International Journal of Trichology最新文献

{"title":"Clinicopathology, Trichoscopy, and Treatment Responsiveness of Folliculitis Decalvans: A Case Series of Three Pediatric Cases.","authors":"Vidya Yadav, Apaopa Jemima Thekho, Vibhu Mendiratta, Md Ali Osama, Smita Singh","doi":"10.4103/ijt.ijt_109_22","DOIUrl":"10.4103/ijt.ijt_109_22","url":null,"abstract":"","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"213-217"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Number of Follicular Stelae and Severity and Treatment Response of Alopecia Areata Cases: A Retrospective Study.","authors":"Güllü Gencebay, Özge Aşkin, Övgü Aydin, Server Serdaroğlu","doi":"10.4103/ijt.ijt_76_21","DOIUrl":"10.4103/ijt.ijt_76_21","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) is an autoimmune disease characterized by peribulbar lymphocytic infiltration, follicular miniaturization, catagen/telogen follicles, and increased follicular stelae (streamers) in skin biopsies.</p><p><strong>Objectives: </strong>Our aim was to assess the number of follicular stelae of patients with AA and to evaluate their association with clinical type and severity and treatment response of AA.</p><p><strong>Materials and methods: </strong>Histopathologic features including the number of follicular stelae were recorded in skin biopsies taken from lesions of AA in 142 patients who attended our dermatology clinic from 2011 to 2017.</p><p><strong>Results: </strong>There was a statistically significant correlation between patient age and the number of follicular stelae (<i>P</i> = 0.001). There was a statistically significant correlation between the severity of disease and number of follicular stelae (<i>P</i> = 0.005). AA subtypes (0%-25% scalp hair loss) had a significantly lower number of follicular stelae than 75%-100% of scalp hair loss and alopecia universalis (7.92 ± 4.21 vs. 13.23 ± 7.28). There was no statistically significant correlation between treatment response and the number of follicular stelae (<i>P</i> = 0.75).</p><p><strong>Conclusion: </strong>Our results showed that the number of follicular stelae varied among AA clinical types and correlated with severity. This study was the first to evaluate the correlation between the number of follicular stelae and severity of AA.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"191-193"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison among Intense Pulsed Light, Alexandrite, and Long-Pulsed Neodymium-Doped Yttrium Aluminum Garnet 1064 Nm Lasers for Lower Leg Hair Removal: Case Series.","authors":"Indri Widya Sari, Yuli Kurniawati, Sarah Diba","doi":"10.4103/ijt.ijt_110_21","DOIUrl":"10.4103/ijt.ijt_110_21","url":null,"abstract":"<p><p>Lower leg hair removal is the method of reducing unwanted lower leg hair. Various technologies for lower leg hair removal include Intense Pulsed Light (IPL), alexandrite laser, and neodymium-doped yttrium aluminum garnet (Nd: YAG) laser. Conventional techniques are abandoned because effectiveness of the latest technological therapies has a longer period with minimal side effects. The comparison of successful treatment among IPL, alexandrite laser, and Nd: YAG laser for lower leg hair removal. Two patients, male and female, 28 years old, Fitzpatrick IV skin type. Three areas in the lower legs are marked for IPL 695 nm, <i>fluence</i> 15 J/cm², <i>pulse duration</i> 60 ms; alexandrite 755 nm, <i>fluence</i> 3 J/cm², <i>pulse duration</i> 2 ms, long-pulsed Nd: YAG 1064 nm, <i>fluence</i> 32 J/cm², <i>pulse duration</i> 60 ms. IPL for 3 sessions at 2-week intervals. The alexandrite and Nd: YAG lasers for 3 sessions at 4-week intervals. Successful parameters with hair reduction and Visual Analog Scale (VAS) can be seen from photography and dermoscopy before and after therapy. In the first case, the most effective reduction terminal hair after IPL (95,1%), alexandrite (91,02%) and Nd: YAG (79,69%), respectively. In the second case, the most effective reduction of terminal hair after alexandrite (91,02%), Nd: YAG (79,69%), and IPL (20%), respectively. Hyperpigmentation and the highest VAS score (6-7) are found in the area treated with alexandrite lasers of two patients. Two patients have decreased Dermatology Life Quality Index scores. Nd: YAG laser may be better suitable for both sexes with minimal side effects. The limitation of this study is the smaller subject group and limited session.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"197-203"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetric Idiopathic MicroPapular Facial Eruption or SIMPLE - Description of a New Entity Featuring Facial Vellus Hair Lichen Planopilaris in the Absence of Frontal Fibrosing Alopecia.","authors":"Vishal Madan","doi":"10.4103/ijt.ijt_107_22","DOIUrl":"10.4103/ijt.ijt_107_22","url":null,"abstract":"<p><p>Patients with frontal fibrosing alopecia (FFA) can present with facial micropapules which histologically represent vellus hair lichen planopilaris (LPP). Noninflammatory vellus hair LPP in the absence of FFA is rarely reported. The report describes noninflammatory vellus hair LPP presenting as symmetrical facial micropapules in the absence of clinical signs of FFA.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"208-212"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targetoid Hair Regrowth Pattern in Alopecia Areata: A Case Series.","authors":"Heera Ramesh, Sachin Somashekhar, Kanathur Shilpa","doi":"10.4103/ijt.ijt_48_22","DOIUrl":"10.4103/ijt.ijt_48_22","url":null,"abstract":"<p><p>Alopecia areata (AA) is an autoimmune disorder leading to nonscarring hair loss of the scalp and/or body. Atypical hair regrowth in AA is considered a rare phenomenon. Many paradoxical forms of hair regrowth have been described in AA. Targetoid hair regrowth pattern in AA was first described in 1988. Here, we report three cases wherein this pattern of hair regrowth was seen.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"204-207"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Adipose-Derived Stem Cells and Their Secretome in Reversible Alopecias: A Systematic Review.","authors":"Alexis Ortega-Cuartiella","doi":"10.4103/ijt.ijt_3_21","DOIUrl":"10.4103/ijt.ijt_3_21","url":null,"abstract":"<p><p>Androgenic alopecia (AGA) and alopecia areata (AA) are two highly prevalent conditions, affecting both men and women of a wide range of ages, which strongly impact their quality of life and self-esteem. Both pathologies are deemed to be reversible, although conventional therapies have shown limited scope and efficacy. New therapeutic approaches, focusing on the degenerative changes that take place in the hair follicle, are needed to achieve better outcomes. For instance, adipose-derived stem cells (ADSC), abundant and easy to obtain, hold great potential in follicular regeneration. ADSCs can be isolated as stromal vascular fraction (SVF) by the enzymatic digestion of the lipoaspirate or as nanofat by the mechanical breakdown of adipocytes. In addition, commercial preparations of the conditioned medium of the ADSCs secretome (ADSC-conditionate medium [CM]) have entered the market as an appealing alternative because of their comparatively lower cost and accessibility. A search was conducted, crossing relevant terms, on PubMed Central and Google Scholar. Criteria for inclusion were studies in the past 10 years on humans with AGA or AA, where either SVF, nanofat, or ADSC-CM was tested as the main treatment. Eleven publications qualified: two studied nanofat, three, ADSC-CM, and six, SVF, either individually or in combination with other therapies. Only one randomized controlled trial (RCT) was found and classified as evidence 2b according to the Sackett scale. The rest were case-control studies or case series with small samples and no control, graded as evidence 3b and 4. A meta-analysis could not be conducted due to the heterogenicity of the study designs. Given the evidence obtained, Level D NICE recommendation was established. However, we consider that the positive findings are sufficiently consistent to support the elaboration of further RCTs that share criteria and methods.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"173-182"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopy in Trichotillomania - Monitoring Treatment Response.","authors":"S Srisukhirthi, Sheela Kuruvila, Parthasarathy Ramamurthy","doi":"10.4103/ijt.ijt_76_22","DOIUrl":"10.4103/ijt.ijt_76_22","url":null,"abstract":"<p><p>Trichotillomania is nonscarring alopecia with recurrent pulling out of one's hair and repeated attempts to reduce hair pulling. Clinical improvement in the urge to pull out hairs in trichotillomania is often not quantifiable and based on unreliable history. Here, we present a case of trichotillomania with follow-up features on trichoscopy during treatment. By this, we propose trichoscopy as an objective tool to visualize clinical improvement in the urge to pull out hairs and assess treatment efficacy.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"218-220"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical, Dermoscopic, and Histopathological Study of Follicular Psoriasis.","authors":"Maqbool Saep, Manjunath Mala Shenoy, Anuradha C K Rao, Malcolm Pinto, Spandana Prakash Hegde, Amina Asfiya M Iqbal","doi":"10.4103/ijt.ijt_168_20","DOIUrl":"10.4103/ijt.ijt_168_20","url":null,"abstract":"<p><strong>Introduction: </strong>Follicular psoriasis is one of the underdiagnosed clinical types of psoriasis. Literature is grossly limited to anecdotal case reports and series. Clinical and investigational aspects are not studied in depth.</p><p><strong>Materials and methods: </strong>A study was conducted to determine the frequency of follicular psoriasis, which includes cases with an exclusive or substantial number of follicular lesions. We analyzed the clinical, dermoscopic, and histopathological features of follicular psoriasis in a descriptive study.</p><p><strong>Results: </strong>A total of 117 patients with psoriasis were screened. An exclusive or substantial number of follicular lesions were found in 22 patients. Four patients had exclusively follicular lesions and others were psoriasis vulgaris with follicular psoriasis. Dermoscopy revealed perifollicular scaling and white homogeneous area with normal terminal hair in all cases. Vascular features were visible in 14 cases and all had dotted vessels, with four having additional globules. Twenty patients revealed one or more features suggestive of follicular psoriasis on histopathology.</p><p><strong>Conclusion: </strong>Follicular lesions can appear exclusively or can coexist with plaque type of lesions in psoriasis. They may indicate early psoriasis lesions. Dermoscopy is a useful and rapid tool to confirm the diagnosis of follicular psoriasis. Histopathology, though confirmatory, demands an astute interpretational skill. Diagnosis of follicular psoriasis can have therapeutic implications.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"127-132"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Response to Diphenylcyclopropenone in Patients with Alopecia Totalis/Universalis.","authors":"Smitha Ancy Varghese, Sandhya S Nair, Anuja Elizabeth George, Induprabha Yadev","doi":"10.4103/ijt.ijt_2_22","DOIUrl":"10.4103/ijt.ijt_2_22","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia totalis (AT) and Alopecia universalis (AU) are forms of Alopecia areata (AA) which represent the strongest predictor of poor prognosis since spontaneous regrowth is <10%. Topical immunotherapy agent, diphenylcyclopropenone (DPCP) has shown clinical efficacy with limited side effects in severe forms of AA. However, its specific role in AT/AU characterized by complete hair loss over the scalp can help highlight the efficacy of the drug with fewer confounders.</p><p><strong>Methodology: </strong>Data were collected from 18 patients diagnosed with AT/AU and treated with topical immunotherapy with DPCP as per protocol by Happle <i>et al</i>. Baseline Severity of Alopecia Tool (SALT) score and subclass was recorded. In the case of AU, baseline body hair loss score was also recorded. Patients were reassessed after 6 months of treatment in terms of change in SALT score and hair regrowth was assessed using the Global Assessment Score. The side effects during treatment were also assessed and recorded.</p><p><strong>Results: </strong>Eighteen patients of whom eleven (61.1%) were diagnosed as AU and seven (38.9%) as AT were treated. The mean age was 21.6, with a male: female ratio of 3:2. The comorbidities noted were atopy in six (33.3%), atopy and hypothyroidism in one (5.5%), Down's syndrome in two (11.1%), and hypothyroidism alone in one (5.5%) patient. The mean duration of disease at the time of presentation was 3 years and all patients had remained refractory to various other modalities of treatment. All patients had a baseline SALT score of 100 corresponding to S5. After 6 months of treatment, 27.7% of patients did not show any response (SALT score S5), 16.6% had a score of S4, 11.1% had a score of S3, 11.1% had a score of S2, 22.2% had a score of S1, and 11.1% had a score of S0. On assessing improvement in body hair loss score, 36.3% of patients showed no improvement, 36.3% showed partial improvement, and 27.2% of patients showed complete body hair regrowth. About 55.5% of patients developed notable side effects that included severe local reactions, cervical lymphadenopathy, acne and pigmentation at the site of application as well as untreated sites.</p><p><strong>Conclusion: </strong>The AT/AU subtypes of AA, was amenable to treatment with contact immunotherapeutic agent DPCP with a >75% hair regrowth in 33.3% of patients. The castling phenomenon was seen in 63.6% of AU patients. The adverse effects noted were not severe enough to deter treatment.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"149-153"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopy Features of Indonesian Males with Androgenetic Alopecia in Association with Disease Severity.","authors":"Lili Legiawati, Lis Surachmiati Suseno, Irma Bernadette S Sitohang, Shannaz Nadia Yusharyahya, Athaya Ardelia, Kanya Paramastri","doi":"10.4103/ijt.ijt_31_22","DOIUrl":"10.4103/ijt.ijt_31_22","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia (AGA) is a progressive loss of terminal hairs in a specific pattern distribution related to androgen. The dermoscopy of hair and scalp, known as trichoscopy, is a noninvasive method for diagnosing alopecia and other hair and scalp disorders.</p><p><strong>Objective: </strong>This study aims to report the correlation between the severity of males with AGA based on Hamilton-Norwood's scale with the clinical characteristics found in trichoscopy.</p><p><strong>Materials and methods: </strong>This study included 40 patients aged 25-58 years who visited the dermatology outpatient clinic in a tertiary health facility in Indonesia. Clinical diagnosis was determined through history taking, physical examination, and trichoscopy. Based on Hamilton-Norwood's criteria, patients were divided into two groups: early and late stage. Parameters examined in trichoscopy include yellow dots, white dots, peripilar sign, vellus hair, hair diameter diversity, single-hair follicles, and empty follicles. The Chi-square test and Fisher's exact test were used to analyze the statistical significance between the groups.</p><p><strong>Results: </strong>All participants presented with hair diameter diversity, vellus hair, and empty follicles (100%). None of the study participants had yellow dots. White dots and single-hair follicles were seen in 32 (80%) and 30 cases (75%), respectively. In the late-stage group, these features were more prevalent. Peripilar sign was found in 25 participants (62.50%), and it was more common in the early-stage group. No significant association was found between disease severity and trichoscopy features.</p><p><strong>Conclusion: </strong>The most common trichoscopy findings in particular order were hair diameter diversity, vellus hair, and empty follicles, followed by white dots, single-hair follicles, and peripilar signs. No significant association between alopecia severity and trichoscopy parameters was observed. Studies with a larger number of participants, including a control group, should be conducted to yield more significant results.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"144-148"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}