International Journal of Vascular Medicine最新文献_第9页

Dependence of Proximal GC Boxes and Binding Transcription Factors in the Regulation of Basal and Valproic Acid-Induced Expression of t-PA 近端GC盒和结合转录因子在基础和丙戊酸诱导的t-PA表达调控中的依赖性

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-02-07 DOI: 10.1155/2016/7928681

E. Ulfhammer, P. Larsson, Mia Magnusson, L. Karlsson, N. Bergh, S. Jern

{"title":"Dependence of Proximal GC Boxes and Binding Transcription Factors in the Regulation of Basal and Valproic Acid-Induced Expression of t-PA","authors":"E. Ulfhammer, P. Larsson, Mia Magnusson, L. Karlsson, N. Bergh, S. Jern","doi":"10.1155/2016/7928681","DOIUrl":"https://doi.org/10.1155/2016/7928681","url":null,"abstract":"Objective. Endothelial tissue-type plasminogen activator (t-PA) release is a pivotal response to protect the circulation from occluding thrombosis. We have shown that the t-PA gene is epigenetically regulated and greatly induced by the histone deacetylase (HDAC) inhibitor valproic acid (VPA). We now investigated involvement of known t-PA promoter regulatory elements and evaluated dependence of potential interacting transcription factors/cofactors. Methods. A reporter vector with an insert, separately mutated at either the t-PA promoter CRE or GC box II or GC box III elements, was transfected into HT-1080 and HUVECs and challenged with VPA. HUVECs were targeted with siRNA against histone acetyl transferases (HAT) and selected transcription factors from the Sp/KLF family. Results. An intact VPA-response was observed with CRE mutated constructs, whereas mutation of GC boxes II and III reduced the magnitude of the induction by 54 and 79% in HT-1080 and 49 and 50% in HUVECs, respectively. An attenuated induction of t-PA mRNA was observed after Sp2, Sp4, and KLF5 depletion. KLF2 and p300 (HAT) were identified as positive regulators of basal t-PA expression and Sp4 and KLF9 as repressors. Conclusion. VPA-induced t-PA expression is dependent on the proximal GC boxes in the t-PA promoter and may involve interactions with Sp2, Sp4, and KLF5.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2016-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7928681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64539817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Imaging Techniques for Diagnosis of Thoracic Aortic Atherosclerosis 胸主动脉粥样硬化的影像学诊断技术

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-02-04 DOI: 10.1155/2016/4726094

W. J. Jansen Klomp, G. J. Brandon Bravo Bruinsma, A. W. van ’t Hof, J. G. Grandjean, A. Nierich

引用次数: 17

A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls 外周动脉疾病患者与年龄、性别匹配对照组内皮功能指标的比较

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-31 DOI: 10.1155/2016/2969740

Richard B. Allan, Simon V. Vun, J. Ian Spark

{"title":"A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls","authors":"Richard B. Allan, Simon V. Vun, J. Ian Spark","doi":"10.1155/2016/2969740","DOIUrl":"https://doi.org/10.1155/2016/2969740","url":null,"abstract":"This study compared flow-mediated dilatation (FMD), peripheral artery tonometry (PAT), and serum nitric oxide (NO) measures of endothelial function in patients with peripheral artery disease (PAD) against age/gender matched controls. 25 patients (mean age: 72.4 years, M : F 18 : 7) with established PAD and an age/gender matched group of 25 healthy controls (mean age: 72.4 years, M : F 18 : 7) were studied. Endothelial function was measured using the % FMD, reactive hyperemia index (RHI) using PAT and serum NO (μmol). Difference for each method between PAD and control patients and correlation between the methods were investigated. FMD and RHI were lower in patients with PAD (median FMD for PAD = 2.16% versus control = 3.77%, p = 0.034 and median RHI in PAD = 1.64 versus control = 1.92, p = 0.005). NO levels were not significantly different between the groups (PAD median = 7.70 μmol, control median = 13.05 μmol, p = 0.662). These results were obtained in elderly patients and cannot be extrapolated to younger individuals. FMD and PAT both demonstrated a lower hyperaemic response in patients with PAD; however, FMD results in PAD patients were unequivocally reduced whereas half the PAD patients had RHI values above the established threshold for endothelial dysfunction. This suggests that FMD is a more appropriate method for the measurement of NO-mediated endothelial function.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2016-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2969740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64309090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Vascular Health in American Football Players: Cardiovascular Risk Increased in Division III Players 美国橄榄球运动员的血管健康:III级运动员心血管风险增加

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-24 DOI: 10.1155/2016/6851256

D. Feairheller, Kristin R. Aichele, Joyann E. Oakman, M. P. Neal, Christina M. Cromwell, Jessica M. Lenzo, Avery N. Perez, Naomi L. Bye, Erica L. Santaniello, Jessica A. Hill, Rachel C. Evans, Karla A. Thiele, Lauren N. Chavis, Allyson K. Getty, Tia R. Wisdo, JoAnna M. McClelland, K. Sturgeon, Pamela S Chlad

{"title":"Vascular Health in American Football Players: Cardiovascular Risk Increased in Division III Players","authors":"D. Feairheller, Kristin R. Aichele, Joyann E. Oakman, M. P. Neal, Christina M. Cromwell, Jessica M. Lenzo, Avery N. Perez, Naomi L. Bye, Erica L. Santaniello, Jessica A. Hill, Rachel C. Evans, Karla A. Thiele, Lauren N. Chavis, Allyson K. Getty, Tia R. Wisdo, JoAnna M. McClelland, K. Sturgeon, Pamela S Chlad","doi":"10.1155/2016/6851256","DOIUrl":"https://doi.org/10.1155/2016/6851256","url":null,"abstract":"Studies report that football players have high blood pressure (BP) and increased cardiovascular risk. There are over 70,000 NCAA football players and 450 Division III schools sponsor football programs, yet limited research exists on vascular health of athletes. This study aimed to compare vascular and cardiovascular health measures between football players and nonathlete controls. Twenty-three athletes and 19 nonathletes participated. Vascular health measures included flow-mediated dilation (FMD) and carotid artery intima-media thickness (IMT). Cardiovascular measures included clinic and 24 hr BP levels, body composition, VO2 max, and fasting glucose/cholesterol levels. Compared to controls, football players had a worse vascular and cardiovascular profile. Football players had thicker carotid artery IMT (0.49 ± 0.06 mm versus 0.46 ± 0.07 mm) and larger brachial artery diameter during FMD (4.3 ± 0.5 mm versus 3.7 ± 0.6 mm), but no difference in percent FMD. Systolic BP was significantly higher in football players at all measurements: resting (128.2 ± 6.4 mmHg versus 122.4 ± 6.8 mmHg), submaximal exercise (150.4 ± 18.8 mmHg versus 137.3 ± 9.5 mmHg), maximal exercise (211.3 ± 25.9 mmHg versus 191.4 ± 19.2 mmHg), and 24-hour BP (124.9 ± 6.3 mmHg versus 109.8 ± 3.7 mmHg). Football players also had higher fasting glucose (91.6 ± 6.5 mg/dL versus 86.6 ± 5.8 mg/dL), lower HDL (36.5 ± 11.2 mg/dL versus 47.1 ± 14.8 mg/dL), and higher body fat percentage (29.2 ± 7.9% versus 23.2 ± 7.0%). Division III collegiate football players remain an understudied population and may be at increased cardiovascular risk.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2016-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6851256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64493135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Retrievable Inferior Vena Cava Filters in Patients with Cancer: Complications and Retrieval Success Rate 可回收下腔静脉过滤器在癌症患者中的并发症及成功率

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-21 DOI: 10.1155/2016/6413541

A. Casanegra, L. Landrum, A. Tafur

{"title":"Retrievable Inferior Vena Cava Filters in Patients with Cancer: Complications and Retrieval Success Rate","authors":"A. Casanegra, L. Landrum, A. Tafur","doi":"10.1155/2016/6413541","DOIUrl":"https://doi.org/10.1155/2016/6413541","url":null,"abstract":"Active cancer (ACa) is strongly associated with venous thromboembolism and bleeding. Retrievable inferior vena cava filters (RIVCF) are frequently placed in these patients when anticoagulation cannot be continued. Objectives. To describe the complications and retrieval rate of inferior vena cava filters in patients with ACa. Methods. Retrospective review of 251 consecutive patients with RIVCF in a single institution. Results. We included 251 patients with RIVCF with a mean age of 58.1 years and a median follow-up of 5.4 months (164 days, IQR: 34–385). Of these patients 32% had ACa. There were no differences in recurrence rate of DVT between patients with ACa and those without ACa (13% versus 17%, p = ns). Also, there were no differences in major filter complications (11% ACa versus 7% no ACa, p = ns). The filter retrieval was not different between groups (log-rank = 0.16). Retrieval rate at 6 months was 49% in ACa patients versus 64% in patients without ACa (p = ns). Filter retrieval was less frequent in ACa patients with metastatic disease (p < 0.01) or a nonsurgical indication for filter placement (p = 0.04). Conclusions. No differences were noted in retrieval rate, recurrent DVT, or filter complications between the two groups. ACa should not preclude the use of RIVCF.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2016-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6413541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64477940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms 胸主动脉瘤内皮和平滑肌细胞的表型和功能改变

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-19 DOI: 10.1155/2016/3107879

A. Malashicheva, D. Kostina, A. Kostina, O. Irtyuga, I. Voronkina, L. Smagina, E. Ignatieva, N. Gavriliuk, V. Uspensky, O. Moiseeva, J. Vaage, A. Kostareva

{"title":"Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms","authors":"A. Malashicheva, D. Kostina, A. Kostina, O. Irtyuga, I. Voronkina, L. Smagina, E. Ignatieva, N. Gavriliuk, V. Uspensky, O. Moiseeva, J. Vaage, A. Kostareva","doi":"10.1155/2016/3107879","DOIUrl":"https://doi.org/10.1155/2016/3107879","url":null,"abstract":"Thoracic aortic aneurysm develops as a result of complex series of events that alter the cellular structure and the composition of the extracellular matrix of the aortic wall. The purpose of the present work was to study the cellular functions of endothelial and smooth muscle cells from the patients with aneurysms of the thoracic aorta. We studied endothelial and smooth muscle cells from aneurysms in patients with bicuspid aortic valve and with tricuspid aortic valve. The expression of key markers of endothelial (CD31, vWF, and VE-cadherin) and smooth muscle (SMA, SM22α, calponin, and vimentin) cells as well extracellular matrix and MMP activity was studied as well as and apoptosis and cell proliferation. Expression of functional markers of endothelial and smooth muscle cells was reduced in patient cells. Cellular proliferation, migration, and synthesis of extracellular matrix proteins are attenuated in the cells of the patients. We show for the first time that aortic endothelial cell phenotype is changed in the thoracic aortic aneurysms compared to normal aortic wall. In conclusion both endothelial and smooth muscle cells from aneurysms of the ascending aorta have downregulated specific cellular markers and altered functional properties, such as growth rate, apoptosis induction, and extracellular matrix synthesis.","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2016-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3107879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64319263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Carotid Intima Media Thickness in Nondiabetic Hypertensive Nigerians: Role of Fasting and Postprandial Blood Glucose. 尼日利亚非糖尿病高血压患者颈动脉内膜中层厚度:空腹和餐后血糖的作用。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-04-10 DOI: 10.1155/2016/1429451

B N Okeahialam, S A Muoneme, H O Kolade-Yunusa

{"title":"Carotid Intima Media Thickness in Nondiabetic Hypertensive Nigerians: Role of Fasting and Postprandial Blood Glucose.","authors":"B N Okeahialam, S A Muoneme, H O Kolade-Yunusa","doi":"10.1155/2016/1429451","DOIUrl":"https://doi.org/10.1155/2016/1429451","url":null,"abstract":"Background/Aims. Carotid intima media thickness (CIMT) tracks atherosclerotic vascular disease. Hypertension and diabetes chiefly contribute to atherosclerosis with 75% of symptomatic cardiovascular disease cases having dysglycaemia even in normal cases. Hypothesising that postprandial hyperglycaemia contributes to cardiovascular morbidity, we sought to determine if any relationship existed between glycaemic profile in nondiabetic hypertensives and atherosclerosis. Methods. In a study of CIMT in nondiabetic, statin-naïve hypertensives, we evaluated fasting blood glucose (FBG) and 2-hour postprandial sugar (2hPPBG) in the patients and compared them with the CIMT. CIMT was measured on both sides, 1 cm proximal to the carotid bulb using a 7.5 mHz transducer of ALOKA SSD-3500 ultrasound machine. Results. The subjects with complete data were 86 (63 F). The mean (SD) of CIMT was 0.89 (0.15) mm, FBG 4.8 (0.097) mmol/L, and 2hPPBG 6.5 (1.81) mmol/L. There was no significant correlation between FBG and 2hPPBG with CIMT. Blood pressure had no bearing on this. When blood glucose data were divided into quartiles and post hoc multiple comparison was done, there was significant difference in CIMT for the different ranges. This was not so for 2hPPBG. Conclusion. Though expected from other studies, we did not show any significant correlation between FBG and 2hPPBG status and CIMT. This may be our pattern as the degree of excursion of 2hPPBG was low. There may be a threshold level above which PPBG starts to impact CIMT. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"1429451"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1429451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34370051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats. 大鼠急性失血性休克后肾血流对血管紧张素 1-7 和 7.5% 高渗氯化钠的反应

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-03-17 DOI: 10.1155/2016/6562017

Maryam Maleki, Mehdi Nematbakhsh

{"title":"Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats.","authors":"Maryam Maleki, Mehdi Nematbakhsh","doi":"10.1155/2016/6562017","DOIUrl":"10.1155/2016/6562017","url":null,"abstract":"Background. Angiotensin 1-7 (Ang1-7) plays an important role in renal circulation. Hemorrhagic shock (HS) may cause kidney circulation disturbance, and this study was designed to investigate the renal blood flow (RBF) response to Ang1-7 after HS. Methods. 27 male Wistar rats were subjected to blood withdrawal to reduce mean arterial pressure (MAP) to 45 mmHg for 45 min. The animals were treated with saline (group 1), Ang1-7 (300 ng·kg(-1) min(-1)), Ang1-7 in hypertonic sodium chloride 7.5% (group 3), and hypertonic solution alone (group 4). Results. MAP was increased in a time-related fashion (P time < 0.0001) in all groups; however, there was a tendency for the increase in MAP in response to hypertonic solution (P = 0.09). Ang1-7, hypertonic solution, or combination of both increased RBF in groups 2-4, and these were significantly different from saline group (P = 0.05); that is, Ang1-7 leads to a significant increase in RBF to 1.35 ± 0.25 mL/min compared with 0.55 ± 0.12 mL/min in saline group (P < 0.05). Conclusion. Although Ang1-7 administration unlike hypertonic solution could not elevate MAP after HS, it potentially could increase RBF similar to hypertonic solution. This suggested that Ang1-7 recovers RBF after HS when therapeutic opportunities of hypertonic solution are limited. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"6562017"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34399849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraoxonase-1 and Simvastatin Treatment in Patients with Stable Coronary Artery Disease. 对氧磷酶-1和辛伐他汀治疗稳定型冠心病患者。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-04-11 DOI: 10.1155/2016/6312478

Rafał Januszek

{"title":"Paraoxonase-1 and Simvastatin Treatment in Patients with Stable Coronary Artery Disease.","authors":"Rafał Januszek","doi":"10.1155/2016/6312478","DOIUrl":"https://doi.org/10.1155/2016/6312478","url":null,"abstract":"Background. Paraoxonase-1 (PON1) is the crucial antioxidant marker of high-density lipoproteins. The present study is aimed at assessing the effect of simvastatin treatment on PON1 activity and its relationship to Q192R and M55L polymorphisms in subjects with stable coronary artery disease (CAD). Methods. The patient group was composed of 53 individuals with stable CAD, and the control group included 53 sex-matched police officers without CAD. CAD patients were treated with simvastatin 40mg/day for 12 months. Respectively, flow mediated dilatation (FMD), serum hs-CRP and TNF-α levels, urinary 8-iso-PGF2α concentrations, and PON1 activity were evaluated in definitive intervals. Results. There was no effect of simvastatin treatment on urinary 8-iso-PGF2α . Simvastatin treatment significantly increased FMD value, decreased CRP and TNF-α concentration. After adjusting for PON1 genotypes, significantly higher PON1 activity was noted in the 192R allele carriers, in both groups. Regardless of genotype, PON1 activity remained stable after simvastatin treatment. Conclusions. The present study confirms a positive effect of simvastatin therapy on endothelial function and inflammatory markers in secondary prevention. Simvastatin treatment shows no effects on PON1 activity and 8-isoprostanes level. The effect of simvastatin therapy on PON1 activity is not modulated by Q192R and M55L polymorphisms. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 ","pages":"6312478"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6312478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34508076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

ABPI against Colour Duplex Scan: A Screening Tool for Detection of Peripheral Arterial Disease in Low Resource Setting Approach to Validation. ABPI 针对彩色双功扫描：在低资源环境中检测外周动脉疾病的筛查工具验证方法。

IF 1.3

International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-03-10 DOI: 10.1155/2016/1390475

Janaka Weragoda, Rohini Seneviratne, Manuj C Weerasinghe, S M Wijeyaratne

{"title":"ABPI against Colour Duplex Scan: A Screening Tool for Detection of Peripheral Arterial Disease in Low Resource Setting Approach to Validation.","authors":"Janaka Weragoda, Rohini Seneviratne, Manuj C Weerasinghe, S M Wijeyaratne","doi":"10.1155/2016/1390475","DOIUrl":"10.1155/2016/1390475","url":null,"abstract":"Background. In Sri Lanka the ABPI has not been used as a screening tool to detect peripheral arterial disease (PAD) in epidemiological studies. This study was conducted to determine the best cutoff value of ABPI to detect PAD in Sri Lankan population. Methods. The ABPI measured by arterial Doppler to detect PAD was validated against colour duplex scan as the criterion using 165 individuals referred to vascular laboratory, National Hospital Sri Lanka. In all selected individuals ABPI was measured and lower limb colour duplex scan was performed. Narrowing of luminal diameter of lower limb arteries 50% or more was considered as haemodynamically significant and having PAD. The discriminative performance of the ABPI was assessed using Receiver Operator Characteristic (ROC) curve and calculating the area under the curve (AUC). The sensitivity and specificity of different threshold levels of ABPI and the best cutoff value of ABPI to detect PAD were determined. Results. ABPI 0.89 was determined as the best cutoff value to identify individuals with PAD. At this level of ABPI high sensitivity (87%), specificity (99.1%), positive predictive value (98.9%), and negative predictive value (88.4%) were observed. Conclusion. ABPI ≤ 0.89 could be used as the best cut off value to detect PAD. ","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2016 1","pages":"1390475"},"PeriodicalIF":1.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64220937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0