International Research Journal Of Pharmacy最新文献_第5页

PHYTOCHEMICAL INVESTIGATION, SPECTRUM ANALYSIS OF SALVADORA PERSICA AND CRESCENTIA CUJETE 木香和月牙的植物化学研究及光谱分析

International Research Journal Of Pharmacy Pub Date : 2021-07-31 DOI: 10.7897/2230-8407.1207150

M. Dhanasekaran, M. Udhayaeswaran, C. Dravid

{"title":"PHYTOCHEMICAL INVESTIGATION, SPECTRUM ANALYSIS OF SALVADORA PERSICA AND CRESCENTIA CUJETE","authors":"M. Dhanasekaran, M. Udhayaeswaran, C. Dravid","doi":"10.7897/2230-8407.1207150","DOIUrl":"https://doi.org/10.7897/2230-8407.1207150","url":null,"abstract":"Salvadora persica is a well-known medicinal plant which belongs to the family Salvadoraceae. It is commonly known as the Meswak tree. Calabash tree or Crescentia cujete tree belongs to the family of Bignoniaceae. It is also known as the gourd tree. These two plants have been studied by preliminary phytochemical and FTIR analysis. Data gathered on solvent extraction and preliminary phytochemical method suggested that the presence of primary and secondary metabolites in leaf tissue. Two solvents such as ethanol and aqueous are used here to reveal the phytocompounds and extend our work to find out the various functional groups present in these two plants through FTIR analysis was done. Spectrum of Salvadora persica showed 5 peaks that are 599.89, 654.86, 1409.06, 1431.24, 2930.96 and spectrum of Crescentia cujete showed that 13 peaks that are 470.65, 520.80, 630.75, 652.93, 776.38, 1060.89, 1155.41, 1248, 1321.30, 1431.24, 1527.69, 2860.56, 2924.21. The present study revealed that the functional groups of both plants, such as alcohols or phenols, alkanes, amines, esters or carboxylic acid or lactones, aldehyde or ketones, acetates and ethylene.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89967092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULATION AND EVALUATION OF SIMVASTATIN LOADED MICROEMULSION BASED GEL: IN VITRO CHARACTERIZATION 辛伐他汀微乳凝胶的制备与评价:体外表征

International Research Journal Of Pharmacy Pub Date : 2021-07-31 DOI: 10.7897/2230-8407.1207149

M. Saifee, Pragati Bhaske, Reshma Toshniwal

{"title":"FORMULATION AND EVALUATION OF SIMVASTATIN LOADED MICROEMULSION BASED GEL: IN VITRO CHARACTERIZATION","authors":"M. Saifee, Pragati Bhaske, Reshma Toshniwal","doi":"10.7897/2230-8407.1207149","DOIUrl":"https://doi.org/10.7897/2230-8407.1207149","url":null,"abstract":"The Simvastatin loaded microemulsion based gel was formulated and in-vitro evaluation was done for the treatment of diabetic wound healing. Simvastatin is BCS class II drug which promotes wound healing by increasing the production of vascular endothelial growth factor (VEGF). Microemulsions (MEs) are oil and water colloidal system stabilized by the mixture of surfactant and co-surfactant offering enhance skin permeability for both hydrophobic and hydrophilic drugs. At first, microemulsion (ME) was prepared by water titration method and the existence of ME region was determined using pseudo-ternary phase diagram. Formulations were prepared using oil (oleic acid), Tween 80 and PEG 400 as surfactant and co-surfactant. Optimization of formulation was done using 32 factorial designs. Carbopol 940 was used as gelling agent for preparing microemulsion gel. The formulations were evaluated for physical appearance globule size, polydispersity index, zeta potential, percent transmittance, thermodynamic stability, dilution test, drug content, and in vitro drug release. The optimized formulation of ME showed average globule size of 151 nm and the optimized ME gel had a homogeneous texture, showed good spreadability and in vitro drug release. The present study indicates the simvastatin loaded microemulsion gel could act as promising vehicle for topical drug delivery of drug for diabetic wound healing.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"77 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89722889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DESIGN AND EVALUATION OF SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEMS OF ALVERINE FOR ENHANCEMENT OF SOLUBILITY 提高溶解度的alverine自纳米乳化给药系统的设计与评价

International Research Journal Of Pharmacy Pub Date : 2021-07-31 DOI: 10.7897/2230-8407.1207153

Pooja, P. Sharma, Viswanath Agrahari

引用次数: 0

PHARMACOINFORMATICS APPROACH OF IDENTIFIED BIOLOGICAL COMPOUNDS FROM SELECTED PLECTRANTHUS (L.) SPECIES IN TAMIL NADU, INDIA: AN IN-SILICO APPROACH 选定胸腺中已鉴定生物化合物的药物信息学方法(1)印度泰米尔纳德邦的物种:一种计算机方法

International Research Journal Of Pharmacy Pub Date : 2021-07-31 DOI: 10.7897/2230-8407.1207151

S. Manikandan, Sabeerali Ansarali, M. Priyadharshini, G. Lakshmanan

{"title":"PHARMACOINFORMATICS APPROACH OF IDENTIFIED BIOLOGICAL COMPOUNDS FROM SELECTED PLECTRANTHUS (L.) SPECIES IN TAMIL NADU, INDIA: AN IN-SILICO APPROACH","authors":"S. Manikandan, Sabeerali Ansarali, M. Priyadharshini, G. Lakshmanan","doi":"10.7897/2230-8407.1207151","DOIUrl":"https://doi.org/10.7897/2230-8407.1207151","url":null,"abstract":"Aim: Plectranthus (Linn) is a typical genus of the Indian flora. It had been used in the folk medicines for its several medicinal properties. In this study, there are twenty-five major biological compounds were selected from Plectranthus forskohlii, Plectranthus coleoides, Plectranthus rotundifolius and Plectranthus vettiveroides for molecular docking analysis and find out the active compounds against Diabetic, Cancer and Tuberculosis diseases. Materials and methods: Biological compounds of Plectranthus Species were identifying and investigated by GC-MS and the biological activities of these compounds were studied with virtual screening, ADMET analysis, Protein ligand interaction through molecular docking analysis. Results: Twenty-five major biological compounds were selected for virtual screening analysis to find out the drug likeness activity. Out of these twenty-five compounds nine compounds are drug likeness in nature. Based on the ADMET analysis, Thymol beta D-Glucoside showed the low toxicity level and it represent Lipinski rule of five. The molecular docking results of Thymol beta D-Glucoside interact with different target proteins used in the study showed the maximum docking energy was obtained against tuberculosis protein -10.1846kcal/mol followed by diabetic protein -10.8736kcal/mol and cancer protein -11.4109kcal/mol. Conclusion: Plectranthus amboinicus leaves showed significant anti-diabetic, anti-cancer, anti-tuberculosis activity when compared to other studied species such as Plectranthus forskohlii, Plectranthus coleoides, Plectranthus rotundifolius and Plectranthus vettiveroides.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84914262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A REVIEW ON ENZYME INHIBITORS 酶抑制剂研究进展

International Research Journal Of Pharmacy Pub Date : 2021-06-30 DOI: 10.7897/2230-8407.1206145

Nikunj Patadiya, Nikita Panchal, V. Vaghela

引用次数: 7

COMBINATION OF METFORMIN AND CURCUMIN THERMOREVERSIBLE NASAL IN SITU GEL FORMULATION AND IN VITRO-EX VIVO EVALUATION FOR DIABETES-INDUCED ALZHEIMER’S DISEASE 二甲双胍和姜黄素复合热可逆鼻腔原位凝胶制剂及对糖尿病诱导的阿尔茨海默病的体外体外评价

International Research Journal Of Pharmacy Pub Date : 2021-06-30 DOI: 10.7897/2230-8407.1206140

A. Anku, K. Abbulu, S. Battu, Kalam Marryswarnalatha, T. S. Lakshmi

{"title":"COMBINATION OF METFORMIN AND CURCUMIN THERMOREVERSIBLE NASAL IN SITU GEL FORMULATION AND IN VITRO-EX VIVO EVALUATION FOR DIABETES-INDUCED ALZHEIMER’S DISEASE","authors":"A. Anku, K. Abbulu, S. Battu, Kalam Marryswarnalatha, T. S. Lakshmi","doi":"10.7897/2230-8407.1206140","DOIUrl":"https://doi.org/10.7897/2230-8407.1206140","url":null,"abstract":"The present research was focused to prepare the formulation containing combination of Metformin and Curcumin to control diabetes-induced Alzheimer’s in elderly population with the utilization of Poloxamer P188 (8%), a thermoreversible gelling polymer, and mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K100 in varying concentrations (0.5%, 1%, 1.5% and 2% respectively) to improve the absorption of drugs by increasing the contact time with nasal mucosa. The in situ gel was prepared by cold method and administered via nasal route to deliver the drug directly to CNS by bypassing BBB and to improve patient compliance, nasal bioavailability of drugs by cumulative its nasal retention time in nasal mucosa. Total 12 nasal in situ gels were prepared and evaluated for in vitro studies and ex vivo drug diffusion studies (goat nasal mucosa) and results were found to be satisfactory. Moreover, histopathological studies revealed that the preparation was safe to be used on nasal mucosa of goat. The prepared nasal in situ gel is an effective alternative to conventional method and can be used to treat diabetes-induced Alzheimer’s disease.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78535167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A REVIEW ON PHYTOPHARMACOLOGY OF MEDICINAL PLANT: EUPHORBIA MILII DES MOUL 药用植物大戟的植物药理学研究进展

International Research Journal Of Pharmacy Pub Date : 2021-06-30 DOI: 10.7897/2230-8407.1206146

S. Sagar, Monika Bisht

引用次数: 3

ETHNOMEDICINAL PLANTS USED BY THE PEOPLE OF SORBHOG (BARNAGAR) AREA OF BARPETA DISTRICT, ASSAM, INDIA FOR VARIOUS AILMENTS 印度阿萨姆邦barpeta区sorbhog (barnagar)地区的人们用于治疗各种疾病的民族药用植物

International Research Journal Of Pharmacy Pub Date : 2021-06-30 DOI: 10.7897/2230-8407.1206143

S. Chakravarty

引用次数: 0

RANDOMIZED CONTROL TRIAL ON ERANDAMULA GHANAVATI WITH NASYA IN MANYAGRAHA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLOSIS 甘纳瓦提与颈椎病联合治疗的随机对照试验

International Research Journal Of Pharmacy Pub Date : 2021-06-30 DOI: 10.7897/2230-8407.1206139

S. Solanke, P. Kabra

{"title":"RANDOMIZED CONTROL TRIAL ON ERANDAMULA GHANAVATI WITH NASYA IN MANYAGRAHA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLOSIS","authors":"S. Solanke, P. Kabra","doi":"10.7897/2230-8407.1206139","DOIUrl":"https://doi.org/10.7897/2230-8407.1206139","url":null,"abstract":"Background: Cervical spondylosis is defined as degenerative changes occurring in the discs and cervical spine. Stating these changes is to be almost universal in the elderly. Cervical Spondylosis correlated with Manyagraha in Ayurvedic perspective. Aim: Aim of the study was to evaluate the effect of Erandamula Ghanavati and Anu Taila Nasya in Manyagraha. Methods: The Group in which Erandamula Ghanavati and Anutaila Nasya were given to patients was termed as Trial Group. The Group in which Panchatikta Ghrita Guggulu and Anutaila Nasya were given to patients was termed as Control Group. During this study 104 patients out of 150 were equally divided into Trial and Control Group by lottery method and comparative study was done. Statistical analysis was done using appropriate tests. Results: Erandamula Ghanavati along with Anu Taila Nasya has reduces symptoms of Manyagraha. Total effect of therapy is more in Trial group as compared to the Control Group. Discussion: As stated by Charak Erandamula is best Vatahara drug. Its Rasa, Virya and Vipak are helpful to alleviate Vata. Erandamula having Snigdha, Madhuraproperties is going to be beneficial in Dhatukshayajanya Vatavyadhi. Conclusion: Erandamula Ghanavati along with Anu Taila Nasya has beneficial for patients of Manyagraha.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"496 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83888318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SUB-ACUTE TOXICITY OF A STEROIDAL GLYCOSIDE FROM THE FLOWERS OF ALANGIUM SALVIIFOLIUM WANG 丹参花甾体苷的亚急性毒性研究

International Research Journal Of Pharmacy Pub Date : 2021-06-30 DOI: 10.7897/2230-8407.1206141

A. Anjum, A. Mosaddik, M. I. I. Wahed, . Md.EkramulHaque

引用次数: 0