International Journal of Tuberculosis and Lung Disease最新文献_第4页

Outcomes of childhood TB in countries with a universal BCG vaccination policy. 实行卡介苗接种普及政策的国家的儿童结核病发病率。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0321

J V Dias, L Varandas, L Gonçalves, B Kagina

{"title":"Outcomes of childhood TB in countries with a universal BCG vaccination policy.","authors":"J V Dias, L Varandas, L Gonçalves, B Kagina","doi":"10.5588/ijtld.23.0321","DOIUrl":"10.5588/ijtld.23.0321","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>TB remains an important cause of childhood morbidity and mortality. Underdiagnosis, underreporting and limited data on the outcomes of childhood TB have led to an underestimation of its impact.</sec><sec id=\"st2\"><title>METHODS</title>This was a systematic review to characterise childhood TB outcomes. Studies reporting relevant epidemiological data on children between 0 and 14 years of age, with a particular focus on treatment outcomes, from countries with universal bacilli Calmette-Guérin (BCG) vaccination and conducted between 2000 and 2020 were selected. Random effects meta-analysis was performed in R software.</sec><sec id=\"st3\"><title>RESULTS</title>We identified 1,806 references and included 35 articles. Among children with TB, the overall proportion of unfavourable outcomes was 19.5% (95% CI 14.4-25.8) and pooled case-fatality ratio was 6.1% (95% CI 4.3-8.4). The proportion of deaths observed among children between 0 and 4 years old was 6.6% (95% CI 4.9-8.7) and 4.6% (95% CI 3.1-6.9) in older children. TB and HIV co-infected children presented a case-fatality ratio of 15.1% (95% CI 7.9-27.0).</sec><sec id=\"st4\"><title>CONCLUSIONS</title>Despite the efforts made in the last decades, treatment outcomes in childhood TB are still worrisome. Efforts to fill existing gaps and design health policies targeting vulnerable populations, such as children, should be intensified to tackle the global TB burden.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"273-277"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB diagnoses and mortality in hospitalized people living with HIV in South Africa. 南非住院艾滋病毒感染者的结核病诊断和死亡率。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0431

K Shearer, E Variava, B Kekana, P Abraham, T Moloantoa, J E Golub, N Martinson, C Hoffmann

引用次数: 0

The clinical impact of heart failure with preserved ejection fraction in interstitial lung diseases. 间质性肺病射血分数保留型心力衰竭的临床影响。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0555

U Zanini, G Ferrara, S Moitra, R Varughese, M Kalluri, J Weatherald

引用次数: 0

An epidemiological analysis of TB trends in native and migrant populations, New Mexico, 1993-2021. 1993-2021 年新墨西哥州原住民和移民人口结核病趋势流行病学分析。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0318

J-M Ramos-Rincon, B Montoya, G Simpson, M Burgos

{"title":"An epidemiological analysis of TB trends in native and migrant populations, New Mexico, 1993-2021.","authors":"J-M Ramos-Rincon, B Montoya, G Simpson, M Burgos","doi":"10.5588/ijtld.23.0318","DOIUrl":"https://doi.org/10.5588/ijtld.23.0318","url":null,"abstract":"<sec id=\"st1\"><title>OBJECTIVES</title>To analyze the epidemiological, demographic, clinical, laboratory, radiographic and treatment outcome trends in non-US-born individuals with TB in New Mexico.</sec><sec id=\"st2\"><title>DESIGNS</title>We retrospectively analyzed TB data from New Mexico TB surveillance system from (1993-2021), comparing variables between non-US-born and US-born individuals.</sec><sec id=\"st3\"><title>RESULTS</title>Of the 1,512 TB cases, 876 (56.5%) were non-US-born and 653 (43.3%) were US-born. The incidence rate among non-US-born patients declined from 15.3/100,000 (1993) to 7.8/100,000 (2021) (54.6% reduction), while among US-born patients it declined from 3.3/100,000 (1993) to 0.5/100,000 (2021) (84.8% reduction). The majority of non-US-born individuals were from Mexico (n = 482, 73.5%). Non-US-born were typically younger adults (median age: 54 vs. 61), predominantly male (64.8% vs. 59.4%), less likely to consume excess alcohol and have extrapulmonary TB. However, they were more likely to exhibit resistance to standard TB drugs (P < 0.01). Non-US-born individuals were less likely to die (7.8% vs. 15.4%), but more likely to be lost to follow-up (P < 0.007). Treatment by providers outside the Department of Health was associated with noncompletion (OR 0.18, 95% CI 0.09-0.35; P < 0.001).</sec><sec id=\"st4\"><title>CONCLUSION</title>These results highlight the need for a detailed understanding of the impact of migration on TB epidemiology and the development of tailored interventions to improve treatment outcomes.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"278-286"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limitations of using tuberculin skin test to screen for TB in patients with psoriasis. 使用结核菌素皮试筛查银屑病患者结核病的局限性。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0497

M M Carvalho, P Barbosa, P Ramos, M Vieira, R Duarte

引用次数: 0

Phenotyping chronic respiratory diseases with airways obstruction. 对气道阻塞的慢性呼吸道疾病进行表型分析。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0383

T C Nguyen, H V T Tran, M H T Tran, I Godin, O Michel

{"title":"Phenotyping chronic respiratory diseases with airways obstruction.","authors":"T C Nguyen, H V T Tran, M H T Tran, I Godin, O Michel","doi":"10.5588/ijtld.23.0383","DOIUrl":"https://doi.org/10.5588/ijtld.23.0383","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Given the high prevalence of asthma-chronic obstructive pulmonary disease overlap (ACO) in Vietnam, there is an urgent need to establish a simplified strategy for categorising patients as either having asthma or chronic obstructive pulmonary disease (COPD). This classification would streamline the application of treatment recommendations outlined by the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD).</sec><sec id=\"st2\"><title>METHODS</title>Patients with obstructive lung function were classified as having COPD, asthma, or ACO based on GINA/GOLD guidelines. We hypothesised that ACO-like asthma (ACO-A) would present with positive skin prick tests (SPTs) or early onset of symptoms without a history of tuberculosis (TB), while those with ACO-like COPD (ACO-B) would exhibit negative SPTs and late onset of symptoms and/or a history of TB.</sec><sec id=\"st3\"><title>RESULTS</title>Among 235 patients, the prevalence of asthma, ACO-A, ACO-B, and COPD was respectively 21%, 22%, 17%, and 40%. Allergic history, rhinitis, and childhood asthma were associated with ACO-A, while high cumulative smoking was correlated with ACO-B. Socio-economic and demographic parameters, medical history, clinical features, smoking habits, lung function, and para-clinical investigations significantly differed between \"all asthma\" (i.e., individuals with asthma combined with ACO-A) and \"all COPD\" (i.e., individuals with COPD combined with ACO-B).</sec><sec id=\"st4\"><title>CONCLUSION</title>Based on SPTs, history of TB, and onset age, ACO patients may be defined as people with asthma or COPD.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"287-294"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB prevalence among pregnant women with HIV in Rio de Janeiro, Brazil. 巴西里约热内卢感染艾滋病毒孕妇的结核病发病率。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0487

M A Patel, B Durovni, N Salazar-Austin, S C Cavalcante, J E Golub, R E Chaisson, L H Chaisson, V Saraceni

引用次数: 0

Facilitators and barriers to adolescent participation in a TB clinical trial. 青少年参与结核病临床试验的促进因素和障碍。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0519

J M Mangan, K N C Hedges, M M Salerno, K Tatum, B Bouwkamp, M W Frick, L McKenna, G Muzanyi, M Engle, J Coetzee, J Yvetot, M Elskamp, D Lamunu, M E Theunissen Tizora, D Namutamba, R E Chaisson, S Swindells, P Nahid, S E Dorman, E Kurbatova

{"title":"Facilitators and barriers to adolescent participation in a TB clinical trial.","authors":"J M Mangan, K N C Hedges, M M Salerno, K Tatum, B Bouwkamp, M W Frick, L McKenna, G Muzanyi, M Engle, J Coetzee, J Yvetot, M Elskamp, D Lamunu, M E Theunissen Tizora, D Namutamba, R E Chaisson, S Swindells, P Nahid, S E Dorman, E Kurbatova","doi":"10.5588/ijtld.23.0519","DOIUrl":"10.5588/ijtld.23.0519","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>The inclusion of adolescents in TB drug trials is essential for the development of safe, child-friendly regimens for the prevention and treatment of TB. TB Trials Consortium Study 31/AIDS Clinical Trials Group A5349 (S31/A5349) enrolled adolescents as young as 12 years old. We assessed investigator and coordinator described facilitators and barriers to adolescent recruitment, enrollment, and retention.</sec><sec id=\"st2\"><title>METHODS</title>Interviews were conducted with six investigators from sites that enrolled adolescent participants and six investigators from non-enrolling sites. Additionally, two focus groups were conducted with study coordinators from enrolling sites and two focus groups with non-enrolling sites. Discussions were transcribed, analyzed, summarized, and summaries were reviewed by Community Research Advisors Group members and research group representatives for content validity.</sec><sec id=\"st3\"><title>RESULTS</title>Investigators and coordinators attributed the successful enrollment of adolescents to the establishment and cultivation of external partnerships, flexibility to accommodate adolescents' schedules, staff engagement, recruitment from multiple locations, dedicated recruitment staff working onsite to access potential participants, creation of youth-friendly environments, and effective communications. Non-enrolling sites were mainly hindered by regulations. Suggestions for improvement in future trials focused on study planning and site preparations.</sec><sec id=\"st4\"><title>CONCLUSION</title>Proactive partnerships and collaboration with institutions serving adolescents helped identify and reduce barriers to their inclusion in this trial.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"243-248"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse oximetry has limited utility in identifying potential patients for long-term oxygen therapy. 脉搏血氧仪在确定可能接受长期氧疗的患者方面作用有限。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0491

C J Crooks, J West, J R Morling, M Simmonds, I Juurlink, S Cruickshank, S Briggs, S Hammond-Pears, D Shaw, T R Card, A W Fogarty

引用次数: 0

Factors associated with referrals for directly observed treatment and unsuccessful treatment. 与转诊接受直接观察治疗和治疗不成功相关的因素。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0396

Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet

{"title":"Factors associated with referrals for directly observed treatment and unsuccessful treatment.","authors":"Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet","doi":"10.5588/ijtld.23.0396","DOIUrl":"https://doi.org/10.5588/ijtld.23.0396","url":null,"abstract":"<sec id=\"st1\"><title>OBJECTIVE</title>To describe the characteristics of people indicated for directly observed treatment (DOT) in Spain, and the factors associated with unsuccessful treatment.</sec><sec id=\"st2\"><title>METHODS</title>This was a multicentre observational study based on a prospective follow-up of patients over 18 years old diagnosed with TB between 2006 and 2019 from the registry of the Programa Integrado de Investigación en Tuberculosis (PII-TB). Sociodemographic and clinical variables were collected. Adjusted odds ratios (aORs) were calculated for the indication of DOT and for having an unsuccessful treatment.</sec><sec id=\"st3\"><title>RESULTS</title>A total of 7,883 patients were included. The indication of DOT was associated with being homeless (aOR 5.93, 95% CI 3.03-11.59), inactivity status (aOR 2.55, 95% CI 2.02-3.23), alcohol consumption (aOR 1.94, 95% CI 1.51-2.48), parenteral drug use (aOR 1.77, 95% CI 1.06-2.95) and HIV diagnosis (aOR 1.96, 95% CI 1.16-3.29). Unsuccessful treatment was associated with having an HIV diagnosis (aPR 2.31, 95% CI 1.31-4.08), having a worse clinical and radiological evolution (clinical progression: APR 15.59, 95% CI 8.21-29.60; radiological progression: aPR 12.84, 95% CI 6.46-25.52), need for hospitalisation (aPR 1.73, 95% CI 1.10-2.73), unsatisfactory tolerability (aPR 2.82, 95% CI 1.49-5.29), the existence of difficulties in understanding the prescribed treatment (aPR 1.92, 95% CI 1.21-3.06), as well as worse treatment satisfaction (aPR 7.27, 95% CI 4.32-12.24).</sec><sec id=\"st4\"><title>CONCLUSION</title>The prioritisation of vulnerable populations is a key aspect to carry out the new Global Plan to End TB 2023-2030. In these groups DOT indication should be increased to ensure adherence and patient follow-up and outcomes.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"237-242"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0