The phenolic profile and biological activities of common Scorzonera species from Eastern Anatolia

Sazgar Hassan Babakr, Emre Erez, Muzaffer Mükemre, Abdullah Dalar
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引用次数: 0

Abstract

The present study focused on chemical composition and base therapeutic potential of common Scorzonera species (Scorzonera mollis, Scorzonera papposa, and Scorzonera semicana), which have been utilized as food and medicine by local people of Eastern Anatolia for a long time. Comparative analytical studies were performed on ethanol-based extracts and traditional preparations (infusions) through chromatographic (HPLC-MS/MS) and reagent-based antioxidant and enzyme inhibitory assays. Results revelated that extracts were rich in phenolics, particularly hydroxycinnamic acids that were confirmed by HPLC-MS/MS, chlorogenic acids and luteolin are the major phytochemical compounds of extracts. With regards to biological activities findings, it was determined that ethanol-based extracts showed better antioxidant activities and effectively suppressed the activities of α-glucosidase. In addition, both of the extracts were found as strong suppressive agents of pancreatic lipase activity so Scorzonera species were rich sources of bioactive compounds that able to deactivate reactive oxygen species and free radicals and as well as suppress the activities of α-glucosidase and pancreatic lipase. Finally, obtained findings reveal base data of Scorzonera species for researches that focused on novel candidates of nutraceuticals and biotherapeutics.
安纳托利亚东部常见Scorzonera属植物的酚类特征及其生物活性
本研究重点研究了常见Scorzonera物种(Scorzoneramollis、ScorzonERApapposa和Scorzonellaseminana)的化学成分和基本治疗潜力,这些物种长期被安纳托利亚东部的当地人用作食品和药物。通过色谱法(HPLC-MS/MS)和基于试剂的抗氧化剂和酶抑制测定,对乙醇提取物和传统制剂(输液)进行了比较分析研究。结果表明,提取物富含酚类物质,特别是羟基肉桂酸,HPLC-MS/MS证实,绿原酸和木犀草素是提取物的主要植物化学成分。关于生物活性的研究结果,确定乙醇提取物表现出更好的抗氧化活性,并有效抑制了α-葡萄糖苷酶的活性。此外,这两种提取物都是胰腺脂肪酶活性的强抑制剂,因此Scorzonera物种是丰富的生物活性化合物来源,能够使活性氧和自由基失活,并抑制α-葡萄糖苷酶和胰腺脂肪酶的活性。最后,所获得的发现揭示了Scorzonera物种的基础数据,用于研究营养药物和生物治疗药物的新候选药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Secondary Metabolite
International Journal of Secondary Metabolite Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
1.40
自引率
0.00%
发文量
28
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