International Journal of Tuberculosis and Lung Disease最新文献

Approaches and processes for paediatric chest X-ray classification used in the SHINE TB treatment-shortening trial. SHINE 结核病缩短治疗试验中使用的儿科胸部 X 光片分类方法和流程。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-11-01 DOI: 10.5588/ijtld.24.0076

M Palmer, M M van der Zalm, H S Schaaf, P Goussard, J Morrison, J A Seddon, S Hissar, D Baskaran, A Kinikar, P Raichur, E Wobudeya, C Chabala, K Lebeau, A M Crook, A Turkova, D Gibb, A C Hesseling

{"title":"Approaches and processes for paediatric chest X-ray classification used in the SHINE TB treatment-shortening trial.","authors":"M Palmer, M M van der Zalm, H S Schaaf, P Goussard, J Morrison, J A Seddon, S Hissar, D Baskaran, A Kinikar, P Raichur, E Wobudeya, C Chabala, K Lebeau, A M Crook, A Turkova, D Gibb, A C Hesseling","doi":"10.5588/ijtld.24.0076","DOIUrl":"10.5588/ijtld.24.0076","url":null,"abstract":"<sec><title>INTRODUCTION</title>SHINE (Shorter Treatment for Minimal Tuberculosis in Children) was the first Phase 3 paediatric TB treatment-shortening trial. Robust chest X-ray (CXR) classification methods were integral to excluding severe disease for trial eligibility and to retrospectively adjudicating TB status at baseline. We describe and critically evaluate the CXR classification approaches and processes used in the SHINE trial.</sec><sec><title>METHODS</title>Children with non-severe TB were randomised to 4- vs 6-months anti-TB treatment. Radiologically non-severe TB was defined on CXR. CXRs were systematically interpreted by on-site clinicians prospectively for eligibility determination and retrospectively by experts to inform adjudication of baseline TB status and disease severity.</sec><sec><title>RESULTS</title>A screening CXR was successfully obtained from all 1,204 enrolled children; 1,134 CXRs from children with intra-thoracic TB were reviewed by expert readers. Compared with the expert panel, enrolling clinicians classified more CXRs as abnormal and 'typical TB' and all as radiologically non-severe. The expert panel retrospectively classified 71/1,134 (6%) CXRs as severe. Of these, 4 (5.6%) had unfavourable outcomes compared with 34 (3.0%) in the trial overall.</sec><sec><title>DISCUSSION</title>Using CXRs to classify radiological disease severity and inform eligibility decisions in real-time by local enrolling clinicians was feasible and safe in this large paediatric TB trial. Retrospective central expert CXR review was successful. Refinement of the CXR methods for the classification of both disease severity and TB status could support standardised implementation in routine care and research.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clearing the air: microcosting the carbon impact of drug-susceptible pulmonary TB treatment. 清除空气：对药物敏感性肺结核治疗的碳影响进行微成本计算。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0157

M F Martins, M R Dauphinais, A Tabackman, P B Narasimhan, M C Nielsen, N S Miller, A Sahay, M Namachivayam, S Janarthanan, C Palanivel, S Lakshminarayanan, K G Koura, P Sinha

{"title":"Clearing the air: microcosting the carbon impact of drug-susceptible pulmonary TB treatment.","authors":"M F Martins, M R Dauphinais, A Tabackman, P B Narasimhan, M C Nielsen, N S Miller, A Sahay, M Namachivayam, S Janarthanan, C Palanivel, S Lakshminarayanan, K G Koura, P Sinha","doi":"10.5588/ijtld.24.0157","DOIUrl":"https://doi.org/10.5588/ijtld.24.0157","url":null,"abstract":"<sec><title>BACKGROUND</title>More than 10 million individuals develop active TB each year. The diagnosis and treatment of TB create greenhouse gas emissions, contributing to climate change. This study estimates the carbon footprint (CF) of successfully treating one person with drug-susceptible pulmonary TB (DS-PTB) in India.</sec><sec><title>METHODS</title>We defined the cascade of care for DS-PTB using national guidelines, interviews, and direct observation. We estimated the inputs for TB diagnosis and treatment in United States dollars, kilowatts per hour, and kilometres travelled; we converted them into carbon dioxide emissions equivalents (CO₂e) using an appropriate calculator.</sec><sec><title>RESULTS</title>The CF of diagnosing and treating one person with DS-PTB in India is 103.8 kg CO₂e: 31.9% attributable to diagnosis and 68.1% to treatment. Emissions came primarily from first-line drugs (21.2%), hospitalisations (17.4%), and laboratory processes.</sec><sec><title>CONCLUSION</title>We conservatively estimate that treating all persons with TB in India would produce at least 290,640 metric tonnes of CO₂e per year, approximately the same emissions as 63,182 passenger cars in the United States. It is evident that one of India's leading public health challenges also contributes meaningfully to climate change.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-genome sequencing drug susceptibility testing is associated with positive MDR-TB treatment response. 全基因组测序药物敏感性检测与阳性 MDR-TB 治疗反应相关。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0052

L Larsson, C Corbett, G Kalmambetova, C Utpatel, S Ahmedov, U Antonenka, A Iskakova, A Kadyrov, T A Kohl, V Barilar, E Sahalchyk, S Niemann, H Hoffmann, K Kranzer

{"title":"Whole-genome sequencing drug susceptibility testing is associated with positive MDR-TB treatment response.","authors":"L Larsson, C Corbett, G Kalmambetova, C Utpatel, S Ahmedov, U Antonenka, A Iskakova, A Kadyrov, T A Kohl, V Barilar, E Sahalchyk, S Niemann, H Hoffmann, K Kranzer","doi":"10.5588/ijtld.24.0052","DOIUrl":"https://doi.org/10.5588/ijtld.24.0052","url":null,"abstract":"<sec><title>BACKGROUND</title>Until recently, multidrug-resistant TB (MDR-TB) was treated with lengthy and toxic regimens. New three-drug anti-TB regimens raise the question of whether they are sufficiently active for MDR-TB in Central Asia, an MDR-TB hotspot region.</sec><sec><title>METHODS</title>In a cohort of rifampicin-resistant (RR) and MDR-TB patients in the Kyrgyz Republic, we investigated the impact of the number of drugs that were tested susceptible by whole-genome sequencing (WGS) and conventional drug susceptibility testing (DST) and used for treatment on the treatment response, defined as 'matches'. Logistic regressions were performed to assess the effect of having ≥ 4 susceptible drugs in a regimen at baseline and at Month 2 on the treatment response.</sec><sec><title>RESULTS</title>The study included 227 participants with RR/MDR-TB (30.8% female; median age 30.4 years). The age- and sex-adjusted analysis showed an association between a regimen with ≥ 4 WGS matches at baseline (adjusted odds ratio [aOR] 2.10, 95% CI 1.00-4.41). No association was found when using conventional DST to define matches.</sec><sec><title>CONCLUSION</title>Our study confirms that the inclusion of four efficacious anti-TB drugs in an MDR-TB regimen increases the chances of a positive treatment response. Susceptibility of at least four drugs in WGS-DST predicts a positive treatment response.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational transmission of TB infection during autopsy. 尸检过程中肺结核感染的职业传播。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0023

S Colomb, M Tricot, E Baccino, F-X Lesage

引用次数: 0

The impact of the COVID-19 pandemic on TB in a low TB burden setting. 在结核病负担较轻的环境中，COVID-19 大流行对结核病的影响。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0040

A Maldari, M Brigham, T I Emeto, O Adegboye, S Barry

引用次数: 0

Making social protection a reality for people with TB: a perspective on new global guidance. 为肺结核患者实现社会保护：对新全球指南的看法。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0361

L Vanleeuw, M Sanchez, R Forse, W Zembe-Mkabile, S Atkins, T Wingfield

引用次数: 0

Nationwide evaluation of treatment outcomes and survival of patients with non-tuberculous mycobacterial pulmonary disease. 对非结核分枝杆菌肺病患者的治疗效果和存活率进行全国性评估。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0068

M J Makek, G Glodic, I Sabol, L Zmak, M Samarzija, A Sola, A Marusic, I Marekovic, L K Bulat, L Corak, M Obrovac, J van Ingen

{"title":"Nationwide evaluation of treatment outcomes and survival of patients with non-tuberculous mycobacterial pulmonary disease.","authors":"M J Makek, G Glodic, I Sabol, L Zmak, M Samarzija, A Sola, A Marusic, I Marekovic, L K Bulat, L Corak, M Obrovac, J van Ingen","doi":"10.5588/ijtld.24.0068","DOIUrl":"https://doi.org/10.5588/ijtld.24.0068","url":null,"abstract":"<sec><title>BACKGROUND</title>Treatment outcomes and long-term survival of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in a real-world setting are difficult to assess, especially for species other than Mycobacterium avium complex (MAC).</sec><sec><title>METHODS</title>This was a retrospective cohort study on all Croatian residents with respiratory NTM isolates from 2006 to 2015, with follow-up to 2020.</sec><sec><title>RESULTS</title>Therapy was started in 98/137 (71.5%) of patients, significantly more often in patients with fibrocavitary disease and/or sputum smear positivity. Unsuccessful treatment outcomes were recorded in 39/98 (39.8%) patients (14 deaths and 25 treatment failures). One-year and 5-year all-cause mortality were respectively 18.2% and 37.6%. Guideline-based treatment (GBT) was started in 50/98 (51%) of treated patients and followed for the recommended duration in 35.7% (35/98). This resulted in a higher chance of cure (OR 3.79, 95% CI 1.29 to 11.1; P = 0.012) than inadequately treated/untreated patients. For Mycobacterium xenopi disease, high cure rates (>80%) were achieved both with GBT and non-GBT treatment regimens.</sec><sec><title>CONCLUSION</title>Guideline-based therapy resulted in a four-time higher chance of being cured. The impact of GBT on treatment outcomes was clear for MAC disease, but no apparent effect was observed for patients with M. xenopi disease.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cavitary lung lesions and quality of life after TB. 肺空洞病变与肺结核后的生活质量

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.23.0590

N Smirnova, C S Bryan, A D Salindri, T Avaliani, L Goginashvili, M Gujabidze, R R Kempker, H Kornfeld, S C Auld, S Vashakidze, Z Avaliani, D Kavalieratos, M Kipiani, M J Magee

引用次数: 0

Health status of Italian children living close to cultivations sprayed with pesticides. 生活在喷洒过杀虫剂的农田附近的意大利儿童的健康状况。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0104

G Sarno, S Maio, S Baldacci, I Stanisci, A Angino, S Tagliaferro, P Silvi, G Viegi

{"title":"Health status of Italian children living close to cultivations sprayed with pesticides.","authors":"G Sarno, S Maio, S Baldacci, I Stanisci, A Angino, S Tagliaferro, P Silvi, G Viegi","doi":"10.5588/ijtld.24.0104","DOIUrl":"https://doi.org/10.5588/ijtld.24.0104","url":null,"abstract":"<sec><title>BACKGROUND</title>Pesticides are used to control pests, but they are toxic and may severely harm children's health. We assessed health outcomes in Italian children living close to cultivations sprayed with pesticides.</sec><sec><title>METHODS</title>In 2011-2012, 2,367 schoolchildren (6-14 years) living in eight Italian cities participated in the Indoor-School observational study. Parents filled in a standardised questionnaire on children's health and related risk factors. Children were classified as exposed to pesticides if living close to cultivations sprayed with pesticides. The association between the last three months of respiratory, allergic or systemic symptoms and pesticide exposure was assessed by multinomial logistic regression models, accounting for host/environmental risk factors.</sec><sec><title>RESULTS</title>Overall, 14% of children were exposed to pesticides, with significant differences among geographical areas: 21.2% in Northern Italy, 11.6% in Central Italy, and 9.7% in Southern Italy. Pesticide exposure was significantly associated with having: 1) 'often': eye symptoms (OR 3.81, 95% CI 2.06-7.05), skin symptoms (OR 2.60, 95% CI 1.34-5.03), lower airway symptoms (OR 2.38, 95% CI 1.41-4.01), systemic symptoms (OR 1.56, 95% CI 0.96-2.53, borderline); 2) 'daily': upper airways symptoms (OR 2.25, 95% CI 1.25-4.07) and systemic symptoms (OR 2.76, 95% CI 1.43-5.34).</sec><sec><title>CONCLUSIONS</title>Self-reported pesticide exposure was associated with respiratory, allergic or systemic symptoms in children. Public authorities should be aware of and intervene to mitigate this health risk.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of testing face-mask filter samples with LAMP shows high rates of detection in pulmonary TB. 用 LAMP 检测面罩过滤器样本的评估显示，肺结核的检出率很高。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0190

T Kodama, K Chikamatsu, K Kamada, K Mizuno, Y Morishige, Y Igarashi, A Osugi, A Aono, Y Murase, M Okumura, T Yoshiyama, A Takaki, S Mitarai

{"title":"Evaluation of testing face-mask filter samples with LAMP shows high rates of detection in pulmonary TB.","authors":"T Kodama, K Chikamatsu, K Kamada, K Mizuno, Y Morishige, Y Igarashi, A Osugi, A Aono, Y Murase, M Okumura, T Yoshiyama, A Takaki, S Mitarai","doi":"10.5588/ijtld.24.0190","DOIUrl":"https://doi.org/10.5588/ijtld.24.0190","url":null,"abstract":"<sec><title>BACKGROUND</title>Detection of Mycobacterium tuberculosis (MTB) in bioaerosols derived from patients with active pulmonary TB is a potential alternative diagnostic method for patients with presumed TB who cannot expectorate sputum.</sec><sec><title>OBJECTIVE</title>To assess the efficacy of a bioaerosol particle collection method to capture MTB and diagnose TB.</sec><sec><title>METHODS</title>A mask-like filter holder (3D mask) with a water-soluble gelatine filter (GF) and one containing a water-insoluble polypropylene filter (PPF) were prepared. Eligible patients wore the 3D mask with GF or PPF within 3 days of starting anti-TB drugs. The GF and PPF filters were collected after 2 and 8 h. DNA was extracted from the filter samples and tested using loop-mediated isothermal amplification (LAMP).</sec><sec><title>RESULTS</title>Filter samples were collected from 57 and 20 patients with and without active pulmonary TB, respectively. The GF and PPF sensitivity was 76.2% and 83.3%, respectively. The specificity of both methods was 100%. Of the 57 patients diagnosed with non-expectorated sputum samples, including suction phlegm, gastric lavage, and bronchial lavage fluid, 55.6% and 50.0% were positive by GF and PPF, respectively.</sec><sec><title>CONCLUSION</title>We present a 3D mask filter sampling method for exhaled bioaerosol particles that can be used in clinical practice to diagnose patients with presumed TB.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0