International Journal of Surgical Pathology最新文献_第4页

Adenomatoid Tumor of the Uterus With Marked Nuclear Atypia: A Case Report Including Next-Generation Sequencing Analysis and Review of the Literature. 子宫腺瘤样肿瘤伴显著核异型：1例报告，包括新一代测序分析和文献复习。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-05 DOI: 10.1177/10668969261443548

Jiří Lenz, Květoslava Michalová, Nikola Ptáková, Miroslav Kavka, Veronika Slonková, Jana Černá, Luděk Fiala

{"title":"Adenomatoid Tumor of the Uterus With Marked Nuclear Atypia: A Case Report Including Next-Generation Sequencing Analysis and Review of the Literature.","authors":"Jiří Lenz, Květoslava Michalová, Nikola Ptáková, Miroslav Kavka, Veronika Slonková, Jana Černá, Luděk Fiala","doi":"10.1177/10668969261443548","DOIUrl":"10.1177/10668969261443548","url":null,"abstract":"Adenomatoid tumor is a rare benign neoplasm of mesothelial origin occurring in various anatomical locations, including the uterus. In this article, we describe an adenomatoid tumor of the uterus exhibiting severe nuclear atypia in the clinical context of long-term hormone therapy. The patient was a 51-year-old woman who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for uterine leiomyomas. Gross evaluation of the uterus revealed multiple intramural and subserosal unencapsulated nodules that were both well and poorly circumscribed and measured from 4 to 25 mm. Microscopically, one of the nodules consisted of hyperplastic leiomyocytes intermixed with irregular vascular-like and tubular spaces lined by flattened cells that occasionally showed moderate to severe nuclear atypia (enlargement, hyperchromasia, and multinucleation). Bizarre pleomorphic cells were also present. Mitotic activity was minimal. The tumor cells showed diffuse positivity for calretinin, keratin AE1/AE3, L1 cell adhesion molecule, and podoplanin, while CD31, CD34, epithelial membrane antigen, HMB45, MDM2, and S100 protein stains were negative. Expression of BRCA1-associated deubiquitinase 1 and methylthioadenosine phosphorylase was retained. This immunophenotype supported a mesothelial origin of the neoplastic cells, leading to the final diagnosis of adenomatoid tumor with marked nuclear atypia. Unusual histopathological findings in adenomatoid tumors, such as marked nuclear atypia and pleomorphism, may pose significant diagnostic challenges and result in misdiagnosis. Despite these unusual features, the tumor in our study showed no evidence of aggressive behavior or malignant transformation. Although we hypothesize that these changes may be related to prolonged hormone therapy, their pathogenesis and clinical significance remain unclear, underscoring the need for further investigation.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1902-1909"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital Rapidly Progressive Perianal Embryonal Rhabdomyosarcoma With Spindle Cell Morphology: A Rare Presentation. 具有梭形细胞形态的先天性快速进展肛周胚胎横纹肌肉瘤：一罕见的表现。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-07 DOI: 10.1177/10668969261441765

Vandna Yadav, Pradeep Gupta, Kiran Saini, Arpita Jindal, Anu Bhandari

引用次数: 0

NUT Carcinoma of the Lacrimal Apparatus Presenting as a Rapidly Enlarging Medial Canthal Mass: A Case Report. 泪器NUT癌表现为快速扩大的内侧眦肿块1例。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-04 DOI: 10.1177/10668969261439157

Pratiksha Vidhe Sharma, Harshala H Lokhande, Shruti Vimal

引用次数: 0

PRRX1::NCOA1 Rearranged Fibroblastic Tumour: A New Report With a Brief Literature Review of an Uncommon Neoplasm. PRRX1::NCOA1重排纤维母细胞瘤：一种罕见肿瘤的新报道及简要文献综述。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-16 DOI: 10.1177/10668969261439164

Sulagna Gupta, Pranav Dorwal, Duncan Lambie

引用次数: 0

Atypical Neurofibromatous Neoplasms of Uncertain Biological Potential in Children with Neurofibromatosis Type 1: Report of Two Patients and Review. 1型神经纤维瘤病患儿生物学潜能不确定的非典型神经纤维瘤肿瘤：2例报告及综述

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-14 DOI: 10.1177/10668969261438511

Nelly Marlene Román-Mendoza, Eunate Martí-Carrera, Daniel Azorín-Cuadrillero, Luis Blasco-Santana, Marta Escribano-Pérez, Felisa Vázquez-Gómez, Fernando Martín-Del-Valle, Anna Duat-Rodríguez, Ángela Hernández-Martín

{"title":"Atypical Neurofibromatous Neoplasms of Uncertain Biological Potential in Children with Neurofibromatosis Type 1: Report of Two Patients and Review.","authors":"Nelly Marlene Román-Mendoza, Eunate Martí-Carrera, Daniel Azorín-Cuadrillero, Luis Blasco-Santana, Marta Escribano-Pérez, Felisa Vázquez-Gómez, Fernando Martín-Del-Valle, Anna Duat-Rodríguez, Ángela Hernández-Martín","doi":"10.1177/10668969261438511","DOIUrl":"10.1177/10668969261438511","url":null,"abstract":"Atypical neurofibromatous neoplasm of uncertain biological potential (ANNUBP) lies between plexiform neurofibroma and malignant peripheral nerve sheath tumor (MPNST) in neurofibromatosis type 1 (NF1). Pediatric data are limited. We report two children with NF1 and rapidly enlarging peripheral nodules. Patient 1: a 13-year-old boy developed a lumbogluteal nodule despite prior selumetinib. Ultrasound showed a hypoechoic lesion with vascularity; magnetic resonance imaging confirmed interval growth. Excision revealed hypercellularity, architectural loss, cytologic atypia, and up to 2 mitotic figures/10 high-power fields. Immunohistochemistry showed S100/SOX10 positivity, focal CD34 loss, p16 loss, p53 wild-type pattern, and Ki-67 ≈1% overall, consistent with ANNUBP. Patient 2: a 15-year-old girl had a painful mass on the volar forearm. Resection disclosed a tumor embedded with a median-nerve fascicle. Histology showed hypercellularity, architectural loss, and 1 mitotic figure/10 high-power fields without necrosis; Immunohistochemistry showed S100, focal CD34/p16 reduction, and Ki-67 < 1%. Both patients remain recurrence-free under risk-adapted surveillance. ANNUBP is defined by ≥2 of atypia, hypercellularity, architectural loss, and low-level mitotic figures. Frameworks integrate morphology with CDKN2A/B and emphasize retained H3K27me3 to distinguish ANNUBP from MPNST. In children, ultrasound, magnetic resonance imaging, and positron emission tomograph support triage and biopsy. When feasible, complete excision is preferred; unresectable lesions need closer imaging. Early recognition widens cure opportunities and may refine risk stratification.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1819-1824"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracavitary Primary Effusion Lymphoma: Diagnostic Challenges and Differential Diagnosis in a Resource-Constrained South African Setting. 原发性腔外积液淋巴瘤：在资源受限的南非环境下诊断挑战和鉴别诊断。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-07 DOI: 10.1177/10668969261442155

Absalom Mwazha, Bonginkosi Gamalenkosi Nhlonzi

{"title":"Extracavitary Primary Effusion Lymphoma: Diagnostic Challenges and Differential Diagnosis in a Resource-Constrained South African Setting.","authors":"Absalom Mwazha, Bonginkosi Gamalenkosi Nhlonzi","doi":"10.1177/10668969261442155","DOIUrl":"10.1177/10668969261442155","url":null,"abstract":"AimsPrimary effusion lymphoma (PEL) is an aggressive, human herpesvirus 8 (HHV8)-associated large B-cell lymphoma characterised by malignant effusions in serous cavities (classic PEL). However, a subset of tumours may present exclusively as solid masses, referred to as extracavitary primary effusion lymphoma (EC-PEL). Despite the high regional prevalence of human immunodeficiency virus (HIV) and Kaposi sarcoma-associated virus /HHV8, PEL is likely under-reported in Sub-Saharan Africa. This study reports on the clinicopathologic features and differential diagnoses of EC-PEL.MethodsA retrospective review of biopsies with a diagnosis of PEL from 2010 to 2019 was performed. Seven patients met the 2024 WHO criteria for PEL. Clinical information was collected and histopathological and immunohistochemical features were reviewed independently.ResultsSeven patients with a median age of 38 years (range, 25-51 years) were identified. Most patients were men (86%), and all were Black African. Five patients (71%) were living with HIV, with CD4 + counts ranging from 137 to 348 cells/µL. Tumour sites were lymph nodes, stomach, maxillary sinus, and soft tissue. All tumours showed diffuse sheets of plasmablastic or immunoblastic cells. Immunohistochemistry showed expression of plasma-cell markers (VS38C, CD138), lacked pan B-cell markers (CD20 and PAX5), and had high proliferative indices (Ki-67: 90-95%). All tumours were positive for HHV8 (LANA-1) and EBER in situ hybridisation was positive in 86%.ConclusionExtracavitary PEL in Sub-Saharan Africa exhibits the characteristic clinicopathologic profile described globally and remains strongly associated with HIV-related immunosuppression. Improved recognition of this rare but aggressive lymphoma can be achieved with increased awareness of the diagnosis and improved access to HHV8 immunohistochemistry.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1748-1758"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Micropapillary Carcinoma of the Breast with an Encapsulated-Like Pattern: An Unreported Entity? 浸润性乳腺微乳头状癌的包封样模式：一个未报道的实体？

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-07 DOI: 10.1177/10668969261444680

Yusuf Aboul-Nasr, Clare F Hartman, Marilin Rosa, Heba Saad, Saeed Bajestani, Sepideh Mehravaran

{"title":"Invasive Micropapillary Carcinoma of the Breast with an Encapsulated-Like Pattern: An Unreported Entity?","authors":"Yusuf Aboul-Nasr, Clare F Hartman, Marilin Rosa, Heba Saad, Saeed Bajestani, Sepideh Mehravaran","doi":"10.1177/10668969261444680","DOIUrl":"10.1177/10668969261444680","url":null,"abstract":"Invasive micropapillary carcinoma (IMPC) is a rare subtype of breast cancer, characterized by infiltrative growth and morula-like cell aggregates without fibrovascular cores. We recently encountered an unusual invasive breast carcinoma with a thick fibrous capsule resembling encapsulated papillary carcinoma but with micropapillary features. A 71-year-old woman presented with a palpable mass in the left breast. MRI revealed a 10 cm enhancing oval mass. Core needle biopsy was performed to diagnose invasive carcinoma with micropapillary features [estrogen receptor (ER) and progesterone receptor (PR)-positive, HER2-negative]. The patient received neoadjuvant chemotherapy, followed by a mastectomy with sentinel lymph node biopsy. The mastectomy revealed a well-circumscribed 11 cm mass surrounded by a fibrous capsule. The tumor consisted of tubulo-micropapillary structures without fibrovascular cores, lined by a single layer of cuboidal cells containing nests of foamy macrophages. Rare foci of lymphovascular invasion were observed. Two sentinel lymph nodes were negative. To our knowledge, invasive micropapillary carcinoma with an encapsulated pattern has not been previously reported.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1918-1924"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Significance and Classification Value of Tumor Budding, Single Cell Invasion, and Spread Through Airspaces (STAS) in Lung Squamous Cell Carcinoma. 肺鳞状细胞癌中肿瘤出芽、单细胞侵袭及间隙扩散（STAS）的预后意义及分类价值。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-11 DOI: 10.1177/10668969261455055

Nurcan Unver, Neslİhan Akanıl Fener

{"title":"Prognostic Significance and Classification Value of Tumor Budding, Single Cell Invasion, and Spread Through Airspaces (STAS) in Lung Squamous Cell Carcinoma.","authors":"Nurcan Unver, Neslİhan Akanıl Fener","doi":"10.1177/10668969261455055","DOIUrl":"10.1177/10668969261455055","url":null,"abstract":"ObjectiveLung squamous cell carcinomas (LSCC) currently lack a standardized histopathological grading system, unlike their adenocarcinoma counterparts. In this retrospective study, we examined the prognostic significance and classification value of tumor budding (TB), single-cell invasion, tumor budding nest size (TBNS) grading system, and spread through airspaces (STAS).MethodsAbout 268 patients who underwent surgical resection for LSCC between November 2011 and December 2021 were evaluated. TB was assessed in hematoxylin and eosin-stained sections at ×200 magnification from the area showing the most prominent budding activity. A 3-tier TBNS grading system was established by combining the number of tumor buds and the size of tumor cell nests. STAS presence was also evaluated.ResultsOur analysis revealed significant associations between high TBNS scores and adverse pathological features, including higher tumor stage, pleural and lymphovascular invasion, increased stromal fibrosis, and lymph node metastasis. Furthermore, survival analysis demonstrated that high TB, single-cell invasion, elevated TBNS scores, and the presence of STAS were all linked to reduced overall and disease-free survival (P < .005).ConclusionThese findings suggest that TB, TBNS, and STAS are valuable histopathological markers that may offer additional prognostic insight beyond traditional staging parameters. Incorporating a standardized assessment of these features into routine pathology reports could improve prognostic stratification and inform clinical decision-making in patients with LSCC.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1782-1790"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory Myofibroblastic Tumor of the Breast Mimicking Complex Fibrocystic Changes, With a Novel CSTF3::ALK Fusion. 乳房炎性肌纤维母细胞瘤模拟复杂纤维囊性改变，伴有新型CSTF3::ALK融合。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-10 DOI: 10.1177/10668969261439165

Michelle Garlin Politis, Mine Yilmaz, Diane Chen, Lisa Wiechmann, Hanina Hibshoosh, Fatemeh Derakhshan, Alireza Salem

{"title":"Inflammatory Myofibroblastic Tumor of the Breast Mimicking Complex Fibrocystic Changes, With a Novel CSTF3::ALK Fusion.","authors":"Michelle Garlin Politis, Mine Yilmaz, Diane Chen, Lisa Wiechmann, Hanina Hibshoosh, Fatemeh Derakhshan, Alireza Salem","doi":"10.1177/10668969261439165","DOIUrl":"10.1177/10668969261439165","url":null,"abstract":"Inflammatory myofibroblastic tumor (IMT) of the breast is an uncommon neoplasm that presents significant diagnostic challenges due to its overlap with more common breast lesions. Clinical and imaging features are often nonspecific, leading to potential misdiagnosis. We present a breast IMT in a 38-year-old woman, initially detected as a 7-mm lesion classified as BI-RADS 3 during routine screening and suspected to represent fibrocystic changes. Follow-up ultrasound demonstrated growth to 10 mm, prompting a core needle biopsy that revealed a spindle cell lesion with prominent inflammatory infiltrates. Immunohistochemistry showed positivity for ALK, CD34, and NTRK, and fluorescence in situ hybridization (FISH) confirmed an ALK rearrangement. Targeted RNA sequencing identified a novel CSTF3::ALK fusion. This report highlights the diagnostic complexity of IMT and underscores the importance of comprehensive histological and molecular evaluation. Accurate diagnosis is essential for appropriate management and adds to the limited body of literature on breast IMT, particularly regarding the significance of genetic testing in confirming the diagnosis.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1853-1859"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Assessing Stromal Invasion and Staging Cervical Carcinomas Arising In or Confined to Endocervical Polyps. 评估发生于或局限于宫颈内息肉的间质浸润和宫颈癌分期的挑战。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-05 DOI: 10.1177/10668969261439139

Hisham F Bahmad

{"title":"Challenges in Assessing Stromal Invasion and Staging Cervical Carcinomas Arising In or Confined to Endocervical Polyps.","authors":"Hisham F Bahmad","doi":"10.1177/10668969261439139","DOIUrl":"10.1177/10668969261439139","url":null,"abstract":"The staging of cervical carcinomas that appear confined to endocervical polyps presents a rare but recurring diagnostic and reporting challenge. Current classification systems, including the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system, the American Joint Committee on Cancer (AJCC) eighth edition, and College of American Pathologists (CAP) protocols, do not provide specific guidance for this scenario. Endocervical polyps are typically benign lesions, but in rare instances they may harbor invasive carcinoma. When invasion appears limited to the polyp stroma, assessment of the depth of invasion and assignment of a pathologic stage becomes challenging due to the polyp's limited, distorted, or fragmented architecture. Importantly, it is often difficult in routine practice to distinguish a truly polyp-confined carcinoma from an exophytic cervical tumor involving a polyp. This review highlights the gaps in staging of cervical carcinomas arising in or confined to endocervical polyps and draws cautious conceptual parallels to staging approaches in other organ systems, not to propose guideline changes, but to highlight existing gaps and reporting ambiguities. Currently, for reporting and staging purposes, pathologists use the same approach as that for other exophytic tumors. Here, we emphasize standardized documentation and transparent reporting of staging limitations as a practical interim approach, while acknowledging the absence of evidence sufficient to support formal staging modifications. Until additional data are available, careful descriptive reporting may facilitate clinical decision-making and enable future data collection needed to inform evidence-based revisions.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1701-1712"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0