International Journal of Tuberculosis and Lung Disease最新文献_第7页

An adapted scale to measure perceived TB and HIV stigma during household contact investigation. 经过改编的量表，用于测量家庭接触调查期间感知到的结核病和艾滋病耻辱感。

IF 3.6 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.23.0395

M Armstrong-Hough, T Shelby, J Ggita, J Nangendo, A J Gupta, J L Davis, A Katamba

{"title":"An adapted scale to measure perceived TB and HIV stigma during household contact investigation.","authors":"M Armstrong-Hough, T Shelby, J Ggita, J Nangendo, A J Gupta, J L Davis, A Katamba","doi":"10.5588/ijtld.23.0395","DOIUrl":"10.5588/ijtld.23.0395","url":null,"abstract":"<sec><title>BACKGROUND</title>Measuring stigma for TB and HIV in households undergoing contact investigation for TB is critical for understanding its impacts on health behaviours and identifying opportunities for intervention. However, standardised measurements for TB-HIV stigma in household contact investigations are limited.</sec><sec><title>METHODS</title>We adapted and validated a household stigma scale in Uganda. This involved field testing measures from another setting with 163 household contacts of newly diagnosed TB patients, conducting cognitive interviews with seven household contacts, adapting scale items using cognitive interview data, and retesting the adapted scales in a random sample of 60 contacts. We assessed inter-item covariance and performed factor analysis to select the final scale items.</sec><sec><title>RESULTS</title>In whole-scale factor analysis, no cross-loading of items with scores ≥0.32 was found after the elimination of items based on covariance and symmetry. All TB items were loaded onto a single factor with scores ≥0.5, and all but one HIV item was loaded onto a second factor with scores ≥0.5. The final subscale internal consistency (Cronbach's alpha) was 0.92 for TB and 0.89 for HIV.</sec><sec><title>CONCLUSIONS</title>The adapted TB-HIV stigma scale demonstrated acceptable psychometric properties and is substantially shorter and easier to administer than previous scales, making it suitable for programmatic research and evaluation.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 9","pages":"433-438"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory impairment after completion of TB treatment: a neglected but vitally important issue. 肺结核治疗结束后的呼吸系统损伤：一个被忽视但极其重要的问题。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.24.0341

L N Nguyen, P T Phan, E Jaramillo, A Dinh, A T Dinh-Xuan

引用次数: 0

Cold temperatures during sample transportation may cause false-negative interferon-γ release assays used to diagnose TB infection. 样本运输过程中的低温可能会导致用于诊断肺结核感染的干扰素-γ 释放检测出现假阴性。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.24.0020

K Takeda, H Nagai, M Kawashima, I Kosai, M Shimozono, K Sato, H Motomura, E Nakano, M Watanabe, T Kato, M Shimada, O Narumoto, M Suzukawa, J Suzuki, K Yamane, Y Sasaki, Y Morio, A Tamura, H Matsui

引用次数: 0

Miliary TB in children and adolescents: a scoping review. 儿童和青少年的传染性结核病：范围界定综述。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.24.0106

D Buonsenso, F Mariani, R Morello, R Song

{"title":"Miliary TB in children and adolescents: a scoping review.","authors":"D Buonsenso, F Mariani, R Morello, R Song","doi":"10.5588/ijtld.24.0106","DOIUrl":"10.5588/ijtld.24.0106","url":null,"abstract":"<sec><title>OBJECTIVE</title>To summarise the available literature regarding clinical presentation, immunological and microbiological diagnosis, treatment, and outcomes of miliary TB in children and adolescents.</sec><sec><title>METHODS</title>Four databases were searched from 1 January 1950 to 31 January 2023. \"Miliary\" and \"disseminated\" TB were the main search concepts.</sec><sec><title>FINDINGS</title>Of 257 studies, 1,883 patients with miliary TB were included. Bacille Calmette-Guérin (BCG) vaccination was confirmed in 223/549 (40.6%) children. Central nervous system (CNS) involvement was reported in 367/924 (39.7%) cases; many of them had no neurological symptoms despite also having abnormal brain imaging. Of 1,112 children with known outcomes, 341 (30.6%) died; mortality was higher in publications before 1995 (41.5%) and in children with CNS involvement (31.9%). TB microbiological confirmation (55.8%) and sensitivity of tuberculin skin test (46.9%) and QuantiFERON Gold (72.4%) were overall low.</sec><sec><title>CONCLUSIONS</title>Evidence is lacking to support best practices for paediatric miliary TB. Whether lumbar puncture (LP) and brain imaging should both be routinely done in miliary TB children, or a step-by-step approach based on initial LP findings, remains unclear. This study should inform policymakers and funding agencies about current significant gaps that need to be addressed by future high-quality studies.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 9","pages":"412-418"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review on the effect of diabetes mellitus on the pharmacokinetics of TB drugs. 糖尿病对结核病药物代谢动力学影响的系统回顾。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-09-01 DOI: 10.5588/ijtld.23.0507

M Cevik, A Sturdy, A E Maraolo, B G J Dekkers, O W Akkerman, S H Gillespie, J W C Alffenaar

{"title":"A systematic review on the effect of diabetes mellitus on the pharmacokinetics of TB drugs.","authors":"M Cevik, A Sturdy, A E Maraolo, B G J Dekkers, O W Akkerman, S H Gillespie, J W C Alffenaar","doi":"10.5588/ijtld.23.0507","DOIUrl":"10.5588/ijtld.23.0507","url":null,"abstract":"<sec><title>OBJECTIVES</title>The coexistence of TB and diabetes mellitus (DM) (TB-DM) is associated with an increased risk of treatment failure, death, delayed culture conversion, and drug resistance. Because plasma concentrations may influence clinical outcomes, we evaluated the evidence on the pharmacokinetic (PK) of TB drugs in individuals with DM to guide management.</sec><sec><title>METHODS</title>We performed a systematic review and meta-analysis through searches of major databases from 1946 to 6 July 2023. PROSPERO (CRD42022323566).</sec><sec><title>RESULTS</title>Of 4,173 potentially relevant articles, we identified 16 studies assessing rifampicin (RIF) PK, 9 on isoniazid (INH), 8 on pyrazinamide (PZA), and 3 on ethambutol (EMB). Two studies reported on second-line anti-TB drugs. According to our meta-analysis, RIF time to maximum concentration (Tmax) was significantly prolonged in patients with DM compared with non-DM patients. We found no significant differences for RIF Cmax, area under the curve (AUC) 0-24 or drug concentration at 2 h (C2h), INH C2h, PZA C2h, PZA Tmax, and EMB Tmax. Although RIF C2h was slightly reduced in patients with TB-DM, this finding was not statistically significant.</sec><sec><title>CONCLUSIONS</title>This review comprehensively examines the impact of DM on the PK of TB drugs. We observed significant heterogeneity among the studies. Given the association between lower plasma concentrations and poor clinical outcomes among patients with DM, we recommend a higher dose limit to compensate for the larger body weight of patients with DM.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 9","pages":"454-460"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The International Consensus for Early TB framework (ICE-TB): Implications from a low-incidence setting. 早期结核病国际共识框架（ICE-TB）：低发病率环境的启示。

IF 3.1 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-08-01 DOI: 10.5588/ijtld.24.0081

J T Denholm, A Coussens, R M G J Houben, K C Horton, E B Wong, E A Kendall, L Martinez, M Musvosi, S M A Zaidi

{"title":"The International Consensus for Early TB framework (ICE-TB): Implications from a low-incidence setting.","authors":"J T Denholm, A Coussens, R M G J Houben, K C Horton, E B Wong, E A Kendall, L Martinez, M Musvosi, S M A Zaidi","doi":"10.5588/ijtld.24.0081","DOIUrl":"10.5588/ijtld.24.0081","url":null,"abstract":"<sec><title>BACKGROUND</title>In recent years, there has been increasing recognition of the public health significance of the spectrum of TB disease presentation, and the existing classification systems of asymptomatic infection and symptomatic TB have been limited in terms of explanatory power. Accordingly, in 2022-2023, a new International Consensus framework for Early TB (ICE-TB) was developed, categorising the spectrum of TB infection and disease into five states based on the presence or absence of macroscopic pathology, host infectiousness, and symptoms and signs.</sec><sec><title>METHODS</title>We used the ICE-TB framework to re-analyse existing notification data for 2022 within a low-incidence setting to explore the potential utility and future challenges for its public health application.</sec><sec><title>RESULTS</title>Existing notification data were sufficient to allow substantial reclassification of currently recognised active disease states, but did not systematically capture Mycobacterium tuberculosis infection or subclinical TB. Fifty percent of existing TB notifications would be classified as 'Clinical, infectious', with the potential need to consider further subclassification.</sec><sec><title>CONCLUSION</title>Our exploration highlighted limitations in existing classification systems and diagnostic approaches and should encourage researchers and programmatic implementers to emphasise person-centred and programmatic needs in the development of new tools for TB management.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 8","pages":"381-386"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmatic implications of a sub-national TB prevalence survey in India. 印度次国家级结核病流行率调查对计划的影响。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0456

G Prathiksha, S Selvaraju, K Thiruvengadam, A Frederick, H Murugesan, P Rajendran, K Nagarajan, M Kumar, R Krishnan, P Kumaran, T S Selvavinayagam, C Padmapriyadarsini

{"title":"Programmatic implications of a sub-national TB prevalence survey in India.","authors":"G Prathiksha, S Selvaraju, K Thiruvengadam, A Frederick, H Murugesan, P Rajendran, K Nagarajan, M Kumar, R Krishnan, P Kumaran, T S Selvavinayagam, C Padmapriyadarsini","doi":"10.5588/ijtld.23.0456","DOIUrl":"https://doi.org/10.5588/ijtld.23.0456","url":null,"abstract":"<sec><title>BACKGROUND</title>Subnational TB estimates are crucial for making informed decisions to tailor TB control activities to local TB epidemiology.</sec><sec><title>METHODS</title>A cross-sectional survey was conducted among 143,005 individuals in Tamil Nadu, India. Participants were screened for symptoms and underwent chest X-ray (CXR). Participants with symptoms of TB and/or abnormal CXR were tested for TB using Xpert, smear, and liquid culture.</sec><sec><title>RESULTS</title>The prevalence of microbiologically confirmed pulmonary TB (MCPTB) was 212 (95% CI 184-239) per 100,000 population. The prevalence-to-notification ratio (P:N) in the state was 2.05 (95% CI 1.8-2.29). Low body mass index and diabetes together had a population attributable fraction of 54.15 (95% CI 45.68-61.97). Approximately 39% of the TB cases were asymptomatic and were identified only by CXR screening. In the general population, only 26.9% sought care at a health facility among those with symptoms suggestive of TB.</sec><sec><title>CONCLUSION</title>The programme needs to prioritise screening with CXR to potentially detect cases earlier and curtail the transmission and upscale molecular tests in the selected population to increase the yield of case finding. Innovative health education strategies must be devised to address health-seeking behaviour.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"348-353"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjugated hyperbilirubinemia associated with accidental rifapentine overdose. 与意外服用利福喷丁过量有关的结合型高胆红素血症。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0494

M Yohane, F Naufal, A Mendoza-Ticona, E M Svensson, I R Weir, K K Scarsi, D W Haas, G Maartens, J Metcalfe

引用次数: 0

Lessons learned from treating drug-resistant TB and how to apply these to drug-susceptible TB. 从治疗耐药性结核病中汲取的经验教训，以及如何将这些经验教训应用于耐药性结核病。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0548

N Godefroy, G Monsel, S Jauréguiberry, B Henry, N Véziris, A Aubry, J Robert, M Jachym, E Caumes, V Pourcher

引用次数: 0

Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. 对饮酒的 HIV 阳性患者进行异烟肼预防性治疗的策略。

IF 3.4 3区医学

International Journal of Tuberculosis and Lung Disease Pub Date : 2024-07-01 DOI: 10.5588/ijtld.23.0303

A Savinkina, W Muyindike, J A Hahn, N I Emenyonu, R Fatch, C Ngabirano, J Adong, K R Jacobson, B P Linas

{"title":"Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol.","authors":"A Savinkina, W Muyindike, J A Hahn, N I Emenyonu, R Fatch, C Ngabirano, J Adong, K R Jacobson, B P Linas","doi":"10.5588/ijtld.23.0303","DOIUrl":"10.5588/ijtld.23.0303","url":null,"abstract":"<sec><title>BACKGROUND</title>WHO guidance to defer isoniazid preventive therapy (IPT) among those with regular alcohol use because of hepatotoxicity concerns may exclude many people living with HIV (PLWH) at high TB risk in these settings.</sec><sec><title>OBJECTIVE</title>To evaluate hepatotoxicity during TB preventive therapy (TPT) in PLWH who report alcohol use in Uganda over 10 years.</sec><sec><title>METHODS</title>We developed a Markov model of latent TB infection, isoniazid preventive therapy (IPT - a type of TPT), and TB disease using data from the Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT) study. We modeled several treatment scenarios, including no IPT, IPT with liver enzyme monitoring (AST/ALT) during treatment, and IPT with pre-screening using the tuberculin skin test (TST).</sec><sec><title>RESULTS</title>The no IPT scenario had 230 TB deaths/100,000 population over 10 years, which is more than that seen in any IPT scenario. IPT, even with no monitoring, was preferred over no IPT when population TB disease incidence was >50 in 100,000.</sec><sec><title>CONCLUSIONS</title>For PLWH who report alcohol use in high TB burden settings, IPT should be offered, ideally with regular AST/ALT monitoring. However, even if regular monitoring is not possible, IPT is still preferable to no IPT in almost every modeled scenario.</sec>.","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":"28 7","pages":"335-342"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0