International Journal of Tuberculosis and Lung Disease最新文献_第8页

Aetiology of pleural effusions in children living in a high TB endemic setting. 结核病高发地区儿童胸腔积液的病因。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0444

S Wordui, A Masu, L Golden, S Chaya, K Reichmuth, A Visagie, A Ayuk, S K Owusu, D Marangu, N Affendi, A Lakhan, D Gray, A Vanker, H J Zar, M Zampoli

{"title":"Aetiology of pleural effusions in children living in a high TB endemic setting.","authors":"S Wordui, A Masu, L Golden, S Chaya, K Reichmuth, A Visagie, A Ayuk, S K Owusu, D Marangu, N Affendi, A Lakhan, D Gray, A Vanker, H J Zar, M Zampoli","doi":"10.5588/ijtld.23.0444","DOIUrl":"https://doi.org/10.5588/ijtld.23.0444","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Confirming the aetiology of pleural effusion in children may be difficult in TB-endemic settings. We investigated the role of polymerase chain reaction (PCR) and routine biochemical tests in discriminating pleural effusion caused by bacteria from other aetiologies.</sec><sec id=\"st2\"><title>METHODS</title>This is a cross-sectional post-hoc analysis among children with pleural effusion in a tertiary hospital in South Africa, incorporating new data from PCR testing of stored pleural fluid. Aetiological classification was defined by microbiological confirmation.</sec><sec id=\"st3\"><title>RESULTS</title>Ninety-one children were enrolled; the median age 31 months (IQR 12-102). The aetiology of pleural effusion was 40% (36/91) bacteria, 11% (10/91) TB, 3% (3/91) viruses, 11% (10/91) polymicrobial and 35% (32/91) had no pathogen identified. The most common pathogen was Staphylococcus aureus (27/91, 30%) with similar yields on culture and PCR, followed by Streptococcus pneumoniae (12/91, 13%), detected more commonly by PCR. PCR reduced the number of children with unconfirmed aetiologies from 48 to 32. Characteristics of children with no pathogen most resembled those with TB. Pleural fluid lactate dehydrogenase ≥1,716 U/L best discriminated bacterial pleural effusion from other aetiologies (sensitivity of 86%; specificity 95%).</sec><sec id=\"st4\"><title>CONCLUSION</title>PCR improved detection of pathogens and reduced number of children with unconfirmed aetiologies in presumed exudative pleural effusion.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"295-300"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric TB treatment outcomes: targets for improvement. 小儿结核病治疗结果：改进目标。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.24.0221

S S Chiang, H E Jenkins

引用次数: 0

Chronic pulmonary aspergillosis: a neglected post-TB lung disease. 慢性肺曲霉菌病：一种被忽视的结核病后肺部疾病。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.24.0165

F Bongomin, D W Denning

引用次数: 0

Did public-private partnerships reduce TB incidence in Korea? 公私合作伙伴关系是否降低了韩国的结核病发病率？

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0286

J Min, S Y Kim, J E Park, J-H Park

引用次数: 0

Careful classification of potential bedaquiline resistance mutations is critical when analysing their clinical impact. 在分析贝达喹啉的临床影响时，对潜在的贝达喹啉耐药突变进行仔细分类至关重要。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.24.0083

J E Phelan, C Utpatel, N Ismail, T Cortes, S Niemann, D M Cirillo, T Schön, P Miotto, C U Köser

引用次数: 0

Outcomes of childhood TB in countries with a universal BCG vaccination policy. 实行卡介苗接种普及政策的国家的儿童结核病发病率。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0321

J V Dias, L Varandas, L Gonçalves, B Kagina

{"title":"Outcomes of childhood TB in countries with a universal BCG vaccination policy.","authors":"J V Dias, L Varandas, L Gonçalves, B Kagina","doi":"10.5588/ijtld.23.0321","DOIUrl":"10.5588/ijtld.23.0321","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>TB remains an important cause of childhood morbidity and mortality. Underdiagnosis, underreporting and limited data on the outcomes of childhood TB have led to an underestimation of its impact.</sec><sec id=\"st2\"><title>METHODS</title>This was a systematic review to characterise childhood TB outcomes. Studies reporting relevant epidemiological data on children between 0 and 14 years of age, with a particular focus on treatment outcomes, from countries with universal bacilli Calmette-Guérin (BCG) vaccination and conducted between 2000 and 2020 were selected. Random effects meta-analysis was performed in R software.</sec><sec id=\"st3\"><title>RESULTS</title>We identified 1,806 references and included 35 articles. Among children with TB, the overall proportion of unfavourable outcomes was 19.5% (95% CI 14.4-25.8) and pooled case-fatality ratio was 6.1% (95% CI 4.3-8.4). The proportion of deaths observed among children between 0 and 4 years old was 6.6% (95% CI 4.9-8.7) and 4.6% (95% CI 3.1-6.9) in older children. TB and HIV co-infected children presented a case-fatality ratio of 15.1% (95% CI 7.9-27.0).</sec><sec id=\"st4\"><title>CONCLUSIONS</title>Despite the efforts made in the last decades, treatment outcomes in childhood TB are still worrisome. Efforts to fill existing gaps and design health policies targeting vulnerable populations, such as children, should be intensified to tackle the global TB burden.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"273-277"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of tuberculous infection in a TB-endemic city. 结核病流行城市的结核病感染率。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0403

N Kiwanuka, T Quach, R Kakaire, S Zalwango, M Castellanos, J Sekandi, C C Whalen

{"title":"Incidence of tuberculous infection in a TB-endemic city.","authors":"N Kiwanuka, T Quach, R Kakaire, S Zalwango, M Castellanos, J Sekandi, C C Whalen","doi":"10.5588/ijtld.23.0403","DOIUrl":"10.5588/ijtld.23.0403","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Current metrics for TB transmission include TB notifications, disease mortality, and prevalence surveys. These metrics are helpful to national TB programs to assess the burden of disease, but they do not directly measure incident infection in the community.</sec><sec id=\"st2\"><title>METHODS</title>To estimate incidence of Mycobacterium tuberculosis infection in Kampala, Uganda, we performed a prospective cohort study between 2014 and 2017 which enrolled of 1,275 adult residents without signs of tuberculous infection (tuberculin skin test [TST] <5 mm and no signs of TB disease) and followed them for conversion of TST at 1 year.</sec><sec id=\"st3\"><title>RESULTS</title>During follow-up, 194 participants converted the TST and 158 converted by one year. The incidence density of TST conversion was 13.2 conversions/100 person-year (95% CI 11.6-15.1), which corresponds to an annual cumulative incidence of tuberculous infection of 12.4% (95% CI 10.7-14.3). Cumulative incidence was greater among older participants and among men. Among participants who reported prior exposure to TB cases, the cumulative risk was highest among those reporting exposure during follow-up.</sec><sec id=\"st4\"><title>CONCLUSIONS</title>The high annual incidence of infection suggests that residents of Kampala have adequate contact for infection with undetected, infectious cases of TB as they go about their daily lives.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"266-272"},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11337811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clinical impact of heart failure with preserved ejection fraction in interstitial lung diseases. 间质性肺病射血分数保留型心力衰竭的临床影响。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0555

U Zanini, G Ferrara, S Moitra, R Varughese, M Kalluri, J Weatherald

引用次数: 0

TB diagnoses and mortality in hospitalized people living with HIV in South Africa. 南非住院艾滋病毒感染者的结核病诊断和死亡率。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0431

K Shearer, E Variava, B Kekana, P Abraham, T Moloantoa, J E Golub, N Martinson, C Hoffmann

引用次数: 0

An epidemiological analysis of TB trends in native and migrant populations, New Mexico, 1993-2021. 1993-2021 年新墨西哥州原住民和移民人口结核病趋势流行病学分析。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0318

J-M Ramos-Rincon, B Montoya, G Simpson, M Burgos

{"title":"An epidemiological analysis of TB trends in native and migrant populations, New Mexico, 1993-2021.","authors":"J-M Ramos-Rincon, B Montoya, G Simpson, M Burgos","doi":"10.5588/ijtld.23.0318","DOIUrl":"https://doi.org/10.5588/ijtld.23.0318","url":null,"abstract":"<sec id=\"st1\"><title>OBJECTIVES</title>To analyze the epidemiological, demographic, clinical, laboratory, radiographic and treatment outcome trends in non-US-born individuals with TB in New Mexico.</sec><sec id=\"st2\"><title>DESIGNS</title>We retrospectively analyzed TB data from New Mexico TB surveillance system from (1993-2021), comparing variables between non-US-born and US-born individuals.</sec><sec id=\"st3\"><title>RESULTS</title>Of the 1,512 TB cases, 876 (56.5%) were non-US-born and 653 (43.3%) were US-born. The incidence rate among non-US-born patients declined from 15.3/100,000 (1993) to 7.8/100,000 (2021) (54.6% reduction), while among US-born patients it declined from 3.3/100,000 (1993) to 0.5/100,000 (2021) (84.8% reduction). The majority of non-US-born individuals were from Mexico (n = 482, 73.5%). Non-US-born were typically younger adults (median age: 54 vs. 61), predominantly male (64.8% vs. 59.4%), less likely to consume excess alcohol and have extrapulmonary TB. However, they were more likely to exhibit resistance to standard TB drugs (P < 0.01). Non-US-born individuals were less likely to die (7.8% vs. 15.4%), but more likely to be lost to follow-up (P < 0.007). Treatment by providers outside the Department of Health was associated with noncompletion (OR 0.18, 95% CI 0.09-0.35; P < 0.001).</sec><sec id=\"st4\"><title>CONCLUSION</title>These results highlight the need for a detailed understanding of the impact of migration on TB epidemiology and the development of tailored interventions to improve treatment outcomes.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"278-286"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0