阿莫西林致史蒂文斯-约翰逊综合征1例

Rispa Darabadi, K. Harini
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引用次数: 1

摘要

史蒂文-约翰逊综合征(SJS)是一种罕见的严重的皮肤和粘膜疾病,通常是对药物的反应。它通常以流感样症状开始,随后出现疼痛的皮疹,扩散并起水泡。其他症状包括发热、口腔和喉咙痛、疲劳、眼睛灼烧、广泛的皮肤和粘膜病变(即口、鼻、食道、肛门和生殖器)、表皮脱落和急性皮肤水泡。在95%的病例报告中,药物被确定为SJS发展的重要原因。以下是一名37岁男性患者,经OTC处方口服阿莫西林治疗咳嗽、喉咙痛后,出现全身皮疹、发热住院。患者服用了三剂阿莫西林,由于缺乏对药物不良反应的认识,患者忽略了第一次服药后出现的皮疹。本案例探讨了阿莫西林极少发生的严重超敏反应的可能性,并简要介绍了史蒂文斯-约翰逊综合征的知识,以及一些控制药物不良反应的预防措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A CASE REPORT ON AMOXICILLIN INDUCED STEVENS- JOHNSON SYNDROME
Steven-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membrane that is usually a reaction to medication. It usually starts with flu-like symptoms, followed by a painful rash that spreads and blisters. Other symptoms include Fever, sore mouth and throat, Fatigue, burning eyes, extensive skin and mucous membrane lesions (i.e., mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95% of case reports, drugs were identified to be an important cause for the development of SJS. The below is a case report of A 37-year-old male patient hospitalized with rashes over the body and fever, after oral consumption of Amoxicillin drug for cough and sore throat through OTC prescription. The patient has taken three doses of Amoxicillin and due to lack of awareness on Adverse drug reactions, the patient ignored the rashes that were developed after the first dose. This case study discusses the possibility of serious hypersensitivity reactions with Amoxicillin that rarely occur and can be extremely harmful and life threatening, brief knowledge on Stevens-Johnson syndrome and also some of the preventive measures to control the adverse reactions due to drugs.
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