International Research Journal Of Pharmacy最新文献_第3页

VALIDATION OF SCREENING MODELS OF PEPTIC ULCER: A REVIEW 消化性溃疡筛选模型的验证:综述

International Research Journal Of Pharmacy Pub Date : 2022-01-15 DOI: 10.7897/2230-8407.1212174

Ankita Tripathi, Shubham Srivastava, Minakshi Gupta, Shristi Raj, Farheen Shareef

引用次数: 0

PREVALENCE OF FAT-SOLUBLE VITAMIN DEFICIENCIES ASSOCIATED WITH SEVERE ACUTE MALNUTRITION: A PROSPECTIVE OBSERVATIONAL STUDY 脂溶性维生素缺乏与严重急性营养不良相关的患病率:一项前瞻性观察研究

International Research Journal Of Pharmacy Pub Date : 2021-12-21 DOI: 10.7897/2230-8407.1211170

M. Shende, S. Kadam, M. Mokal, M. P. Balvir

{"title":"PREVALENCE OF FAT-SOLUBLE VITAMIN DEFICIENCIES ASSOCIATED WITH SEVERE ACUTE MALNUTRITION: A PROSPECTIVE OBSERVATIONAL STUDY","authors":"M. Shende, S. Kadam, M. Mokal, M. P. Balvir","doi":"10.7897/2230-8407.1211170","DOIUrl":"https://doi.org/10.7897/2230-8407.1211170","url":null,"abstract":"Background: Severe acute malnutrition (SAM), among children below five years of age is global health problem contributing to childhood morbidity, mortality and remains a major embarrassment to optimal human capital development in India. Objectives: Study aim was to accesses fat soluble vitamins deficiencies among children with SAM and outcomes after treatments with F-75/F-100 plus vitamins mix. Methods: The study was prospective observational conducted in the nutritional rehabilitation center (NRC) at district general hospital for 6 months. Anthropometric measurements were taken to determine their nutritional status. Results: 100 patients of NRC were enrolled in the study. Sixty nine percent (69) patients had weight/height (WT/HT) Z score<−3 standard deviation (3 SD), 16 % with Z score<−2 and 15% of them had Z score<−4 malnutrition. Out of 100 children, 46% children were males, and 56% children were females. Vitamin E deficiencies (54%) were highly prevalent in hospitalized SAM groups, followed by 28% vitamin D and 18% were vitamin A deficient. Conclusion: Micronutrient deficiencies were highly prevalent with fat soluble vitamins and recovered on application of WHO protocols during hospitalization induced satisfactory fat-soluble vitamin status recovery significant (p<0.05).","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90938431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PHYSICO CHEMICAL EVALUATION OF NEELIBHRINGADI KERA TAILAM MANUFACTURED BY AYURVEDIC COMPANIES IN KERALA 喀拉拉邦阿育吠陀公司生产的neelibhringadi kera tailam的理化评价

International Research Journal Of Pharmacy Pub Date : 2021-12-21 DOI: 10.7897/2230-8407.1211171

R. A., T. S

{"title":"PHYSICO CHEMICAL EVALUATION OF NEELIBHRINGADI KERA TAILAM MANUFACTURED BY AYURVEDIC COMPANIES IN KERALA","authors":"R. A., T. S","doi":"10.7897/2230-8407.1211171","DOIUrl":"https://doi.org/10.7897/2230-8407.1211171","url":null,"abstract":"The quality control of herbal medicines has become a major concern to health authorities, health care providers and the manufacturing industries at every stage of production. The standardization of raw drugs and formulations with the help of modern analytical tools increase their scope, acceptance and scientific validity. The safety and efficacy of herbal medicines largely depend on their quality. Neelibhringadi keratailam is an excellent hair growth promoting oil widely prescribed and marketed in Kerala. All the ingredients in the formulation are best hair growth promoters. The knowledge of hair products, their mode of action, efficacy and ingredients has become more relevant today. Neelibhringadi keratailam manufactured by GMP certified Ayurvedic companies in Kerala was assessed by evaluating and comparing the physico chemical parameters of market samples of Neelibhringadi keratailam with that of prepared Neelibhringadi keratailam. Physico chemical parameters such as Acid value (AV), Iodine value (IV), Refractive index (RI) Saponification value (SV), Specific gravity (SG), Weight per milliliter, HPTLC, ICP-MS and microbial contamination of market samples were evaluated and compared with those of prepared sample. Neelibhringadi keram was prepared and its physicochemical analysis was done and compared with market samples. Analysis of the market samples showed significant variation in physicochemical analytical parameters, colour and consistency from the prepared samples.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77930471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REVIEW OF DESIGN APPROACHES AND CLINICAL PROGRESS OF MDM2 INHIBITORS mdm2抑制剂的设计方法及临床进展综述

International Research Journal Of Pharmacy Pub Date : 2021-12-21 DOI: 10.7897/2230-8407.1211169

Chiragkumar J. Gohil, M. Noolvi, C. Patel, D. Sen

{"title":"REVIEW OF DESIGN APPROACHES AND CLINICAL PROGRESS OF MDM2 INHIBITORS","authors":"Chiragkumar J. Gohil, M. Noolvi, C. Patel, D. Sen","doi":"10.7897/2230-8407.1211169","DOIUrl":"https://doi.org/10.7897/2230-8407.1211169","url":null,"abstract":"Activation of the oncogenes and inhibition of the apoptotic function of the p53 protein is a gateway for the cancer genesis. Interaction of the MDM2 protein with p53 protein is responsible for the inhibition of the p53 function. Inhibiting the p53-MDM2 interaction by drug will lead to the p53 release in the cancer cells. And can restart the apoptosis in the cancer cell. Computational methods successfully used for the design and development of the new, potent MDM2 inhibitors. Researchers and pharma companies used rational approach like target-based drug design or ligand-based drug design to develop the novel MDM2 inhibitors. The number of MDM2 inhibitors, has been designed by the computer-aided drug design and in-silico studies. In clinical studies, MDM2 inhibitors are led by RG7112. RG7112 completed its phase-1 trials in 2016, and recently it is under phase-2 trials. Along with RG7112, the number of potent MDM2 inhibitors entered the clinical trials successfully. It indicates the successful development of this class (MDM2 inhibitors). MDM2 inhibitors were found very effective in various studies for the treatment of various kinds of cancers. They have good selectivity for the tumor cells over the normal cells. It induced the dose dependent cell cycle arrest only; in the normal cells. In studies, MDM2 inhibitors successfully detached the p53 protein from the MDM2 protein. And restart the cell-killing function of the p53 protein in the cancer cells. Hence, MDM2 inhibitors can selectively kill the cancer cells over the normal cells.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80849433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

TECHNOLOGY TRANSFER FROM R & D TO PRODUCTION AND ITS DOCUMENTATION IN PHARMACEUTICAL INDUSTRY: A REVIEW 医药工业从研发到生产的技术转移及其文件编制综述

International Research Journal Of Pharmacy Pub Date : 2021-10-14 DOI: 10.7897/2230-8407.1210166

V. Manikandan, K. Kathiresan

引用次数: 0

PRACTICAL UTILITY OF SAMSARJANA KRAMA: A REVIEW 轮回羯摩的实际效用:述评

International Research Journal Of Pharmacy Pub Date : 2021-10-14 DOI: 10.7897/2230-8407.1210167

Anjaly Pr, Madhushree Hs, Ganesh Puttur

引用次数: 0

A REVIEW ON PHARMACEUTICAL VALIDATION AND ITS IMPORTANCE AND IMPUTATION 药品验证及其重要性和归算方法综述

International Research Journal Of Pharmacy Pub Date : 2021-10-14 DOI: 10.7897/2230-8407.1210168

M. Mohankumar, G. Sivakamasundari

引用次数: 0

FORMULATE AND EVALUATE THE ORAL DISPERSIBLE TABLET OF ANTIDIABETIC DRUG TENELIGLIPTIN 降糖药替尼格列汀口服分散片的研制与评价

International Research Journal Of Pharmacy Pub Date : 2021-10-14 DOI: 10.7897/2230-8407.1210165

Arpana Maurya, D. Gupta, Munendra Mohan Varshaney

{"title":"FORMULATE AND EVALUATE THE ORAL DISPERSIBLE TABLET OF ANTIDIABETIC DRUG TENELIGLIPTIN","authors":"Arpana Maurya, D. Gupta, Munendra Mohan Varshaney","doi":"10.7897/2230-8407.1210165","DOIUrl":"https://doi.org/10.7897/2230-8407.1210165","url":null,"abstract":"Orodispersible tablets (ODTs) are novel drug delivery systems that have the potential to significantly affect conventional dosage forms in terms of patient compliance, convenience, bioavailability, and time to action. Despite the fact that significant research has gone into developing ODT formulations and technologies, in order to produce newer, more expense technologies and better items, more research is needed in these major destinations. Because of the availability of new technologies, as well as good market acceptance and patient compliance, the potential of dosage forms is attractive. Pharmaceutical companies can use ODTs for new product lines or first-to-market products, which is a factor in technology. With the continuing development of new pharmaceutical excipients, more unique ODT technologies are likely to occur soon. Method -For the orodispersible tablet optimized formulation, a direct compression method was used. Result: The pure dosage calibration curve was created by dissolving the medication in ethanol and measuring the absorbance with a UV spectrophotometer set at 243.5 nm. The value of the slope was 1.025. Light microscopy was used to predict the size of teneligliptin particles. The average length and breadth of drug particles were 2.10 µm and 1.14µm. In-vitro drug release study profile of formulation demonstrated around 71 % of the drug diffused in 60 min., while the formulation 85 % of the rug release in 60 min.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79572330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AROHANA KRAMA MATRA BASTI IN JANU SANDHIGATA VATA: A CASE STUDY 在janu sandhigata vata中的Arohana krama matra basti:一个案例研究

International Research Journal Of Pharmacy Pub Date : 2021-10-14 DOI: 10.7897/2230-8407.1210164

Deeya Baboo, Prajwal Narayan, Ganesh Puttur

{"title":"AROHANA KRAMA MATRA BASTI IN JANU SANDHIGATA VATA: A CASE STUDY","authors":"Deeya Baboo, Prajwal Narayan, Ganesh Puttur","doi":"10.7897/2230-8407.1210164","DOIUrl":"https://doi.org/10.7897/2230-8407.1210164","url":null,"abstract":"Ayurveda (Science of life) has explained about the pathogenesis and the treatment of various disorders, the incidence of some of which have increased in the present scenario due to altered diet habits and lifestyle. Janu Sandhigata Vata is one among the Vata Vyadhi which causes a lot of inconvenience and disability in day-to-day activities. It is compared to Osteoarthritis of knee in modern Science. In this case study, a female aged about 57 years presented in the OPD of SSCASRH, Bengaluru was diagnosed with Janu Sandhigata Vata of both the knee joints. Arohana Krama Matra Basti with Prasarini taila was planned as per Sharangadhara’s reference. There was significant improvement in the patient and was evaluated after treatment and also during follow up. There was marked relief with respect to her subjective complaints like pain, improved joint space, walking time, degree of flexion and extension & X ray. This type of Arohana Krama Matra Basti can be adopted in future for planning treatment in Janu Sandhigata Vata and also taken up in a larger group study to check for better relief, long term effect and reduced side effects. The case is further elaborated in the article","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"394 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72611511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SIMULTANEOUS DETERMINATION OF PARACETAMOL AND TAPENTADOL IN TABLETS BY RATIO SPECTRA DERIVATIVE SPECTROPHOTOMETRY 比值光谱导数分光光度法同时测定片剂中扑热息痛和他他他多的含量

International Research Journal Of Pharmacy Pub Date : 2021-10-11 DOI: 10.7897/2230-8407.1209162

S. Bhavin, G. Anuradha

引用次数: 0