate outcome. The aim of the study was the analysis of risks and outcome after simultaneous carotid and cardiac surgery.Methods: We retrospectively reviewed the medical records of 100 consecutive patients who underwent simultaneous carotid surgery and open-heart surgery during a 5-year period (from 2006 to 2010). Seventy patients were male and 30 female; the mean age was 70.9±7.9 years (median: 71.8 years). Seventy-three patients underwent coronary bypass grafting (CABG), 18 patients combined CABG and valve procedures, 7 patients CABG combined with other procedures, and 3 patients isolated valve surgery. More than half of patients had had bilateral carotid artery pathology (n=51) including contralateral carotid artery occlusion in 12 cases.Results: Carotid artery patch plasty was performed in 71 patients and eversion technique in 29. In 75 cases an intraluminal shunt was used. Thirty-day mortality rate was 7% due to cardiac complications (n=5), metabolic disturbance (n=1), and diffuse cerebral embolism (n=1). There were no carotid surgery-related deaths. Postoperatively, transient cerebral ischemia occurred in one patient and stroke with mild permanent neurological deficit (Rankin level 2) in another patient.Conclusion: Simultaneous carotid artery surgery and open-heart surgery have low risk. The underlying cardiac disease influences outcome.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"7205903"},"PeriodicalIF":1.3,"publicationDate":"2018-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36466054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Carotid Wall Shear Rate and Arterial Stiffness in Patients with Hypertension and Atherosclerosis of Peripheral Arteries. 高血压和外周动脉粥样硬化患者颈动脉壁剪切率与动脉僵硬度的关系。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-08-01 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6486234

Vadim V Genkel, Alexey O Salashenko, Tatyana N Shamaeva, Veronika A Sumerkina, Igor I Shaposhnik

{"title":"Association between Carotid Wall Shear Rate and Arterial Stiffness in Patients with Hypertension and Atherosclerosis of Peripheral Arteries.","authors":"Vadim V Genkel, Alexey O Salashenko, Tatyana N Shamaeva, Veronika A Sumerkina, Igor I Shaposhnik","doi":"10.1155/2018/6486234","DOIUrl":"https://doi.org/10.1155/2018/6486234","url":null,"abstract":"Aim: To evaluate carotid wall shear rate (WSR) in association with local and regional vascular stiffness in patients with hypertension (HTN) and atherosclerosis of peripheral arteries and to study the pattern of change of WSR in patients with HTN with increasing severity of peripheral artery atherosclerosis.Materials and methods: Study involved 133 patients with HTN, 65 men and 48 women, aged in average 57.9±10.8 years. All patients were divided into four groups in accordance with ultrasound morphologic classification of vessel wall. Duplex scanning of carotid and lower limb arteries was performed. Carotid-femoral (cfPWV) and carotid-radial (crPWV) pulse wave velocity (PWV) were measured. Local carotid stiffness was evaluated by carotid ultrasound.Results: WSR of patients with plaques without and with hemodynamic disturbance was 416±128 s-1 and 405±117 s-1, respectively, which was significantly less than the WSR in patients with intact peripheral arteries - 546±112 s-1. Decreased carotid WSR was associated with increased crPVW, cfPWV, Peterson's elastic modulus, decreased distensibility, and distensibility coefficient.Conclusion: In patients with HTN and atherosclerotic lesions of peripheral arteries, it is registered that the carotid WSR decreased with increasing severity of atherosclerosis. Decreased carotid WSR is associated with increased local carotid stiffness, regional vascular stiffness of muscular, and elastic vessels.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"6486234"},"PeriodicalIF":1.3,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6486234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36436355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Sentry Bioconvertible Inferior Vena Cava Filter: Study of Stages of Incorporation in an Experimental Ovine Model. 哨兵生物可转换下腔静脉过滤器:在实验羊模型中掺入阶段的研究。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-07-19 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6981505

Peter A Gaines, Frank D Kolodgie, Gordon Crowley, Steven Horan, Megan MacDonagh, Emily McLucas, David Rosenthal, Ashley Strong, Michael Sweet, Deepal K Panchal

{"title":"Sentry Bioconvertible Inferior Vena Cava Filter: Study of Stages of Incorporation in an Experimental Ovine Model.","authors":"Peter A Gaines, Frank D Kolodgie, Gordon Crowley, Steven Horan, Megan MacDonagh, Emily McLucas, David Rosenthal, Ashley Strong, Michael Sweet, Deepal K Panchal","doi":"10.1155/2018/6981505","DOIUrl":"https://doi.org/10.1155/2018/6981505","url":null,"abstract":"The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection from pulmonary embolism (PE) and then bioconvert to become incorporated in the vessel wall, leaving a patent IVC lumen. Objective. To evaluate the performance and stages of incorporation of the Sentry IVC filter in an ovine model. Methods. Twenty-four bioconvertible devices and 1 control retrievable filter were implanted in the infrarenal IVC of 25 sheep, with extensive daily monitoring and intensive imaging. Vessels and devices were analyzed at early (≤98 days, n = 10) and late (180 ± 30 days, n = 14 study devices, 1 control) termination and necropsy time-points. Results. Deployment success was 100% with all devices confirmed in filtering configuration, there were no filter-related complications, and bioconversion was 100% at termination with vessels widely patent. By 98 days for all early-incorporation analysis animals, the stabilizing cylindrical part of the Sentry frame was incorporated in the vessel wall, and the filter arms were retracted. By 180 days for all late-incorporation analysis animals, the filter arms as well as frames were stably incorporated. Conclusions. Through 180 days, there were no filter-related complications, and the study devices were all bioconverted and stably incorporated, leaving all IVCs patent.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"6981505"},"PeriodicalIF":1.3,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6981505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36399792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Clinical Arterial Peripheral Vascular Pathology Does Not Impact Short- or Long-Term Survival after Transcatheter Aortic Valve Replacement. 经导管主动脉瓣置换术后的临床动脉外周血管病理不影响短期或长期生存。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-07-17 eCollection Date: 2018-01-01 DOI: 10.1155/2018/2707421

Brent Klinkhammer

{"title":"Clinical Arterial Peripheral Vascular Pathology Does Not Impact Short- or Long-Term Survival after Transcatheter Aortic Valve Replacement.","authors":"Brent Klinkhammer","doi":"10.1155/2018/2707421","DOIUrl":"https://doi.org/10.1155/2018/2707421","url":null,"abstract":"Introduction: The dramatic changes in vascular hemodynamics after transcatheter aortic valve replacement (TAVR) are well noted. However, little postprocedural data exists on the outcomes in patients with clinical arterial peripheral vascular pathology [abdominal aortic aneurysm (AAA), carotid artery stenosis (CAS), and peripheral artery disease (PAD)] undergoing TAVR for severe aortic stenosis.Setting: A single center healthcare system.Methodology: A retrospective chart review case-control study of 342 consecutive patients who underwent a TAVR for severe aortic stenosis at Sanford Health in Fargo; ND was performed to determine if preprocedural comorbid AAA, CAS, or PAD was associated with worse outcomes after TAVR.Results: Patients with preprocedural comorbid AAA, CAS, or PAD had no significant difference overall survival at 1 month (94% versus 95% p =.812), 6 months (88% versus 89% p = .847), 1 year (74% versus 83%, p =.130), or 2 years (58% versus 63%, p =.611) after TAVR. Patients with clinical arterial peripheral vascular pathology also had no significant difference in preprocedural outcomes.Conclusion: This study gives evidence to suggest that patients with a comorbid clinical peripheral arterial pathology at the time of TAVR do not have a statistically significant increase in mortality out to 2 years after TAVR and no increase in procedural complications. These results affirm the safety and feasibility of TAVR in patients with AAA, CAS, and/or PAD.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"2707421"},"PeriodicalIF":1.3,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/2707421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36399791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Appropriateness of Pharmacologic Prophylaxis against Deep Vein Thrombosis in Medical Wards of an Ethiopian Referral Hospital. 埃塞俄比亚一家转诊医院内科病房对深静脉血栓的药物预防是否适当？

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-07-11 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8176898

Mohammed Biset Ayalew, Boressa Adugna Horsa, Meseret Tilahun Zeleke

{"title":"Appropriateness of Pharmacologic Prophylaxis against Deep Vein Thrombosis in Medical Wards of an Ethiopian Referral Hospital.","authors":"Mohammed Biset Ayalew, Boressa Adugna Horsa, Meseret Tilahun Zeleke","doi":"10.1155/2018/8176898","DOIUrl":"10.1155/2018/8176898","url":null,"abstract":"Background: Most of hospitalized patents are at risk of developing deep vein thrombosis (DVT). The use of pharmacological prophylaxis significantly reduces the incidence of thromboembolic events in high risk patients. The aim of this study was to assess appropriateness of DVT prophylaxis in hospitalized medical patients in an Ethiopian referral hospital.Methods: Cross-sectional study design was employed. Patients with a diagnosis of DVT, taking anticoagulant therapy, and those who refused to participate were excluded from the study. Two hundred and six patients were included in the study using simple random sampling method. Modified Padua Risk Assessment Model was used to determine the risk of thromboembolism. SPSS (version 21) was used for analysis.Result: The total risk score for the study subjects ranged from 0 to 11 with a mean score of 3.41 ± 2.55. Nearly half (47.6%) of study participants had high risk to develop thromboembolism. Thrombocytopenia (platelets < 50 billion/L) or coagulopathy, active hemorrhage, and end stage liver disease (INR > 1.5) were the frequently observed absolute contraindications that potentially prevent patients from receiving thromboprophylaxis. Thromboprophylaxis use in nearly one-third (31.6%) of patients admitted in the medical ward of UoGRH was irrational. Patients who had high risk for thromboembolism are more likely to be inappropriately managed for their risk of thromboembolism and patients with thrombocytopenia or coagulopathy were more likely to be managed appropriately.Conclusion: There is underutilization of pharmacologic thromboprophylaxis in medical ward patients. Physicians working there should be aware of risk factors for DVT and indications for pharmacologic thromboprophylaxis and should adhere to guideline recommendations.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"8176898"},"PeriodicalIF":1.3,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36393568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis". 对“运动干预对超重和肥胖成人血流介导扩张的影响:meta分析”的评论。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-06-05 eCollection Date: 2018-01-01 DOI: 10.1155/2018/5082903

Mohammad Alwardat

引用次数: 1

Treatment of Aortic and Iliac Artery Aneurysms with Multilayer Flow Modulator: Single Centre Experiences. 多层血流调节剂治疗主动脉和髂动脉瘤:单中心经验。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-05-31 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7543817

Cengiz Ovalı, Aykut Şahin, Murat Eroğlu, Sinan Balçın, Sadettin Dernek, Mustafa Behçet Sevin

{"title":"Treatment of Aortic and Iliac Artery Aneurysms with Multilayer Flow Modulator: Single Centre Experiences.","authors":"Cengiz Ovalı, Aykut Şahin, Murat Eroğlu, Sinan Balçın, Sadettin Dernek, Mustafa Behçet Sevin","doi":"10.1155/2018/7543817","DOIUrl":"https://doi.org/10.1155/2018/7543817","url":null,"abstract":"Objective: Presenting early and midterm results of aortic and iliac artery aneurysms treated with Multilayer Flow Modulators (MFM).Methods: We retrospectively reviewed the medical records of 23 patients (19 males and 4 females) who are admitted to our clinic between April of 2014 and February of 2016, diagnosed with thoracoabdominal aortic aneurysm and/or iliac aneurysm, and treated using MFM. The patients were followed up for the development of potential clinical presentations for 12 months.Results: MFM implantation was successfully completed in all the patients. During the process, two patients developed endoleak and so they were treated with postdilatation that was performed through balloon intervention, whereby the patients fully recovered. Although a short-term ischemic cerebrovascular event occurred in one of the patients 36 hours after the MFM, the patient recuperated without any noticeable neurological sequelae. Overall, three patients died after the procedure, one of whom died in hospital three days following the intervention due to acute renal failure, while the second one lost his life at the end of the first month due to the occlusion of superior mesenteric and celiac arteries. The third patient died at the end of the third month due to acute myocardial infarction. The rest of the patients developed no complications or had no mortality at their 12-month follow-ups.Conclusion: MFM can be preferred as an alternative approach in the treatment of aorta and iliac artery aneurysms including major lateral branches. The present results should be confirmed with additional future studies conducted with larger patient groups for longer periods.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"7543817"},"PeriodicalIF":1.3,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7543817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36269417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Review of Percutaneous Transluminal Angioplasty in Hemodialysis Fistula. 经皮腔内血管成形术治疗血液透析瘘的研究进展。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-03-27 eCollection Date: 2018-01-01 DOI: 10.1155/2018/1420136

Ioannis Bountouris, Georgia Kritikou, Nikolaos Degermetzoglou, Konstantinos Ioannis Avgerinos

{"title":"A Review of Percutaneous Transluminal Angioplasty in Hemodialysis Fistula.","authors":"Ioannis Bountouris, Georgia Kritikou, Nikolaos Degermetzoglou, Konstantinos Ioannis Avgerinos","doi":"10.1155/2018/1420136","DOIUrl":"https://doi.org/10.1155/2018/1420136","url":null,"abstract":"The number of patients in dialysis increases every year. In this review, we will evaluate the role of percutaneous transluminal angioplasty (PTA) according to patency of arteriovenous fistula and grafts. The main indication of PΤΑ is stenosis > 50% or obstruction of the vascular lumen of an arteriovenous fistula and graft. It is usually performed under local anesthesia. The infection rate is as low as the number of complications. Fistula can be used in dialysis in the same day without the need for a central venous catheter. Primary patency is >50% in the first year while primary assisted patency is 80-90% in the same time period. Repeated PTA is as durable as the primary PTA. An early PTA carries a risk of new interventions. Cutting balloon can be used as a second-line method. Stents and covered stents are kept for the management of complications and central outflow venous stenosis. PTA is the treatment of choice for stenosis or obstruction of dialysis fistulas. Repeated PTA may be needed for better patency. Drug eluting balloon may become the future in PTA of dialysis fistula, but more trials are needed.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"1420136"},"PeriodicalIF":1.3,"publicationDate":"2018-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/1420136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36118038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Swirling Flow and Wall Shear: Evaluating the BioMimics 3D Helical Centerline Stent for the Femoropopliteal Segment. 旋流与壁剪切:股腘段三维仿生螺旋中心线支架的评估。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-02-26 eCollection Date: 2018-01-01 DOI: 10.1155/2018/9795174

Timothy M Sullivan, Thomas Zeller, Masato Nakamura, Colin G Caro, Michael Lichtenberg

{"title":"Swirling Flow and Wall Shear: Evaluating the BioMimics 3D Helical Centerline Stent for the Femoropopliteal Segment.","authors":"Timothy M Sullivan, Thomas Zeller, Masato Nakamura, Colin G Caro, Michael Lichtenberg","doi":"10.1155/2018/9795174","DOIUrl":"https://doi.org/10.1155/2018/9795174","url":null,"abstract":"The BioMimics 3D self-expanding nitinol stent represents a strategy for femoropopliteal intervention that is alternative or complementary to deployment of drug-coated stents or balloons. Whereas conventional straight stents reduce arterial curvature and disturb blood flow, creating areas of low wall shear, where neointimal hyperplasia predominantly develops, the helical centerline geometry of the BioMimics 3D maintains or imparts arterial curvature, promotes laminar swirling blood flow, and elevates wall shear to protect against atherosclerosis and restenosis. In the multicenter randomized MIMICS trial, treatment of femoropopliteal disease with the BioMimics 3D (n = 50) significantly improved 2-year primary patency (log-rank test p = 0.05) versus a control straight stent (n = 26), with no cases of clinically driven target lesion revascularization between 12 and 24 months (log-rank test p = 0.03 versus controls). In geometric X-ray analysis, the BioMimics stent was significantly more effective in imparting a helical shape even when the arterial segment was moderately to severely calcified. Computational fluid dynamics analysis showed that average wall shear was significantly higher with the helical centerline stent (1.13 ± 0.13 Pa versus 1.06 ± 0.12 Pa, p = 0.05). A 271-patient multicenter international MIMICS-2 trial and a 500-patient real-world MIMICS-3D registry are underway.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"9795174"},"PeriodicalIF":1.3,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/9795174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36034294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats. n -乙酰半胱氨酸对stz诱导糖尿病大鼠血脂异常及碳水化合物代谢的影响。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2018-01-28 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6428630

Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes

{"title":"Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats.","authors":"Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes","doi":"10.1155/2018/6428630","DOIUrl":"https://doi.org/10.1155/2018/6428630","url":null,"abstract":"Background: Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.Method: 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n = 8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.Results: NAC decreased (p < 0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p < 0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p < 0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM.Conclusion: NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"6428630"},"PeriodicalIF":1.3,"publicationDate":"2018-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6428630","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36127280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14