International Journal of Secondary Metabolite最新文献_第8页

Pharmacological potential of fungal endophytes associated with the genus Ocimum L. 木霉属内生真菌的药理潜力。

International Journal of Secondary Metabolite Pub Date : 2023-02-14 DOI: 10.21448/ijsm.1055749

K. M, R. A. R

引用次数: 3

Biological activities of different plant species belonging to the Asteraceae family 菊科不同植物的生物学活性

International Journal of Secondary Metabolite Pub Date : 2023-02-14 DOI: 10.21448/ijsm.1107819

Gülşen Güçlü, M. İnanir, E. Uçar, Nuraniye Eruygur, M. Atas, T. Uskutoğlu, Belgin Çoşge Şenkal

{"title":"Biological activities of different plant species belonging to the Asteraceae family","authors":"Gülşen Güçlü, M. İnanir, E. Uçar, Nuraniye Eruygur, M. Atas, T. Uskutoğlu, Belgin Çoşge Şenkal","doi":"10.21448/ijsm.1107819","DOIUrl":"https://doi.org/10.21448/ijsm.1107819","url":null,"abstract":"Achillea biebersteinii and Anthemis tinctoria, which are widely distributed species of the Asteraceae family, are used in folk medicine in the form of herbal tea or extract in the treatment of many diseases. The aim of this study was to investigate the chemical content, antimicrobial, antioxidant, enzyme inhibitor activities and cytotoxic effects of 80% ethanol extract of these two species and make a comparative analysis. In accordance with the data obtained, the major component of A. biebersteinii was determined as Cyclododecane (14.47%), while that of A. tinctoria was determined as Phytol (23.15%). A. biebersteinii, which showed moderate activity in terms of antimicrobial activity, produced more active inhibition than A. tinctoria did. Both plants showed high levels of antioxidant activity. The total phenol and total flavonoid contents of A. tinctoria were higher than those of A. biebersteinii. It was determined that there was no significant activity when the extracts were compared with galanthamine, which is the reference drug in terms of enzyme inhibitory activity. When the in vitro anticancer activity of human breast cancer cell line was examined, it was determined that A. tinctoria had a cytotoxic effect at high concentrations (IC50;0.82mg/mL), and A. biebersteinii showed strong cytotoxicity at all concentrations (IC50;<0.0625mg/mL). These two plants of the same family were evaluated in terms of many different biological parameters and it was revealed that A. biebersteinii was more active than A. tinctoria. However, in vivo studies are needed to determine whether these plants can be used as phytotherapeutic agents.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47388412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of supercritical fluid CO2 extraction of Opoponax essential oil (C. erythraea) 赤芍精油超临界流体CO2萃取工艺优化

International Journal of Secondary Metabolite Pub Date : 2023-02-14 DOI: 10.21448/ijsm.1093888

F. Durak, Aydın Aydin, M. Sökmen

引用次数: 0

Medicinal uses, chemical constituents and biological activities of Rumex abyssinicus: A Comprehensive review 深海酸模的药用、化学成分和生物活性综述

International Journal of Secondary Metabolite Pub Date : 2022-12-30 DOI: 10.21448/ijsm.1095643

Gashaw Nigussie, M. Tola, Tiruwork Fanta

{"title":"Medicinal uses, chemical constituents and biological activities of Rumex abyssinicus: A Comprehensive review","authors":"Gashaw Nigussie, M. Tola, Tiruwork Fanta","doi":"10.21448/ijsm.1095643","DOIUrl":"https://doi.org/10.21448/ijsm.1095643","url":null,"abstract":"Rumex abyssinicus is a valuable medicinal plant species that is native to tropical Africa. Traditionally, R. abyssinicus is used to treat different disease such as, liver diseases, hepatitis, malaria, scabies, blood pressure, jaundice, wound and pneumonia. The purpose of the current study was to review the literature on the ethnomedicinal uses, chemical constitutes and biological activities of R. abyssinicus in an attempt to create information for future studies aimed towards exploring the therapeutic ability of the species. A scientific search engines, namely Google Scholar, PubMed, Scopus, Science Direct and Web of knowledge for the search terms: Rumex abyssinicus, ethnomedicinal studies, phytochemical investigations, and pharmacological activities were undertaken. The search strategy included all articles with descriptors that were available until December 30, 2021. Only published works in English have been used on this study. The data was collected using textual descriptions of the studies, tabulation, grouping, and figures. The principal phytochemicals of R. abyssinicus are anthraquinones, flavonoids, terepenoids and phenolic compounds. The in vitro and in vivo studies on the crude extracts and compounds of R. abyssinicus showed antibacterial, antioxidant, anticancer, anti-inflammatory, antifungal, wound healing, antialzeimer’s and hepatoprotective activities of it. R. abyssinicus afforded drug leads such as helminthosporin (4) with anti-alzheimer and physicon (3) with antifungal and antioxidant activity. R. abyssinicus have traditionally been used to cure a variety of diseases. Pharmacological actions of phytochemicals were shown to be promising. Despite this, further studies on crude extracts and promising compounds are needed to find new drug candidates.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48851893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The phenolic profile and biological activities of common Scorzonera species from Eastern Anatolia 安纳托利亚东部常见Scorzonera属植物的酚类特征及其生物活性

International Journal of Secondary Metabolite Pub Date : 2022-12-21 DOI: 10.21448/ijsm.1084743

Sazgar Hassan Babakr, Emre Erez, Muzaffer Mükemre, Abdullah Dalar

{"title":"The phenolic profile and biological activities of common Scorzonera species from Eastern Anatolia","authors":"Sazgar Hassan Babakr, Emre Erez, Muzaffer Mükemre, Abdullah Dalar","doi":"10.21448/ijsm.1084743","DOIUrl":"https://doi.org/10.21448/ijsm.1084743","url":null,"abstract":"The present study focused on chemical composition and base therapeutic potential of common Scorzonera species (Scorzonera mollis, Scorzonera papposa, and Scorzonera semicana), which have been utilized as food and medicine by local people of Eastern Anatolia for a long time. Comparative analytical studies were performed on ethanol-based extracts and traditional preparations (infusions) through chromatographic (HPLC-MS/MS) and reagent-based antioxidant and enzyme inhibitory assays. \u0000Results revelated that extracts were rich in phenolics, particularly hydroxycinnamic acids that were confirmed by HPLC-MS/MS, chlorogenic acids and luteolin are the major phytochemical compounds of extracts. With regards to biological activities findings, it was determined that ethanol-based extracts showed better antioxidant activities and effectively suppressed the activities of α-glucosidase. In addition, both of the extracts were found as strong suppressive agents of pancreatic lipase activity so Scorzonera species were rich sources of bioactive compounds that able to deactivate reactive oxygen species and free radicals and as well as suppress the activities of α-glucosidase and pancreatic lipase. Finally, obtained findings reveal base data of Scorzonera species for researches that focused on novel candidates of nutraceuticals and biotherapeutics.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47248317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of heavy metal concentrations and soil samples of Betula pendula and Populus tremula in Nemrut Crater Lake 内穆鲁特火山口湖白桦和白杨重金属含量及土壤样品测定

International Journal of Secondary Metabolite Pub Date : 2022-12-20 DOI: 10.21448/ijsm.1082781

Ş. Hayta, E. Firat

引用次数: 0

Medical physiological perspective to biochemical assays and GC-MS results of corn tassel 玉米穗子生化分析及GC-MS结果的医学生理学观点

International Journal of Secondary Metabolite Pub Date : 2022-12-20 DOI: 10.21448/ijsm.1148489

Burak Yaman

{"title":"Medical physiological perspective to biochemical assays and GC-MS results of corn tassel","authors":"Burak Yaman","doi":"10.21448/ijsm.1148489","DOIUrl":"https://doi.org/10.21448/ijsm.1148489","url":null,"abstract":"Corn tassel (Zea may L.) is rich in phenolic compounds including flavonoids and anthocyanins. The aim of this study is to consider the results of the contents of phenolics (TPC), flavonoids (TFC), flavonol (TF), anthocyanins (TAC), alfa-amylase inhibitory activity, and antioxidant activity including FRAP and metal chelating capabilities (MCC) as potential Antiviral and anti-Rheumatoid arthritis. Significantly high levels of antioxidant capacity, total flavonol and alfa-amylase inhibition were found in ethanolic extracts of corn tassels. It was found that their concentrations are TPC= 40 mg GA/g, TFC= 13 mg QE/g, TF= 45 mg R/g, and TAC= 8 mg cyanidin-3-glucoside/g based on dry extract. Additionally, the extracts showed relatively higher antioxidant activities due to metal chelating capabilities (MCC) were found to be 217 mg Fe2+/g dry extract. From the GC-MS analysis, corn tassel was found to be good source of arctigenin that has antiviral and anti- rheumatic properties. Further, the extracts of corn tassels showed significantly higher α-amylase inhibitory activity up to 90 %. Thus, it was concluded that extracts of corn tassels may be considered as pharmacological potential in rheumatoid and antiviral treatment.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42496321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and antimicrobial activities of methanol extracts from Adonis paryadrica (Asteraceae) – a critically endangered endemic species growing in the Turkish flora 阿多（菊科）甲醇提取物的抗氧化和抗菌活性

International Journal of Secondary Metabolite Pub Date : 2022-12-20 DOI: 10.21448/ijsm.1071234

Mustafa Cüce

引用次数: 0

Pharmacokinetics, drug-likeness, antibacterial and antioxidant activity of secondary metabolites from the roots extracts of Crinum abyssinicum and Calotropis procera and in silico molecular docking study 深海牛蒡根提取物次级代谢产物的药代动力学、药物相似性、抗菌抗氧化活性及计算机分子对接研究

International Journal of Secondary Metabolite Pub Date : 2022-12-20 DOI: 10.21448/ijsm.1107685

Getachew Tegegn, Y. Melaku, Milkyas ENDALE ANNİSA, R. Eswaramoorthy

{"title":"Pharmacokinetics, drug-likeness, antibacterial and antioxidant activity of secondary metabolites from the roots extracts of Crinum abyssinicum and Calotropis procera and in silico molecular docking study","authors":"Getachew Tegegn, Y. Melaku, Milkyas ENDALE ANNİSA, R. Eswaramoorthy","doi":"10.21448/ijsm.1107685","DOIUrl":"https://doi.org/10.21448/ijsm.1107685","url":null,"abstract":"Crinum abyssinicum and Calotropis procera were traditionally used for the treatment of different diseases such as hypertension, diabetes, hepatitis B, skin infection, anticancer, asthma, fever, and diarrhea. The structures of the compounds were characterized by 1H NMR, 13C NMR, and DEPT-135 spectra. Compounds 1-3 were reported herein for the first time from the species of C. abyssinicum. The DCM/MeOH (1:1) and MeOH roots extracts of C. abyssinicum showed significant inhibitory activity against S. aureus and P. aeruginosa with a mean inhibition zone of 16.67 ± 1.20 and 16.33 ± 0.33 mm, respectively. Compounds 4 and 5 showed promising activity against E. coli with a mean inhibition zone of 17.7  0.8 and 17.7  1.2 mm, respectively. The results of DPPH activity showed the DCM: MeOH (1:1) and MeOH roots extracts of C. abyssinicum inhibited the DPPH radical by 52.86  0.24 % and 45.6  0.11 %, respectively, whereas compound 5 displayed 85.7 % of inhibition. The drug-likeness analysis showed that compounds 2-4 satisfy Lipinski’s rule of five with zero violations. Compounds 2, and 6 showed binding affinities of −6.0, and −6.7 kcal/mol against E. coli DNA gyrase B, respectively, while 3 and 5 showed −5.0 and −5.0 kcal/mol, respectively against human peroxiredoxin 5. Therefore, the in vitro antibacterial, radical scavenging activity along with the molecular docking analysis suggest the potential use of the extracts of C. abyssinicum and compounds 2, 5, 6, and 3, 5 can be considered as promising antibacterial agents and free radical scavengers, respectively.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44851267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Combined effect of nitrogen and phosphorus on growth and biochemical composition of Tetradesmus obliquus (Turpin) M.J. Wynne 氮磷复合处理对斜四角草生长及生化组成的影响

International Journal of Secondary Metabolite Pub Date : 2022-12-20 DOI: 10.21448/ijsm.1102592

F. Akgül, R. Akgül

引用次数: 0