International Journal of Tuberculosis and Lung Disease最新文献_第10页

Pancreatitis delays the absorption of first-line anti-TB drugs. 胰腺炎会延迟一线抗结核药物的吸收。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-03-01 DOI: 10.5588/ijtld.23.0274

S Lever, O W Akkerman, B G J Dekkers

引用次数: 0

Reply to 'Therapeutic drug monitoring for isoniazid and rifampicin exposure'. 对 "异烟肼和利福平暴露的治疗药物监测 "的答复

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-03-01 DOI: 10.5588/ijtld.24.0022

O W Akkerman, H A M Kerstjens, M Kingma, M S Bolhuis, M G G Sturkenboom

引用次数: 0

Impact of annual TB screening on stone quarry workers in high-incidence Portuguese municipalities. 每年对葡萄牙高发病率城市的采石场工人进行结核病筛查的影响。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-03-01 DOI: 10.5588/ijtld.23.0350

S Sousa, S Santos, C M Alves, G Gonçalves, C Carvalho, R Duarte

{"title":"Impact of annual TB screening on stone quarry workers in high-incidence Portuguese municipalities.","authors":"S Sousa, S Santos, C M Alves, G Gonçalves, C Carvalho, R Duarte","doi":"10.5588/ijtld.23.0350","DOIUrl":"10.5588/ijtld.23.0350","url":null,"abstract":"<sec id=\"st1\"><title>SETTING</title>The Portuguese municipalities of Penafiel and Marco de Canaveses are high TB incidence areas, where stone quarry workers represent a vulnerable population.</sec><sec id=\"st2\"><title>OBJECTIVE</title>To assess the annual rate of TB infection (ARI) in stone quarry workers and to compare it with the TB notification rate in the general community.</sec><sec id=\"st3\"><title>DESIGN</title>An annual TB infection screening strategy using interferon-gamma release assay (IGRA) was implemented in 2018 for workers from high-risk stone quarries. A prospective cohort was enrolled and workers screened in periods of 2 years were included. IGRA-positive workers were referred for preventive treatment. ARI was calculated as the proportion of workers with IGRA conversion.</sec><sec id=\"st4\"><title>RESULTS</title>Of the 232 IGRA-negative workers in 2018, 20 tested positive in 2019 (8.6% ARI). Of 171 IGRA-negative workers in 2019, eight tested positive in 2021 (4.7% in 2 years). Two of the 150 IGRA-negative workers in 2021 tested positive in 2022 (1.3% ARI). ARI decreased by 84.9% between 2019 and 2022. In the two municipalities, the TB notification rate declined 23.9% between 2018 and 2021.</sec><sec id=\"st5\"><title>CONCLUSION</title>A more pronounced reduction in ARI was observed among stone quarry workers regularly screened for TB infection compared to the notification rate among the general population in high-incidence municipalities. A screening strategy for high-risk populations, together with enforced community measures, could foster risk reduction in the community.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 3","pages":"136-141"},"PeriodicalIF":4.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using timeliness metrics for household contact tracing and TB preventive therapy in the private sector, India. 在印度私营部门使用家庭接触者追踪和结核病预防治疗的及时性指标。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-03-01 DOI: 10.5588/ijtld.23.0285

P Thekkur, R Thiagesan, D Nair, N Karunakaran, M Khogali, R Zachariah, S Dar Berger, S Satyanarayana, A M V Kumar, A F Bochner, A McClelland, R Ananthakrishnan, A D Harries

{"title":"Using timeliness metrics for household contact tracing and TB preventive therapy in the private sector, India.","authors":"P Thekkur, R Thiagesan, D Nair, N Karunakaran, M Khogali, R Zachariah, S Dar Berger, S Satyanarayana, A M V Kumar, A F Bochner, A McClelland, R Ananthakrishnan, A D Harries","doi":"10.5588/ijtld.23.0285","DOIUrl":"10.5588/ijtld.23.0285","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Although screening of household contacts (HHCs) of TB patients and provision of TB preventive therapy (TPT) is a key intervention to end the TB epidemic, their implementation globally is dismal. We assessed whether introducing a '7-1-7' timeliness metric was workable for implementing HHC screening among index patients with pulmonary TB diagnosed by private providers in Chennai, India, between November 2022 and March 2023.</sec><sec id=\"st2\"><title>METHODS</title>This was an explanatory mixed-methods study (quantitative-cohort and qualitative-descriptive).</sec><sec id=\"st3\"><title>RESULTS</title>There were 263 index patients with 556 HHCs. In 90% of index patients, HHCs were line-listed within 7 days of anti-TB treatment initiation. Screening outcomes were ascertained in 48% of HHCs within 1 day of line-listing. Start of anti-TB treatment, TPT or a decision to receive neither was achieved in 57% of HHC within 7 days of screening. Overall, 24% of screened HHCs in the '7-1-7' period started TPT compared with 16% in a historical control (P < 0.01). Barriers to achieving '7-1-7' included HHC reluctance for evaluation or TPT, refusal of private providers to prescribe TPT and reliance on facility-based screening of HHCs instead of home visits by health workers for screening.</sec><sec id=\"st4\"><title>CONCLUSIONS</title>Introduction of a timeliness metric is a workable intervention that adds structure to HHC screening and timely management.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 3","pages":"122-139"},"PeriodicalIF":4.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Community-level variation in TB testing history in Blantyre, Malawi. 马拉维布兰太尔结核病检测史的社区差异。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-02-01 DOI: 10.5588/ijtld.23.0213

E S Nightingale, H R A Feasey, M Khundi, R N Soko, R M Burke, M Nliwasa, H Twabi, J A Mpunga, K Fielding, P MacPherson, E L Corbett

{"title":"Community-level variation in TB testing history in Blantyre, Malawi.","authors":"E S Nightingale, H R A Feasey, M Khundi, R N Soko, R M Burke, M Nliwasa, H Twabi, J A Mpunga, K Fielding, P MacPherson, E L Corbett","doi":"10.5588/ijtld.23.0213","DOIUrl":"10.5588/ijtld.23.0213","url":null,"abstract":"SETTING: Equitable access to TB testing is vital for achieving global diagnosis and treatment targets, but access to diagnostic services is often worse in poorer communities. The SCALE (Sustainable Community-wide Active case-finding for Lung hEalth) survey estimated TB prevalence in Blantyre City, Malawi, and recorded previous engagement with TB services.OBJECTIVE: To explore local variation in the prevalence of ever-testing for TB in Blantyre and investigate potential socio-economic drivers.DESIGN: We fit a mixed-effects model to self-reported prior TB testing from survey participants across 72 neighbourhood clusters, adjusted for sex, age and HIV status and with cluster-level random intercepts. We then evaluated to what extent cluster-level variation was explained by two alternate poverty indicators.RESULTS: We observed substantial variation between clusters in previous TB testing, with little correlation between neighbouring clusters. Individuals residing in less affluent households, on average, had lower odds of having undergone prior testing. However, adjusting for poverty did not explain the cluster-level variations observed.CONCLUSION: Despite a decade of increased active case-finding efforts, access to TB testing is inconsistent across the population of Blantyre. This likely reflects health inequities that also apply to TB testing in many other settings, and motivates collection and analysis of TB testing data to identify the drivers behind these inequities.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 2","pages":"99-105"},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing incidence of TB in a low burden TB country due to migration from Ukraine. 在一个结核病负担较轻的国家，由于来自乌克兰的移民，结核病发病率不断上升。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-02-01 DOI: 10.5588/ijtld.23.0292

K Doležalová, V Kika, J Wallenfels

引用次数: 0

Cost-effectiveness of pretomanid-based regimen for highly drugresistant TB in a low-burden setting. 在低负担环境中，以预马尼为基础的高耐药性结核病治疗方案的成本效益。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-02-01 DOI: 10.5588/ijtld.23.0163

G Fekadu, Y Wang, J H S You

{"title":"Cost-effectiveness of pretomanid-based regimen for highly drugresistant TB in a low-burden setting.","authors":"G Fekadu, Y Wang, J H S You","doi":"10.5588/ijtld.23.0163","DOIUrl":"10.5588/ijtld.23.0163","url":null,"abstract":"BACKGROUND: Recent clinical findings reported improvement in the treatment outcomes of highly resistant TB (HDR-TB) with the pretomanid (Pa) based regimen. This study aimed to evaluate the cost-effectiveness of the Pa-based regimen for HDR-TB treatment from the perspective of the healthcare sector in the United States.METHODS: A lifelong decision-analytic model was constructed to simulate potential treatment outcomes of 1) the bedaquiline-Pa-linezolid (BPaL) regimen, and 2) the bedaquiline-linezolid (B-L) based regimen in a hypothetical cohort of adult patients with HDR-TB. Primary model outputs were TB-related direct medical costs, qualityadjusted life-years (QALYs) and incremental cost per QALY gained (ICER).RESULTS: In the base-case analysis, the BPaL regimen gained 3.0054 QALYs and saved costs by USD60,433 when compared to the B-L-based regimen. In the probabilistic sensitivity analysis, the BPaL regimen gained higher QALYs at a lower cost in 80.3% of the time, and gained higher QALYs at a higher cost with ICER less than the willingness-to-pay (WTP) threshold (100,000 USD/QALY) in 19.0% of the simulations. The probability of the BPaL regimen being cost-effective was higher than the B-L-based regimen throughout the variation of WTP.CONCLUSION: BPaL therapy is likely the cost-effective option for HDR-TB treatment from the US healthcare sector perspective.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 2","pages":"81-85"},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential for vaccines to aid the treatment of post-TB lung disease. 疫苗辅助治疗结核病后肺部疾病的潜力。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-02-01 DOI: 10.5588/ijtld.23.0524

D R Silva, A P Santos, D Visca, S Bombarda, M M P Dalcolmo, T Galvão, S S de Miranda, A A A I Parente, M F Rabahi, R K B de Sales, G B Migliori, F C de Queiroz Mello

引用次数: 0

Emphasis on post-TB lung disease and other sequelae of TB is good but a public health approach to TB is morally ambitious??? 重视结核病后肺部疾病和其他结核病后遗症是好事，但对结核病采取公共卫生方法在道义上是否雄心勃勃？

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-02-01 DOI: 10.5588/ijtld.23.0392

R Long, C Heffernan, A Lau

引用次数: 0

Nirmatrelvir/ritonavir and pharmacovigilance data. Nirmatrelvir/ritonavir 和药物警戒数据。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-02-01 DOI: 10.5588/ijtld.23.0326

S Lassan, M Gocova, I Solovic, T Tesar, Z Motesicka, M Lassanova

引用次数: 0