International Journal of Secondary Metabolite最新文献_第7页

Antioxidant and antimicrobial activities of methanol extracts from Adonis paryadrica (Ranunculaceae) – a critically endangered endemic species growing in the Turkish flora 土耳其一种濒危特有物种——毛茛科(Adonis paryadrica)甲醇提取物的抗氧化和抗菌活性

International Journal of Secondary Metabolite Pub Date : 2023-03-26 DOI: 10.21448/ijsm.1271974

Mustafa CÜCE

引用次数: 0

A systematic review on Hammada scoparia medicinal plant: Phytochemicals, traditional uses and biological activities 哈马药用植物：植物化学物质、传统用途和生物活性系统综述

International Journal of Secondary Metabolite Pub Date : 2023-03-24 DOI: 10.21448/ijsm.1132549

Chaima Benine, Ali Boutlelis Djahra, Laiche AMMAR TOUHAMİ, A. Rebiai

{"title":"A systematic review on Hammada scoparia medicinal plant: Phytochemicals, traditional uses and biological activities","authors":"Chaima Benine, Ali Boutlelis Djahra, Laiche AMMAR TOUHAMİ, A. Rebiai","doi":"10.21448/ijsm.1132549","DOIUrl":"https://doi.org/10.21448/ijsm.1132549","url":null,"abstract":"Medicinal plants have played an important influence in the development of human society; they were always at the forefront of all cultures and civilizations as a source of medicine. Medicinal plants are considered rich sources of secondary compounds, and many modern medications are derived from them. Hammada scoparia is a medicinal plant that belongs to the Chenopodiaceae family. It is currently found in North Africa (Morocco, Algeria, Libya, and Egypt) and has many medicinal properties used as folk medicine. The present research discusses the phytochemical components and biological activities of Hammada scoparia. The corresponding data were collected from various online databases, new research, and published resources. Different secondary compounds from the species have been documented, including flavonoids, tannins, alkaloids, terpenoids, and saponins. Pharmacological research has demonstrated that the major bioactives have antimicrobial, antioxidant, cytotoxic, and antimalarial activities and anticancer, reno-protective, and hepatoprotective effects. In conclusion, this study provides much information about the interests of vegetal species: Hammada scoparia.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47286810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oxidative stress induced by fluorine in Xanthoria parietina (L.) Th. Fr. 氟对黄原菌氧化应激的诱导作用。

International Journal of Secondary Metabolite Pub Date : 2023-03-23 DOI: 10.21448/ijsm.1136546

Ouahiba Benhamada, Nabila Benhamada, E. Leghouchi

{"title":"Oxidative stress induced by fluorine in Xanthoria parietina (L.) Th. Fr.","authors":"Ouahiba Benhamada, Nabila Benhamada, E. Leghouchi","doi":"10.21448/ijsm.1136546","DOIUrl":"https://doi.org/10.21448/ijsm.1136546","url":null,"abstract":"In our work we were interested in the toxicity of fluorine on the various parameters of stress: chlorophyll, proteins, and antioxidant system in the lichen Xanthoria parietina (L.) Th. Fr., and for this purpose, lichen thalli were treated by sodium fluoride (NaF) at concentrations of 0, 0.5, 1.0, 5.0 and 10.0 mM, for time scale 0, 24, 48 and 96 h. The analysis results obtained revealed that all the parameters evaluated showed significant variations compared to those of the controls. From the analysis results obtained, it was noted that chlorophyll a (Ca), chlorophyll b (Cb) and total chlorophyll (Ca+b) decreased correlating with exposure times to NaF (r = -0.785, p < 0.001; r = -0.955, p < 0.001; r = -0.899, p < 0.001, respectively), with a significant increase of Ca/b ratio (p = 0.00572**) showing that Cb was more affected than Ca. However, hydrogen peroxide (H2O2) increased (r = 0.949, p < 0.001). In correlation with NaF concentrations, Glutathione (GSH) increased (r = 0.969, p < 0.001), while proteins decreased (r = -0.872, p < 0.001). Furthermore, results showed that catalase activity (CAT) increased correlating with increasing exposure time of X. parietina to increasing concentrations of NaF. Long-term exposure (48 h -96 h) caused a significant decrease in GSH content (p = 0.02*) followed by total destruction at time 96 h.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48366016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility of bacterial species isolated from mares to ozonated sunflower oil 从母马中分离的细菌对臭氧葵花油的敏感性

International Journal of Secondary Metabolite Pub Date : 2023-03-16 DOI: 10.21448/ijsm.1167867

Gabriel Souza dos Santos, Arthur Azevedo Perpétuo, Marcus Vinícius DİAS SOUZA

引用次数: 0

Assessment of genetic diversity based on agro-morphological traits and ISSR molecular markers in einkorn wheat (Triticum monococcum ssp. monococcum) landrace populations from Turkey 基于农业形态特征和ISSR分子标记的土耳其小麦地方品种群体遗传多样性评估

International Journal of Secondary Metabolite Pub Date : 2023-03-16 DOI: 10.21448/ijsm.1084853

Suliman Zommita, Gülgez Gökçe Yıldız, N. Zencirci, Ö. Özbek, Ömer Can Ünüvar, E. Ünlü

{"title":"Assessment of genetic diversity based on agro-morphological traits and ISSR molecular markers in einkorn wheat (Triticum monococcum ssp. monococcum) landrace populations from Turkey","authors":"Suliman Zommita, Gülgez Gökçe Yıldız, N. Zencirci, Ö. Özbek, Ömer Can Ünüvar, E. Ünlü","doi":"10.21448/ijsm.1084853","DOIUrl":"https://doi.org/10.21448/ijsm.1084853","url":null,"abstract":"The aim of this study is to investigate genetic diversity in 48 einkorn (Triticum monococcum L. ssp. monococcum) landraces grown in agricultural areas of Bolu and Kastamonu. Therefore, variation in seven agro-morphological traits was investigated. Agro-morphological traits such as leaf weight (mg), coleoptile length (cm), root number (n), root length (cm), fresh root weight (mg), and dry root weight (mg) were examined by the coefficient of variation, ANOVA, and principal components analysis. The highest coefficient of variation (%) was observed in fresh root weight (FRW = 52.09%), while the lowest was in leaf weight (LW = 8.9%). Principal Component Analysis (PCA) was calculated as 76.93% variation in two main components. For molecular characterization, data obtained with iSSR primers were analyzed with the population genetics analysis program PopGene (ver. 1.32). According to PopGene results, the mean number of alleles, the mean number of effective alleles, and average genetic diversity values were calculated as na = 2, nea = 1.33, and h = 0.13, respectively. Among the agro-morphological traits, germination power, root number, and coleoptile length appeared to be reliable traits. The results show that the use of morphological characters alone for genetic diversity in populations is not sufficient to determine the difference between populations and their genetic structure.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42442864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactive effects of salicylic acid and jasmonic acid on secondary metabolite production in Echinacea purpurea 水杨酸和茉莉酸对紫锥菊次生代谢产物产生的相互作用

International Journal of Secondary Metabolite Pub Date : 2023-03-16 DOI: 10.21448/ijsm.1079812

Fatemeh Rasoli̇, M. Gholipoor

{"title":"Interactive effects of salicylic acid and jasmonic acid on secondary metabolite production in Echinacea purpurea","authors":"Fatemeh Rasoli̇, M. Gholipoor","doi":"10.21448/ijsm.1079812","DOIUrl":"https://doi.org/10.21448/ijsm.1079812","url":null,"abstract":"Secondary metabolites are highly beneficial to human health and have commercial and industrial values. So, this research aimed to study the effects of exogenous salicylic acid (SA) and jasmonic acid (JA) on some secondary metabolites in purple coneflower. A field experiment as a randomized complete block design with three replications was conducted in Shahrood, Iran. Treatments were the factorial arrangement of 3 SA (0, 0.5, and 1 millimole) and 4 JA concentrations (0, 5, 20, and 50 micromole). The non-linear regression procedure was employed to quantify the relation of these materials with each other. The results indicated that the SA effect on all ten measured secondary metabolites changed with changing the JA levels as there was the interaction between these elicitors. On average, most (7 out of 11) of the combined SA_JA levels up-regulated the production of secondary metabolites as compared to the plants not sprayed with SA and JA. In terms of average response to elicitation with 11 combined SA_JA levels, they ranked from higher to lower as the guaiacol peroxidase, hydrogen proxide (H2O2), polyphenol oxidase, glutathione S-transferase, superoxide dismutase, NADPH oxidase, total phenolic content, phenylalanine ammonia-lyase, anthocyanin, and flavonoid. A few secondary metabolites appeared to have a biphasic relationship with each other. For instance, over lower and medium values of NADPH oxidase activity, anthocyanin content increased linearly with increasing NADPH oxidase activity; over higher values of NADPH oxidase activity, it showed a plateau state.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48738480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of phytochemical composition and biological activities of Helichrysum pallasii (Sprengel) ledeb leaves 黄蜡菊叶片的植物化学成分及生物活性分析

International Journal of Secondary Metabolite Pub Date : 2023-03-15 DOI: 10.21448/ijsm.1132698

Nejmi Işik, Muzaffer Mükemre, Rabia Sena Türker, G. Zengin, Abdullah Dalar

{"title":"Analysis of phytochemical composition and biological activities of Helichrysum pallasii (Sprengel) ledeb leaves","authors":"Nejmi Işik, Muzaffer Mükemre, Rabia Sena Türker, G. Zengin, Abdullah Dalar","doi":"10.21448/ijsm.1132698","DOIUrl":"https://doi.org/10.21448/ijsm.1132698","url":null,"abstract":"This study aimed at the investigation of in vitro biological activities (antioxidant and enzyme inhibition) and phytochemical composition of various extracts (ethanol maceration, aqueous infusion, and aqueous decoction) obtained from leaf organs of Helichrysum pallasii, which has been traditionally used as herbal tea and medicine in Eastern Anatolia.\u0000Experimental analysis showed that ethanol-based extract had higher total phenolic content (TPC: 103 mg GAE/gE) and showed superior antioxidant potentials (FRAP: 2205 μmol Fe2+/gE; ORAC: 2540 μmol Trolox Eq./gE; DPPH: IC50=0.58 mg/ml; CUPRAC: IC50=0.37 mg/ml; Phosphomolybdenum: IC50=1.34 mg/ml ve metal chelation: IC50=1.42 mg/ml) and enzyme inhibition (Acetylcholinesterase: IC50=1.49 mg/ml; Butyrylcholinesterase: IC50=1.98 mg/ml; Tyrosinase: IC50=0.68 mg/ml; Alpha-amylase: IC50=2.09 mg/ml; Alpha-glucosidase: IC50=0.51 mg/ml; and Pancreatic lipase: IC50=42.5 μg/ml) and contained higher amounts of phenolic (chlorogenic acid isomers and rutin) and fatty acid (palmitic, linoleic, and linolenic acids) compounds than traditional preparations (infusion and decoction). \u0000The current study's findings indicate that the leaves of the Helichrysum pallasii are a source of phytochemicals with strong antioxidant and enzyme inhibitory properties, implying that it could be a candidate for biotherapeutic agent research and development.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42853399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antioxidant activity, analgesic activity, and phytochemical analysis of Ammi majus (L.) extracts 麻仁提取物的抗氧化、镇痛活性及植物化学分析

International Journal of Secondary Metabolite Pub Date : 2023-03-14 DOI: 10.21448/ijsm.1139246

O. El-Guourrami, Soufiane Drioua, Mouna Ameggouz, N. Salhi, K. Sayah, G. Zengin, Ahmed Zahidi, A. Doukkali, H. Benzeid

{"title":"Antioxidant activity, analgesic activity, and phytochemical analysis of Ammi majus (L.) extracts","authors":"O. El-Guourrami, Soufiane Drioua, Mouna Ameggouz, N. Salhi, K. Sayah, G. Zengin, Ahmed Zahidi, A. Doukkali, H. Benzeid","doi":"10.21448/ijsm.1139246","DOIUrl":"https://doi.org/10.21448/ijsm.1139246","url":null,"abstract":"Ammi majus (L.) is commonly used to cure many diseases in Moroccan folk medicine, especially vitiligo. This research tries to evaluate the phytochemical constituents of two aqueous extracts (E1; Maceration; 48 h) and (E2: Infusion; 1h) and three organic fractions (F1: Cyclohexane), (F2: Ethyl acetate (EtOAc)) and (F3: Ethanolic (EtOH)) of A. majus (L.) seeds, as well as to study the antioxidant and analgesic activity of the species. Phytochemical analysis, antioxidant activity (DPPH, FRAP, ABTS, and TAC tests), and analgesic activity (writhing and tail immersion were induced by Acetic acid tests) were analyzed according to the literature. A quantitative phytochemical study indicate that the E1 had the highest content of total polyphenols (26.95 ± 0.53 mg GAE/g extract) and flavonoids (37.92 ± 0.46 mg QE/g extract), while F3 showed a promising flavonol content (24.26±0.08 mg QE/g extract). Tannins were found to be high in F1 (59.27 ± 0.16 mg CE/g extract) and F2 (57.65 ± 1.18 mg CE/g extract). Antioxidant results reveals that DPPH (IC50 = 179.68 ± 0.47 μg/mL) and FRAP (EC50 = 367.03 ± 0.12 μg/mL) show to E1 a high antioxidant activity. Regarding the analgesic activity of the different studied extracts, it was found that E1 has a high peripheral analgesic effect with 62.32 % and a high central analgesic potential throughout the experimentation at 500 mg/kg. Our studies demonstrated for the first time that A. majus seeds extracts have high antioxidant and analgesic activities through different analysis techniques.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45196434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Promising antioxidant activity of crude extract from Calliandra tweedii Benth 杜鹃花粗提物抗氧化活性研究

International Journal of Secondary Metabolite Pub Date : 2023-03-06 DOI: 10.21448/ijsm.953427

Kátia Pereira dos Santos, Alice Nagai, Carmen E. Palacios, Bruno Evangelista, Carlos Pri̇ante, Débora Zamban, C. Furlan

{"title":"Promising antioxidant activity of crude extract from Calliandra tweedii Benth","authors":"Kátia Pereira dos Santos, Alice Nagai, Carmen E. Palacios, Bruno Evangelista, Carlos Pri̇ante, Débora Zamban, C. Furlan","doi":"10.21448/ijsm.953427","DOIUrl":"https://doi.org/10.21448/ijsm.953427","url":null,"abstract":"The interest in medicinal plants encourages new research studies on plant extracts, as they are sources for treatments in medicine, agriculture, and veterinary. Calliandra tweedii is a native Brazilian species with broad use in folk medicine. This study aimed to examine the leaf crude extract (CE) of C. tweedii and its methanolic (MP) and hexane (HP) phases concerning total phenolic compounds (TPC), proanthocyanidins (PRO), and flavonoid profile, and correlate it to their antioxidant activity (DPPH and FRAP). CE and MP revealed high contents of TPC, PRO and high antioxidant activity (DPPH and FRAP) in relation to HP. Opposite, HP showed reduced antioxidant activity, according to the scarce phenolic constituents obtained from the partition. Five flavonols were detected by HPLC-UV-DAD, being quercitrin the major constituent. Also, one kaempferol derivate, and a series of three quercetin derivates were detected. Strong positive correlations were observed between DPPH, FRAP, and phenolic compounds. These discoveries are important to highlight the promising antioxidant activity of CE of C. tweedii, which could contribute to the expansion of popular herbal medicines and new drug discovery.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44997339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extracts willdenowii和atlanticus富含多酚提取物的体外生物活性研究

International Journal of Secondary Metabolite Pub Date : 2023-03-05 DOI: 10.21448/ijsm.1110715

Elbouny Hamza, Ouahzizi Brahi̇m, S. Khalid, Alem Chakib

{"title":"In vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extracts","authors":"Elbouny Hamza, Ouahzizi Brahi̇m, S. Khalid, Alem Chakib","doi":"10.21448/ijsm.1110715","DOIUrl":"https://doi.org/10.21448/ijsm.1110715","url":null,"abstract":"Thyme species produce a wide variety of phenolic compounds including tannins, phenolic acids, and flavonoids. Thymus atlanticus (T. atlanticus) and Thymus willdenowii (T. willdenowii) are important thyme species in the southeast of Morocco, with numerous biological properties. The polyphenolic extracts of these two thyme species were obtained using ethanol through Soxhlet apparatus. Antioxidant (DPPH, FRAP, and TAC methods), antihemolytic (2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) induced hemolysis test), hypolipidemic (3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity inhibition test), and anti-inflammatory (protein denaturation inhibition) effects of extracts were carried out using in vitro methods. The results showed that the polyphenolic extracts of these two species revealed important amounts of phenolic compounds. The contents of flavonoids were significant in the two species, while the contents of tannins and anthocyanin were very low. T. atlanticus showed an important antioxidant activity and a considerable antihemolytic effect in AAPH-induced hemolysis test (IC50 = 0.29 mg/mL), while T. willdenowii showed an important anti-inflammatory activity in heat-induced protein denaturation test (IC50 = 1.61 mg/mL). Moreover, both extracts at a dose of 20 µg/mL showed an important in vitro hypolipidemic activity by inhibiting HMG-CoA reductase activity (T. willdenowii: 51.16 %; T. atlanticus: 62.83 %). In conclusion, T. willdenowii and T. atlanticus extracts have considerable antioxidant, antihemolytic, hypolipidemic, and anti-inflammatory effects. The richness of these species in polyphenols gives them a large specter of biological properties, making them a valuable source of natural bioactive compounds that could prevent or treat various diseases.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46899246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2