International Journal of Tuberculosis and Lung Disease最新文献_第2页

TB outpatient care in a high-income, low-incidence country. 一个高收入、低发病率国家的结核病门诊护理。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-10-01 DOI: 10.5588/ijtld.24.0059

N Riccardi, C Monari, R M Antonello, L Saderi, S Occhineri, A Pontarelli, P Zucchi, D Buonsenso, E Falbo, P Faverio, S Aliberti, R Parrella, M Falcone, G Besozzi, A Calcagno, D Goletti, G Gualano, G Sotgiu, M Tadolini, L Codecasa

引用次数: 0

Cold temperatures during sample transportation may cause false-negative interferon-γ release assays used to diagnose TB infection. 样本运输过程中的低温可能会导致用于诊断肺结核感染的干扰素-γ 释放检测出现假阴性。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.24.0020

K Takeda, H Nagai, M Kawashima, I Kosai, M Shimozono, K Sato, H Motomura, E Nakano, M Watanabe, T Kato, M Shimada, O Narumoto, M Suzukawa, J Suzuki, K Yamane, Y Sasaki, Y Morio, A Tamura, H Matsui

引用次数: 0

Miliary TB in children and adolescents: a scoping review. 儿童和青少年的传染性结核病：范围界定综述。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.24.0106

D Buonsenso, F Mariani, R Morello, R Song

{"title":"Miliary TB in children and adolescents: a scoping review.","authors":"D Buonsenso, F Mariani, R Morello, R Song","doi":"10.5588/ijtld.24.0106","DOIUrl":"10.5588/ijtld.24.0106","url":null,"abstract":"<sec><title>OBJECTIVE</title>To summarise the available literature regarding clinical presentation, immunological and microbiological diagnosis, treatment, and outcomes of miliary TB in children and adolescents.</sec><sec><title>METHODS</title>Four databases were searched from 1 January 1950 to 31 January 2023. \"Miliary\" and \"disseminated\" TB were the main search concepts.</sec><sec><title>FINDINGS</title>Of 257 studies, 1,883 patients with miliary TB were included. Bacille Calmette-Guérin (BCG) vaccination was confirmed in 223/549 (40.6%) children. Central nervous system (CNS) involvement was reported in 367/924 (39.7%) cases; many of them had no neurological symptoms despite also having abnormal brain imaging. Of 1,112 children with known outcomes, 341 (30.6%) died; mortality was higher in publications before 1995 (41.5%) and in children with CNS involvement (31.9%). TB microbiological confirmation (55.8%) and sensitivity of tuberculin skin test (46.9%) and QuantiFERON Gold (72.4%) were overall low.</sec><sec><title>CONCLUSIONS</title>Evidence is lacking to support best practices for paediatric miliary TB. Whether lumbar puncture (LP) and brain imaging should both be routinely done in miliary TB children, or a step-by-step approach based on initial LP findings, remains unclear. This study should inform policymakers and funding agencies about current significant gaps that need to be addressed by future high-quality studies.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review on the effect of diabetes mellitus on the pharmacokinetics of TB drugs. 糖尿病对结核病药物代谢动力学影响的系统回顾。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.23.0507

M Cevik, A Sturdy, A E Maraolo, B G J Dekkers, O W Akkerman, S H Gillespie, J W C Alffenaar

{"title":"A systematic review on the effect of diabetes mellitus on the pharmacokinetics of TB drugs.","authors":"M Cevik, A Sturdy, A E Maraolo, B G J Dekkers, O W Akkerman, S H Gillespie, J W C Alffenaar","doi":"10.5588/ijtld.23.0507","DOIUrl":"10.5588/ijtld.23.0507","url":null,"abstract":"<sec><title>OBJECTIVES</title>The coexistence of TB and diabetes mellitus (DM) (TB-DM) is associated with an increased risk of treatment failure, death, delayed culture conversion, and drug resistance. Because plasma concentrations may influence clinical outcomes, we evaluated the evidence on the pharmacokinetic (PK) of TB drugs in individuals with DM to guide management.</sec><sec><title>METHODS</title>We performed a systematic review and meta-analysis through searches of major databases from 1946 to 6 July 2023. PROSPERO (CRD42022323566).</sec><sec><title>RESULTS</title>Of 4,173 potentially relevant articles, we identified 16 studies assessing rifampicin (RIF) PK, 9 on isoniazid (INH), 8 on pyrazinamide (PZA), and 3 on ethambutol (EMB). Two studies reported on second-line anti-TB drugs. According to our meta-analysis, RIF time to maximum concentration (Tmax) was significantly prolonged in patients with DM compared with non-DM patients. We found no significant differences for RIF Cmax, area under the curve (AUC) 0-24 or drug concentration at 2 h (C2h), INH C2h, PZA C2h, PZA Tmax, and EMB Tmax. Although RIF C2h was slightly reduced in patients with TB-DM, this finding was not statistically significant.</sec><sec><title>CONCLUSIONS</title>This review comprehensively examines the impact of DM on the PK of TB drugs. We observed significant heterogeneity among the studies. Given the association between lower plasma concentrations and poor clinical outcomes among patients with DM, we recommend a higher dose limit to compensate for the larger body weight of patients with DM.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmatic implications of a sub-national TB prevalence survey in India. 印度次国家级结核病流行率调查对计划的影响。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0456

G Prathiksha, S Selvaraju, K Thiruvengadam, A Frederick, H Murugesan, P Rajendran, K Nagarajan, M Kumar, R Krishnan, P Kumaran, T S Selvavinayagam, C Padmapriyadarsini

{"title":"Programmatic implications of a sub-national TB prevalence survey in India.","authors":"G Prathiksha, S Selvaraju, K Thiruvengadam, A Frederick, H Murugesan, P Rajendran, K Nagarajan, M Kumar, R Krishnan, P Kumaran, T S Selvavinayagam, C Padmapriyadarsini","doi":"10.5588/ijtld.23.0456","DOIUrl":"https://doi.org/10.5588/ijtld.23.0456","url":null,"abstract":"<sec><title>BACKGROUND</title>Subnational TB estimates are crucial for making informed decisions to tailor TB control activities to local TB epidemiology.</sec><sec><title>METHODS</title>A cross-sectional survey was conducted among 143,005 individuals in Tamil Nadu, India. Participants were screened for symptoms and underwent chest X-ray (CXR). Participants with symptoms of TB and/or abnormal CXR were tested for TB using Xpert, smear, and liquid culture.</sec><sec><title>RESULTS</title>The prevalence of microbiologically confirmed pulmonary TB (MCPTB) was 212 (95% CI 184-239) per 100,000 population. The prevalence-to-notification ratio (P:N) in the state was 2.05 (95% CI 1.8-2.29). Low body mass index and diabetes together had a population attributable fraction of 54.15 (95% CI 45.68-61.97). Approximately 39% of the TB cases were asymptomatic and were identified only by CXR screening. In the general population, only 26.9% sought care at a health facility among those with symptoms suggestive of TB.</sec><sec><title>CONCLUSION</title>The programme needs to prioritise screening with CXR to potentially detect cases earlier and curtail the transmission and upscale molecular tests in the selected population to increase the yield of case finding. Innovative health education strategies must be devised to address health-seeking behaviour.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from treating drug-resistant TB and how to apply these to drug-susceptible TB. 从治疗耐药性结核病中汲取的经验教训，以及如何将这些经验教训应用于耐药性结核病。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0548

N Godefroy, G Monsel, S Jauréguiberry, B Henry, N Véziris, A Aubry, J Robert, M Jachym, E Caumes, V Pourcher

引用次数: 0

Conjugated hyperbilirubinemia associated with accidental rifapentine overdose. 与意外服用利福喷丁过量有关的结合型高胆红素血症。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0494

M Yohane, F Naufal, A Mendoza-Ticona, E M Svensson, I R Weir, K K Scarsi, D W Haas, G Maartens, J Metcalfe

引用次数: 0

Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. 对饮酒的 HIV 阳性患者进行异烟肼预防性治疗的策略。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0303

A Savinkina, W Muyindike, J A Hahn, N I Emenyonu, R Fatch, C Ngabirano, J Adong, K R Jacobson, B P Linas

{"title":"Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol.","authors":"A Savinkina, W Muyindike, J A Hahn, N I Emenyonu, R Fatch, C Ngabirano, J Adong, K R Jacobson, B P Linas","doi":"10.5588/ijtld.23.0303","DOIUrl":"10.5588/ijtld.23.0303","url":null,"abstract":"<sec><title>BACKGROUND</title>WHO guidance to defer isoniazid preventive therapy (IPT) among those with regular alcohol use because of hepatotoxicity concerns may exclude many people living with HIV (PLWH) at high TB risk in these settings.</sec><sec><title>OBJECTIVE</title>To evaluate hepatotoxicity during TB preventive therapy (TPT) in PLWH who report alcohol use in Uganda over 10 years.</sec><sec><title>METHODS</title>We developed a Markov model of latent TB infection, isoniazid preventive therapy (IPT - a type of TPT), and TB disease using data from the Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT) study. We modeled several treatment scenarios, including no IPT, IPT with liver enzyme monitoring (AST/ALT) during treatment, and IPT with pre-screening using the tuberculin skin test (TST).</sec><sec><title>RESULTS</title>The no IPT scenario had 230 TB deaths/100,000 population over 10 years, which is more than that seen in any IPT scenario. IPT, even with no monitoring, was preferred over no IPT when population TB disease incidence was >50 in 100,000.</sec><sec><title>CONCLUSIONS</title>For PLWH who report alcohol use in high TB burden settings, IPT should be offered, ideally with regular AST/ALT monitoring. However, even if regular monitoring is not possible, IPT is still preferable to no IPT in almost every modeled scenario.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Private pharmacy and community health worker engagement in the provision of TB services. 私营药店和社区保健员参与提供结核病防治服务。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0439

L Semakula, I Kakai, S Zawedde-Muyanja, P Nerima, J Bayigga, M Nansereko, S G Aheebwa, B Castelnuovo, A D Okello, C Oundo, A Ddungu, S Turyahabwe, E Laker, C Sekaggya-Wiltshire

{"title":"Private pharmacy and community health worker engagement in the provision of TB services.","authors":"L Semakula, I Kakai, S Zawedde-Muyanja, P Nerima, J Bayigga, M Nansereko, S G Aheebwa, B Castelnuovo, A D Okello, C Oundo, A Ddungu, S Turyahabwe, E Laker, C Sekaggya-Wiltshire","doi":"10.5588/ijtld.23.0439","DOIUrl":"https://doi.org/10.5588/ijtld.23.0439","url":null,"abstract":"<sec><title>BACKGROUND</title>Engaging private health providers and community healthcare workers (CHWs) in the provision of TB care services can increase TB case notification and limit community transmission. We determined whether private pharmacy and community engagement could affect access to TB diagnostic and treatment services in Uganda.</sec><sec><title>METHODS</title>We conducted a cross-sectional study on patients diagnosed with TB through three different pathways; by private pharmacies, CHWs, and public health facilities. We collected data on patient demographics, time between symptom recognition and TB treatment initiation, and the amount of money spent on TB care seeking.</sec><sec><title>RESULTS</title>We collected data from 325 participants; 65.2% were male, with a mean age of 35 years (SD 11.50). The time in days between the onset of symptoms and initiation of treatment was significantly different: respectively 149 (IQR 65.5-295), 119 (IQR 51-200), and 106.5 (IQR 60-201) days for CHWs, pharmacies, and public facilities (P = 0.04). The longest time was between the first contact with a health provider and the TB diagnosis (51 days, IQR 19-104). Participants diagnosed at public health facilities incurred the highest costs.</sec><sec><title>CONCLUSION</title>Although the use of CHWs and pharmacies did not shorten the TB treatment pathway, the costs incurred were lower than those in private health facilities.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the use of exhaled breath as a diagnostic tool for pulmonary TB. 探索使用呼出的气体作为肺结核的诊断工具。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0411

M Happaerts, N Lorent, E André

引用次数: 0