International Journal of Tuberculosis and Lung Disease最新文献_第9页

Limitations of using tuberculin skin test to screen for TB in patients with psoriasis. 使用结核菌素皮试筛查银屑病患者结核病的局限性。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0497

M M Carvalho, P Barbosa, P Ramos, M Vieira, R Duarte

引用次数: 0

Phenotyping chronic respiratory diseases with airways obstruction. 对气道阻塞的慢性呼吸道疾病进行表型分析。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0383

T C Nguyen, H V T Tran, M H T Tran, I Godin, O Michel

{"title":"Phenotyping chronic respiratory diseases with airways obstruction.","authors":"T C Nguyen, H V T Tran, M H T Tran, I Godin, O Michel","doi":"10.5588/ijtld.23.0383","DOIUrl":"https://doi.org/10.5588/ijtld.23.0383","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Given the high prevalence of asthma-chronic obstructive pulmonary disease overlap (ACO) in Vietnam, there is an urgent need to establish a simplified strategy for categorising patients as either having asthma or chronic obstructive pulmonary disease (COPD). This classification would streamline the application of treatment recommendations outlined by the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD).</sec><sec id=\"st2\"><title>METHODS</title>Patients with obstructive lung function were classified as having COPD, asthma, or ACO based on GINA/GOLD guidelines. We hypothesised that ACO-like asthma (ACO-A) would present with positive skin prick tests (SPTs) or early onset of symptoms without a history of tuberculosis (TB), while those with ACO-like COPD (ACO-B) would exhibit negative SPTs and late onset of symptoms and/or a history of TB.</sec><sec id=\"st3\"><title>RESULTS</title>Among 235 patients, the prevalence of asthma, ACO-A, ACO-B, and COPD was respectively 21%, 22%, 17%, and 40%. Allergic history, rhinitis, and childhood asthma were associated with ACO-A, while high cumulative smoking was correlated with ACO-B. Socio-economic and demographic parameters, medical history, clinical features, smoking habits, lung function, and para-clinical investigations significantly differed between \"all asthma\" (i.e., individuals with asthma combined with ACO-A) and \"all COPD\" (i.e., individuals with COPD combined with ACO-B).</sec><sec id=\"st4\"><title>CONCLUSION</title>Based on SPTs, history of TB, and onset age, ACO patients may be defined as people with asthma or COPD.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"287-294"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB prevalence among pregnant women with HIV in Rio de Janeiro, Brazil. 巴西里约热内卢感染艾滋病毒孕妇的结核病发病率。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0487

M A Patel, B Durovni, N Salazar-Austin, S C Cavalcante, J E Golub, R E Chaisson, L H Chaisson, V Saraceni

引用次数: 0

Facilitators and barriers to adolescent participation in a TB clinical trial. 青少年参与结核病临床试验的促进因素和障碍。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0519

J M Mangan, K N C Hedges, M M Salerno, K Tatum, B Bouwkamp, M W Frick, L McKenna, G Muzanyi, M Engle, J Coetzee, J Yvetot, M Elskamp, D Lamunu, M E Theunissen Tizora, D Namutamba, R E Chaisson, S Swindells, P Nahid, S E Dorman, E Kurbatova

{"title":"Facilitators and barriers to adolescent participation in a TB clinical trial.","authors":"J M Mangan, K N C Hedges, M M Salerno, K Tatum, B Bouwkamp, M W Frick, L McKenna, G Muzanyi, M Engle, J Coetzee, J Yvetot, M Elskamp, D Lamunu, M E Theunissen Tizora, D Namutamba, R E Chaisson, S Swindells, P Nahid, S E Dorman, E Kurbatova","doi":"10.5588/ijtld.23.0519","DOIUrl":"10.5588/ijtld.23.0519","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>The inclusion of adolescents in TB drug trials is essential for the development of safe, child-friendly regimens for the prevention and treatment of TB. TB Trials Consortium Study 31/AIDS Clinical Trials Group A5349 (S31/A5349) enrolled adolescents as young as 12 years old. We assessed investigator and coordinator described facilitators and barriers to adolescent recruitment, enrollment, and retention.</sec><sec id=\"st2\"><title>METHODS</title>Interviews were conducted with six investigators from sites that enrolled adolescent participants and six investigators from non-enrolling sites. Additionally, two focus groups were conducted with study coordinators from enrolling sites and two focus groups with non-enrolling sites. Discussions were transcribed, analyzed, summarized, and summaries were reviewed by Community Research Advisors Group members and research group representatives for content validity.</sec><sec id=\"st3\"><title>RESULTS</title>Investigators and coordinators attributed the successful enrollment of adolescents to the establishment and cultivation of external partnerships, flexibility to accommodate adolescents' schedules, staff engagement, recruitment from multiple locations, dedicated recruitment staff working onsite to access potential participants, creation of youth-friendly environments, and effective communications. Non-enrolling sites were mainly hindered by regulations. Suggestions for improvement in future trials focused on study planning and site preparations.</sec><sec id=\"st4\"><title>CONCLUSION</title>Proactive partnerships and collaboration with institutions serving adolescents helped identify and reduce barriers to their inclusion in this trial.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"243-248"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse oximetry has limited utility in identifying potential patients for long-term oxygen therapy. 脉搏血氧仪在确定可能接受长期氧疗的患者方面作用有限。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0491

C J Crooks, J West, J R Morling, M Simmonds, I Juurlink, S Cruickshank, S Briggs, S Hammond-Pears, D Shaw, T R Card, A W Fogarty

引用次数: 0

Factors associated with referrals for directly observed treatment and unsuccessful treatment. 与转诊接受直接观察治疗和治疗不成功相关的因素。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0396

Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet

{"title":"Factors associated with referrals for directly observed treatment and unsuccessful treatment.","authors":"Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet","doi":"10.5588/ijtld.23.0396","DOIUrl":"https://doi.org/10.5588/ijtld.23.0396","url":null,"abstract":"<sec id=\"st1\"><title>OBJECTIVE</title>To describe the characteristics of people indicated for directly observed treatment (DOT) in Spain, and the factors associated with unsuccessful treatment.</sec><sec id=\"st2\"><title>METHODS</title>This was a multicentre observational study based on a prospective follow-up of patients over 18 years old diagnosed with TB between 2006 and 2019 from the registry of the Programa Integrado de Investigación en Tuberculosis (PII-TB). Sociodemographic and clinical variables were collected. Adjusted odds ratios (aORs) were calculated for the indication of DOT and for having an unsuccessful treatment.</sec><sec id=\"st3\"><title>RESULTS</title>A total of 7,883 patients were included. The indication of DOT was associated with being homeless (aOR 5.93, 95% CI 3.03-11.59), inactivity status (aOR 2.55, 95% CI 2.02-3.23), alcohol consumption (aOR 1.94, 95% CI 1.51-2.48), parenteral drug use (aOR 1.77, 95% CI 1.06-2.95) and HIV diagnosis (aOR 1.96, 95% CI 1.16-3.29). Unsuccessful treatment was associated with having an HIV diagnosis (aPR 2.31, 95% CI 1.31-4.08), having a worse clinical and radiological evolution (clinical progression: APR 15.59, 95% CI 8.21-29.60; radiological progression: aPR 12.84, 95% CI 6.46-25.52), need for hospitalisation (aPR 1.73, 95% CI 1.10-2.73), unsatisfactory tolerability (aPR 2.82, 95% CI 1.49-5.29), the existence of difficulties in understanding the prescribed treatment (aPR 1.92, 95% CI 1.21-3.06), as well as worse treatment satisfaction (aPR 7.27, 95% CI 4.32-12.24).</sec><sec id=\"st4\"><title>CONCLUSION</title>The prioritisation of vulnerable populations is a key aspect to carry out the new Global Plan to End TB 2023-2030. In these groups DOT indication should be increased to ensure adherence and patient follow-up and outcomes.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"237-242"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha-1 deficiency in severe asthma patients. 严重哮喘患者的α-1 缺乏症。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0493

M Zappa, S Grossi, P Pignatti, L Pini, R Centis, G B Migliori, F Ardesi, G Sotgiu, A G Corsico, A Spanevello, D Visca

{"title":"Alpha-1 deficiency in severe asthma patients.","authors":"M Zappa, S Grossi, P Pignatti, L Pini, R Centis, G B Migliori, F Ardesi, G Sotgiu, A G Corsico, A Spanevello, D Visca","doi":"10.5588/ijtld.23.0493","DOIUrl":"https://doi.org/10.5588/ijtld.23.0493","url":null,"abstract":"<sec id=\"st1\"><title>INTRODUCTION</title>Alpha-1 antitrypsin (AAT) deficiency, an autosomal co-dominant condition, decreases protein concentration and activity at both serum and tissue levels. Few studies investigated whether the type of SERPINA1 gene phenotype in patients with severe asthma can influence symptoms and disease control during follow-up.</sec><sec id=\"st2\"><title>OBJECTIVE</title>To assess whether the presence of a non-MM genotype of SERPINA1 in patients with severe asthma is associated with disease control, systemic and airway inflammation, lung function and comorbidities prevalence compared to severe asthma patients with a homozygous genotype (MM).</sec><sec id=\"st3\"><title>METHODS</title>Asthmatic patients belonging to Global Initiative for Asthma (GINA) step 5 were retrospectively analysed in an Italian reference asthma clinic. We collected clinical, biological and functional variables at baseline and for the three following years.</sec><sec id=\"st4\"><title>RESULTS</title>Out of 73 patients enrolled, 14 (19.18%) were non-MM and 59 (80.8%) were MM. Asthmatics with non-MM genotype had lower serum AAT concentration (P = 0.004) and higher emphysema prevalence than the MM group (P = 0.003) at baseline. During follow up, only MM patients showed a significant improvement of both ACQ-6 score (P < 0.0001) and eosinophilic systemic inflammation (P < 0.0001).</sec><sec id=\"st5\"><title>CONCLUSIONS</title>Our findings emphasise the importance of a screening for AAT deficiency in severe asthma, as alleles mutation may influence patient's follow-up.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"225-230"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of TB cases without documented sputum culture in the United States, 2011-2021. 2011-2021 年美国无痰培养记录肺结核病例的特征。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0432

L H Rautman, J S Kammerer, B J Silk, V C Marconi, M E Youngblood, J A Edwards, J M Wortham, J L Self

{"title":"Characteristics of TB cases without documented sputum culture in the United States, 2011-2021.","authors":"L H Rautman, J S Kammerer, B J Silk, V C Marconi, M E Youngblood, J A Edwards, J M Wortham, J L Self","doi":"10.5588/ijtld.23.0432","DOIUrl":"10.5588/ijtld.23.0432","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Culture-based diagnostics are the gold standard for diagnosing pulmonary TB (PTB). We characterized culture practices by comparing cases with documented sputum culture to those without.</sec><sec id=\"st2\"><title>METHODS</title>Using multivariable logistic regression, we examined associations between PTB case characteristics and no documented sputum culture reported to the U.S. National TB Surveillance System during 2011-2021.</sec><sec id=\"st3\"><title>RESULTS</title>Among 69,538 PTB cases analyzed, no sputum culture attempt was documented for 5,869 (8%). Non-sputum culture specimens were documented for 54%, 80%, and 89% of cases without documented sputum culture attempts among persons aged <15 years, 15-64, and 65+ years, respectively; bronchial fluid and lung tissue were common non-sputum specimens among cases in persons >15 years old. Having no documented sputum culture was associated with age <15 years (aOR 23.84, 99% CI 20.09-28.27) or ≥65 years (aOR 1.22, 99% CI 1.07-1.39), culture of a non-sputum specimen (aOR 6.57, 99% CI 5.93-7.28), residence in a long-term care facility (aOR 1.58, 99% CI 1.23-2.01), and receiving TB care outside of a health department (aOR 1.79, 99% CI 1.61-1.98).</sec><sec id=\"st4\"><title>CONCLUSIONS</title>Inability to obtain sputum from children and higher diagnostic suspicion for disease processes that require tissue-based diagnostics could explain these findings.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"231-236"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11103590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with patient delay in the diagnosis of TB - a study of health-seeking behaviour. 肺结核患者延误诊断的相关因素--一项关于寻求健康行为的研究。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0502

M S Marques, T Silva, A Gomes, C Pereira, M Pinto, A Aguiar, R Duarte

引用次数: 0

Acceptability of clofazimine capsules in children and adolescents with rifampicin-resistant TB. 耐利福平结核病儿童和青少年对氯唑明胶囊的接受程度。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0517

D T Wademan, Z Saule, A Marthinus, L Viljoen, E Nortier, J Hughes, I Courtney, M Palmer, A J Garcia-Prats, A C Hesseling, G Hoddinott

引用次数: 0