International Research Journal Of Pharmacy最新文献

{"title":"Inhibition of α-glucosidase activity by polyphenol compounds from C. occidentalis: Phytochemical screening and antidiabetic studies","authors":"Wende-Konté Hazael Conania Nikiema, Yssouf Karanga, Ousmane Ilboudo, Téeda Hamidou Ganamé, Téeda Hamidou Ganamé, Issa Tapsoba","doi":"10.52711/0974-4150.2023.00043","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00043","url":null,"abstract":"Medicinal plants are recognized as a source of active molecules that can treat several diseases. Cassia occidentalis (C. occidentalis) is a medicinal plant traditionally used in rural areas of Burkina Faso for the treatment of diabetes. The objective of this work is to evaluate the antioxidant and antidiabetic properties of the fractions of this plant. The antidiabetic activity was investigated by following the inhibitory effect of the different fractions of plant extract on α-glucosidase. The antioxidant activities were performed using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods. TLC analysis revealed the presence of quercetin in the ethyl acetate fractions of stems and leaves of C. occidentalis. Ethyl acetate fractions of stems and leaves of C. occidentalis demonstrated significant antidiabetic properties with IC50 values ca. 0.274 ± 0.003 and 0.538 ± 0.011 mg/mL respectively compared to the reference acarbose with IC50 ca. 0.215 ± 0.004 mg/mL. The same fractions exhibited respectively the highest FRAP values close to 167.055 ± 0.008 and 128.490 ± 5.227 μg ET/mg and DPPH values of 114.062 ± 2.698 and 82.962 ± 3.189 μg ET/mg. Phytochemical screening revealed the presence of flavonoids, tannins and quinones. These results show that C. occidentalis possess molecules with interesting antidiabetic properties and demonstrate its use in the treatment of diabetes.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A. Chemistry Corrosion potential of reinforced EDTA Zn-Fe Alloy in Acidic and Basic medium.","authors":"R. K. Pathak, Mukta Rani Bhawsar","doi":"10.52711/0974-4150.2023.00047","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00047","url":null,"abstract":"The manuscript presented the successfully synthesis of Zn-Fe alloy thin film deposition in sulfate bath on mild steel substrate. The hexadanted ligand EDTA was incorporated in alloy solution as corrosion inhibitor. All depositions were conducted at constant current density 2 mA/cm2 for 40 min. The morphological characterization of the thin film was analyzed with X-ray diffraction analysis (XRD) and Confocal laser microscopy. The Tafel polarization experiment was performed to determine the anticorrosion behavior of thin film in 3.5% NaCl and 0.1 M HCl solutions. The corresponding maximum corrosion efficiency of reinforced EDTA alloy is 93.57 and 94.02% in 3.5% NaCl and 0.1 M HCl solutions respectively.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of bio-accumulated Cd, Cr, Cu, Ni and Pb in a wild plant Lantana camara L. Verbenaceae, grown on waste dump site and assessment of its phyto-extraction potential for studied metals","authors":"Alok Awasthi","doi":"10.52711/0974-4150.2023.00045","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00045","url":null,"abstract":"The inputs of chemical fertilizers, street runoffs and regular use of heavy metal contaminated water to irrigate farm crops may result in elevated levels of heavy metals in agri-soil. The food crops growing on such soils may selectively bio-accumulate these metals, which usually depend on the concerned plant’s bio- accumulation potential for concerned metal and characteristics of the soil. This study was aimed to evaluate the bio-accumulation of Cd, Cr, Cu, Ni and Pb in the root, stem and leaves of the wild plant Lantana camara L., Verbenaceae, grown on waste dump site, by analyzing levels of studied metals in soil and plant parts. The bio-concentration factors (BCFs) and translocation factors (TFs) for metals under study were also evaluated, to find out the suitability of Lantana plant for phytoextration of the tested metals. The observed order of metal concentrations in soil samples was Pb (8.91± 0.54) > Cr (6.42 ±0.43) >Cu (1.91± 0.17) > Ni (1.42± 0.13) > Cd (0.86± 0.09, mg/Kg). The observed levels of studied metals in roots, stem and leaves of Lantana were, Pb(8.73±0.32)> Cr (2.96± 0.18)> Cu (2.16±0.15)> Ni (1.38±0.12)>Cd (0.54±0.03mg/kg); Pb(5.18±0.24)>Cr (3.18±0.18)>Cu (2.42±0.17) >Ni (1.49±0.12) >Cd (0.28±0.02, mg/Kg) and Pb (6.07±0.27)> Cr (1.30±0.13) >Cu (0.88±0.07) Ni (0.16±0.02) >Cd (0.10 ±0.01, mg/Kg), respectively. The bio-concentration factors for Lantana from soil to roots (BCFRoot) and from roots to shoots (BCFShoot) for Cd, Cr, Cu, Ni and Pb were 0.63, 0.46, 1.13, 0.97 (~ 1.00) and 0.98 (~ 1.00) and 0.70, 1.51, 1.49, 1.20 and 1.29, respectively. The translocation factors from root to stem (TFStem) and from stem to leaves (TFLeaf) for tested metals in Lantana camara were, 0.52, 1.07, 1.12, 1.08, 0.59 and 0.36, 0.41, 0.36, 0.11, 1.17, respectively. Thus, the recorded BCF values, mostly being >1, makes Lantana suitable for phyto-extraction of tested metals from agri-soil and medium to good translocation factors (TF) suggested the potential of the plant to translocate the tested metals into the stem and leaves.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzimidazole: A Promising target for the development of novel drug molecules against breast cancer","authors":"Balgovind Balgovind, Omprakash Goshain","doi":"10.52711/0974-4150.2023.00050","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00050","url":null,"abstract":"Breast cancer is considered as one of the deadliest diseases dominantly in developed and developing countries. Continuous research is required in order to design and develop better therapeutic agents for cancer treatment with more selectivity, efficacy and reduced toxicity. Fused heterocyclic ring system has been identified as a privileged structure by several researchers that can be used as a template for drug discovery and development in Medicinal Chemistry. Wide range of drugs with therapeutic potential contain hetero-aromatic bicyclic ring system as pharmacophore. According to various research outputs in the literature substituted benzimidazoles have wide range of pharmacological profiles with multi-targeting ability, making them an important basic nucleus for the design and development of novel therapeutic agents for the treatment of complex cancers including breast cancer, skin cancer, and blood cancer. In the presented article we have discussed research outputs by many scientists in the last few years that support the candidature of benzimidazole scaffold for the development of novel therapeutic agents against breast cancer along with their mechanism of action. This review also focuses on little introductory idea about benzimidazole nucleus and types of breast cancer.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"258 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzene System: A Theoretical Exploration of its Secular Determinant, π-Energy, Delocalization Energy, Wave Functions, Electron Density, and Charge Density","authors":"Kuldeep B. Handage, Snehal S. Jadhav, Vikram R. Jadhav","doi":"10.52711/0974-4150.2023.00044","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00044","url":null,"abstract":"In this work, we leveraged the unique characteristics of the Huckel strategy to obtain significant insights into the Benzene system. In addition to expressing the delocalization energy of the conjugated Benzene ring framework, we used a theoretical method to construct secular equations, energy, wave functions, electron density, and charge density for the C6H6+ (cation), C6H6- (anion), and C6H6. (radical). To determine the orbital energies, electron and charge density, and charge density of this stable configuration, we provided the secular determinant of the Huckel approach and applied it to the Benzene system. Our method makes it simple for graduate and post-graduate students to comprehend the complexities of stable configuration analysis and its related parameters since it is based on the assumptions of local comparabilities, such as coulomb integrals, exchange integrals, and overlap integrals. The Benzene system may be studied, and its underlying electrical characteristics can be understood using our straightforward, hypothetical approach.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Thiruvarur region groundwater samples using Physicochemical parameters","authors":"D. Kannan, N. Mani, T. Durgadevi","doi":"10.52711/0974-4150.2023.00042","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00042","url":null,"abstract":"Groundwater is one of the most important sources of water for drinking and irrigation purpose in the world. So water quality analysis is important one. Hence we choose to determine physicochemical parameter of Thiruvarur region groundwater. In this study, 10 groundwater samples were collected and analyzed various physicochemical parameters such as Ca2+, Mg2+, Fe3+, pH, TDS, etc., and compare with BIS limit value for determine the drinking water quality. From the research Results the groundwater sample numbers S3, S5, S6, S7 and S8 was slightly alkaline in nature, because these region groundwater has slightly excess of TDS and Total Alkalinity (TA) compare than BIS limit. However, all the water samples has low hardness, SO4-, NO3-, etc., Hence, we are concluded the collected groundwater samples is suitable for drinking and irrigation purpose.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"7 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio- accumulation of Cd, Cr, Cu, Ni and Pb in a wild grass, Parthenium hysterophorus L. Asteraceae, growing naturally on barren land and evaluation of phyto-extraction potential of the plant for studied metals","authors":"Alok Awasthi","doi":"10.52711/0974-4150.2023.00046","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00046","url":null,"abstract":"Because of the inbuilt bio-accumulation mechanism several plants have shown a remarkable capability of accumulation of metals from contaminated soil into roots, tubers and upper parts of the plants. This study was undertaken to evaluate the bio-accumulation potential of a wild grass, Parthenium hysterophorus L., Asteraceae grown on the barren land along with the National highways for Cd, Cr, Cu, Ni and Pb by determining the bio-accumulated levels of these metals in the samples of soil, roots and shoot of the plant. The various bio-concentration factors (BCFs), translocation factors (TFs) and Biological accumulation coefficients (BACs) for studied metals were evaluated, to find out the suitability of Parthenium plant for phyto-extration of the studied metals. The order of observed levels of heavy metals in the samples of soil, root and shoots were: Pb (8.12±0.48) > Cr (7.18± 0.39) > Cu (5.64± 0.26) > Ni (3.91± 0.21) > Cd (1.31± 0.08) and Pb (6.67± 0.34) > Cu (6.11 ±0.27) >Cr (6.05± 0.23) >Ni (4.14± 0.18) > Cd (1.42± 0.11) and Pb (7.22±0.29) > Cr (5.97±0.23)>Cu (5.96 ±0.25)>Ni (5.13±0.21) > Cd (1.70±0.14 mg/Kg, dw), respectively. The soil to roots bio-concentration factors, BCFRoot for studied metals were: Cd (1.08) > Cu (1.08) >Ni (1.06) > Cr (0.84)>Pb (0.82). The order of root to shoot translocation factors, TFShoot for these metals in Parthenium hysterophorus L., was: Ni (1.24) > Cd (1.20) > Pb (1.08) > Cr (0.99~1.00)> Cu (0.98~1.00). The various soil to shoot biological accumulation coefficients, BACShoot for studied metals in Parthenium plant were, Ni (1.31) > Cd (1.30)> Cu (1.06) > Pb (0.89) >Cr (0.83), respectively. Comparatively higher BCF >1, TF >1 and higher BAC values for metals under study suggested that the plant Parthenium hysterophorus L has potential to translocate these metals to the above ground parts of the plants and thereby their phyto-extraction from contaminated soil.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromotag application in quantification of alogliptin","authors":"Syed Sara Afreen, Durga Panikumar Anumolu, Pulusu Veera Shakar, Ceema Mathew, Devilal Jarpula, Rahul Nalluri","doi":"10.52711/0974-4150.2023.00048","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00048","url":null,"abstract":"Two simple, specific, accurate, precise, sensitive and cost-effective spectrophotometric methods have been developed and validated for quantification of alogliptin in pure form and pharmaceutical formulations. Method 1 is based on the measurement of absorbance of bluish green coloured chromogenic complex at 452 nm which is formed by reaction of alogliptin with ferric chloride and potassium ferricyanide (redox technique). Method-2 is based on the oxidative coupling reaction of MBTH with alogliptin in the presence of ferric chloride to form green coloured chromogen with absorption maximum at 608 nm. The methods obeyed Beer’s law in concentration range of 5-30 µg/ml and 20-100 µg/ml with good correlation coefficients of 0.9994 and 0.999 for method 1 and 2 respectively. The limit of detection, limit of quantification and sandell’s sensitivity values are reported for all the two spectrophotometric methods. The developed method was validated statistically as per ICH guidelines. No significant interference was observed from the excipients commonly used as pharmaceutical aids with the assay procedure. The reliability of both the methods is further ascertained by performing recovery tests by standard addition method. The developed method is simple, sensitive, specific and can be successfully employed in routine analysis of alogliptin in pharmaceutical dosage forms.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The vast scientific vision and scientific ingenuity in the field of nanofiltration, nanotechnology and water sustainability- A state of the art review","authors":"Sukanchan Palit","doi":"10.52711/0974-4150.2023.00049","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00049","url":null,"abstract":"Science, man, mankind and vision are today in the avenues of scientific regeneration as regards application of United Nations and Global Sustainable Development Goals. Water sustainability and water integrity are the pillars of scientific regeneration today. They are the pillars of environmental pollution control today. Engineering, applied sciences and natural sciences needs to be re-envisioned and reframed as regards protection of human environment and ecological biodiversity. Human civilisation today stands in the pathway and crevice of scientific adjudication and engineering vision. Water sustainability and environmental sustainability are two opposite sides of the visionary engineering coin. In this article, the author deeply elucidates of the scientific and engineering vision of membrane separation processes such as nanofiltration, ultrafiltration and reverse osmosis. Besides the author deeply targets the needs of water sustainability in the futuristic emancipation of global research and development initiatives. A newer dawn in the field of water science and technology will usher in as humankind moves forward.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136083590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse Phase High Performance Liquid Chromatography for Validation of Epinastine Hydrochloride in Bulk and Pharmaceutical Dosage Form","authors":"Rajan V. Rele., Prathamesh P. Tiwatane","doi":"10.52711/0974-4150.2023.00039","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00039","url":null,"abstract":"The validation method of epinastine hydrochloride from combined dosage form i.e. eye drops was described by high performance liquid chromatography method with separation of drugs on Water symmetry RP18 (150 x 4.6 mm i.d.) and 5 µ particle size. A mixture of buffer and acetonitrile (73:27 % (v/v)) was constituted as mobile phase. The chromatograms were studied at 220 nm as wavelength. The mobile phase was also used as a diluent. A validated of method was studied for linear regression, accuracy, method as well as system precision. The robustness study was done for change in wavelength, mobile phase composition and flow rate as per ICH guidelines. The method has been successfully used to analyze epinastine hydrochloride from dosage form i.e. eye drops.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135353970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}