International Journal of Tuberculosis and Lung Disease最新文献_第5页

Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. 对饮酒的 HIV 阳性患者进行异烟肼预防性治疗的策略。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0303

A Savinkina, W Muyindike, J A Hahn, N I Emenyonu, R Fatch, C Ngabirano, J Adong, K R Jacobson, B P Linas

{"title":"Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol.","authors":"A Savinkina, W Muyindike, J A Hahn, N I Emenyonu, R Fatch, C Ngabirano, J Adong, K R Jacobson, B P Linas","doi":"10.5588/ijtld.23.0303","DOIUrl":"10.5588/ijtld.23.0303","url":null,"abstract":"<sec><title>BACKGROUND</title>WHO guidance to defer isoniazid preventive therapy (IPT) among those with regular alcohol use because of hepatotoxicity concerns may exclude many people living with HIV (PLWH) at high TB risk in these settings.</sec><sec><title>OBJECTIVE</title>To evaluate hepatotoxicity during TB preventive therapy (TPT) in PLWH who report alcohol use in Uganda over 10 years.</sec><sec><title>METHODS</title>We developed a Markov model of latent TB infection, isoniazid preventive therapy (IPT - a type of TPT), and TB disease using data from the Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT) study. We modeled several treatment scenarios, including no IPT, IPT with liver enzyme monitoring (AST/ALT) during treatment, and IPT with pre-screening using the tuberculin skin test (TST).</sec><sec><title>RESULTS</title>The no IPT scenario had 230 TB deaths/100,000 population over 10 years, which is more than that seen in any IPT scenario. IPT, even with no monitoring, was preferred over no IPT when population TB disease incidence was >50 in 100,000.</sec><sec><title>CONCLUSIONS</title>For PLWH who report alcohol use in high TB burden settings, IPT should be offered, ideally with regular AST/ALT monitoring. However, even if regular monitoring is not possible, IPT is still preferable to no IPT in almost every modeled scenario.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"335-342"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Private pharmacy and community health worker engagement in the provision of TB services. 私营药店和社区保健员参与提供结核病防治服务。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0439

L Semakula, I Kakai, S Zawedde-Muyanja, P Nerima, J Bayigga, M Nansereko, S G Aheebwa, B Castelnuovo, A D Okello, C Oundo, A Ddungu, S Turyahabwe, E Laker, C Sekaggya-Wiltshire

{"title":"Private pharmacy and community health worker engagement in the provision of TB services.","authors":"L Semakula, I Kakai, S Zawedde-Muyanja, P Nerima, J Bayigga, M Nansereko, S G Aheebwa, B Castelnuovo, A D Okello, C Oundo, A Ddungu, S Turyahabwe, E Laker, C Sekaggya-Wiltshire","doi":"10.5588/ijtld.23.0439","DOIUrl":"https://doi.org/10.5588/ijtld.23.0439","url":null,"abstract":"<sec><title>BACKGROUND</title>Engaging private health providers and community healthcare workers (CHWs) in the provision of TB care services can increase TB case notification and limit community transmission. We determined whether private pharmacy and community engagement could affect access to TB diagnostic and treatment services in Uganda.</sec><sec><title>METHODS</title>We conducted a cross-sectional study on patients diagnosed with TB through three different pathways; by private pharmacies, CHWs, and public health facilities. We collected data on patient demographics, time between symptom recognition and TB treatment initiation, and the amount of money spent on TB care seeking.</sec><sec><title>RESULTS</title>We collected data from 325 participants; 65.2% were male, with a mean age of 35 years (SD 11.50). The time in days between the onset of symptoms and initiation of treatment was significantly different: respectively 149 (IQR 65.5-295), 119 (IQR 51-200), and 106.5 (IQR 60-201) days for CHWs, pharmacies, and public facilities (P = 0.04). The longest time was between the first contact with a health provider and the TB diagnosis (51 days, IQR 19-104). Participants diagnosed at public health facilities incurred the highest costs.</sec><sec><title>CONCLUSION</title>Although the use of CHWs and pharmacies did not shorten the TB treatment pathway, the costs incurred were lower than those in private health facilities.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"343-347"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the use of exhaled breath as a diagnostic tool for pulmonary TB. 探索使用呼出的气体作为肺结核的诊断工具。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0411

M Happaerts, N Lorent, E André

引用次数: 0

Digital surveillance of ocular toxicity during TB treatment. 在结核病治疗期间对眼部毒性进行数字化监控。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0500

O Dytko, M Park, R Nicholas, R Akshikar, O M Kon

引用次数: 0

Ocular TB in Western Australia. 西澳大利亚州的眼结核病。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0353

M Suo, M K Kenworthy, J Richards, M L Tay-Kearney, H Farah, R Perera

{"title":"Ocular TB in Western Australia.","authors":"M Suo, M K Kenworthy, J Richards, M L Tay-Kearney, H Farah, R Perera","doi":"10.5588/ijtld.23.0353","DOIUrl":"https://doi.org/10.5588/ijtld.23.0353","url":null,"abstract":"<sec><title>SETTING</title>This was a retrospective chart review in Western Australia, Australia.</sec><sec><title>OBJECTIVE</title>To describe the diagnosis, management, and treatment outcomes of ocular TB in Western Australia (WA).</sec><sec><title>DESIGN</title>This was a retrospective review of ocular TB cases in WA from 2007 to 2018 with a minimum 2-year follow-up upon completion of anti-TB therapy (ATT).</sec><sec><title>RESULTS</title>A total of 44 patients were referred to WA TB clinic. Ten were excluded from the analysis of treatment response; 34 met the inclusion criteria, of whom 97.1% were born overseas. No patients had symptomatic extraocular TB. Chest X-ray showed prior pulmonary TB in 11.7% of patients (n = 4). All patients were treated with three or four ATT drugs. The most common ocular TB manifestation was retinal vasculitis (23.5%). Full resolution of ocular inflammation following ATT occurred in 66.7% (n = 22), and reduced ocular inflammation requiring only topical steroid treatment was seen in 21.2% (n = 7). Treatment failure occurred in 12.1% (n = 4). Side effects were reported in 45.6% of patients, with gastrointestinal symptoms most common (27.2%).</sec><sec><title>CONCLUSION</title>Our study is the first Australian study examining the management of ocular TB. Our study highlights the challenges in diagnosing TB ocular disease in a low-endemicity setting and the importance of the collaboration between uveitis and TB subspecialists.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"322-327"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TAPSE/sPAP ratio can be used to predict pulmonary hypertension in fibrosing interstitial lung disease. TAPSE/sPAP 比值可用于预测纤维化间质性肺病的肺动脉高压。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0613

A Sonaglioni, A Caminati, M Zompatori, R Cassandro, M Colleoni, F Luisi, D Elia, M Lombardo, S Harari

引用次数: 0

TB notifications among citizens and non-citizens in Taiwan. 台湾公民和非公民的结核病通报。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0567

H-Y Lo, Y-C Huang, P-C Chan, C-C Lee, C-Y Chiang

{"title":"TB notifications among citizens and non-citizens in Taiwan.","authors":"H-Y Lo, Y-C Huang, P-C Chan, C-C Lee, C-Y Chiang","doi":"10.5588/ijtld.23.0567","DOIUrl":"10.5588/ijtld.23.0567","url":null,"abstract":"<sec><title>BACKGROUND</title>Substantial under-notification of TB among non-citizens has been noted previously. Foreign workers with TB who were deported previously could stay for anti-TB treatment since 2014. We assessed whether TB notification improved.</sec><sec><title>METHODS</title>We used the National Health Insurance (NHI) reimbursement database to identify potential TB cases that required notification. We matched potential TB cases with the national TB registry to determine whether they had been notified. Cases notified within 7 days of the initiation of anti-TB treatment were classified as having timely notification.</sec><sec><title>RESULTS</title>Of 53,208 potential TB cases identified in 2016-2020, 96.6% had been notified. The notification proportion increased from 95.5% in 2016 to 97.1% in 2020 among citizens and from 89.0% in 2016 to 96.9% in 2020 among non-citizens. Factors significantly associated with non-notification among non-citizens were previously notified TB (aOR 35.5, 95% CI 17.7-70.9), without health insurance (aOR 15.4, 95% CI 9.3-25.2) and having only one visit to health care facilities in 6 months (aOR 2.3, 95% CI 1.4-3.8). The proportion of TB cases notified within 7 days was 87% overall, 86.2% among citizens, and 96.5% among non-citizens.</sec><sec><title>CONCLUSION</title>TB notification has improved, especially among non-citizens, following a policy change that allows foreign workers to stay for anti-TB treatment.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"328-334"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aetiology of pleural effusions in children living in a high TB endemic setting. 结核病高发地区儿童胸腔积液的病因。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.23.0444

S Wordui, A Masu, L Golden, S Chaya, K Reichmuth, A Visagie, A Ayuk, S K Owusu, D Marangu, N Affendi, A Lakhan, D Gray, A Vanker, H J Zar, M Zampoli

{"title":"Aetiology of pleural effusions in children living in a high TB endemic setting.","authors":"S Wordui, A Masu, L Golden, S Chaya, K Reichmuth, A Visagie, A Ayuk, S K Owusu, D Marangu, N Affendi, A Lakhan, D Gray, A Vanker, H J Zar, M Zampoli","doi":"10.5588/ijtld.23.0444","DOIUrl":"https://doi.org/10.5588/ijtld.23.0444","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Confirming the aetiology of pleural effusion in children may be difficult in TB-endemic settings. We investigated the role of polymerase chain reaction (PCR) and routine biochemical tests in discriminating pleural effusion caused by bacteria from other aetiologies.</sec><sec id=\"st2\"><title>METHODS</title>This is a cross-sectional post-hoc analysis among children with pleural effusion in a tertiary hospital in South Africa, incorporating new data from PCR testing of stored pleural fluid. Aetiological classification was defined by microbiological confirmation.</sec><sec id=\"st3\"><title>RESULTS</title>Ninety-one children were enrolled; the median age 31 months (IQR 12-102). The aetiology of pleural effusion was 40% (36/91) bacteria, 11% (10/91) TB, 3% (3/91) viruses, 11% (10/91) polymicrobial and 35% (32/91) had no pathogen identified. The most common pathogen was Staphylococcus aureus (27/91, 30%) with similar yields on culture and PCR, followed by Streptococcus pneumoniae (12/91, 13%), detected more commonly by PCR. PCR reduced the number of children with unconfirmed aetiologies from 48 to 32. Characteristics of children with no pathogen most resembled those with TB. Pleural fluid lactate dehydrogenase ≥1,716 U/L best discriminated bacterial pleural effusion from other aetiologies (sensitivity of 86%; specificity 95%).</sec><sec id=\"st4\"><title>CONCLUSION</title>PCR improved detection of pathogens and reduced number of children with unconfirmed aetiologies in presumed exudative pleural effusion.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 6","pages":"295-300"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric TB treatment outcomes: targets for improvement. 小儿结核病治疗结果：改进目标。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.24.0221

S S Chiang, H E Jenkins

引用次数: 0

Chronic pulmonary aspergillosis: a neglected post-TB lung disease. 慢性肺曲霉菌病：一种被忽视的结核病后肺部疾病。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-06-01 DOI: 10.5588/ijtld.24.0165

F Bongomin, D W Denning

引用次数: 0