DESIGN AND EVALUATION OF SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEMS OF ALVERINE FOR ENHANCEMENT OF SOLUBILITY

International Research Journal Of Pharmacy Pub Date : 2021-07-31 DOI:10.7897/2230-8407.1207153

Pooja, P. Sharma, Viswanath Agrahari

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Abstract

Background: The aim of this study is to develop a liquid self-nano emulsifying drug delivery system for alverine (liquid-SNEDDS).Excipients in the alverine SNEDDS include Ethyl oleate as the oil phase, Tween 80 as a surfactant, and PEG600, Propylene glycol as a cosurfactant.The prepared eleven formulations of alverine SNEDDS were performed for emulsification time, percentage transmittance, particle size, drug release, in vitro dissolution and stability studies.The optimised alverine liquid SNEDDS formulation (D1) was studied for drug-excipient compatibility using infrared spectroscopy, as well as particle size, zeta potential, transmission electron microscopy, and stability. Alverine SNEDDS have a spherical shape with uniform particle distribution, according to their morphology. D1's optimised formulation's drug release percentage (96.6). The stability data revealed no discernible changes in drug content, emulsifying properties, drug release, or appearance. As a result, a potential SNEDDS formulation of alverine with improved solubility, dissolution rate, and bioavailability was developed.

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提高溶解度的alverine自纳米乳化给药系统的设计与评价

背景:本研究的目的是建立一种自纳米乳化液给药系统(liquid- snedds)。alverine SNEDDS中的辅料包括油酸乙酯作为油相，Tween 80作为表面活性剂，PEG600，丙二醇作为助表面活性剂。对制备的11种阿尔佛林SNEDDS进行了乳化时间、透光率、粒径、药物释放度、体外溶出度和稳定性的研究。采用红外光谱、粒径、zeta电位、透射电镜和稳定性等方法研究了优化后的alverine液体SNEDDS (D1)与辅料的相容性。从形态上看，Alverine SNEDDS呈球形，颗粒分布均匀。D1优化制剂的释药率为96.6。稳定性数据显示在药物含量、乳化特性、药物释放或外观方面没有明显的变化。因此，开发了一种具有提高溶解度，溶出率和生物利用度的潜在的alverine SNEDDS配方。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Research Journal Of Pharmacy

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