International Journal of Tuberculosis and Lung Disease最新文献_第7页

Facilitators and barriers to adolescent participation in a TB clinical trial. 青少年参与结核病临床试验的促进因素和障碍。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0519

J M Mangan, K N C Hedges, M M Salerno, K Tatum, B Bouwkamp, M W Frick, L McKenna, G Muzanyi, M Engle, J Coetzee, J Yvetot, M Elskamp, D Lamunu, M E Theunissen Tizora, D Namutamba, R E Chaisson, S Swindells, P Nahid, S E Dorman, E Kurbatova

{"title":"Facilitators and barriers to adolescent participation in a TB clinical trial.","authors":"J M Mangan, K N C Hedges, M M Salerno, K Tatum, B Bouwkamp, M W Frick, L McKenna, G Muzanyi, M Engle, J Coetzee, J Yvetot, M Elskamp, D Lamunu, M E Theunissen Tizora, D Namutamba, R E Chaisson, S Swindells, P Nahid, S E Dorman, E Kurbatova","doi":"10.5588/ijtld.23.0519","DOIUrl":"10.5588/ijtld.23.0519","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>The inclusion of adolescents in TB drug trials is essential for the development of safe, child-friendly regimens for the prevention and treatment of TB. TB Trials Consortium Study 31/AIDS Clinical Trials Group A5349 (S31/A5349) enrolled adolescents as young as 12 years old. We assessed investigator and coordinator described facilitators and barriers to adolescent recruitment, enrollment, and retention.</sec><sec id=\"st2\"><title>METHODS</title>Interviews were conducted with six investigators from sites that enrolled adolescent participants and six investigators from non-enrolling sites. Additionally, two focus groups were conducted with study coordinators from enrolling sites and two focus groups with non-enrolling sites. Discussions were transcribed, analyzed, summarized, and summaries were reviewed by Community Research Advisors Group members and research group representatives for content validity.</sec><sec id=\"st3\"><title>RESULTS</title>Investigators and coordinators attributed the successful enrollment of adolescents to the establishment and cultivation of external partnerships, flexibility to accommodate adolescents' schedules, staff engagement, recruitment from multiple locations, dedicated recruitment staff working onsite to access potential participants, creation of youth-friendly environments, and effective communications. Non-enrolling sites were mainly hindered by regulations. Suggestions for improvement in future trials focused on study planning and site preparations.</sec><sec id=\"st4\"><title>CONCLUSION</title>Proactive partnerships and collaboration with institutions serving adolescents helped identify and reduce barriers to their inclusion in this trial.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"243-248"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse oximetry has limited utility in identifying potential patients for long-term oxygen therapy. 脉搏血氧仪在确定可能接受长期氧疗的患者方面作用有限。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0491

C J Crooks, J West, J R Morling, M Simmonds, I Juurlink, S Cruickshank, S Briggs, S Hammond-Pears, D Shaw, T R Card, A W Fogarty

引用次数: 0

Factors associated with referrals for directly observed treatment and unsuccessful treatment. 与转诊接受直接观察治疗和治疗不成功相关的因素。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0396

Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet

{"title":"Factors associated with referrals for directly observed treatment and unsuccessful treatment.","authors":"Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet","doi":"10.5588/ijtld.23.0396","DOIUrl":"https://doi.org/10.5588/ijtld.23.0396","url":null,"abstract":"<sec id=\"st1\"><title>OBJECTIVE</title>To describe the characteristics of people indicated for directly observed treatment (DOT) in Spain, and the factors associated with unsuccessful treatment.</sec><sec id=\"st2\"><title>METHODS</title>This was a multicentre observational study based on a prospective follow-up of patients over 18 years old diagnosed with TB between 2006 and 2019 from the registry of the Programa Integrado de Investigación en Tuberculosis (PII-TB). Sociodemographic and clinical variables were collected. Adjusted odds ratios (aORs) were calculated for the indication of DOT and for having an unsuccessful treatment.</sec><sec id=\"st3\"><title>RESULTS</title>A total of 7,883 patients were included. The indication of DOT was associated with being homeless (aOR 5.93, 95% CI 3.03-11.59), inactivity status (aOR 2.55, 95% CI 2.02-3.23), alcohol consumption (aOR 1.94, 95% CI 1.51-2.48), parenteral drug use (aOR 1.77, 95% CI 1.06-2.95) and HIV diagnosis (aOR 1.96, 95% CI 1.16-3.29). Unsuccessful treatment was associated with having an HIV diagnosis (aPR 2.31, 95% CI 1.31-4.08), having a worse clinical and radiological evolution (clinical progression: APR 15.59, 95% CI 8.21-29.60; radiological progression: aPR 12.84, 95% CI 6.46-25.52), need for hospitalisation (aPR 1.73, 95% CI 1.10-2.73), unsatisfactory tolerability (aPR 2.82, 95% CI 1.49-5.29), the existence of difficulties in understanding the prescribed treatment (aPR 1.92, 95% CI 1.21-3.06), as well as worse treatment satisfaction (aPR 7.27, 95% CI 4.32-12.24).</sec><sec id=\"st4\"><title>CONCLUSION</title>The prioritisation of vulnerable populations is a key aspect to carry out the new Global Plan to End TB 2023-2030. In these groups DOT indication should be increased to ensure adherence and patient follow-up and outcomes.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"237-242"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha-1 deficiency in severe asthma patients. 严重哮喘患者的α-1 缺乏症。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0493

M Zappa, S Grossi, P Pignatti, L Pini, R Centis, G B Migliori, F Ardesi, G Sotgiu, A G Corsico, A Spanevello, D Visca

{"title":"Alpha-1 deficiency in severe asthma patients.","authors":"M Zappa, S Grossi, P Pignatti, L Pini, R Centis, G B Migliori, F Ardesi, G Sotgiu, A G Corsico, A Spanevello, D Visca","doi":"10.5588/ijtld.23.0493","DOIUrl":"https://doi.org/10.5588/ijtld.23.0493","url":null,"abstract":"<sec id=\"st1\"><title>INTRODUCTION</title>Alpha-1 antitrypsin (AAT) deficiency, an autosomal co-dominant condition, decreases protein concentration and activity at both serum and tissue levels. Few studies investigated whether the type of SERPINA1 gene phenotype in patients with severe asthma can influence symptoms and disease control during follow-up.</sec><sec id=\"st2\"><title>OBJECTIVE</title>To assess whether the presence of a non-MM genotype of SERPINA1 in patients with severe asthma is associated with disease control, systemic and airway inflammation, lung function and comorbidities prevalence compared to severe asthma patients with a homozygous genotype (MM).</sec><sec id=\"st3\"><title>METHODS</title>Asthmatic patients belonging to Global Initiative for Asthma (GINA) step 5 were retrospectively analysed in an Italian reference asthma clinic. We collected clinical, biological and functional variables at baseline and for the three following years.</sec><sec id=\"st4\"><title>RESULTS</title>Out of 73 patients enrolled, 14 (19.18%) were non-MM and 59 (80.8%) were MM. Asthmatics with non-MM genotype had lower serum AAT concentration (P = 0.004) and higher emphysema prevalence than the MM group (P = 0.003) at baseline. During follow up, only MM patients showed a significant improvement of both ACQ-6 score (P < 0.0001) and eosinophilic systemic inflammation (P < 0.0001).</sec><sec id=\"st5\"><title>CONCLUSIONS</title>Our findings emphasise the importance of a screening for AAT deficiency in severe asthma, as alleles mutation may influence patient's follow-up.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"225-230"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of TB cases without documented sputum culture in the United States, 2011-2021. 2011-2021 年美国无痰培养记录肺结核病例的特征。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0432

L H Rautman, J S Kammerer, B J Silk, V C Marconi, M E Youngblood, J A Edwards, J M Wortham, J L Self

{"title":"Characteristics of TB cases without documented sputum culture in the United States, 2011-2021.","authors":"L H Rautman, J S Kammerer, B J Silk, V C Marconi, M E Youngblood, J A Edwards, J M Wortham, J L Self","doi":"10.5588/ijtld.23.0432","DOIUrl":"10.5588/ijtld.23.0432","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Culture-based diagnostics are the gold standard for diagnosing pulmonary TB (PTB). We characterized culture practices by comparing cases with documented sputum culture to those without.</sec><sec id=\"st2\"><title>METHODS</title>Using multivariable logistic regression, we examined associations between PTB case characteristics and no documented sputum culture reported to the U.S. National TB Surveillance System during 2011-2021.</sec><sec id=\"st3\"><title>RESULTS</title>Among 69,538 PTB cases analyzed, no sputum culture attempt was documented for 5,869 (8%). Non-sputum culture specimens were documented for 54%, 80%, and 89% of cases without documented sputum culture attempts among persons aged <15 years, 15-64, and 65+ years, respectively; bronchial fluid and lung tissue were common non-sputum specimens among cases in persons >15 years old. Having no documented sputum culture was associated with age <15 years (aOR 23.84, 99% CI 20.09-28.27) or ≥65 years (aOR 1.22, 99% CI 1.07-1.39), culture of a non-sputum specimen (aOR 6.57, 99% CI 5.93-7.28), residence in a long-term care facility (aOR 1.58, 99% CI 1.23-2.01), and receiving TB care outside of a health department (aOR 1.79, 99% CI 1.61-1.98).</sec><sec id=\"st4\"><title>CONCLUSIONS</title>Inability to obtain sputum from children and higher diagnostic suspicion for disease processes that require tissue-based diagnostics could explain these findings.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"231-236"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11103590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with patient delay in the diagnosis of TB - a study of health-seeking behaviour. 肺结核患者延误诊断的相关因素--一项关于寻求健康行为的研究。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0502

M S Marques, T Silva, A Gomes, C Pereira, M Pinto, A Aguiar, R Duarte

引用次数: 0

Acceptability of clofazimine capsules in children and adolescents with rifampicin-resistant TB. 耐利福平结核病儿童和青少年对氯唑明胶囊的接受程度。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0517

D T Wademan, Z Saule, A Marthinus, L Viljoen, E Nortier, J Hughes, I Courtney, M Palmer, A J Garcia-Prats, A C Hesseling, G Hoddinott

引用次数: 0

Point-of-care ultrasound for diagnosing extrapulmonary TB. 用于诊断肺外结核病的护理点超声波。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI: 10.5588/ijtld.23.0471

L T Allan-Blitz, C Yarbrough, M Ndayizigiye, C Wade, A J Goldsmith, N M Duggan

{"title":"Point-of-care ultrasound for diagnosing extrapulmonary TB.","authors":"L T Allan-Blitz, C Yarbrough, M Ndayizigiye, C Wade, A J Goldsmith, N M Duggan","doi":"10.5588/ijtld.23.0471","DOIUrl":"10.5588/ijtld.23.0471","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Despite the high morbidity and mortality globally, standard microbiologic diagnosis for TB requires laboratory infrastructure inaccessible in many resource-limited areas and may be insufficient for identifying extrapulmonary disease. Point-of-care (POC) ultrasound facilitates visualization of extrapulmonary manifestations, permitting laboratory-independent diagnosis, but its diagnostic utility remains unclear.</sec><sec id=\"st2\"><title>METHODS</title>We conducted a systematic review of five online databases for studies reporting ultrasound findings among cases with and without extrapulmonary TB (EPTB). A minimum of two authors independently screened and reviewed each article, and extracted data elements of interest. We conducted a series of univariate meta-analyses using a random-effects model to calculate the pooled effect estimate and 95% confidence interval (CI) for each outcome: sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).</sec><sec id=\"st3\"><title>RESULTS</title>Of 279 articles identified, 6 were included. There were 699 cases of EPTB among 1,633 participants. The pooled sensitivity estimate was 0.72 (95% CI 0.57-0.88). The pooled specificity estimate was 0.77 (95% CI 0.63-0.90). The pooled PPV and NPV estimates were respectively 0.67 (95% CI 0.47-0.87) and 0.85 (95% CI 0.77-0.93).</sec><sec id=\"st4\"><title>CONCLUSION</title>POC ultrasound showed modest test characteristics for diagnosing EPTB, which may constitute an improvement over some currently available diagnostics.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 5","pages":"217-224"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMaRT-PCR: sampling using masks and RT-PCR, a non-invasive diagnostic tool for paediatric pulmonary TB. SMaRT-PCR：使用口罩和 RT-PCR 进行采样，这是一种针对小儿肺结核的无创诊断工具。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0291

A Shaikh, K Sriraman, S Vaswani, I Shah, V Poojari, V Oswal, S Mane, S Rajagara, N Mistry

{"title":"SMaRT-PCR: sampling using masks and RT-PCR, a non-invasive diagnostic tool for paediatric pulmonary TB.","authors":"A Shaikh, K Sriraman, S Vaswani, I Shah, V Poojari, V Oswal, S Mane, S Rajagara, N Mistry","doi":"10.5588/ijtld.23.0291","DOIUrl":"10.5588/ijtld.23.0291","url":null,"abstract":"<sec id=\"st1\"><title>BACKGROUND</title>Key challenges in paediatric TB diagnosis are invasive sampling and poor sensitivity of standard methods. This study demonstrates the diagnostic potential of non-invasive sampling of bioaerosols from children using SMaRT-PCR, comprising mask sampling combined with reverse transcriptase-polymerase chain reaction (RT-PCR) for TB.</sec><sec id=\"st2\"><title>METHODS</title>Exhaled bioaerosols were captured on modified N-95 masks in a 10-min talk-cough-breathe process from 51 children (30 with TB confirmed using standard sampling methods and 21 without TB) aged 2-15 years. All mask samples were tested using in-house RT-PCR for 16s and rpoB RNA transcripts. Additional mask samples from children with TB were tested using Xpert® MTB/RIF (n = 3) and Xpert® MTB/RIF Ultra (n = 27).</sec><sec id=\"st3\"><title>RESULTS</title>SMaRT-PCR sensitivity for detecting TB among treatment-naïve children was 96% if 16s or rpoB was present, and 75% if both genes were present, comparable to standard methods (71%) in the same cohort. Specificity was better for both genes, at 95%, than 85% for a single gene detection. Mask sampling with Xpert MTB/RIF or Ultra had a sensitivity of only 13%.</sec><sec id=\"st4\"><title>CONCLUSION</title>This is the first study to provide evidence for testing bioaerosols as a promising alternative for detecting paediatric TB. Sampling is non-invasive and simple, with the potential for point-of-care applications. This pilot study also suggests that RNA transcript-based detection may improve TB diagnostic sensitivity in children; however, further investigation is required to establish its adaptability in clinical settings.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 4","pages":"189-194"},"PeriodicalIF":4.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advantages and limitations of virtual multi-disciplinary team meetings on difficult-to-treat mycobacteria. 针对难治分枝杆菌的虚拟多学科团队会议的优势和局限性。

IF 4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-04-01 DOI: 10.5588/ijtld.23.0551

V N Dahl, A Burke, A Fløe, J Bruchfeld, T Schön, C M Wejse, A B Andersen, E Svensson, J van Ingen, L Davies Forsman

引用次数: 0