International Journal of Veterinary Medicine最新文献

{"title":"Features of the structure of the lower jaw of the common hedgehog in connection with their type of nutrition","authors":"S. Glushonok, N. Zelenevsky","doi":"10.52419/issn2072-2419.2023.4.244","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.244","url":null,"abstract":"Taking into account the diet of the common hedgehog, we were faced with the question  of  the  features  of  the  structure  of  the chewing  apparatus  of  the  common  hedge-hogs. We decided to study and establish anatomical, topographic and morphometric features of the structure of the lower jaw in the common  hedgehog.  The  purpose  of  our study  is  to  study  the  anatomical  and  topographic features of the structure of the lower jaw  of  the  common  hedgehog  associated with the type of nutrition, as well as to establish  morphometric  data  of  the  mandibular apparatus. To study the anatomical and topographic features of the structure of the mandibular bone of this individual, five corpses of the common hedgehog from the forestry of the Leningrad region were obtained. All representatives of this species were sexually mature. As a result of our research, we have established anatomical and topographic features of the structure of the lower jaw of the common hedgehog associated with the type of  nutrition,  and  also  determined  the  morphometric data of the mandibular apparatus. According  to  the  results  of  the  study,  we came  to  the  conclusion  that  the  common hedgehog  has  a  very  powerful  and  well-developed  lower  jaw,  which  consists  of  a body and a branch. The root part of the mandibular  bone  is  2.10  times  longer  than  the incisor  part,  and  they  are  almost  equal  in width.  This  fact  indicates  the  compression power of both incisor and molar teeth during biting and chewing solid food. On the incisor part there are incisor teeth in the amount of four pieces, on the root part of the body there are molars and premolars in the form of molars and premolars with a total of four pieces.  Thanks  to  this,  hedgehogs  are  able  to easily grab food lying on the surface of the earth  and  chew  thoroughly.  The  branch  of the lower jaw has well-developed processes, thanks to which strong joints are formed and muscles are securely attached during the act of  chewing.  On  the  lateral  surface  of  the lower  jaw  branch  there  is  a  well-defined depression  that  forms  the  pit  of  the  large masticatory  muscle,  this  certainly  indicates the presence of highly developed masticatory muscles in this animal.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"161 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of erythropoiesis in sows during different periods of the production cycle","authors":"О. А. Voronina, S. Y. Zaitsev","doi":"10.52419/issn2072-2419.2023.4.227","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.227","url":null,"abstract":"The tactics of periodic monitoring of the hematology of sows allows timely measures to prevent anemia, which inevitably occurs, since the targeted screening and selection of industrial  breeds  are  aimed  at  multiple births,  which  increases  the  risks of  anemia during pregnancy and suckling period. With periodic and constant monitoring, it is possible to deduce individual reference intervals of  hematological  indicators  for  a  particular animal and control the response to compensatory measures that directly affects the yield of viable piglets and their survival rate. The purpose of this study was to study the number  of  red  blood  cells,  hemoglobin  level, hematocrit,  average  volume  of  red  blood cells  and  erythrocyte  indices  depending  on the production cycle of the sow. The groups were formed from sows on the 80th day of pregnancy  (group  1,  n=5),  after  farrowing (group  2,  n=5)  and  before  weaning  piglets (group  3, n=5). The  Vet ABCTM analyzer (Horiba Medical Poland) was used. Counting of reticulocytes by “supravital staining” with a solution of “brilliant cresyl blue”. Statistical  processing  in  the  Microsoft  Excel  program (Data Analysis package), evaluation of the  reliability  of  differences  based  on  the Mann—Whitney U criterion. As a result, it was  found  that  the  average  volume  of  red blood cells increases with a decrease in their number  and  hemoglobin  concentration, which is quite natural and indicates a regenerative response with the appearance of reticulocytes in the blood. The correlation coefficient between erythrocytes and the average  volume  of  erythrocytes  was  r=-0.53 (r2=0.28, p=0.01), between the average volume  of  erythrocytes  and  reticulocytes  r=-0.50 (r2=0.25, p=0.05). There were no significant differences among the groups in reticulocytes and the average volume of erythrocytes. The dynamics and intensity of regeneration are moderate in all three groups.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"55 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139005540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood supply to the stomach of Yorkshire pigs at the stages of postnatal ontogenesis","authors":"A. I. Polyanskaya, M. Shchipakin","doi":"10.52419/issn2072-2419.2023.4.213","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.213","url":null,"abstract":"The  development  of  the  agro–industrial complex of the Russian Federation is one of the priorities in agriculture. Pig breeding is one of the most profitable branches of animal husbandry. This is due to the fact that pigs  have  a  number  of  biological  features that are successfully used to produce products (pork, bacon, bacon). With the intensification  of  pig  breeding,  special  attention  is paid  to  scientific  approaches  to  improving pig feeding. In this regard, we set ourselves the goal of the study – to study the arterial vascularization of the stomach in Yorkshire piglets  and  to  determine  the  morphometric data of the organ at the stages of postnatal ontogenesis. The study was conducted at the Department  of  Animal  Anatomy  of  the  St. Petersburg  State  University  of  Veterinary Medicine.  Cadaver  material  for  the  study was delivered to the Department of Animal Anatomy of the St. Petersburg State University  of  Veterinary  Medicine  from  the  Idavang Agro pig breeding complex in Nurma village, Tosnensky district of the Leningrad Region.  The  study  was  conducted  in  three age groups, according to the periodization of the life of pigs. To achieve this task, traditional morphological research methods were used,  namely:  fine  anatomical  dissection, photographing,  vasorentgenography  with morphometry  in  the  \"RadiAnt\"  program. During the study, it was found that arterial gastric  vascularization  in  Yorkshire  piglets at the stages of postnatal ontogenesis is carried out due to the hepatic and splenic arteries,  which  are  branches  of  the  abdominal artery.  The  branches  of  the  arteries  of  the first order branch in a loose type. When conducting a comparative analysis of the morphometric characteristics of the hepatic and splenic arteries and their branches, we came to  the  conclusion  that  the  diameter  of  the hepatic artery will prevail over the splenic, and their branches of the first order are diametrically opposed to each other.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"11 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139003725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the age dynamics of morphological parameters of rainbow trout blood in aquaculture conditions","authors":"L. Karpenko, N. A. Sidorova, P. A. Polistovskaya, A. Bakhta, A. I. Savushkin, O. O. Babich, S. A. Sukhikh, I. N. Nikonov","doi":"10.52419/issn2072-2419.2023.4.236","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.236","url":null,"abstract":"Rainbow  trout  (Parasalmo  mykiss)  is  a promising  type  of  aquaculture  with  one  of the  largest  production  potentials  in  Russia. The  Republic  of  Karelia  currently  holds  a leading position in cage trout farming, supplying more than 80% of commercial trout produced  in  the  Russian  Federation  to  the domestic  market.  Increasing  the  output  of aquaculture products is an important condition  for  supporting  Russia's  food  security and  ensuring  the  socio-economic  development of the regions. Given the rate of spread of  diseases  in  trout,  the  rapid  change  of phases  of  the  immune  response  in  fish,  as well as the location of farms in sparsely populated remote areas, research remains particularly  relevant  on  the  search  for  sensitive molecular  methods  of  rapid  diagnosis  that identify the pathogen in the early stages of the  infectious  process  to  develop  rational treatment  and  prevention  tactics.  The  purpose of the presented study was to monitor the condition of rainbow trout in ontogenesis based on hematological studies. During the study, significant (P<0.05) differences were noted in the number of red blood cells and the total number of white blood cells (TLC), depending on the sex of the fish. In addition, clearly  distinguishable  morphometric  features  were  also  seen  among  erythrocytes, leukocytes  (lymphocytes,  neutrophils  and monocytes)  and  platelets.  Thus,  during  the monitoring of the physiological state of rainbow trout in aquaculture conditions, it was found  that  the  condition  of  the  fish  body worsens with age, which affects the morphological parameters of the blood. The hemoglobin content varied widely. A decrease in its  concentration  indicates  acute  blood  loss and hemolytic anemia. The results obtained are  the  basis  for  the  development  of  new promising natural adaptogens that normalize the physiological state of fish and ensure the production of biosafety trout products.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"194 1‐6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of modern hepatotoxicants on the elimination of caffeine","authors":"O. Popova, V. S. Ponamarev, A. Kostrova, L. Agafonova","doi":"10.52419/issn2072-2419.2023.4.154","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.154","url":null,"abstract":"Hepatotoxicants are a variety of chemical substances that can have organ-specific damaging  effects,  which  may  be  the  result  of their direct effects on both hepatocytes and other structural units of the liver. The purpose of this study is to evaluate the effect of modern hepatotoxicants on caffeine elimination. The studies were carried out in the vivarium of the Department of Pharmacology and Toxicology of the Federal State Budgetary Educational Institution of Higher Education  of  St.  Petersburg  State  University  of Medicine. Industrial substances of different chemical  groups  have  been  used  to  induce hepatotoxic  conditions:  phthalic  anhydride, ethylenediamine and chloroform. All of the above  toxicants  were  given  in  dosages  for the immediate (within 24 hours) induction of hepatotoxic  conditions.  One  day  after  the completion  of  the  simulation,  the  levels  of caffeine  in  the  blood  serum  of  the  experimental animals were determined in full accordance with the previous series of experiments, using a dosage of 100 mg/kg, since with this dosage regimen  we identified  the most stable pharmacokinetic profiles of caffeine.  Mathematical  and  statistical  processing of the obtained data was carried out using  the  STATISTICA  6.1  program.  The arithmetic mean (M) and its mean error (m) were calculated; the significance of the difference (p) was not calculated using the Student's test due to the  exploratory nature of the study and the lack of comparison groups. Based  on  the  conducted  research,  we  can conclude that each hepatotoxicant has individual  characteristic  characteristics,  which allows us to recommend a caffeine test for different types of hepatotoxicity, incl. unexpressed. That is, in this way it is possible to diagnose  hepatotoxic  conditions  even  in  a latent form, which can be used as a method for  assessing  the  toxicity  of  a  drug  at  the stage of preclinical development.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"15 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138977116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anthelmintic efficacy of the drug Expresstabs in helminthiasis of dogs","authors":"A. Tokarev, O. A. Tokareva","doi":"10.52419/issn2072-2419.2023.4.186","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.186","url":null,"abstract":"The purpose of the research is to study the  effectiveness  of  the  drug  ExpressTabs tested on dogs infected with helminths. The drug  contains  spinosad,  praziquantel  and moxidectin as active ingredients. Animals of mixed  breeds  of  both  sexes  aged  from  7 months to 2 years were selected for the experiments. Experimental and control groups of dogs with toxocariasis, toxascariasis and dipylidiasis  were  formed.  ExpressTabs was administered  to  dogs  individually,  once, orally in a mixture with food or immediately after feeding (on  the  root  of  the  tongue or with a treat) in a minimum dose of 30 mg of spinosad, 0.2 mg of moxidectin and 5 mg of praziquantel per 1 kg of animal weight. Animals  in  the  control  groups  were  not  given tablets. A control examination in the case of dipylidiasis  was  carried  out  on  the  second day then if the animal continued to remain in the  hospital  once  a  week.  For  toxocariasis and toxascariasis fecal examination was carried out on day 7 then on days 14, 21 and 28. The drug ExpressTabs showed high (100%) effectiveness  in  the  treatment  of dogs with toxocariasis,  toxaccariasis  and  dipylidiasis. In one animal re-infection with toxocariasis was  observed  because  helminth  eggs  were again  detected  on  day  28  in  the  control study. Taking into account the development cycle  of  parasites  it  is  obvious  that  re-infection occurred no later than a week after the  experimental  deworming  with  ExpressTabs. At recommended doses the drug did not cause unwanted side effects.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"23 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139009000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the identification of the omnivorous humpback fly Megaselia scalaris (Loew)","authors":"P. S. Zhmurkina, M. V. Budovich, A. A. Karpenko, T. Kalyuzhnaya, D. Orlova","doi":"10.52419/issn2072-2419.2023.4.206","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.206","url":null,"abstract":"Ant-decapitating  flies  (lat.  Megaselia scalaris (Loew)) is a quarantine object in the Russian  Federation  and  is  included  in  the Single list of quarantine objects of the Eurasian  Economic  Union,  approved  by  the  of the Council of the Eurasian Economic Commission dated 30.11.2016 No. 158, because it is a vector of dangerous diseases that cause great  economic  damage.  The  range  covers large areas of North America, Africa, southern  Europe,  Australia,  Southeast  Asia,  as well as the European part of Russia, namely the Southern Federal District and the Republic of Crimea. The list of regulated products subject  to  research  to  identify M.  scalaris (Loew) is very extensive, and accurate identification to species of the received samples by entomological method by morphological features of copulatory organs is very labor-intensive and not accurate. Therefore, methods of molecular diagnostics were developed for identification, namely, comparison of the studied  nucleotide  sequence with  the  reference one using NCBI database and determination of genetic distances. The studies were carried out on the basis of the Department of Molecular Research of the North-West Testing Laboratory of FGBU «ARRIAH».  Six samples of the genus Megaselia were used in this work. At the first stage, DNA was isolated  using  DNA-Extran  2  kits.  Then  genetic markers  were  obtained  by  classical  PCR with subsequent detection by electrophoresis using the T100 Thermal Cycler, sequenced on  a  3500  Genetic  Analyzer.  Identification was  performed  by  comparing  the  obtained sequence  in  BioEdit  program  using  NCBI database and by calculating genetic distances using two-parameter Kimura model and Tajima-Nei  model.  The  study  revealed  advantages and disadvantages of the presented methods of molecular identification.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"15 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of an enzyme additive in combination with zinc in an ultrafine form on the productive performance of broiler chickens","authors":"K. S. Nechitailo, E. A. Sizova, K. V. Ryazantseva, O. Kvan","doi":"10.52419/issn2072-2419.2023.4.197","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.197","url":null,"abstract":"Poultry  farming  is  one of  the  most  important  and  promising  branches  of  animal husbandry. Given the increasing rate of industrial poultry farming, for the stable development of the industry and improving competitiveness  in  world  markets,  more  and more attention is paid to the search for safe alternative  agents  to  increase  productivity. The study examined the strategy of feeding substances of different nature as feed additives, in particular, enzyme complexes separately  (group  I  (0,05%;  endo-1,4-beta-xylanase - 4000 units/g, alpha-amylase - 400 units/g and subtilisin - 8000 units/g)) and in combination with ultradispersed zinc (group II  (3  mg/kg;  164±31,2  nm)).  It  was  found that  in  group  I  the  digestibility  ratios  of crude  protein  were  higher  by  6.03  % (P≤0.05), crude  fiber  by  3.68  %  (P≤0.05), nitrogen-free  extractive  substances  by  2.39 %  (P≤0.05) compared  to  control.  At  the same time, in group II, changes were recorded in crude protein and crude fiber - an increase  of  6.51%  (P≤0.01)  and  7.59% (P≤0.05), respectively.  At  42  days  of  age, the  live  weight  of  broiler  chickens  I  was 10.1% higher than control (P≤0.05), and in group II by 11.32% (P≤0.01). At the same time, the cost of feed per 1 kg of growth was minimal in group II, 16.79% lower than the control values. Thus, the maximum productive effect was observed with the introduction  of  a  complex  enzyme  supplement  in combination  with  zinc  in  ultradispersed form.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"19 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139009405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicators of uterine contractile activity in highly productive sows using supraphysiological doses of oxytocin","authors":"A. V. Filatov, A. V. Minin","doi":"10.52419/issn2072-2419.2023.4.173","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.173","url":null,"abstract":"The  use  of  large  doses  of  oxytocin  to sows in the early postpartum period is indicated  to  normalize  lactogenesis,  increase immune proteins in colostrum and transitional  milk,  prevent  postpartum  complications, and  increase  the  viability  of  the  offspring. However, the effect of these doses of myotropic drug on the contractile activity of the uterus  is  not  shown.  The  aim  of  the  work was to study the contractile function of the uterus of highly productive sows in the early postpartum period and the peculiarities of its reaction to supraphysiological doses of oxytocin.  Scientific  and  production  experience was carried out on the basis of a large pig breeding  complex.  The  object  of  the  study was  highly  productive  sows  16 hours  after the completion of normal labor. The hormonal  drug  oxytocin  was  administered  intra-muscularly to animals at a supraphysiological dose of 75 units. Hysterograms of uterine contractions were recorded by internal hysterography  before  and  immediately  after administration of the myotropic drug, as well as one hour after injection. On hysterograms, spontaneous contractile activity of the uterus in highly productive sows was characterized by  regular,  short-term  contractions  of  the optimal amplitude. Activation of the contractile function of the myometrium occurs 5-7 minutes  after  injection  of  the  drug.  After administration of oxytocin, an increase in the amplitude  of  contraction  of  uterine  smooth muscle cells was noted by 39.17% (p<0.05), while  a  longer  period  of  contractions  was recorded by 31.64%. The frequency of uterine  contractions  increased  2.0  times (p<0.01). The contract index was significantly  3.66  times  (p<0.05)  higher  than  that  in relation to the initial level. After 1 hour after oxytocin  administration,  an  increase  in  the contraction period by 5.42% was noted, with a decrease in amplitude by 37.87% (p<0.01) and the number of contractions by 49.91% (p<0.01),  the  contractional  index  decreased by 3.05 times (p<0.01) relative to the previous level. In relation to the initial level, the contract  index  was  20.0%  higher.  At  the same  time,  an  increase  in  the  duration  of contractions  by  38.78%  and  a  decrease  in their amplitude by 13.53% were noted. Consequently, oxytocin at a dose of 75 ME not violate the contractile ability of the myometrium.  The  response  of  the  smooth  muscle cells of the uterus to the supraphysiological dose of oxytocin is maximally manifested in the first hour after the administration of the myotropic drug.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"37 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139009883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Architectonics of parenchymal organs of white rats under conditions of induced immunosuppression and the use of Interferon lambda","authors":"G. Vostroilova, N. Khokhlova, E. Mikhailov, D. I. Shabanov, A. Korchagina, A. V. Nekrasov, B. Shabunin","doi":"10.52419/issn2072-2419.2023.4.161","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.161","url":null,"abstract":"Violation of the functioning of the organs of the immune system, both in humans and in animals, is due to the influence of unfavorable factors of natural and anthropogenic origin on the body, as well as infectious diseases of various etiologies. The article discusses changes in the architectonics  of parenchymal organs of white laboratory rats after exposure to the drug interferon lambda on  the  background  of  cyclophosphamide (CF). It was found that modeling of immunosuppression through the use of CF led to a decrease  in  the  number  of  lymphoid  cells and the appearance of foci of accumulation of  blast  cells  and  megakaryocytes,  which indicates a lesion of lymphoid and hematopoietic tissues. In addition, an immunosuppressive effect on the spleen was revealed, the mass coefficient of which in the group with the use of CF was increased 3.53 times, in the group with the simultaneous use of CF and the drug interferon lambda – 2.75 times relative to the control group.  There was also a decrease in the mass coefficient of the thymus  by  47.6-50.0%  in  the  same  groups, which can be regarded as damage to the organs  of  the  immune  system.  The negative effect of CF on the spleen was confirmed by histological examination. Thus, when inducing immunosuppression, the loss of  white pulp was 73.0-77.5% relative to the group of control animals, which is 20.0% higher than in rats treated with interferon lambda, which may indicate a positive immunotropic effect of the drug under study. In addition, no significant morphological changes were detected  when  the  body  of  healthy  rats  was  exposed  to  interferon  lambda  in  the  studied organs, the morphological picture is similar to that of intact animals, which may indicate the safety of its use to animals.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}