International Journal of Reproductive Biomedicine最新文献

{"title":"Intrauterine autologous platelet-rich plasma treatment in women with at least two implantation failures: A retrospective cohort study.","authors":"Neda Fattahi Meybodi, Maryam Eftekhar, Behnaz Gandom","doi":"10.18502/ijrm.v22i1.15236","DOIUrl":"10.18502/ijrm.v22i1.15236","url":null,"abstract":"<p><strong>Background: </strong>Finding the most effective way to improve implantation rate in women who are receiving assisted reproductive technology treatment is still a challenge.</p><p><strong>Objective: </strong>This study aimed to assess the pregnancy outcomes of intrauterine platelet-rich plasma (PRP) therapy in women with a history of at least 2 implantation failures.</p><p><strong>Materials and methods: </strong>In this retrospective cohort study, data of 852 women who were candidates for frozen-thawed embryo transfer was extracted from their medical records from April 2017 to September 2021 at Yazd Reproductive Sciences Institute, Yazd, Iran. Of these, 432 received intrauterine PRP treatment 48 hr before transfer (PRP group), and the results of the pregnancy outcomes compared with 420 of the control group who did not receive the treatment before transfer.</p><p><strong>Results: </strong>Pregnancy outcomes, including chemical, clinical, ongoing pregnancy, and live birth rate were statistically significant in the PRP group (p <math><mo><</mo></math> 0.001). However, when categorized according to the implantation history, this significant improvement in all 4 was only seen in women with at least 2 prior implantation failures. In women with a history of only one implantation failure, PRP therapy significantly improved the ongoing pregnancy and live birth rate (19.5%, p = 0.04). Also, in women who received donor eggs and had repeated implantation failure, PRP improved pregnancy outcomes clinically but not statistically (p = 0.15).</p><p><strong>Conclusion: </strong>PRP seems to be effective in improving the pregnancy rate in women with a history of 2 or more implantation failures and also shows an increase in the live birth rate in women with only one implantation failure.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 1","pages":"9-16"},"PeriodicalIF":1.3,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10963874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing <i>Cas9</i> gene: A lab resource report.","authors":"Farzad Soheilipour, Sohrab Boozarpour, Shiva Aghaei, Ehsan Farashahi Yazd","doi":"10.18502/ijrm.v22i1.15243","DOIUrl":"10.18502/ijrm.v22i1.15243","url":null,"abstract":"<p><strong>Background: </strong>Stable Cas9 (CRISPR-associated protein 9)-expressing cell lines have emerged as valuable tools in genetic research, enhancing the efficiency of the CRISPR/Cas9 system and streamlining gene editing procedures. These cell lines enable simultaneous editing of multiple genes and reduce the overall editing time.</p><p><strong>Objective: </strong>This study aimed to develop a stable human fibroblast cell line capable of genetic conversion into a mutant form, serving as a cellular model for a specific genetic disease. The established cell line facilitates investigation of disease mechanisms, testing of potential treatments, and gaining insights into underlying molecular processes.</p><p><strong>Materials and methods: </strong>Human embryonic kidney 293LTV cells were used to produce pseudo-virus particles, while Yazd human foreskin fibroblasts batch 8 (YhFF#8) cells were targeted for genetic modification. Transfection of human embryonic kidney 293LTV cells with pCDH-Cas9 plasmid DNA generated pseudo-viral particles. YhFF#8 cells were transduced and selected using antibiotics. Green fluorescent protein (GFP) detection confirmed successful transduction and selection. Relative expression levels of the <i>Cas9</i> gene were determined by quantitative polymerase chain reaction.</p><p><strong>Results: </strong>The study validated the fidelity of the <i>Cas9</i> gene cassette sequence and its transcriptional activity. Transduced YhFF#8 cells exhibited green fluorescence, with antibiotic selection resulting in nearly 100% transduced cells. A reporter <i>GFP</i> gene enabled real-time monitoring of YhFF#8-Cas9-GFP-PuroR cells using fluorescence microscopy.</p><p><strong>Conclusion: </strong>YhFF#8-Cas9-GFP-PuroR cells, labeled and susceptible to genomic editing, provide an optimal source for generating induced pluripotent stem cell lines for future biomedical research.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 1","pages":"61-68"},"PeriodicalIF":1.3,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10963875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of underweight, short stature, and microcephaly based on brain diffusion-weighted imaging sequence in neonates with stage.2 of hypoxic-ischemic encephalopathy: A follow-up study.","authors":"Mohammad Golshan Tafti, Marjan Jafari, Seyed Reza Mirjalili, Razieh Fallah, Farimah Shamsi","doi":"10.18502/ijrm.v22i1.15235","DOIUrl":"10.18502/ijrm.v22i1.15235","url":null,"abstract":"<p><strong>Background: </strong>Hypoxic-ischemic encephalopathy (HIE), caused due to reduced oxygenation and brain blood flow, occurs in 1-8 per 1000 live full-term births in developed countries and up to 26 per 1000 live in the developing world. The growth status of survivors of birth HIE has not been evaluated sufficiently.</p><p><strong>Objective: </strong>This study evaluated, the growth parameters (weight, height, and head circumference) of neonates with Sarnat stage.2 of HIE at 6, 10, and 12 months and its relationship with findings of neonatal brain diffusion-weighted imaging (DWI) sequence.</p><p><strong>Materials and methods: </strong>Medical records and growth parameters of 35 neonates with gestational age <math><mo>></mo></math> 34 wk who were admitted with stage.2 of HIE in Neonatal Intensive Care Unit of Shahid Sadoughi hospital, Yazd, Iran from March 2021-March 2022, and its relationship with neonatal brain DWI sequence finding was evaluated.</p><p><strong>Results: </strong>15 girls and 20 boys with a mean birth weight of 2880.3 <math><mo>±</mo></math> 221.8 gr were evaluated. Conventional magnetic resonance imaging and DWI were found to be abnormal in 6 (17.1%) and 18 neonates (51.4%). The most abnormal finding of DWI was high signal in basal ganglia/thalamus in 9 neonates (25.7%). Abnormal DWI is more frequent in neonates with seizures and low birth weight. Hospital stay days were more prolonged in neonates with abnormal DWI. Microcephaly at 12 months was more frequent in children with abnormal DWI.</p><p><strong>Conclusion: </strong>In survivors of moderate neonatal HIE, abnormal brain DWI sequence might predict inappropriate head growth, and need close medical and nutritional interventions for growth improvement.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 1","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10963878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sertoli cell-conditioned medium can improve blood-testis-barrier function and spermatogenesis in azoospermia mice induced by scrotal hyperthermia: An experimental study.","authors":"Fakhroddin Aghajanpour, Reza Soltani, Azar Afshar, Hojjat-Allah Abbaszadeh, Fatemeh Fadaei Fathabadi, Nafiseh Moeinian, Abbas Aliaghaei, Ali Dehghani Nejad, Reza Mastery Farahani, Mohsen Norouzian, Mohammad-Amin Abdollahifar","doi":"10.18502/ijrm.v22i1.15238","DOIUrl":"10.18502/ijrm.v22i1.15238","url":null,"abstract":"<p><strong>Background: </strong>An increase in the temperature of the testis is associated with damage to the epithelium of seminiferous tubules and disruption of sperm production.</p><p><strong>Objective: </strong>The current study aimed to investigate the effect of the Sertoli cell-conditioned medium (SCCM) on the blood-testis-barrier associated genes and spermatogenesis process following scrotal hyperthermia.</p><p><strong>Materials and methods: </strong>In this experimental study, 40 adult NMRI mice (8 wk, 25-30 gr) were allocated into 4 groups: I) control, II) DMEM (10 μl Dulbecco's Modified Eagle Medium), III) scrotal hyperthermia, and IV) scrotal hyperthermia+SCCM (10 μl SCCM). Hyperthermia was induced by placing the mice scrotum in water at 43 C for 20 min every other day for 10 days. Mice were treated every other day for 5 wk. Then the animals were euthanized, and the tails of epididymis were removed to analyze sperm parameters, testis were taken for stereological assessment, reactive oxygen spices and glutathione levels, and the expression of <i>Ocln</i>, <i>Gja1</i>, <i>Cdh2</i>, and <i>Itgb1</i>.</p><p><strong>Results: </strong>The results of sperm analysis indicated that SCCM-treated mice significantly increased sperm count and motility and reduced DNA fragmentation. In addition, histological and molecular findings showed that the volume of testicular tissue, the number of germ cells, the glutathione level, and the expression of <i>Ocln</i>, <i>Gja1</i>, <i>Cdh2</i>, and <i>Itgb1</i> genes were significantly increased in the SCCM-treated mice.</p><p><strong>Conclusion: </strong>Findings suggest that growth factors of SCCM stimulate the proliferation and differentiation of germ cells through paracrine effects and upregulate the blood-testis-barrier-associated genes in mice subjected to scrotal hyperthermia.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 1","pages":"17-30"},"PeriodicalIF":1.6,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10963876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin administration from early pregnancy versus initiation after 11 weeks of gestation for prevention of pre-eclampsia in high-risk pregnant women: Study protocol for randomized controlled trial.","authors":"Sedigheh Hantoushzadeh, Arezoo Behzadian, Mohammad Mehdi Hasheminejad, Faezeh Hasheminejad, Alireza Helal Birjandi, Mojtaba Akbari, Marjan Ghaemi","doi":"10.18502/ijrm.v22i1.15244","DOIUrl":"10.18502/ijrm.v22i1.15244","url":null,"abstract":"<p><strong>Background: </strong>Pre-eclampsia (PE) is a multiorgan disorder that affects 2-5% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after 11 wk of gestation.</p><p><strong>Objective: </strong>We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after 11 wk in reducing the occurrence of PE?</p><p><strong>Materials and methods: </strong>All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January 2023, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October 2023.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 1","pages":"69-80"},"PeriodicalIF":1.3,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10963873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Protective effects of <i>Ceratonia siliqua</i> extract on protamine gene expression, testicular function, and testicular histology in doxorubicin-treated adult rats: An experimental study\" [Int J Reprod BioMed 2020; 18: 667-682].","authors":"Hengameh Mehdikhani, Mehrdad Shariati, Mohsen Forouzanfar, Seyed Ebrahim Hosseini","doi":"10.18502/ijrm.v21i12.15044","DOIUrl":"10.18502/ijrm.v21i12.15044","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.18502/ijrm.v13i8.7507.].</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 12","pages":"1035"},"PeriodicalIF":1.3,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of platelet-rich plasma in pelvic floor disorders: A systematic review.","authors":"Eighty Mardiyan Kurniawati, Nur Anisah Rahmawati, Gatut Hardianto, Hari Paraton, Tri Hastono Setyo Hadi","doi":"10.18502/ijrm.v21i12.15034","DOIUrl":"10.18502/ijrm.v21i12.15034","url":null,"abstract":"<p><strong>Background: </strong>Management for pelvic floor disorders needs to be improved. Platelet-rich plasma (PRP) offers an innovative treatment in general medical care to promote cell regeneration.</p><p><strong>Objective: </strong>This review aims to investigate the role of PRP in pelvic floor disorders.</p><p><strong>Materials and methods: </strong>6 international databases were accessed using several keywords namely PubMed, Science Direct, Cochrane Library, ProQuest, Google Scholar, and Scopus. The inclusion criteria were articles written in English, published in 10-yr period from 2012 until 2022, and investigated the relevant topic. This systematic review followed PRISMA guideline.</p><p><strong>Results: </strong>644 articles were found in several databases and 15 articles met the criteria. Management for pelvic floor disorders needs to be improved, but there are still many challenges, such as less effective treatments, risk of recurrence, and postoperative wound healing. PRP offers an innovative treatment in general medical care to promote cell regeneration. A total of 644 articles from the database were found, but 15 studies met the criteria. A total of 600 women with various pelvic floor disorders treated with PRP were analyzed. PRP positively impacts female sexual dysfunction, perineal trauma, vulvovaginal atrophy, stress urinary incontinence, vesicovaginal fistula, perineal rupture, and pelvic organ prolapse. Dosages, preparation techniques, injection techniques, and additive materials are varied. Most studies do not report side effects from the therapy, but the urinary disorder complaints must be paid attention to.</p><p><strong>Conclusion: </strong>PRP can be used to manage pelvic floor disorders. Future studies should clarify and standardize the dose in each case and how to make PRP produce the best results.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 12","pages":"957-974"},"PeriodicalIF":1.3,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex assignment and psychosexual peculiarities of individuals with different forms of androgen insensitivity syndrome: A qualitative study.","authors":"Jenaro Kristesashvili, Levan Kobaladze, Mariam Chipashvili, Anna Jibladze","doi":"10.18502/ijrm.v21i12.15036","DOIUrl":"10.18502/ijrm.v21i12.15036","url":null,"abstract":"<p><strong>Background: </strong>A mismatch between chromosomal, gonadal, and phenotypic sexes in individuals with androgen insensitivity syndrome (AIS) creates problems in sex assignment and psychosexual identification.</p><p><strong>Objective: </strong>To identify psychosexual and sex assignment peculiarities of individuals with different forms of AIS.</p><p><strong>Materials and methods: </strong>In this qualitative study, 41 individuals with AIS aged between 15 and 31 yr who referred to the Universe Center for Reproductive Medicine Tbilisi, Georgia between 2016 and 2021 were studied. All individuals underwent clinical, genealogical, hormonal, ultrasonographic, and cytogenetic examinations. In-depth interviews and medical records assessed psychosexual profiles and sex assignment histories.</p><p><strong>Results: </strong>32 cases were diagnosed with the complete form of AIS (CAIS), 8 individuals with the partial form (PAIS), and one with a mild form (MAIS). Individuals with CAIS and PAIS were assessed at birth and raised as girls. Individuals with CAIS and female psychosexual disposition were referred to us due to amenorrhea. Adolescent individuals with PAIS assessed as girls referred to us due to masculinization detected in puberty. An individual with MAIS was assessed at birth and raised as a boy with male genitalia. All individuals with AIS had typical hormonal data and sex chromosome complex for men. 20 sexually active individuals with CAIS had penile-vaginal contact with the man. None of the individuals with CAIS and PAIS thought about gender reassignment after being diagnosed, only the individual with MAIS aimed for male-to-female transition.</p><p><strong>Conclusion: </strong>Psychosexual identification remains a significant challenge in AIS management. Detection of female psychosexual disposition in one participant that is unusual to MAIS may be associated with somatic mosaicism of the androgen receptor gene.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 12","pages":"985-994"},"PeriodicalIF":1.3,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does body mass index compromise assisted reproductive technique outcomes? A cross-sectional study.","authors":"Fereshteh Bahrami, Saeideh Dashti, Esmat Mangoli, Hanie Sadat Hosseini","doi":"10.18502/ijrm.v21i12.15040","DOIUrl":"10.18502/ijrm.v21i12.15040","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obese people face several health problems. Female obesity has been shown to reduce fertility in the general population. Assisted reproductive technology outcomes in obese cases are widely studied, but the results are inconclusive.</p><p><strong>Objective: </strong>This study aimed to compare live birth rate (LBR) among women with 4 different types of body mass index (BMI).</p><p><strong>Materials and methods: </strong>In this cross-sectional study, data of 1611 women, who were candidates for fresh and frozen embryo transfer cycles, was extracted from 2051 medical files at the Reproductive Sciences Institute, Yazd, Iran from May 2019-May 2021. The participants were divided into 4 groups (underweight, normal, overweight, and obese) according to their BMI, and LBR was considered to be the main outcome.</p><p><strong>Results: </strong>Of 1611 women, 39 were underweight, 585 were normal, 676 were overweight, and 311 were obese. Underweight women had the lowest LBR (12.8%), but there was no statistically significant difference (p = 0.55). In addition, LBR was compared in the 4 BMI groups according to age, type of transfer cycle (fresh or freeze), and cause of infertility, and there was comparable LBR in the 4 BMI groups. However, metaphase 2 oocyte rate, doses of gonadotropin usage in the cycles, and estradiol level had statistically significant differences (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>According to our study, obesity does not affect LBR in the IVF cycle, regardless of fresh or frozen embryo transfer cycles, different age groups, and causes of infertility.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 12","pages":"1021-1030"},"PeriodicalIF":1.3,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid feature selection algorithm to determine effective factors in predictive model of success rate for in vitro fertilization/intracytoplasmic sperm injection treatment: A cross-sectional study.","authors":"Ameneh Mehrjerd, Hassan Rezaei, Saeid Eslami, Nayyere Khadem Ghaebi","doi":"10.18502/ijrm.v21i12.15038","DOIUrl":"10.18502/ijrm.v21i12.15038","url":null,"abstract":"<p><strong>Background: </strong>Previous research has identified key factors affecting in vitro fertilization or intracytoplasmic sperm injection success, yet the lack of a standardized approach for various treatments remains a challenge.</p><p><strong>Objective: </strong>The objective of this study is to utilize a machine learning approach to identify the principal predictors of success in in vitro fertilization and intracytoplasmic sperm injection treatments.</p><p><strong>Materials and methods: </strong>We collected data from 734 individuals at 2 infertility centers in Mashhad, Iran between November 2016 and March 2017. We employed feature selection methods to reduce dimensionality in a random forest model, guided by hesitant fuzzy sets (HFSs). A hybrid approach enhanced predictor identification and accuracy (ACC), as assessed using machine learning metrics such as Matthew's correlation coefficient, runtime, ACC, area under the receiver operating characteristic curve, precision or positive predictive value, recall, and F-Score, demonstrating the effectiveness of combining feature selection methods.</p><p><strong>Results: </strong>Our hybrid feature selection method excelled with the highest ACC (0.795), area under the receiver operating characteristic curve (0.72), and F-Score (0.8), while selecting only 7 features. These included follicle-stimulation hormone (FSH), 16Cells, FAge, oocytes, quality of transferred embryos (GIII), compact, and unsuccessful.</p><p><strong>Conclusion: </strong>We introduced HFSs in our novel method to select influential features for predicting infertility success rates. Using a multi-center dataset, HFSs improved feature selection by reducing the number of features based on standard deviation among criteria. Results showed significant differences between pregnant and non-pregnant groups for selected features, including FSH, FAge, 16Cells, oocytes, GIII, and compact. We also found a significant correlation between FAge and fetal heart rate and clinical pregnancy rate, with the highest FSH level (31.87%) observed for doses ranging from 10-13 (mIU/ml).</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 12","pages":"995-1012"},"PeriodicalIF":1.3,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}