International Research Journal Of Pharmacy最新文献_第4页

A REVIEW ON THE APPLICATION OF SOLID LIPID NANOPARTICLES IN TRANSDERMAL PATCH DRUG DELIVERY 固体脂质纳米颗粒在经皮贴剂给药中的应用综述

International Research Journal Of Pharmacy Pub Date : 2021-10-11 DOI: 10.7897/2230-8407.1209160

Rabnoor Alam, K. ., Aastha Arora, Harsh Gupta, P. Sharma

{"title":"A REVIEW ON THE APPLICATION OF SOLID LIPID NANOPARTICLES IN TRANSDERMAL PATCH DRUG DELIVERY","authors":"Rabnoor Alam, K. ., Aastha Arora, Harsh Gupta, P. Sharma","doi":"10.7897/2230-8407.1209160","DOIUrl":"https://doi.org/10.7897/2230-8407.1209160","url":null,"abstract":"The transdermal patches are used to deliver medication through the skin to treat the entire ailment. These depend on a unique size property of skins to encoded drugs solid lipid nanoparticles (SLNs) current a chance to create upon novel therapeutic properties used for drugs transmission SLN targeting holds great potential for target achieving, a penalty area, Many aspects of the loaded of SLN sin transdermal patches for increasing mechanism of penetration, formulation, characterization parameters, future advantages, limitations of SLNs, had better biocompatibility, low harmfulness, SLNs is physically stable, and better delivery for Lipophilic drugs are discussed here. SLNs are a hybrid of liposomes and polymer-based carriers that could be used to encapsulate both lipid and water-soluble medicines. SLN is a low-cost product that can be scaled up. They also have a long-life span and could be customized by using different lipids. Because of their multiple significant qualities, SLNs also started to emerge when effective drug delivery carriers, as well as the prospect with liposome delivery of drugs, depends heavily on them. Many patents relating to SLNs have already been submitted, there are more invented SLN-based delivery systems on the way soon.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89951614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CRITICAL ANALYSIS ON NIRUHA BASTI SAMMELANA VIDHI 对《无为》的批判性分析

International Research Journal Of Pharmacy Pub Date : 2021-10-11 DOI: 10.7897/2230-8407.1209163

Reeny Ravina Dias, Madhushree Hs, Ganesh Puttur

{"title":"A CRITICAL ANALYSIS ON NIRUHA BASTI SAMMELANA VIDHI","authors":"Reeny Ravina Dias, Madhushree Hs, Ganesh Puttur","doi":"10.7897/2230-8407.1209163","DOIUrl":"https://doi.org/10.7897/2230-8407.1209163","url":null,"abstract":"Niruha Basti (therapeutic decoction enema) is one of the important Panchakarma procedures (five internal bio-cleansing procedures) which is the best treatment modality in the diseases caused due to not only Vata, but also when associated with other Doshas as well. The preparation of Niruha Basti comprises of step wise mixing of ingredients as described in the Ayurveda classics. In the present study, simple Erandamoola Niruha Basti was prepared by adding Madhu (honey), Saindhava (rock salt), Moorchita Tila Taila (medicated sesame oil), Shatapushpa Kalka (paste of Athenum sowa) and Erandamoola Kwatha (decoction of root of Ricinus communis) in classical method to assess the changes in particle size distribution in each step of preparation at specific intervals. The changes taken place during the Bhavana of the ingredients was observed under microscope. The Erandamoola Niruha Basti was prepared in classical method as well as contemporary methods like churner, mixer, etc., to assess the emulsion stability. Another Erandamoola Niruha Basti was also prepared replacing Madhu (honey) with egg yolk to check for emulsion stability and particle size & distribution.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74030940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CONCEPTUAL STUDY ON PREVENTING LIFESTYLE DISORDERS IN AYURVEDA 阿育吠陀预防生活方式紊乱的概念研究

International Research Journal Of Pharmacy Pub Date : 2021-10-11 DOI: 10.7897/2230-8407.1209161

H. Vasudev, Madhushree Hs, Ganesh Puttur

引用次数: 0

BASTI AS ARDHA CHIKITSA: A REVIEW basi as ardha chikitsa:回顾

International Research Journal Of Pharmacy Pub Date : 2021-10-11 DOI: 10.7897/2230-8407.1209159

Biraj Jung Khadka, M. H. S, Ganesh Puttur

引用次数: 0

FORMULATION DEVELOPMENT AND EVALUATION OF MATRIX TABLET TRAZODONE HYDROCHLORIDE USING NATURAL POLYMER 天然高分子基质片盐酸曲唑酮的研制与评价

International Research Journal Of Pharmacy Pub Date : 2021-08-31 DOI: 10.7897/2230-8407.1208156

Jeetendra Kushwaha, D. Chaturvedi, M. Verma, K. Tiwari, Neelesh Anuragi

{"title":"FORMULATION DEVELOPMENT AND EVALUATION OF MATRIX TABLET TRAZODONE HYDROCHLORIDE USING NATURAL POLYMER","authors":"Jeetendra Kushwaha, D. Chaturvedi, M. Verma, K. Tiwari, Neelesh Anuragi","doi":"10.7897/2230-8407.1208156","DOIUrl":"https://doi.org/10.7897/2230-8407.1208156","url":null,"abstract":"Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Trazodone Hydrochloride (TRZ) is a well-known chemical compound that is used as an antidepressant that belongs to a selective serotonin reuptake inhibitor (SARI). The objective of present work was to develop and evaluated oral sustained release matrix tablet of TRZ. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. No interactions were observed between TRZ and excipients from the Fourier transform infrared spectroscopy. The present research work was successful in improving the efficacy TRZ oral therapy as the drug release was extended for 12 hours thus reducing dosing frequency thereby improving patient compliance. The study also revealed the applicability of HPMC K-15, Gaur gum and PVP K30 as rate-controlling polymers in matrix tablets. The hydrophilic matrix of HPMC alone cannot control the release TRZ effective for 12 h while when combined with guar gum, may slow down the release of the drug and therefore, can be successfully employed for the formulation of matrix tablets SR. It may be concluded from the study that; the optimized formulation F-8 was shown maximum drug release 99.12 % in 12 h of dissolution. The release kinetic data of formulation F-8 shown first order release kinetics (R2 = 0.980).","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90965870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STABILITY INDICATING HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND DAPAGLIFLOZIN IN API AND PHARMACEUTICAL DOSAGE FORM 稳定性指示高效液相色谱法同时测定原料药和制剂剂型中盐酸二甲双胍和达格列净的含量

International Research Journal Of Pharmacy Pub Date : 2021-08-31 DOI: 10.7897/2230-8407.1208157

Chaitali Dhale, R. RaoJ

{"title":"STABILITY INDICATING HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND DAPAGLIFLOZIN IN API AND PHARMACEUTICAL DOSAGE FORM","authors":"Chaitali Dhale, R. RaoJ","doi":"10.7897/2230-8407.1208157","DOIUrl":"https://doi.org/10.7897/2230-8407.1208157","url":null,"abstract":"A simple and specific stability indicating reversed-phase high-performance liquid chromatography technique has been developed and validated for the concurrent estimation of metformin hydrochloride and dapagliflozin in bulk and pharmaceutical dosage form. The ideal conditions were established for the study or analysis of the drug such as chromatographic separation was carried out on THERMO fisher ODS C18 column containing mobile phase of water and acetonitrile 65:35 % v/v of pH 6.8 adjusted with 0.1 % ortho phosphoric acid at a flow rate of 1 ml/minutes detected wavelength at 240 nm. The retention time was found to be 2.13 minutes and 5.41 minutes for metformin hydrochloride (MET) and dapagliflozin (DAPA) respectively. The proposed method was found to be linear in the concentration range of 100-600 ug/ml for MET (R2=0.9999) and 1-6 ug/ml for DAP (R2=0.9996), respectively. Method was validated according to ICH guidelines. Co-relation coefficients for both the drugs were found to be less than one. The mean % recoveries obtained were found to be 99.06-100.32% for metformin and 99.1-100.18% for dapagliflozin respectively. Stress testing is carried out for both drugs in acid, base, peroxide, photolytic and thermal degradation. The developed method can be effectively applied for routine analysis in simultaneous determination of metformin hydrochloride and dapagliflozin in bulk and combined tablet dosage form.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90841828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IN SILICO STUDIES OF N-(PHENYL SUBSTITUTED) 2-([PHENYL SUBSTITUTED) METHYLIDENE] AMINO)-N,4- DIPHENYL-6H-1,3-OXAZIN-6-AMINE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS n -(苯基取代)2-([苯基取代)亚甲基]氨基)- n,4-二苯基- 6h -1,3-恶嗪-6-胺衍生物作为潜在抗菌剂的硅片研究

International Research Journal Of Pharmacy Pub Date : 2021-08-31 DOI: 10.7897/2230-8407.1208155

K. Beena

{"title":"IN SILICO STUDIES OF N-(PHENYL SUBSTITUTED) 2-([PHENYL SUBSTITUTED) METHYLIDENE] AMINO)-N,4- DIPHENYL-6H-1,3-OXAZIN-6-AMINE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS","authors":"K. Beena","doi":"10.7897/2230-8407.1208155","DOIUrl":"https://doi.org/10.7897/2230-8407.1208155","url":null,"abstract":"Resistance to bacteria is a growing threat to human health worldwide. The rate of discovery of new antibacterial is far outshined by the rate at which resistance is spreading. Therefore, there remains a pressing need for the development of new antibacterial drugs. Recent alarm estimates that deaths due to antimicrobial resistance may increase from 700,000 million lives annually by 2050. Glucosamine-6-phosphate (GlcN-6-P) synthase represents an interesting protein target because it plays an essential role in the protection of cell wall. The primary aim and objective of this study is to identify lead molecules as promising antibacterial agents by inhibiting Glucosamine-6-phosphate (GlcN-6-P) synthase enzyme. Autodock 4. 2, the effective tool for exploring the binding affinity of small molecule to enzyme target was used to study the interactions between the oxazine derivatives and the GlcN-6-P synthase binding site. The ligands were optimized for improving their efficacy and safety. Lead optimization was performed using Molinspiration server and the ligands were optimized for evaluating their oral bioavailability. With Glucosamine 6 phosphate synthase receptor, the binding energy was found to be best for 5 compounds SZ-3 (-5.27 kcal/mol), SZ-4 (-6.02 kcal/mol), SZ-5 (-5.35 kcal/mol), SZ-8 (-5.62kcal/mol), SZ-10 (-5.29 kcal/mol) when compared to the standard ligand, Ciprofloxacin (-5.09 kcal/mol) and were interacting well with the key residues TYR 304, GLU 438, LEU 484. Docking study strongly enhanced the activity of oxazine derivatives as new discovered hits.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83493017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PILOT PLANT SCALE-UP STUDIES FOR PARENTERAL - A REVIEW 肠外注射的中试工厂放大研究综述

International Research Journal Of Pharmacy Pub Date : 2021-08-31 DOI: 10.7897/2230-8407.1208158

V. Manikandan

{"title":"PILOT PLANT SCALE-UP STUDIES FOR PARENTERAL - A REVIEW","authors":"V. Manikandan","doi":"10.7897/2230-8407.1208158","DOIUrl":"https://doi.org/10.7897/2230-8407.1208158","url":null,"abstract":"The dosage form of parenteral is sterile and gives a quick beginning of activity and gives an immediate action to accomplishing the medication impact inside the body. The route of parenteral administration is the most well-known and productive route for the conveyance of dynamic medication substances with poor bioavailability and medications with a tight therapeutic index. The principal objective of the technique was to endeavour to talk about the different procedures needed for the pilot plant production considers. The pilot plant is the term that is normally more modest than large-scale production plants yet it is the underlying scope of sizes. It is planned for learning, and making the definitions on a limited scale to accomplish the relationship with the enormous scope production, and they are normally more adaptable perhaps to the detriment of the economy. Most of the pilot plants are implicit in the maker's own research centres of the manufacturer utilizing stock lab hardware. These pilot plant studies are performed by using a technology transfer (TT) documentation report which is made by the research and development department for product development. Hence, this process would meet product quality, safety, and efficacy and further this production techniques will transfer to large-scale production for parenteral preparation.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"30 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91512626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DEVELOPMENT SODIUM ALGINATE SODIUM BICARBONATE CALCIUM CARBONATE ORAL SUSPENSION USING TURBISCAN TOWER AND ZETA POTENTIAL 利用浊塔和zeta电位研制海藻酸钠碳酸氢钠碳酸钙口服混悬液

International Research Journal Of Pharmacy Pub Date : 2021-08-31 DOI: 10.7897/2230-8407.1208154

Canberk Yılmaz, C. Toprak, Gökay Gün

引用次数: 0

A CASE REPORT ON AMOXICILLIN INDUCED STEVENS- JOHNSON SYNDROME 阿莫西林致史蒂文斯-约翰逊综合征1例

International Research Journal Of Pharmacy Pub Date : 2021-07-31 DOI: 10.7897/2230-8407.1207152

Rispa Darabadi, K. Harini

{"title":"A CASE REPORT ON AMOXICILLIN INDUCED STEVENS- JOHNSON SYNDROME","authors":"Rispa Darabadi, K. Harini","doi":"10.7897/2230-8407.1207152","DOIUrl":"https://doi.org/10.7897/2230-8407.1207152","url":null,"abstract":"Steven-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membrane that is usually a reaction to medication. It usually starts with flu-like symptoms, followed by a painful rash that spreads and blisters. Other symptoms include Fever, sore mouth and throat, Fatigue, burning eyes, extensive skin and mucous membrane lesions (i.e., mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95% of case reports, drugs were identified to be an important cause for the development of SJS. The below is a case report of A 37-year-old male patient hospitalized with rashes over the body and fever, after oral consumption of Amoxicillin drug for cough and sore throat through OTC prescription. The patient has taken three doses of Amoxicillin and due to lack of awareness on Adverse drug reactions, the patient ignored the rashes that were developed after the first dose. This case study discusses the possibility of serious hypersensitivity reactions with Amoxicillin that rarely occur and can be extremely harmful and life threatening, brief knowledge on Stevens-Johnson syndrome and also some of the preventive measures to control the adverse reactions due to drugs.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"7 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78310948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1