International Journal of Vascular Medicine最新文献_第10页

Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms 胸主动脉瘤内皮和平滑肌细胞的表型和功能改变

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-19 DOI: 10.1155/2016/3107879

A. Malashicheva, D. Kostina, A. Kostina, O. Irtyuga, I. Voronkina, L. Smagina, E. Ignatieva, N. Gavriliuk, V. Uspensky, O. Moiseeva, J. Vaage, A. Kostareva

{"title":"Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms","authors":"A. Malashicheva, D. Kostina, A. Kostina, O. Irtyuga, I. Voronkina, L. Smagina, E. Ignatieva, N. Gavriliuk, V. Uspensky, O. Moiseeva, J. Vaage, A. Kostareva","doi":"10.1155/2016/3107879","DOIUrl":"https://doi.org/10.1155/2016/3107879","url":null,"abstract":"Thoracic aortic aneurysm develops as a result of complex series of events that alter the cellular structure and the composition of the extracellular matrix of the aortic wall. The purpose of the present work was to study the cellular functions of endothelial and smooth muscle cells from the patients with aneurysms of the thoracic aorta. We studied endothelial and smooth muscle cells from aneurysms in patients with bicuspid aortic valve and with tricuspid aortic valve. The expression of key markers of endothelial (CD31, vWF, and VE-cadherin) and smooth muscle (SMA, SM22α, calponin, and vimentin) cells as well extracellular matrix and MMP activity was studied as well as and apoptosis and cell proliferation. Expression of functional markers of endothelial and smooth muscle cells was reduced in patient cells. Cellular proliferation, migration, and synthesis of extracellular matrix proteins are attenuated in the cells of the patients. We show for the first time that aortic endothelial cell phenotype is changed in the thoracic aortic aneurysms compared to normal aortic wall. In conclusion both endothelial and smooth muscle cells from aneurysms of the ascending aorta have downregulated specific cellular markers and altered functional properties, such as growth rate, apoptosis induction, and extracellular matrix synthesis.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2016-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3107879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64319263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Carotid Intima Media Thickness in Nondiabetic Hypertensive Nigerians: Role of Fasting and Postprandial Blood Glucose. 尼日利亚非糖尿病高血压患者颈动脉内膜中层厚度:空腹和餐后血糖的作用。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-04-10 DOI: 10.1155/2016/1429451

B N Okeahialam, S A Muoneme, H O Kolade-Yunusa

{"title":"Carotid Intima Media Thickness in Nondiabetic Hypertensive Nigerians: Role of Fasting and Postprandial Blood Glucose.","authors":"B N Okeahialam, S A Muoneme, H O Kolade-Yunusa","doi":"10.1155/2016/1429451","DOIUrl":"https://doi.org/10.1155/2016/1429451","url":null,"abstract":"Background/Aims. Carotid intima media thickness (CIMT) tracks atherosclerotic vascular disease. Hypertension and diabetes chiefly contribute to atherosclerosis with 75% of symptomatic cardiovascular disease cases having dysglycaemia even in normal cases. Hypothesising that postprandial hyperglycaemia contributes to cardiovascular morbidity, we sought to determine if any relationship existed between glycaemic profile in nondiabetic hypertensives and atherosclerosis. Methods. In a study of CIMT in nondiabetic, statin-naïve hypertensives, we evaluated fasting blood glucose (FBG) and 2-hour postprandial sugar (2hPPBG) in the patients and compared them with the CIMT. CIMT was measured on both sides, 1 cm proximal to the carotid bulb using a 7.5 mHz transducer of ALOKA SSD-3500 ultrasound machine. Results. The subjects with complete data were 86 (63 F). The mean (SD) of CIMT was 0.89 (0.15) mm, FBG 4.8 (0.097) mmol/L, and 2hPPBG 6.5 (1.81) mmol/L. There was no significant correlation between FBG and 2hPPBG with CIMT. Blood pressure had no bearing on this. When blood glucose data were divided into quartiles and post hoc multiple comparison was done, there was significant difference in CIMT for the different ranges. This was not so for 2hPPBG. Conclusion. Though expected from other studies, we did not show any significant correlation between FBG and 2hPPBG status and CIMT. This may be our pattern as the degree of excursion of 2hPPBG was low. There may be a threshold level above which PPBG starts to impact CIMT. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"1429451"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1429451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34370051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats. 大鼠急性失血性休克后肾血流对血管紧张素 1-7 和 7.5% 高渗氯化钠的反应

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-03-17 DOI: 10.1155/2016/6562017

Maryam Maleki, Mehdi Nematbakhsh

{"title":"Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats.","authors":"Maryam Maleki, Mehdi Nematbakhsh","doi":"10.1155/2016/6562017","DOIUrl":"10.1155/2016/6562017","url":null,"abstract":"Background. Angiotensin 1-7 (Ang1-7) plays an important role in renal circulation. Hemorrhagic shock (HS) may cause kidney circulation disturbance, and this study was designed to investigate the renal blood flow (RBF) response to Ang1-7 after HS. Methods. 27 male Wistar rats were subjected to blood withdrawal to reduce mean arterial pressure (MAP) to 45 mmHg for 45 min. The animals were treated with saline (group 1), Ang1-7 (300 ng·kg(-1) min(-1)), Ang1-7 in hypertonic sodium chloride 7.5% (group 3), and hypertonic solution alone (group 4). Results. MAP was increased in a time-related fashion (P time < 0.0001) in all groups; however, there was a tendency for the increase in MAP in response to hypertonic solution (P = 0.09). Ang1-7, hypertonic solution, or combination of both increased RBF in groups 2-4, and these were significantly different from saline group (P = 0.05); that is, Ang1-7 leads to a significant increase in RBF to 1.35 ± 0.25 mL/min compared with 0.55 ± 0.12 mL/min in saline group (P < 0.05). Conclusion. Although Ang1-7 administration unlike hypertonic solution could not elevate MAP after HS, it potentially could increase RBF similar to hypertonic solution. This suggested that Ang1-7 recovers RBF after HS when therapeutic opportunities of hypertonic solution are limited. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"6562017"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34399849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraoxonase-1 and Simvastatin Treatment in Patients with Stable Coronary Artery Disease. 对氧磷酶-1和辛伐他汀治疗稳定型冠心病患者。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-04-11 DOI: 10.1155/2016/6312478

Rafał Januszek

{"title":"Paraoxonase-1 and Simvastatin Treatment in Patients with Stable Coronary Artery Disease.","authors":"Rafał Januszek","doi":"10.1155/2016/6312478","DOIUrl":"https://doi.org/10.1155/2016/6312478","url":null,"abstract":"Background. Paraoxonase-1 (PON1) is the crucial antioxidant marker of high-density lipoproteins. The present study is aimed at assessing the effect of simvastatin treatment on PON1 activity and its relationship to Q192R and M55L polymorphisms in subjects with stable coronary artery disease (CAD). Methods. The patient group was composed of 53 individuals with stable CAD, and the control group included 53 sex-matched police officers without CAD. CAD patients were treated with simvastatin 40mg/day for 12 months. Respectively, flow mediated dilatation (FMD), serum hs-CRP and TNF-α levels, urinary 8-iso-PGF2α concentrations, and PON1 activity were evaluated in definitive intervals. Results. There was no effect of simvastatin treatment on urinary 8-iso-PGF2α . Simvastatin treatment significantly increased FMD value, decreased CRP and TNF-α concentration. After adjusting for PON1 genotypes, significantly higher PON1 activity was noted in the 192R allele carriers, in both groups. Regardless of genotype, PON1 activity remained stable after simvastatin treatment. Conclusions. The present study confirms a positive effect of simvastatin therapy on endothelial function and inflammatory markers in secondary prevention. Simvastatin treatment shows no effects on PON1 activity and 8-isoprostanes level. The effect of simvastatin therapy on PON1 activity is not modulated by Q192R and M55L polymorphisms. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"6312478"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6312478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34508076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

ABPI against Colour Duplex Scan: A Screening Tool for Detection of Peripheral Arterial Disease in Low Resource Setting Approach to Validation. ABPI 针对彩色双功扫描：在低资源环境中检测外周动脉疾病的筛查工具验证方法。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-03-10 DOI: 10.1155/2016/1390475

Janaka Weragoda, Rohini Seneviratne, Manuj C Weerasinghe, S M Wijeyaratne

{"title":"ABPI against Colour Duplex Scan: A Screening Tool for Detection of Peripheral Arterial Disease in Low Resource Setting Approach to Validation.","authors":"Janaka Weragoda, Rohini Seneviratne, Manuj C Weerasinghe, S M Wijeyaratne","doi":"10.1155/2016/1390475","DOIUrl":"10.1155/2016/1390475","url":null,"abstract":"Background. In Sri Lanka the ABPI has not been used as a screening tool to detect peripheral arterial disease (PAD) in epidemiological studies. This study was conducted to determine the best cutoff value of ABPI to detect PAD in Sri Lankan population. Methods. The ABPI measured by arterial Doppler to detect PAD was validated against colour duplex scan as the criterion using 165 individuals referred to vascular laboratory, National Hospital Sri Lanka. In all selected individuals ABPI was measured and lower limb colour duplex scan was performed. Narrowing of luminal diameter of lower limb arteries 50% or more was considered as haemodynamically significant and having PAD. The discriminative performance of the ABPI was assessed using Receiver Operator Characteristic (ROC) curve and calculating the area under the curve (AUC). The sensitivity and specificity of different threshold levels of ABPI and the best cutoff value of ABPI to detect PAD were determined. Results. ABPI 0.89 was determined as the best cutoff value to identify individuals with PAD. At this level of ABPI high sensitivity (87%), specificity (99.1%), positive predictive value (98.9%), and negative predictive value (88.4%) were observed. Conclusion. ABPI ≤ 0.89 could be used as the best cut off value to detect PAD. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":"1390475"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64220937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of Inflammatory Biomarkers with Severity of Peripheral Arterial Disease. 炎症生物标志物与外周动脉疾病严重程度的关系。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-07-31 DOI: 10.1155/2016/6015701

Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue

{"title":"Relationship of Inflammatory Biomarkers with Severity of Peripheral Arterial Disease.","authors":"Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue","doi":"10.1155/2016/6015701","DOIUrl":"https://doi.org/10.1155/2016/6015701","url":null,"abstract":"Objective. The pentraxin family, including high-sensitivity C-reactive protein (hs-CRP), serum amyloid P (SAP), and pentraxin 3 (PTX3), has been identified as playing a key role in inflammatory reactions such as in atherosclerosis and cardiovascular disease. In this study, we examined the relationship between peripheral arterial disease (PAD) and serum levels of pentraxins. Methods. This study was undertaken via a retrospective review of PAD patients with surgical intervention for lesions of the common femoral artery. We evaluated the preoperative patient conditions, hemodynamic status, such as ankle brachial index (ABI), and clinical ischemic conditions according to Rutherford classification. Preoperatively, we collected blood samples for determining the serum levels of hs-CRP, SAP, and PTX3. Results. Twelve PAD patients with common femoral arterial lesions were treated and examined. The hemodynamic severity of PAD was not negatively correlated with hs-CRP, SAP, or PTX3. The clinical severity evaluated by Rutherford classification was significantly positively correlated with the serum level of PTX3 (p = 0.019). Conclusion. We demonstrated that PTX3 might be a better marker of PAD than hs-CRP and SAP. Furthermore, PTX3 might be a prognostic marker to evaluate the severity of PAD. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"6015701"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6015701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34335917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells. tgf - β1诱导内皮细胞长链非编码rna的研究。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-04-10 DOI: 10.1155/2016/2459687

Krishna K Singh, Pratiek N Matkar, Adrian Quan, Laura-Eve Mantella, Hwee Teoh, Mohammed Al-Omran, Subodh Verma

{"title":"Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells.","authors":"Krishna K Singh, Pratiek N Matkar, Adrian Quan, Laura-Eve Mantella, Hwee Teoh, Mohammed Al-Omran, Subodh Verma","doi":"10.1155/2016/2459687","DOIUrl":"https://doi.org/10.1155/2016/2459687","url":null,"abstract":"Objective. To evaluate the relationship between TGFβ signaling and endothelial lncRNA expression. Methods. Human umbilical vein endothelial cell (HUVECs) lncRNAs and mRNAs were profiled with the Arraystar Human lncRNA Expression Microarray V3.0 after 24 hours of exposure to TGFβ1 (10 ng/mL). Results. Of the 30,584 lncRNAs screened, 2,051 were significantly upregulated and 2,393 were appreciably downregulated (P < 0.05) in response to TGFβ. In the same HUVEC samples, 2,148 of the 26,106 mRNAs screened were upregulated and 1,290 were downregulated. Of these 2,051 differentially expressed upregulated lncRNAs, MALAT1, which is known to be induced by TGFβ in endothelial cells, was the most (~220-fold) upregulated lncRNA. Bioinformatics analyses indicated that the differentially expressed upregulated mRNAs are primarily enriched in hippo signaling, Wnt signaling, focal adhesion, neuroactive ligand-receptor interaction, and pathways in cancer. The most downregulated are notably involved in olfactory transduction, PI3-Akt signaling, Ras signaling, neuroactive ligand-receptor interaction, and apoptosis. Conclusions. This is the first lncRNA and mRNA transcriptome profile of TGFβ-mediated changes in human endothelial cells. These observations may reveal potential new targets of TGFβ in endothelial cells and novel therapeutic avenues for cardiovascular disease-associated endothelial dysfunction. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"2459687"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2459687","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34370052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Simple In-Hospital Interventions to Reduce Door-to-CT Time in Acute Stroke. 简单的院内干预减少急性脑卒中患者从门到ct的时间。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-07-10 DOI: 10.1155/2016/1656212

Elyar Sadeghi-Hokmabadi, Aliakbar Taheraghdam, Mazyar Hashemilar, Reza Rikhtegar, Kaveh Mehrvar, Mehrdad Mehrara, Reshad Mirnour, Rogayyeh Hassasi, Hannane Aliyar, Mohammadamin Farzi, Somayyeh Hasaneh Tamar

{"title":"Simple In-Hospital Interventions to Reduce Door-to-CT Time in Acute Stroke.","authors":"Elyar Sadeghi-Hokmabadi, Aliakbar Taheraghdam, Mazyar Hashemilar, Reza Rikhtegar, Kaveh Mehrvar, Mehrdad Mehrara, Reshad Mirnour, Rogayyeh Hassasi, Hannane Aliyar, Mohammadamin Farzi, Somayyeh Hasaneh Tamar","doi":"10.1155/2016/1656212","DOIUrl":"https://doi.org/10.1155/2016/1656212","url":null,"abstract":"Background. Intravenous tissue plasminogen activator, a time dependent therapy, can reduce the morbidity and mortality of acute ischemic stroke. This study was designed to assess the effect of simple in-hospital interventions on reducing door-to-CT (DTC) time and reaching door-to-needle (DTN) time of less than 60 minutes. Methods. Before any intervention, DTC time was recorded for 213 patients over a one-year period at our center. Five simple quality-improvement interventions were implemented, namely, call notification, prioritizing patients for CT scan, prioritizing patients for lab analysis, specifying a bed for acute stroke patients, and staff education. After intervention, over a course of 44 months, DTC time was recorded for 276 patients with the stroke code. Furthermore DTN time was recorded for 106 patients who were treated with IV thrombolytic therapy. Results. The median DTC time significantly decreased in the postintervention period comparing to the preintervention period [median (IQR); 20 (12-30) versus 75 (52.5-105), P < 0.001]. At the postintervention period, the median (IQR) DTN time was 55 (40-73) minutes and proportion of patients with DTN time less than 60 minutes was 62.4% (P < 0.001). Conclusion. Our interventions significantly reduced DTC time and resulted in an acceptable DTN time. These interventions are feasible in most hospitals and should be considered. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"1656212"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1656212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34611538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries' Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration. 儿童和青少年肥胖与颈动脉和股动脉僵硬度的压力依赖性和年龄相关性增加有关，而与肱动脉无关，这表明动脉壁发生了非内在性改变。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-03-15 DOI: 10.1155/2016/4916246

Victoria García-Espinosa, Santiago Curcio, Juan Manuel Castro, Maite Arana, Gustavo Giachetto, Pedro Chiesa, Yanina Zócalo, Daniel Bia

{"title":"Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries' Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration.","authors":"Victoria García-Espinosa, Santiago Curcio, Juan Manuel Castro, Maite Arana, Gustavo Giachetto, Pedro Chiesa, Yanina Zócalo, Daniel Bia","doi":"10.1155/2016/4916246","DOIUrl":"10.1155/2016/4916246","url":null,"abstract":"Aim. To analyze if childhood obesity associates with changes in elastic, transitional, and/or muscular arteries' stiffness. Methods. 221 subjects (4-15 years, 92 females) were assigned to normal weight (NW, n = 137) or obesity (OB, n = 84) groups, considering their body mass index z-score. Age groups were defined: 4-8; 8-12; 12-15 years old. Carotid, femoral, and brachial artery local stiffness was determined through systodiastolic pressure-diameter and stress-strain relationships. To this end, arterial diameter and peripheral and aortic blood pressure (BP) levels and waveforms were recorded. Carotid-femoral, femoropedal, and carotid-radial pulse wave velocities were determined to evaluate aortic, lower-limb, and upper-limb regional arterial stiffness, respectively. Correlation analysis between stiffness parameters and BP was done. Results. Compared to NW, OB subjects showed higher peripheral and central BP and carotid and femoral stiffness, reaching statistical significance in subjects aged 12 and older. Arterial stiffness differences disappeared when levels were normalized for BP. There were no differences in intrinsic arterial wall stiffness (elastic modulus), BP stiffness relationships, and regional stiffness parameters. Conclusion. OB associates with BP-dependent and age-related increase in carotid and femoral (but not brachial) stiffness. Stiffness changes would not be explained by intrinsic arterial wall alterations but could be associated with the higher BP levels observed in obese children. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"4916246"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34392914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CT Angiography Analysis of Axillary Artery Diameter versus Common Femoral Artery Diameter: Implications for Axillary Approach for Transcatheter Aortic Valve Replacement in Patients with Hostile Aortoiliac Segment and Advanced Lung Disease. 腋窝动脉直径与股总动脉直径的CT血管造影分析:腋窝入路经导管主动脉瓣置换术对不良髂主动脉段和晚期肺部疾病患者的意义

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-03-27 DOI: 10.1155/2016/3610705

Rajiv Tayal, Humayun Iftikhar, Benjamin LeSar, Rahul Patel, Naveen Tyagi, Marc Cohen, Najam Wasty

{"title":"CT Angiography Analysis of Axillary Artery Diameter versus Common Femoral Artery Diameter: Implications for Axillary Approach for Transcatheter Aortic Valve Replacement in Patients with Hostile Aortoiliac Segment and Advanced Lung Disease.","authors":"Rajiv Tayal, Humayun Iftikhar, Benjamin LeSar, Rahul Patel, Naveen Tyagi, Marc Cohen, Najam Wasty","doi":"10.1155/2016/3610705","DOIUrl":"https://doi.org/10.1155/2016/3610705","url":null,"abstract":"Objective. The use of the axillary artery as an access site has lost favor in percutaneous intervention due to the success of these procedures from a radial or brachial alternative. However, these distal access points are unable to safely accommodate anything larger than a 7-French sheath. To date no studies exist describing the size of the axillary artery in relation to the common femoral artery in a patient population. We hypothesized that the axillary artery is of comparable size to the CFA in most patients and less frequently diseased. Methods. We retrospectively reviewed 110 CT scans of the thoracic and abdominal aorta done at our institution to rule out aortic dissection in which the right axillary artery, right CFA, left axillary artery, and left CFA were visualized. Images were then reconstructed using commercially available TeraRecon software and comparative measurements made of the axillary and femoral arteries. Results. In 96 patients with complete data, the mean sizes of the right and left axillary artery were slightly smaller than the left and right CFA. A direct comparison of the sizes of the axillary artery and CFA in the same patient yielded a mean difference of 1.69 mm ± 1.74. In all patients combined, the mean difference between the axillary artery and CFA was 1.88 mm on the right and 1.68 mm on the left. In 19 patients (19.8%), the axillary artery was of the same caliber as the associated CFA. In 8 of 96 patients (8.3%), the axillary artery was larger compared to the CFA. Conclusions. Although typically smaller, the axillary artery is often of comparable size to the CFA, significantly less frequently calcified or diseased, and in almost all observed cases large enough to accommodate a sheath with up to 18 French. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"3610705"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3610705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34429120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40