The anthelmintic efficacy of the drug Expresstabs in helminthiasis of dogs

A. Tokarev, O. A. Tokareva
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Abstract

The purpose of the research is to study the  effectiveness  of  the  drug  ExpressTabs tested on dogs infected with helminths. The drug  contains  spinosad,  praziquantel  and moxidectin as active ingredients. Animals of mixed  breeds  of  both  sexes  aged  from  7 months to 2 years were selected for the experiments. Experimental and control groups of dogs with toxocariasis, toxascariasis and dipylidiasis  were  formed.  ExpressTabs was administered  to  dogs  individually,  once, orally in a mixture with food or immediately after feeding (on  the  root  of  the  tongue or with a treat) in a minimum dose of 30 mg of spinosad, 0.2 mg of moxidectin and 5 mg of praziquantel per 1 kg of animal weight. Animals  in  the  control  groups  were  not  given tablets. A control examination in the case of dipylidiasis  was  carried  out  on  the  second day then if the animal continued to remain in the  hospital  once  a  week.  For  toxocariasis and toxascariasis fecal examination was carried out on day 7 then on days 14, 21 and 28. The drug ExpressTabs showed high (100%) effectiveness  in  the  treatment  of dogs with toxocariasis,  toxaccariasis  and  dipylidiasis. In one animal re-infection with toxocariasis was  observed  because  helminth  eggs  were again  detected  on  day  28  in  the  control study. Taking into account the development cycle  of  parasites  it  is  obvious  that  re-infection occurred no later than a week after the  experimental  deworming  with  ExpressTabs. At recommended doses the drug did not cause unwanted side effects.
Expresstabs药物对犬蠕虫病的驱虫疗效
这项研究的目的是研究在感染蠕虫的狗身上试验的药物 ExpressTabs 的有效性。该药物的有效成分包括spinosad、praziquantel和moxidectin。实验选择了 7 个月至 2 岁的雌雄混种动物。实验组和对照组分别为患有弓形虫病、弓形虫病和二联线虫病的狗。 给狗单独服用 ExpressTabs 一次,与食物混合口服或喂食后立即口服(舌根部或与食物一起服用),最低剂量为每 1 公斤动物体重 30 毫克 spinosad、0.2 毫克莫西菌素和 5 毫克吡喹酮。对照组的动物不给药片。如果动物继续住院,则在第二天进行对照检查,然后每周一次。 对于弓形虫病和蛔虫病,则在第 7 天、第 14 天、第 21 天和第 28 天进行粪便检查。药物 ExpressTabs 对患有弓形虫病、弓形虫病和双鞭毛虫病的狗的治疗效果很好(100%)。有一只动物再次感染了弓形虫病,因为在对照研究的第 28 天再次检测到了虫卵。考虑到寄生虫的发育周期,很明显,在使用 ExpressTabs 进行实验性驱虫后一周内就会发生再次感染。在推荐剂量下,该药物不会产生不必要的副作用。
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