International Journal of Tuberculosis and Lung Disease最新文献_第10页

Point-of-care ultrasound for diagnosing extrapulmonary TB. 用于诊断肺外结核病的护理点超声波。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0471

L T Allan-Blitz, C Yarbrough, M Ndayizigiye, C Wade, A J Goldsmith, N M Duggan

{"title":"Point-of-care ultrasound for diagnosing extrapulmonary TB.","authors":"L T Allan-Blitz, C Yarbrough, M Ndayizigiye, C Wade, A J Goldsmith, N M Duggan","doi":"10.5588/ijtld.23.0471","DOIUrl":"10.5588/ijtld.23.0471","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Despite the high morbidity and mortality globally, standard microbiologic diagnosis for TB requires laboratory infrastructure inaccessible in many resource-limited areas and may be insufficient for identifying extrapulmonary disease. Point-of-care (POC) ultrasound facilitates visualization of extrapulmonary manifestations, permitting laboratory-independent diagnosis, but its diagnostic utility remains unclear.</sec><sec id=\"st2\"><title>METHODS</title>We conducted a systematic review of five online databases for studies reporting ultrasound findings among cases with and without extrapulmonary TB (EPTB). A minimum of two authors independently screened and reviewed each article, and extracted data elements of interest. We conducted a series of univariate meta-analyses using a random-effects model to calculate the pooled effect estimate and 95% confidence interval (CI) for each outcome: sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).</sec><sec id=\"st3\"><title>RESULTS</title>Of 279 articles identified, 6 were included. There were 699 cases of EPTB among 1,633 participants. The pooled sensitivity estimate was 0.72 (95% CI 0.57-0.88). The pooled specificity estimate was 0.77 (95% CI 0.63-0.90). The pooled PPV and NPV estimates were respectively 0.67 (95% CI 0.47-0.87) and 0.85 (95% CI 0.77-0.93).</sec><sec id=\"st4\"><title>CONCLUSION</title>POC ultrasound showed modest test characteristics for diagnosing EPTB, which may constitute an improvement over some currently available diagnostics.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"217-224"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMaRT-PCR: sampling using masks and RT-PCR, a non-invasive diagnostic tool for paediatric pulmonary TB. SMaRT-PCR：使用口罩和 RT-PCR 进行采样，这是一种针对小儿肺结核的无创诊断工具。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0291

A Shaikh, K Sriraman, S Vaswani, I Shah, V Poojari, V Oswal, S Mane, S Rajagara, N Mistry

{"title":"SMaRT-PCR: sampling using masks and RT-PCR, a non-invasive diagnostic tool for paediatric pulmonary TB.","authors":"A Shaikh, K Sriraman, S Vaswani, I Shah, V Poojari, V Oswal, S Mane, S Rajagara, N Mistry","doi":"10.5588/ijtld.23.0291","DOIUrl":"10.5588/ijtld.23.0291","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Key challenges in paediatric TB diagnosis are invasive sampling and poor sensitivity of standard methods. This study demonstrates the diagnostic potential of non-invasive sampling of bioaerosols from children using SMaRT-PCR, comprising mask sampling combined with reverse transcriptase-polymerase chain reaction (RT-PCR) for TB.</sec><sec id=\"st2\"><title>METHODS</title>Exhaled bioaerosols were captured on modified N-95 masks in a 10-min talk-cough-breathe process from 51 children (30 with TB confirmed using standard sampling methods and 21 without TB) aged 2-15 years. All mask samples were tested using in-house RT-PCR for 16s and rpoB RNA transcripts. Additional mask samples from children with TB were tested using Xpert® MTB/RIF (n = 3) and Xpert® MTB/RIF Ultra (n = 27).</sec><sec id=\"st3\"><title>RESULTS</title>SMaRT-PCR sensitivity for detecting TB among treatment-naïve children was 96% if 16s or rpoB was present, and 75% if both genes were present, comparable to standard methods (71%) in the same cohort. Specificity was better for both genes, at 95%, than 85% for a single gene detection. Mask sampling with Xpert MTB/RIF or Ultra had a sensitivity of only 13%.</sec><sec id=\"st4\"><title>CONCLUSION</title>This is the first study to provide evidence for testing bioaerosols as a promising alternative for detecting paediatric TB. Sampling is non-invasive and simple, with the potential for point-of-care applications. This pilot study also suggests that RNA transcript-based detection may improve TB diagnostic sensitivity in children; however, further investigation is required to establish its adaptability in clinical settings.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 4","pages":"189-194"},"PeriodicalIF":4.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advantages and limitations of virtual multi-disciplinary team meetings on difficult-to-treat mycobacteria. 针对难治分枝杆菌的虚拟多学科团队会议的优势和局限性。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0551

V N Dahl, A Burke, A Fløe, J Bruchfeld, T Schön, C M Wejse, A B Andersen, E Svensson, J van Ingen, L Davies Forsman

引用次数: 0

Population attributable fraction for smoking and diabetes in TB. 肺结核中吸烟和糖尿病的人口可归因分数。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0338

S Ghosh, F Garden, K B Luu, N V Nguyen, P T B Nguyen, T-A Nguyen, H B Nguyen, G Marks

引用次数: 0

New perspectives on the secular trend in pulmonary TB in post-war Japan (1953-1980). 战后日本（1953-1980 年）肺结核长期趋势的新视角。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0405

L Kawatsu, K Uchimura, A Schwalb, R Houben

引用次数: 0

Cash transfers to enhance completion of TB screening among household contacts in rural Tanzania. 坦桑尼亚农村地区通过现金转移促进家庭接触者完成肺结核筛查。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0412

G Ilaiwy, S K Heysell, S Lukumay, D Agustino, P Mejan, K Simeon, T A Thomas, E Mduma

{"title":"Cash transfers to enhance completion of TB screening among household contacts in rural Tanzania.","authors":"G Ilaiwy, S K Heysell, S Lukumay, D Agustino, P Mejan, K Simeon, T A Thomas, E Mduma","doi":"10.5588/ijtld.23.0412","DOIUrl":"10.5588/ijtld.23.0412","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Tanzanian TB guidelines recommend facility-based TB screening for symptomatic household contacts (HHCs) or those aged <5 years, but cost remains a major barrier. In this study, we evaluate the use of unconditional cash transfers (UCTs) to facilitate completion of HHC TB screening.</sec><sec id=\"st2\"><title>METHODS</title>In this prospective interventional study, we enrolled index people diagnosed with TB (PWTB) within 8 weeks of TB treatment initiation from the TB clinic at Haydom Lutheran Hospital, Haydom, Tanzania, and surrounding TB dispensaries in rural Tanzania. The study provided at the time of enrollment an UCT up to 40,000 Tanzanian shillings (USD16.91) directly to heads of households with PWTB, covered medical costs from screening activities and provided three bi-weekly phone reminders to facilitate HHC TB screening. The primary outcome was TB screening completion for all HHCs compared to the same period of the preceding year.</sec><sec id=\"st3\"><title>RESULTS</title>We enrolled 120 index PWTB, including 398 HHCs between July and December 2022. The median age for index PWTB was 35 years; 38% were females. Sixty-five (54%) households completed screening for all HHCs, compared to 7% during the same period of the preceding year.</sec><sec id=\"st4\"><title>CONCLUSION</title>These interventions may considerably improve completion of HHC TB screening in rural Tanzania.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 4","pages":"176-182"},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated treatment costs for multidrug-resistant TB in the United States. 美国耐多药结核病治疗费用估算。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0621

S M Marks, C A Winston

引用次数: 0

Monocyte-lymphocyte ratio - diagnostic cut-off values and TB infection or disease. 单核细胞-淋巴细胞比率--诊断临界值与肺结核感染或疾病。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0564

G H Bothamley

引用次数: 0

Chest X-ray evaluation using machine learning to support the early diagnosis of pulmonary TB. 利用机器学习对胸部 X 光片进行评估，以支持肺结核的早期诊断。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0230

P L Parreira, A U Fonseca, F Soares, M B Conte, M F Rabahi

{"title":"Chest X-ray evaluation using machine learning to support the early diagnosis of pulmonary TB.","authors":"P L Parreira, A U Fonseca, F Soares, M B Conte, M F Rabahi","doi":"10.5588/ijtld.23.0230","DOIUrl":"10.5588/ijtld.23.0230","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>TB is a public health problem, and its diagnosis can be challenging. Among imaging methods, chest X-ray (CXR) is the leading choice for assessing pulmonary TB (PTB). Recent advancements in the field of artificial intelligence have stimulated studies evaluating the performance of machine learning (ML) for medical diagnosis. This study validated a new original Brazilian tool, the XmarTB, applied to CXR images to support the early diagnosis of PTB.</sec><sec id=\"st2\"><title>METHODS</title>An ML model was trained on 3,800 normal images, 3,800 abnormal CXRs without PTB and 1,376 with PTB manifestations from the publicly available TBX11K database.</sec><sec id=\"st3\"><title>RESULTS</title>The binary classification can distinguish between normal and abnormal CXR with a sensitivity of 99.4% and specificity of 99.4%. The XmarTB tool had a sensitivity of 98.1% and a specificity of 99.7% in detecting TB cases among CXRs with abnormal CXRs; sensitivity was 96.7% and specificity 98.7% in detecting TB cases among all samples.</sec><sec id=\"st4\"><title>CONCLUSION</title>This diagnostic tool can accurately and automatically detect abnormal CXRs and satisfactorily differentiate PTB from other pulmonary diseases. This tool holds significant promise in aiding the proactive detection of TB cases, providing rapid and accurate support for early diagnosis.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 4","pages":"171-175"},"PeriodicalIF":4.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TAPSE/SPAP ratio stratifies mortality risk in mild-to-moderate idiopathic pulmonary fibrosis. TAPSE/SPAP 比率可对轻度至中度特发性肺纤维化患者的死亡风险进行分层。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0474

A Sonaglioni, A Caminati, E Grasso, M Colleoni, G L Nicolosi, M Lombardo, S Harari

{"title":"TAPSE/SPAP ratio stratifies mortality risk in mild-to-moderate idiopathic pulmonary fibrosis.","authors":"A Sonaglioni, A Caminati, E Grasso, M Colleoni, G L Nicolosi, M Lombardo, S Harari","doi":"10.5588/ijtld.23.0474","DOIUrl":"10.5588/ijtld.23.0474","url":null,"abstract":"BACKGROUND: Due to paucity of literature data, we aimed at evaluating the prognostic role of the ratio of tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary artery pressure (SPAP) in idiopathic pulmonary fibrosis (IPF) patients without severe pulmonary hypertension and at assessing its correlation with effective arterial elastance index (EaI).\u0000METHODS: Multi-instrumental data obtained in 60 IPF patients (73.2 ± 6.8 years) and 60 matched controls were retrospectively analysed. Primary endpoint was all-cause mortality, while secondary endpoint was the composite of all-cause mortality and re-hospitalisations for all-causes over medium-term follow-up.\u0000RESULTS: ;At baseline, TAPSE/SPAP was significantly lower in patients with IPF than in controls (0.36 ± 0.25 vs. 0.77 ± 0.18 mm/mmHg; P < 0.001). TAPSE/SPAP was inversely correlated with EaI (r = -0.96) in IPF patients. During follow-up (3.5 ± 1.5 years), 21 patients died and 25 were re-hospitalised due to cardiopulmonary causes. TAPSE/SPAP was independently associated with both primary (HR 0.79, 95%CI 0.65-0.97) and secondary (HR 0.94, 95%CI 0.92-0.97) endpoints. A TAPSE/SPAP ratio of <0.20 and <0.44 mm/mmHg showed the greatest sensitivity and specificity for predicting primary (AUC 0.98) and secondary (AUC 0.99) endpoints, respectively.\u0000CONCLUSIONS: TAPSE/SPAP is a strong predictor of adverse outcomes in mild-to-moderate IPF. The strong correlation between TAPSE/SPAP and EaI might be an expression of a systemic fibrotic process which involves the heart, lungs and circulation.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 4","pages":"183-188"},"PeriodicalIF":4.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0