International Journal of Surgical Pathology最新文献_第5页

Challenges in Assessing Stromal Invasion and Staging Cervical Carcinomas Arising In or Confined to Endocervical Polyps. 评估发生于或局限于宫颈内息肉的间质浸润和宫颈癌分期的挑战。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-05 DOI: 10.1177/10668969261439139

Hisham F Bahmad

{"title":"Challenges in Assessing Stromal Invasion and Staging Cervical Carcinomas Arising In or Confined to Endocervical Polyps.","authors":"Hisham F Bahmad","doi":"10.1177/10668969261439139","DOIUrl":"10.1177/10668969261439139","url":null,"abstract":"The staging of cervical carcinomas that appear confined to endocervical polyps presents a rare but recurring diagnostic and reporting challenge. Current classification systems, including the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system, the American Joint Committee on Cancer (AJCC) eighth edition, and College of American Pathologists (CAP) protocols, do not provide specific guidance for this scenario. Endocervical polyps are typically benign lesions, but in rare instances they may harbor invasive carcinoma. When invasion appears limited to the polyp stroma, assessment of the depth of invasion and assignment of a pathologic stage becomes challenging due to the polyp's limited, distorted, or fragmented architecture. Importantly, it is often difficult in routine practice to distinguish a truly polyp-confined carcinoma from an exophytic cervical tumor involving a polyp. This review highlights the gaps in staging of cervical carcinomas arising in or confined to endocervical polyps and draws cautious conceptual parallels to staging approaches in other organ systems, not to propose guideline changes, but to highlight existing gaps and reporting ambiguities. Currently, for reporting and staging purposes, pathologists use the same approach as that for other exophytic tumors. Here, we emphasize standardized documentation and transparent reporting of staging limitations as a practical interim approach, while acknowledging the absence of evidence sufficient to support formal staging modifications. Until additional data are available, careful descriptive reporting may facilitate clinical decision-making and enable future data collection needed to inform evidence-based revisions.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1701-1712"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to "Clinical-Imaging Discordance in Suspected Osteoid Osteoma: Importance of Targeted CT Evaluation". 答复“疑似骨样骨瘤的临床-影像学不一致：靶向CT评价的重要性”。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-05 DOI: 10.1177/10668969251414708

Shunsuke Koga, Wei Du, Cara A Cipriano, Kumarasen Cooper

引用次数: 0

Epithelioid Fibrous Histiocytoma with LRRFIP1::ALK Fusion and Smooth Muscle Hyperplasia. 上皮样纤维组织细胞瘤伴LRRFIP1: ALK融合和平滑肌增生。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-06 DOI: 10.1177/10668969261445048

Eric Davenne, Alex Fortun, Marine Matthews, Léo-Paul Secco

引用次数: 0

Expression Patterns of Succinate Dehydrogenase B: An Immunohistochemical Study of 57 Tumors With Known SDHx Germline Pathogenic Alterations. 琥珀酸脱氢酶B的表达模式：57例已知SDHx种系致病改变肿瘤的免疫组织化学研究

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-04-15 DOI: 10.1177/10668969261439732

Michael Jared Ornstead, Deepika Sirohi, Daniel J Albertson, Samantha E Greenberg, Jonathon Mahlow

{"title":"Expression Patterns of Succinate Dehydrogenase B: An Immunohistochemical Study of 57 Tumors With Known SDHx Germline Pathogenic Alterations.","authors":"Michael Jared Ornstead, Deepika Sirohi, Daniel J Albertson, Samantha E Greenberg, Jonathon Mahlow","doi":"10.1177/10668969261439732","DOIUrl":"10.1177/10668969261439732","url":null,"abstract":"A clinical algorithm originally proposed by van Nederveen et al. recommends that succinate dehydrogenase B immunohistochemical testing (SDH IHC) be performed on all pheochromocytomas and paragangliomas to screen for SDH deficiency, with abnormal staining (loss) referred to genetic counselors for confirmatory testing. However, the interpretation of SDHB IHC is challenging, with frequent partial staining or weak diffuse expression. This study sought to better characterize atypical SDHB IHC staining patterns in patients with genetically confirmed germline pathogenic or likely pathogenic variants involving SDH subunit (SDHx) genes. The cohort was identified from patients with known SDHx germline pathogenic or likely pathogenic variants within the familial cancer assessment and paraganglioma clinic of an academic tertiary medical center. Fifty-seven SDH-related tumors were identified (paraganglioma, pheochromocytoma, renal cell carcinoma, gastrointestinal stromal tumor, and seminoma) and stained with the SDHB immunohistochemical stain (polyclonal anti-SDHB antibody, Sigma Aldrich, HPA002868). Fourteen control specimens were identified from similar tumors. Stained slides were analyzed by a subspecialty genitourinary pathologist and a medical student completing a postsophomore fellowship in pathology. Twenty-eight of 57 tumors (49%) showed aberrant retained staining, divided into 4 observable staining patterns: fine granular staining/blush (9/28 abnormally staining tumors), focal retention (15/28), retained staining weaker than internal control (2/28), and retained staining either equal to internal control or without internal control present (2/28). We recognize the clinical utility of SDHB IHC as an affordable, but nuanced, method for screening for SDHx pathogenic or likely pathogenic variants and recommend subsequent genetic testing for any amount of abnormally lost staining.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1737-1747"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elastic Staining Features in Pulmonary Non-Mucinous Adenocarcinoma and Associated In Situ Lesions: Diagnostic Implications. 肺非粘液性腺癌及相关原位病变的弹性染色特征：诊断意义。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-16 DOI: 10.1177/10668969261439152

Jun Zhou, Anran Wang, Xue Wang, Wenjing Zhang, Qin Shen, Xiao-Jun Zhou

{"title":"Elastic Staining Features in Pulmonary Non-Mucinous Adenocarcinoma and Associated In Situ Lesions: Diagnostic Implications.","authors":"Jun Zhou, Anran Wang, Xue Wang, Wenjing Zhang, Qin Shen, Xiao-Jun Zhou","doi":"10.1177/10668969261439152","DOIUrl":"10.1177/10668969261439152","url":null,"abstract":"Elastic staining may aid in the diagnosis of pulmonary non-mucinous adenocarcinoma and its in situ lesions. This study evaluated elastic staining patterns and their diagnostic utility in a multi-cohort series. Elastic staining was performed in 120 lesions, including a principal cohort (n = 60), an internal validation cohort (n = 30), an external validation cohort (n = 30), and an interobserver agreement cohort (n = 40). Staining patterns were analyzed and their impact on diagnostic accuracy was assessed. Four elastic staining patterns were identified: a point-and-linear pattern, an intensified point-and-linear pattern, a disorderly thickened and recoiled pattern with continuous and discontinuous variants, and a decreased or disappeared pattern. All adenocarcinoma in situ lesions and the in situ components of minimally invasive adenocarcinoma and invasive adenocarcinoma demonstrated the continuous disorderly thickened and recoiled pattern. The decreased or disappeared pattern was observed in the majority of invasive adenocarcinomas and in all invasive components of minimally invasive adenocarcinoma, whereas a subset of invasive adenocarcinomas exhibited the discontinuous variant associated with extensive carcinomatous collapse. Non-neoplastic lesions displayed a point-and-linear pattern, with an intensified point-and-linear pattern observed in regions of iatrogenic or mechanical collapse. No significant differences were identified between validation cohorts (P > 0.05). Diagnostic accuracy and histologic identification improved with the use of elastic staining among both trainee and general pathologists, and interobserver agreement was high (Kappa = 0.945). Overall, elastic staining represents a useful adjunct for improving diagnostic accuracy and histologic classification of pulmonary non-mucinous adenocarcinoma and its in situ lesions.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1727-1736"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytologic and Surgical Correlation of TERT-Mutated Indeterminate Thyroid Nodules: A Case Series. tert突变的不确定甲状腺结节的细胞学和外科相关性：一个病例系列。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-04 DOI: 10.1177/10668969261448578

Saroja Devi Geetha, Neha Seth, Karen Chau, Kasturi Das

{"title":"Cytologic and Surgical Correlation of TERT-Mutated Indeterminate Thyroid Nodules: A Case Series.","authors":"Saroja Devi Geetha, Neha Seth, Karen Chau, Kasturi Das","doi":"10.1177/10668969261448578","DOIUrl":"10.1177/10668969261448578","url":null,"abstract":"IntroductionTelomerase reverse transcriptase (TERT) promoter mutations is a relatively novel mutation that has been linked with thyroid cancers. This study examines the frequency, cytology and histo-morphologic features, and clinical outcomes of TERT-mutated indeterminate thyroid nodules.MethodsA retrospective review of Bethesda III and IV thyroid cytology specimen sent for ThyroSeq® testing (2019-2022) was performed, selecting those with TERT mutations. Demographics, cytologic features, surgical diagnoses, and follow-up data were analyzed.ResultsAmong 567 specimens tested, 12 (2%) harbored TERT mutations; 4 had TERT alone, and 8 had additional mutations. Average age of patients was 69 years (92% > 50 years). Eight had surgical follow-up: 50% were malignant, 25% were benign and 25% were of uncertain malignant potential. Additionally, 62% were oncocytic nodules. Clinical follow-up showed all evaluated patients were alive without recurrences or metastases at last contact.ConclusionIn our cohort, TERT promoter mutations were rare in indeterminate thyroid nodules (2%) and frequently accompanied by additional molecular changes. It is more frequently detected in older patients. Unlike prior reports describing TERT mutations exclusively in malignant thyroid tumors, our findings encompassed a broader histological spectrum, including benign, uncertain malignant potential and malignant lesions.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1800-1805"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical-Imaging Discordance in Suspected Osteoid Osteoma: Importance of Targeted Computed Tomography (CT) Evaluation. 疑似骨样骨瘤的临床影像学差异：目标计算机断层扫描（CT）评估的重要性。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-01-09 DOI: 10.1177/10668969251409413

Audai Abudayeh, Iakiv Fishchenko

引用次数: 0

A Rare Case Report of Renal Hilar Teratoma Associated With a Well-Differentiated Neuroendocrine Tumor and High-Grade Upper Urinary Tract Urothelial Carcinoma. 肾门畸胎瘤合并高分化神经内分泌肿瘤及高级别上尿路尿路上皮癌1例报告。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-07 DOI: 10.1177/10668969261439153

Birgül Tok, Doğan Sabri Tok, Erhan Demirelli, Ercan Öğreden, Ural Oğuz, Hüseyin Batur

{"title":"A Rare Case Report of Renal Hilar Teratoma Associated With a Well-Differentiated Neuroendocrine Tumor and High-Grade Upper Urinary Tract Urothelial Carcinoma.","authors":"Birgül Tok, Doğan Sabri Tok, Erhan Demirelli, Ercan Öğreden, Ural Oğuz, Hüseyin Batur","doi":"10.1177/10668969261439153","DOIUrl":"10.1177/10668969261439153","url":null,"abstract":"Teratomas are rare germ cell neoplasms composed of elements derived from all three germ layers, which are most commonly encountered in childhood. Renal teratomas in adults are exceedingly uncommon, and involvement of the renal hilar region is exceptionally rare. We present a 70-year-old man with a renal hilar (retroperitoneal) mature teratoma containing a well-differentiated neuroendocrine tumor coexisting with a high-grade upper urinary tract urothelial carcinoma. Preoperative imaging revealed distinct lesions in the renal hilum and distal ureter. Histopathological examination demonstrated a mature teratoma with a well-differentiated neuroendocrine component, separate from the urothelial carcinoma. This report highlights the importance of recognizing unusual mixed neoplasms in the renal hilar region and emphasizes the value of comprehensive radiologic and pathologic assessment in adult patients presenting with atypical retroperitoneal masses. This report represents the first documented instance of a renal hilar mature teratoma harboring a well-differentiated neuroendocrine tumor coexisting with a high-grade upper urinary tract urothelial carcinoma. Such an unusual presentation underscores the diagnostic complexity of these lesions and reinforces the need for multidisciplinary evaluation. Teratoma should be included in the differential diagnosis of incidentally detected renal hilar masses in adults.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1721-1726"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Prostatic Alveolar Rhabdomyosarcoma in Adult, a Diagnostic Pitfall: Report of an Extremely Rare Tumor. 成人原发性前列腺肺泡横纹肌肉瘤，一个诊断缺陷：一份极其罕见的肿瘤报告。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-04-16 DOI: 10.1177/10668969261439158

Saikat Mitra, Abhishek Choube, Chetana Ratnaparkhi, Shantanu Pande

{"title":"Primary Prostatic Alveolar Rhabdomyosarcoma in Adult, a Diagnostic Pitfall: Report of an Extremely Rare Tumor.","authors":"Saikat Mitra, Abhishek Choube, Chetana Ratnaparkhi, Shantanu Pande","doi":"10.1177/10668969261439158","DOIUrl":"10.1177/10668969261439158","url":null,"abstract":"IntroductionPrimary sarcoma of the prostate is extremely rare and accounts for less than 1% of all prostatic malignancies. Alveolar rhabdomyosarcoma arising from the prostate in an adult man is exceedingly rare. Establishing a correct diagnosis is often challenging in a prostatic core biopsy.Patient presentationA 30-year-old man presented to the emergency department after a period of acute urinary retention. Clinical examination revealed an indurated prostatic mass. Serum prostate-specific antigen level was normal. Imaging work-up showed pelvic lymph node and vertebral metastases. A malignant pleural effusion was noted. Transrectal ultrasound-guided core biopsy from the prostate revealed a cellular malignant neoplasm with small round tumor cells arranged in nests and sheets. Initial diagnosis of prostatic adenocarcinoma, Gleason score 5 + 5, grade group 5 was made. Immunohistochemical work-up showed positive skeletal muscle markers (desmin, myogenin and MYOD1) with negative keratin (AE1/AE3), NKX3.1, synaptophysin, chromogranin. CD56 showed patchy positivity. A revised diagnosis of primary alveolar rhabdomyosarcoma was established. The patient succumbed to the disease soon after the diagnosis.DiscussionPrimary alveolar rhabdomyosarcoma of the adult prostate has been rarely reported. The tumor has an aggressive clinical course with dismal prognosis. The diagnosis can be challenging as the histomorphology closely resembles poorly differentiated carcinoma, non-Hodgkin lymphoma, small cell carcinoma and other small round cell sarcomas. Aberrant immunohistochemical expression causes diagnostic dilemma. The treatment protocol and adjuvant drugs differ significantly from prostatic adenocarcinoma or small cell carcinoma, necessitating an accurate histological diagnosis for appropriate patient management. A molecular work-up can be useful in challenging specimens.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1841-1848"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathologic Features of Gastric Schwannomas: A Retrospective Analysis. 胃神经鞘瘤的临床病理特征回顾性分析。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-14 DOI: 10.1177/10668969261448580

Antonio Lira Diaz, Nasir Ud Din, Manahil Khan, Bushra Z Sayeed, Beena U Ahsan

{"title":"Clinicopathologic Features of Gastric Schwannomas: A Retrospective Analysis.","authors":"Antonio Lira Diaz, Nasir Ud Din, Manahil Khan, Bushra Z Sayeed, Beena U Ahsan","doi":"10.1177/10668969261448580","DOIUrl":"10.1177/10668969261448580","url":null,"abstract":"Gastric schwannomas are rare, benign gastrointestinal mesenchymal tumors that pose diagnostic challenges because they overlap histologically with other mesenchymal neoplasms, particularly gastrointestinal stromal tumors (GISTs). Thus, reliable diagnostic criteria are critical for distinguishing gastric schwannomas from GISTs to ensure timely, appropriate therapy. We conducted a retrospective study of patients diagnosed with gastric schwannoma at 2 institutions to evaluate the pathological features of gastric schwannomas and their distinguishing characteristics. Patient demographics, radiologic, histopathologic, and immunohistochemical features were analyzed. A total of 22 patients with a median age of 66 years (range, 36-77) were included: 7 men (32%) and 15 women (68%). The median tumor diameter was 5.3 cm (range, 1.0-10.0), and preoperative imaging suggested an initial diagnosis of GISTs in 7 patients (32%). Histologically, Verocay bodies were observed in 10 tumors (45%), vascular hyalinization in 13 (59%), discrete lymphoid aggregates in 5 (23%), and plasma cells in 8 (36%). Immunohistochemically, all tumors were positive for the gastric schwannoma markers S100 and SOX10, had variable CD34 expression, and were negative for α-smooth muscle actin and the GIST markers CD117 (KIT) and DOG1 (ANO1). Our findings aligned with previously reported demographic patterns and gastric schwannoma immunoprofiles; however, we also observed several histologic features less frequently described in the literature. Our observations refine the histopathologic characterization of gastric schwannomas and underscore the importance of thorough tissue evaluation for accurate diagnosis of this rare tumor.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1806-1812"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0