International Journal of Surgical Pathology最新文献

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Cutaneous Angiosarcoma: Clinicopathologic Spectrum, Immunohistochemical Features, and Diagnostic Pearls. 皮肤血管肉瘤:临床病理谱、免疫组织化学特征和诊断珍珠。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-25 DOI: 10.1177/10668969261478605
Krista-Gaie Grant, Akshitha Thatiparthi, Kiran Motaparthi
{"title":"Cutaneous Angiosarcoma: Clinicopathologic Spectrum, Immunohistochemical Features, and Diagnostic Pearls.","authors":"Krista-Gaie Grant, Akshitha Thatiparthi, Kiran Motaparthi","doi":"10.1177/10668969261478605","DOIUrl":"https://doi.org/10.1177/10668969261478605","url":null,"abstract":"<p><p>BackgroundCutaneous angiosarcoma (cutaneous AS) is a rare, aggressive endothelial malignancy characterized by rapid growth, early metastasis, and poor prognosis. Accurate diagnosis remains challenging due to variable clinical presentations, a broad histologic spectrum, and overlap with benign vascular proliferations.ObjectiveTo provide a comprehensive review of cutaneous AS, emphasizing clinical contexts, histopathologic subtypes, immunohistochemical features, molecular alterations, and key diagnostic distinctions from histologic mimics.MethodsA literature review of recent clinicopathologic, immunohistochemical, and genomic studies was performed to synthesize current diagnostic and molecular insights into primary and secondary cutaneous AS.FindingsPrimary cutaneous AS most often arises on sun-damaged skin of older adults, whereas secondary cutaneous AS develops after radiation exposure or chronic lymphedema. Cutaneous AS exhibits diverse morphologies ranging from well-differentiated vasoformative to solid or epithelioid patterns. Immunohistochemistry supports endothelial lineage (CD31, ERG, FLI1) and excludes morphologic mimics, although keratin expression represents a diagnostic pitfall. MYC amplification, detected by FISH or IHC, is a hallmark of secondary cutaneous AS and distinguishes it from benign atypical vascular lesions. Next-generation sequencing (NGS) further identifies <i>MYC</i>/<i>FLT4</i> co-amplification, UV mutational signatures, and DNA damage response pathway alterations, providing both diagnostic and therapeutic implications.ConclusionsDiagnosis of cutaneous AS requires integration of clinical context, histopathology, and ancillary testing. MYC testing is critical for differentiating secondary cutaneous AS from post-radiation atypical vascular lesions, while NGS expands the molecular understanding of cutaneous AS. Early biopsy, adequate tissue sampling, and judicious use of IHC, FISH, and NGS improve diagnostic precision and may guide targeted or immune-based therapies.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261478605"},"PeriodicalIF":0.9,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous Odontogenic Fibromyxoma and Compact Osteoma in a Pediatric Patient: A Rare Case Report Mimicking Ameloblastic Fibro-Odontoma. 小儿同步牙源性纤维黏液瘤和致密骨瘤:一例罕见的模仿成釉纤维-牙瘤的病例报告。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-24 DOI: 10.1177/10668969261472125
Josivaldo Soares, Rebeca Souza, Davi Costa, Claúdia Figueiredo
{"title":"Synchronous Odontogenic Fibromyxoma and Compact Osteoma in a Pediatric Patient: A Rare Case Report Mimicking Ameloblastic Fibro-Odontoma.","authors":"Josivaldo Soares, Rebeca Souza, Davi Costa, Claúdia Figueiredo","doi":"10.1177/10668969261472125","DOIUrl":"https://doi.org/10.1177/10668969261472125","url":null,"abstract":"<p><p>Odontogenic myxoma is a rare, benign mesenchymal odontogenic neoplasm. Microscopically, odontogenic myxoma consists of spindle-shaped or stellate cells within an myxoid stroma. In rare tumors, the stroma contains heavy collagen deposition, and they are then termed odontogenic fibromyxomas. We report an unusual synchronous presentation of an odontogenic fibromyxoma and an osteoma in a 12-year-old boy, which clinically mimicked an ameloblastic fibro-odontoma. The patient presented with a left mandibular mass. Imaging revealed an extensive 51-mm osteolytic lesion accompanied by a hyperdense calcified mass. Radiographic findings were suggestive of an ameloblastic fibro-odontoma. A biopsy of the tumor was performed, and the calcified mass was excised. Histopathological analysis confirmed the diagnosis of an odontogenic fibromyxoma with an associated compact osteoma. The patient underwent a partial mandibular resection and remains disease-free at the 12-month follow-up. A synchronous occurrence of an odontogenic myxoma and an osteoma is rare and can mimic other lesions, making diagnosis challenging.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261472125"},"PeriodicalIF":0.9,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathological Features of Mammary Myofibroblastoma: A Single Institution Case Series. 乳腺肌成纤维细胞瘤的临床病理特征:单一机构病例系列。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-24 DOI: 10.1177/10668969261469873
Hania Naveed, Romana Idrees, Fatima Safdar, Nasir Ud Din, Naila Kayani
{"title":"Clinicopathological Features of Mammary Myofibroblastoma: A Single Institution Case Series.","authors":"Hania Naveed, Romana Idrees, Fatima Safdar, Nasir Ud Din, Naila Kayani","doi":"10.1177/10668969261469873","DOIUrl":"https://doi.org/10.1177/10668969261469873","url":null,"abstract":"<p><p>Mammary myofibroblastoma (MFB) is a rare benign mesenchymal tumor of the breast with myofibroblastic differentiation. Its diverse morphological spectrum may pose diagnostic challenges, particularly in limited biopsy specimens. All MFB patients diagnosed at a tertiary care center between 2015 and 2024 were reviewed retrospectively. Eleven patients were identified, including 7 women and 4 men, with a mean age of 56.5 years (range: 31-75 years). All patients presented with a solitary, painless breast mass. Tumor size ranged from 2.3 to 14 cm. Histologically, 9 tumors showed spindle cell morphology, whereas 2 showed epithelioid features. The common findings included short intersecting fascicles of bland spindle cells, variable collagen deposition, ectatic blood vessels, and focal adipocytic components. Immunohistochemically, CD34 was positive in 9 tumors, desmin in 8, smooth muscle actin (ACTA2) in 5, BCL2 and CD99 in 7 each, and CD10 in 4 tumors. Keratin AE1/AE3, p63, S100, and STAT6 were negative in all tumors. Follow-up data was available in 9 patients and no recurrence was reported. Recognition of its characteristic morphological and immunohistochemical features is essential to avoid diagnostic pitfalls. Complete surgical excision is curative, with an excellent prognosis.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261469873"},"PeriodicalIF":0.9,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influencing Factors of Prognosis in Adjuvant Trastuzumab Therapy for HER2-Positive Breast Cancer. her2阳性乳腺癌辅助曲妥珠单抗治疗预后的影响因素
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-23 DOI: 10.1177/10668969261472118
Lei Guan, Lu Wang, Chenying Liu, Xiaozi Wang, Jiazhen Li, Yihang Yang, Liu Yang, Jiamei Liu, Yafang Zhao, Weidong Li, Xiaolong Qian, Xiaojing Guo
{"title":"Influencing Factors of Prognosis in Adjuvant Trastuzumab Therapy for HER2-Positive Breast Cancer.","authors":"Lei Guan, Lu Wang, Chenying Liu, Xiaozi Wang, Jiazhen Li, Yihang Yang, Liu Yang, Jiamei Liu, Yafang Zhao, Weidong Li, Xiaolong Qian, Xiaojing Guo","doi":"10.1177/10668969261472118","DOIUrl":"https://doi.org/10.1177/10668969261472118","url":null,"abstract":"<p><p>ObjectiveThis study aims to conduct a comprehensive, multidimensional evaluation of how clinical and pathological factors influence invasive disease-free survival (IDFS) and cancer-specific survival (CSS) in patients with human epidermal growth factor receptor 2 (<i>ERBB2</i>/HER2) positive breast cancer receiving adjuvant trastuzumab therapy. Additionally, a stratified assessment will be conducted based on the hormone receptor (HR) status; thereby providing a practical basis for clinical treatment.MethodA total of 643 patients with HER2-positive breast cancer who received adjuvant trastuzumab therapy were retrospectively included. The patients' clinical and pathological information, as well as IDFS and CSS data, were systematically collected and evaluated. Survival analysis was conducted via the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards regression models were used to assess the effects of menstrual status, tumor size, vascular invasion, lymph node involvement, histological grade, histological type, HR status, MKI67 expression, tumor-infiltrating lymphocytes (TILs), HER2 expression, and anthracycline-based chemotherapy on IDFS and CSS. Additionally, clinicopathological characteristics of patients with HER2-positive breast cancer who received trastuzumab treatment were analyzed.ResultAmong all patients, HER2(3+), absence of lymph node metastasis, and anthracycline-based chemotherapy were independently associated with prolonged CSS. Notably, anthracycline use was an independent predictor of longer CSS in HR-negative patients. In the HR-positive subgroup, patients with HER2(3+) status demonstrated a significant CSS benefit compared to those with HER2(2+)/FISH(+) status.ConclusionHER2 expression status affects CSS in patients with HER2-positive breast cancer receiving adjuvant trastuzumab therapy. HR-negative patients may derive clinical benefit from anthracyclines, providing evidence to support anthracycline-based regimens combined with trastuzumab as the adjuvant treatment for HR-negative, HER2-positive breast cancer.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261472118"},"PeriodicalIF":0.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine Tumor Resembling Ovarian Sex Cord Tumor With GREB1::NCOA2 Fusion and Neuroendocrine Marker Expression: A Case Report and Literature Review. 类似卵巢性索瘤的子宫肿瘤伴GREB1::NCOA2融合及神经内分泌标志物表达1例并文献复习。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-22 DOI: 10.1177/10668969261457884
Fatma Lina Emiroglu, Bogdan Firsov, Saroja Devi Geetha, Sudarshana Roychoudhury, Tahyna Hernandez, Seema Khutti, Cao Jin
{"title":"Uterine Tumor Resembling Ovarian Sex Cord Tumor With <i>GREB1::NCOA2</i> Fusion and Neuroendocrine Marker Expression: A Case Report and Literature Review.","authors":"Fatma Lina Emiroglu, Bogdan Firsov, Saroja Devi Geetha, Sudarshana Roychoudhury, Tahyna Hernandez, Seema Khutti, Cao Jin","doi":"10.1177/10668969261457884","DOIUrl":"https://doi.org/10.1177/10668969261457884","url":null,"abstract":"<p><p>The uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare mesenchymal tumor of the uterus. Morphological patterns can show sheets, cords, and trabeculae that are similar to those seen in ovarian sex cord-stromal tumors. Immunohistochemically, they exhibit a polyphenotypic variable pattern, including epithelial, myoid, and sex cord lineage as well as hormone receptors. We report a female patient with a UTROSCT harboring a <i>GREB1::NCOA2</i> fusion that demonstrated a diffuse, strong positivity with chromogranin, synaptophysin, and CD56. INSM1 was performed to rule out true neuroendocrine differentiation. While neuroendocrine marker expression is rare in UTROSCT, this report adds to the limited literature describing this unusual immunoprofile, particularly in the context of <i>GREB1</i> rearrangements. This study remains important to highlight the inclusion of this type of immunohistochemical staining in the spectrum of features UTROSCT can represent. Recent systematic review evidence suggests that <i>GREB1</i>-rearranged UTROSCTs may represent a biologically and clinically distinct subset from <i>ESR1</i>-rearranged tumors, with differences in clinicopathological features and molecular characteristics.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261457884"},"PeriodicalIF":0.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NECTIN4, TROP2 and PDL1 in Breast Cancer: Immunohistochemical Profiling and Clinical Associations. 乳腺癌中的NECTIN4, TROP2和PDL1:免疫组织化学分析和临床关联。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-22 DOI: 10.1177/10668969261479344
Huamin Gu, Ling Kang, Liujing Huang, Junxuan Zhu, Tingting Wang, Yao Qian, Kai He, Lilong Fan, Hongsheng Lu, Rong Deng, Siqi Wang, Yingzhi Yu
{"title":"NECTIN4, TROP2 and PDL1 in Breast Cancer: Immunohistochemical Profiling and Clinical Associations.","authors":"Huamin Gu, Ling Kang, Liujing Huang, Junxuan Zhu, Tingting Wang, Yao Qian, Kai He, Lilong Fan, Hongsheng Lu, Rong Deng, Siqi Wang, Yingzhi Yu","doi":"10.1177/10668969261479344","DOIUrl":"https://doi.org/10.1177/10668969261479344","url":null,"abstract":"<p><p>AimsTo systematically analyze the immunohistochemical expression patterns of NECTIN4 and TROP2 in breast cancer, their clinicopathological correlations, and associations with PDL1 status.Materials and methodsNECTIN4 (H-score), TROP2 (H-score), and PDL1 (Combined Positive Score, CPS) expression were evaluated in 112 surgically resected breast carcinomas using validated immunohistochemical assays. Associations with clinicopathological variables were analyzed using Spearman's correlation, χ<sup>2</sup> tests, and Mann-Whitney <i>U</i> tests.ResultsNECTIN4 exhibited moderate-to-high expression (H-score ≥ 100) in 78% of specimens, predominantly localized to the cell membrane, and showed a significant positive correlation with HER2 positivity (ρ = 0.27, <i>P</i> < .01). TROP2 displayed near-ubiquitous moderate-to-high expression (96%) and exhibited higher expression in the triple-negative breast cancer (TNBC) subtype. Notably, there was no significant correlation between NECTIN4 or TROP2 and PDL1 co-expression.ConclusionsThis study provides a comprehensive characterization of NECTIN4 and TROP2 expression in breast cancer, suggesting their potential as biomarkers. The observed associations with PDL1 and clinicopathological features may inform future investigations into their biological roles and clinical relevance.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261479344"},"PeriodicalIF":0.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Langerhans Cell Histiocytosis of the Stomach in an Adult: A Mimicker of Gastric Antral Vascular Ectasia. 成人胃朗格汉斯细胞组织细胞增多症:胃窦血管扩张的模拟物。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-21 DOI: 10.1177/10668969261470845
Vaclav Stejskal
{"title":"Langerhans Cell Histiocytosis of the Stomach in an Adult: A Mimicker of Gastric Antral Vascular Ectasia.","authors":"Vaclav Stejskal","doi":"10.1177/10668969261470845","DOIUrl":"https://doi.org/10.1177/10668969261470845","url":null,"abstract":"","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261470845"},"PeriodicalIF":0.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathological Features and Prognostic Significance of CLDN18 in Gastric-Type Endocervical Adenocarcinoma: A Study of 13 Patients-A Single Institution Experience. 13例胃型宫颈内腺癌CLDN18的临床病理特征及预后意义
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-20 DOI: 10.1177/10668969261478610
Kaijian Zhang
{"title":"Clinicopathological Features and Prognostic Significance of CLDN18 in Gastric-Type Endocervical Adenocarcinoma: A Study of 13 Patients-A Single Institution Experience.","authors":"Kaijian Zhang","doi":"10.1177/10668969261478610","DOIUrl":"https://doi.org/10.1177/10668969261478610","url":null,"abstract":"<p><p>ObjectiveGastric-type endocervical adenocarcinoma (G-EAC) is a rare, non-HPV-associated subtype of endocervical adenocarcinoma with challenging diagnosis and poor prognosis. This study aims to characterize its clinicopathological features and evaluate the expression and prognostic significance of CLDN18.MethodsA total of 13 patients with pathologically confirmed G-EAC were collected.ResultsThe 13 patients, aged 39 to 64 years (mean 51.6 years), mostly sought medical attention due to abnormal findings on physical examination or specific symptoms, including abnormal vaginal discharge. Ten specimens were well-differentiated G-EAC, and 3 were moderately to poorly differentiated G-EAC. Atypical lobular endocervical gland hyperplasia (LEGH) was observed adjacent to G-EAC in 12 specimens. The International Federation of Gynecology and Obstetrics (FIGO) stage was stage I in 12 specimens and stage III in 1 specimen. The Ki-67 proliferation index ranged from <5% to 90%. Mutant-type immunostaining of p53 (overexpression or null pattern) was observed in 9 specimens; all 13 specimens were negative for estrogen receptor (ER), and 7 specimens showed positive CLDN18 expression. An exploratory survival analysis showed a trend toward shorter progression-free survival (PFS) in patients with positive CLDN18 expression (<i>P</i> = .044), a finding limited by the small sample size. Thus, CLDN18 may serve as a highly specific diagnostic adjunct in a panel, and its potential prognostic significance warrants further investigation in larger cohorts.ConclusionG-EAC is rare, and its clinical diagnosis is challenging. Clinicians should maintain a high index of suspicion, perform colposcopy with multi-site biopsy and endocervical curettage for suspicious specimens. Pathologists should integrate a panel of immunohistochemical markers with morphology to differentiate it from benign mimics. In addition, CLDN18 may not only serve as a diagnostic marker for G-EAC but may also be associated with patient prognosis, demonstrating its potential predictive value.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261478610"},"PeriodicalIF":0.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary Duct Carcinoma With Rhabdoid and Signet-Ring Cell Features Mimicking Invasive Lobular Carcinoma of the Breast: A Case Report and Review of the Literature. 涎腺导管癌伴横纹肌样及印戒细胞特征与乳腺浸润性小叶癌相似:1例报告及文献复习。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-19 DOI: 10.1177/10668969261479347
Muhammad Hassaan Khalid, Phuoc T Christie-Nguyen, Maryam Ashfaq, Bhanupriya Kakarala, Nourhan G Ibrahim, Karan Saluja
{"title":"Salivary Duct Carcinoma With Rhabdoid and Signet-Ring Cell Features Mimicking Invasive Lobular Carcinoma of the Breast: A Case Report and Review of the Literature.","authors":"Muhammad Hassaan Khalid, Phuoc T Christie-Nguyen, Maryam Ashfaq, Bhanupriya Kakarala, Nourhan G Ibrahim, Karan Saluja","doi":"10.1177/10668969261479347","DOIUrl":"https://doi.org/10.1177/10668969261479347","url":null,"abstract":"<p><p>Salivary duct carcinoma is a rare, aggressive salivary gland malignancy that morphologically and immunophenotypically resembles breast ductal carcinoma. The rhabdoid variant is characterized by discohesive tumor cells with rhabdoid cytomorphology, frequent loss of E-cadherin expression, and morphologic overlap with pleomorphic invasive lobular carcinoma of the breast. We report a 74-year-old man who presented with an enlarging right buccal mass and trismus. Positron emission tomography-computed tomography demonstrated right cervical lymphadenopathy with no evidence of breast or lung primary. Resection revealed a discohesive, infiltrative tumor composed of pleomorphic rhabdoid cells, with scattered cells containing intracytoplasmic mucin imparting a signet-ring morphology, and prominent targetoid perineural invasion. Immunohistochemically, the tumor showed diffuse positivity for keratin 7, gross cystic disease fluid protein 15 (GCDFP15/PIP), androgen receptor, weak GATA3 expression, loss of E-cadherin, and cytoplasmic p120-catenin (CTNND1) staining, a profile closely resembling that of invasive lobular carcinoma. Extensive nodal metastases were identified. Despite multimodal therapy, the disease recurred. This report highlights the importance of recognizing salivary duct carcinoma with rhabdoid features to avoid misdiagnosis and guide appropriate management.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261479347"},"PeriodicalIF":0.9,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the Gap Between Endoscopy and Histology Indices: A Multi-Index Comparison in 146 Ulcerative Colitis Patients. 弥合内镜和组织学指标之间的差距:146例溃疡性结肠炎患者的多指标比较。
IF 0.9 4区 医学
International Journal of Surgical Pathology Pub Date : 2026-09-19 DOI: 10.1177/10668969261470847
Zahed Ali Qamer, Prashant Durgapal, Arvind Kumar, Ashok Singh, Itish Patnaik, Sanjeev Kishore, Ravi Hari Phulware
{"title":"Bridging the Gap Between Endoscopy and Histology Indices: A Multi-Index Comparison in 146 Ulcerative Colitis Patients.","authors":"Zahed Ali Qamer, Prashant Durgapal, Arvind Kumar, Ashok Singh, Itish Patnaik, Sanjeev Kishore, Ravi Hari Phulware","doi":"10.1177/10668969261470847","DOIUrl":"https://doi.org/10.1177/10668969261470847","url":null,"abstract":"<p><p>BackgroundUlcerative Colitis (UC) is a chronic inflammatory bowel disease affecting the colonic mucosa, with a relapsing-remitting course. Disease activity is assessed using clinical, serologic, endoscopic, and histological parameters, among which the latter two remain the cornerstone for assessing disease severity and therapeutic response. However, limited studies have evaluated the correlation between endoscopic and histological activity. This study evaluates the correlation between the Mayo endoscopic score (MES) and validated histological indices, namely the Geboes score (GS), Nancy index (NI), and Robarts histological index (RHI), to determine the most practical and reliable histological scoring system.MethodsThis cross-sectional study was conducted over a period of two and a half years at a tertiary care hospital in North India and included 146 established UC patients. Colonoscopic evaluation was performed by a single gastroenterologist, and biopsies were obtained from areas showing the highest possible MES. Subsequent histopathological examination and scoring using the histological indices (GS, NI, and RHI) were performed independently by pathologists masked to the endoscopic findings. Correlations were assessed using the Chi-Square test and Spearman's rho to evaluate relationships between endoscopic and histopathological scores.ResultsA total of 146 biopsies were analyzed, with a median patient age of 34 years; male patients constituted 56% of patients, and the recto-sigmoid region was the most commonly affected site (62%). Moderate (50%) and severe (32%) endoscopic aspects suggestive of UC activity were predominant. Correlation coefficients between MES and GS/RHI/NI were moderate (rho = .617/.622/.599, respectively; <i>P</i> < .001 for all three correlations). The NI was the fastest to evaluate and demonstrated a similar correlation with the MES compared to the GS and RHI.ConclusionA moderate yet consistent correlation was observed between the MES and all three histopathological indices, highlighting their reliability in reflecting disease severity and supporting their interchangeable use in routine practice. Among them, the NI emerged as the most practical and user-friendly scoring system due to its simplicity and rapid applicability, while maintaining diagnostic performance comparable to the GS and RHI.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261470847"},"PeriodicalIF":0.9,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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