{"title":"Digital surveillance of ocular toxicity during TB treatment.","authors":"O Dytko, M Park, R Nicholas, R Akshikar, O M Kon","doi":"10.5588/ijtld.23.0500","DOIUrl":"https://doi.org/10.5588/ijtld.23.0500","url":null,"abstract":"","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"360-361"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Suo, M K Kenworthy, J Richards, M L Tay-Kearney, H Farah, R Perera
{"title":"Ocular TB in Western Australia.","authors":"M Suo, M K Kenworthy, J Richards, M L Tay-Kearney, H Farah, R Perera","doi":"10.5588/ijtld.23.0353","DOIUrl":"https://doi.org/10.5588/ijtld.23.0353","url":null,"abstract":"<p><p><sec><title>SETTING</title>This was a retrospective chart review in Western Australia, Australia.</sec><sec><title>OBJECTIVE</title>To describe the diagnosis, management, and treatment outcomes of ocular TB in Western Australia (WA).</sec><sec><title>DESIGN</title>This was a retrospective review of ocular TB cases in WA from 2007 to 2018 with a minimum 2-year follow-up upon completion of anti-TB therapy (ATT).</sec><sec><title>RESULTS</title>A total of 44 patients were referred to WA TB clinic. Ten were excluded from the analysis of treatment response; 34 met the inclusion criteria, of whom 97.1% were born overseas. No patients had symptomatic extraocular TB. Chest X-ray showed prior pulmonary TB in 11.7% of patients (<i>n</i> = 4). All patients were treated with three or four ATT drugs. The most common ocular TB manifestation was retinal vasculitis (23.5%). Full resolution of ocular inflammation following ATT occurred in 66.7% (<i>n</i> = 22), and reduced ocular inflammation requiring only topical steroid treatment was seen in 21.2% (<i>n</i> = 7). Treatment failure occurred in 12.1% (<i>n</i> = 4). Side effects were reported in 45.6% of patients, with gastrointestinal symptoms most common (27.2%).</sec><sec><title>CONCLUSION</title>Our study is the first Australian study examining the management of ocular TB. Our study highlights the challenges in diagnosing TB ocular disease in a low-endemicity setting and the importance of the collaboration between uveitis and TB subspecialists.</sec>.</p>","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"322-327"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Sonaglioni, A Caminati, M Zompatori, R Cassandro, M Colleoni, F Luisi, D Elia, M Lombardo, S Harari
{"title":"TAPSE/sPAP ratio can be used to predict pulmonary hypertension in fibrosing interstitial lung disease.","authors":"A Sonaglioni, A Caminati, M Zompatori, R Cassandro, M Colleoni, F Luisi, D Elia, M Lombardo, S Harari","doi":"10.5588/ijtld.23.0613","DOIUrl":"10.5588/ijtld.23.0613","url":null,"abstract":"","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"362-364"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TB notifications among citizens and non-citizens in Taiwan.","authors":"H-Y Lo, Y-C Huang, P-C Chan, C-C Lee, C-Y Chiang","doi":"10.5588/ijtld.23.0567","DOIUrl":"10.5588/ijtld.23.0567","url":null,"abstract":"<p><p><sec><title>BACKGROUND</title>Substantial under-notification of TB among non-citizens has been noted previously. Foreign workers with TB who were deported previously could stay for anti-TB treatment since 2014. We assessed whether TB notification improved.</sec><sec><title>METHODS</title>We used the National Health Insurance (NHI) reimbursement database to identify potential TB cases that required notification. We matched potential TB cases with the national TB registry to determine whether they had been notified. Cases notified within 7 days of the initiation of anti-TB treatment were classified as having timely notification.</sec><sec><title>RESULTS</title>Of 53,208 potential TB cases identified in 2016-2020, 96.6% had been notified. The notification proportion increased from 95.5% in 2016 to 97.1% in 2020 among citizens and from 89.0% in 2016 to 96.9% in 2020 among non-citizens. Factors significantly associated with non-notification among non-citizens were previously notified TB (aOR 35.5, 95% CI 17.7-70.9), without health insurance (aOR 15.4, 95% CI 9.3-25.2) and having only one visit to health care facilities in 6 months (aOR 2.3, 95% CI 1.4-3.8). The proportion of TB cases notified within 7 days was 87% overall, 86.2% among citizens, and 96.5% among non-citizens.</sec><sec><title>CONCLUSION</title>TB notification has improved, especially among non-citizens, following a policy change that allows foreign workers to stay for anti-TB treatment.</sec>.</p>","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"328-334"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Wordui, A Masu, L Golden, S Chaya, K Reichmuth, A Visagie, A Ayuk, S K Owusu, D Marangu, N Affendi, A Lakhan, D Gray, A Vanker, H J Zar, M Zampoli
{"title":"Aetiology of pleural effusions in children living in a high TB endemic setting.","authors":"S Wordui, A Masu, L Golden, S Chaya, K Reichmuth, A Visagie, A Ayuk, S K Owusu, D Marangu, N Affendi, A Lakhan, D Gray, A Vanker, H J Zar, M Zampoli","doi":"10.5588/ijtld.23.0444","DOIUrl":"https://doi.org/10.5588/ijtld.23.0444","url":null,"abstract":"<p><p><sec id=\"st1\"><title>BACKGROUND</title>Confirming the aetiology of pleural effusion in children may be difficult in TB-endemic settings. We investigated the role of polymerase chain reaction (PCR) and routine biochemical tests in discriminating pleural effusion caused by bacteria from other aetiologies.</sec><sec id=\"st2\"><title>METHODS</title>This is a cross-sectional post-hoc analysis among children with pleural effusion in a tertiary hospital in South Africa, incorporating new data from PCR testing of stored pleural fluid. Aetiological classification was defined by microbiological confirmation.</sec><sec id=\"st3\"><title>RESULTS</title>Ninety-one children were enrolled; the median age 31 months (IQR 12-102). The aetiology of pleural effusion was 40% (36/91) bacteria, 11% (10/91) TB, 3% (3/91) viruses, 11% (10/91) polymicrobial and 35% (32/91) had no pathogen identified. The most common pathogen was <i>Staphylococcus aureus</i> (27/91, 30%) with similar yields on culture and PCR, followed by <i>Streptococcus pneumoniae</i> (12/91, 13%), detected more commonly by PCR. PCR reduced the number of children with unconfirmed aetiologies from 48 to 32. Characteristics of children with no pathogen most resembled those with TB. Pleural fluid lactate dehydrogenase ≥1,716 U/L best discriminated bacterial pleural effusion from other aetiologies (sensitivity of 86%; specificity 95%).</sec><sec id=\"st4\"><title>CONCLUSION</title>PCR improved detection of pathogens and reduced number of children with unconfirmed aetiologies in presumed exudative pleural effusion.</sec>.</p>","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"295-300"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric TB treatment outcomes: targets for improvement.","authors":"S S Chiang, H E Jenkins","doi":"10.5588/ijtld.24.0221","DOIUrl":"https://doi.org/10.5588/ijtld.24.0221","url":null,"abstract":"","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"263-265"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic pulmonary aspergillosis: a neglected post-TB lung disease.","authors":"F Bongomin, D W Denning","doi":"10.5588/ijtld.24.0165","DOIUrl":"10.5588/ijtld.24.0165","url":null,"abstract":"","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"314-315"},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Did public-private partnerships reduce TB incidence in Korea?","authors":"J Min, S Y Kim, J E Park, J-H Park","doi":"10.5588/ijtld.23.0286","DOIUrl":"https://doi.org/10.5588/ijtld.23.0286","url":null,"abstract":"","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"306-308"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J E Phelan, C Utpatel, N Ismail, T Cortes, S Niemann, D M Cirillo, T Schön, P Miotto, C U Köser
{"title":"Careful classification of potential bedaquiline resistance mutations is critical when analysing their clinical impact.","authors":"J E Phelan, C Utpatel, N Ismail, T Cortes, S Niemann, D M Cirillo, T Schön, P Miotto, C U Köser","doi":"10.5588/ijtld.24.0083","DOIUrl":"https://doi.org/10.5588/ijtld.24.0083","url":null,"abstract":"","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"312-313"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Kiwanuka, T Quach, R Kakaire, S Zalwango, M Castellanos, J Sekandi, C C Whalen
{"title":"Incidence of tuberculous infection in a TB-endemic city.","authors":"N Kiwanuka, T Quach, R Kakaire, S Zalwango, M Castellanos, J Sekandi, C C Whalen","doi":"10.5588/ijtld.23.0403","DOIUrl":"10.5588/ijtld.23.0403","url":null,"abstract":"<p><p><sec id=\"st1\"><title>BACKGROUND</title>Current metrics for TB transmission include TB notifications, disease mortality, and prevalence surveys. These metrics are helpful to national TB programs to assess the burden of disease, but they do not directly measure incident infection in the community.</sec><sec id=\"st2\"><title>METHODS</title>To estimate incidence of <i>Mycobacterium tuberculosis</i> infection in Kampala, Uganda, we performed a prospective cohort study between 2014 and 2017 which enrolled of 1,275 adult residents without signs of tuberculous infection (tuberculin skin test [TST] <5 mm and no signs of TB disease) and followed them for conversion of TST at 1 year.</sec><sec id=\"st3\"><title>RESULTS</title>During follow-up, 194 participants converted the TST and 158 converted by one year. The incidence density of TST conversion was 13.2 conversions/100 person-year (95% CI 11.6-15.1), which corresponds to an annual cumulative incidence of tuberculous infection of 12.4% (95% CI 10.7-14.3). Cumulative incidence was greater among older participants and among men. Among participants who reported prior exposure to TB cases, the cumulative risk was highest among those reporting exposure during follow-up.</sec><sec id=\"st4\"><title>CONCLUSIONS</title>The high annual incidence of infection suggests that residents of Kampala have adequate contact for infection with undetected, infectious cases of TB as they go about their daily lives.</sec>.</p>","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"266-272"},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11337811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}