International Journal of Research in Dermatology最新文献

Dupilumab as a treatment for a case of benign familial pemphigus 用杜匹单抗治疗一例良性家族性丘疹性荨麻疹

International Journal of Research in Dermatology Pub Date : 2024-08-09 DOI: 10.18203/issn.2455-4529.intjresdermatol20242272

Kyle T. Machynia

引用次数: 0

A phase III randomized controlled clinical trial evaluating the efficacy and safety of naftifine 2% cream versus terbinafine 1% cream in patients with superficial fungal infection of the skin 一项 III 期随机对照临床试验，评估萘替芬 2% 乳膏和特比萘芬 1%乳膏对皮肤浅表真菌感染患者的疗效和安全性

International Journal of Research in Dermatology Pub Date : 2024-06-05 DOI: 10.18203/issn.2455-4529.intjresdermatol20241599

Nibedita Patro, Prerna R. Suryatale, Ipsa Pandya, Nadia Zakir Mian, Monika Chinda, Pavankumar M. Daultani, Ravindra Mittal, Ashok D. Jaiswal, Anit Singh

{"title":"A phase III randomized controlled clinical trial evaluating the efficacy and safety of naftifine 2% cream versus terbinafine 1% cream in patients with superficial fungal infection of the skin","authors":"Nibedita Patro, Prerna R. Suryatale, Ipsa Pandya, Nadia Zakir Mian, Monika Chinda, Pavankumar M. Daultani, Ravindra Mittal, Ashok D. Jaiswal, Anit Singh","doi":"10.18203/issn.2455-4529.intjresdermatol20241599","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20241599","url":null,"abstract":"Background: Dermatophytosis is the prevailing fungal infection, typically addressed through topical, systemic antifungal medications, or a combination of both. Naftifine hydrochloride, belonging to the allylamine group, is a topical antifungal, exhibiting fungicidal properties alongside antibacterial and anti-inflammatory effects. This study evaluated the efficacy and safety of naftifine hydrochloride 2% w/w in 268 patients with dermatophytosis versus terbinafine hydrochloride 1% w/w.\u0000Methods: The drugs were applied daily for two weeks, with the primary endpoint being a clinical cure at the end of the treatment. Secondary endpoints included mycological cure, composite cure, global efficacy assessment, and post-treatment relapse.\u0000Results: In both groups, most patients experienced both clinical and mycological cures, with composite cures observed in 94.07% of the test group and 87.97% of the reference group. The global assessment of efficacy was 3.59 in the test group and 3.48 in the reference group, showing no notable difference between the two groups. All adverse events in both groups were mild and resolved within four days. Overall tolerability was comparable between the study groups.\u0000Conclusions: The study concluded that topical naftifine was effective and safe in patients with dermatophytosis and its efficacy and safety were found comparable to topical terbinafine.\u0000 ","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"7 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141385060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tofaticinib as a potential therapeutic agent: a review 托法替尼作为一种潜在的治疗药物：综述

International Journal of Research in Dermatology Pub Date : 2024-06-04 DOI: 10.18203/issn.2455-4529.intjresdermatol20241595

S. Mohan, Neelu Singh, Lalit Mohan

{"title":"Tofaticinib as a potential therapeutic agent: a review","authors":"S. Mohan, Neelu Singh, Lalit Mohan","doi":"10.18203/issn.2455-4529.intjresdermatol20241595","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20241595","url":null,"abstract":"Tofacitinib is a Food and Drug Administration (FDA) approved second generation immunosuppressive disease-modifying anti-rheumatic drug (DMARD) that is used in the treatment of conditions like rheumatoid arthritis, ulcerative colitis polyarticular course juvenile idiopathic arthritis and psoriatic arthritis. Tofacitinib can be used to treat adult RA patients who are intolerant to methotrexate. At cellular level tofacitinib selectively inhibits Janus kinase (JAKs) in human genome and thereby stops the cytokine receptor-based signalling of interleukins viz., IL2, IL4, IL6, IL7, IL15, IL21, interferon alpha (IFNa) and IFNc in synovial fibroblasts and CD14 monocytes, thereby leading to disruption of immune and inflammatory responses. Tofacitinib is marketed as orally administered conventional tablets (5 mg and 10 mg doses) extended-release tablets (11 mg dose) and oral solutions (1 mg/ml dose). Tofacitinib is quickly absorbed after oral administration with systemic bioavailability of 74%. Tofacitinib is metabolized majorly by CYP3A4 and clearance is 70% via hepatic metabolism and 30% via renal excretion. Half-life of orally administered tofacitinib was observed to be 3 hours. Patients receiving tofacitinib therapy should be monitored for TB, renal impairment, hepatic impairment or any kind of bacterial, viral or fungal infections before initiating or during therapy. Most common reported adverse events of tofacitinib are headache, diarrhoea, nasopharyngitis, sore throat, hypertension and respiratory tract infections. Tofacitinib therapy should be cautiously used in females of reproductive age and in patients receiving renal transplant. Tofacitinib is not recommended with other immunosuppressants and vaccines. Thus, tofacitinib being a potential therapeutic agent the current review elaborates the history, detailed pharmacology, dosing, adverse events, interactions and contraindications of tofacitinib.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"269 19‐23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141386724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evaluation of serum vitamin D3 in androgenetic alopecia: a case-control study 雄激素性脱发患者血清维生素 D3 的评估：一项病例对照研究

International Journal of Research in Dermatology Pub Date : 2024-05-04 DOI: 10.18203/issn.2455-4529.intjresdermatol20241284

Raj Kumar, Swale Iftikhar, Durga Prasad Dubey, Urjasweta Singh, Anil Kumar Gupta

{"title":"The evaluation of serum vitamin D3 in androgenetic alopecia: a case-control study","authors":"Raj Kumar, Swale Iftikhar, Durga Prasad Dubey, Urjasweta Singh, Anil Kumar Gupta","doi":"10.18203/issn.2455-4529.intjresdermatol20241284","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20241284","url":null,"abstract":"Background: Androgenetic alopecia (AGA) is a common hereditary condition characterized by progressive hair loss influenced by androgens. Vitamin D has been implicated in various hair disorders, yet its association with AGA, particularly in South Asian populations, remains inconclusive.\u0000Methods: We conducted a case-control study involving 100 male subjects from eastern Uttar Pradesh, India, comprising 50 AGA cases and 50 age-matched controls. Serum vitamin D levels were measured, and participants underwent clinical evaluations. Statistical analyses were performed using unpaired t tests and chi-square tests.\u0000Results: Vitamin D deficiency (<20 ng/ml) was significantly more prevalent in AGA cases (56%) compared to controls (24%) (p<0.001), with an odds ratio of 4.0303. Mean serum vitamin D levels were significantly lower in cases (33.1±10.6 ng/ml) than controls (40.3±9.51 ng/ml) (p=0.0005). Severe AGA cases exhibited lower vitamin D levels compared to mild to moderate cases, although the difference was not statistically significant (p=0.32).\u0000Conclusions: This study highlights the importance of vitamin D in AGA pathogenesis and suggests the need for routine monitoring of serum vitamin D levels in AGA patients. Further large-scale studies are warranted to confirm these findings and investigate the efficacy of vitamin D supplementation as a therapeutic intervention for AGA.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"155 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report on Kyrle’s disease in patient with diabetes mellitus 糖尿病患者克氏病病例报告

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240975

Yashmeen Nikhat P., Jutla V. Kumar, Chennasamudram C. Kesavulu

{"title":"A case report on Kyrle’s disease in patient with diabetes mellitus","authors":"Yashmeen Nikhat P., Jutla V. Kumar, Chennasamudram C. Kesavulu","doi":"10.18203/issn.2455-4529.intjresdermatol20240975","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240975","url":null,"abstract":"Kyrles disease classified under acquired perforating dermatosis, is a rare skin condition predominantly affecting 30-50-year-old females. Characterized by pruritic hyperkeratotic and ulcerated nodules, the disease involves the transepidermal clearance of aberrant endogenous components, leading to inflammatory reactions and expulsion of keratin and cellular material. The etiology though not fully understood, suggests changes in dermal connective tissue may play a role. In case report, a 56-year-old male with type II diabetes mellitus presented knee pain and 3 mm papules on lower limbs. Laboratory findings revealed hematological and metabolic abnormalities, and a skin biopsy confirmed Kyrle’s disease features. Laboratory reports indicated abnormalities in hematology, blood glucose, lipid profile, hepatic and renal function. Biopsy results confirmed acanthosis, hyperkeratosis, dysplsia and granulomatous inflammation. The association of Kyrle’s disease and metabolic abnormalities, emphasizing diabetes and chronic renal failure. Potential pathways involve oxidative damage, endoplasmic stress, and vasculopathy. Treatment options include keratolytics, emollients, antihistamines. Kyrle’s disease often linked to diabetes and chronic renal failure, is a chronic condition with variable remission periods. Early detection and appropriate management are crucial for improving patients’ quality of life. Understanding the association with metabolic abnormalities guides effective therapeutic approaches for this rare dermatological condition.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"9 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of diabetes mellitus in patients at risk in dermatology outpatient department 皮肤科门诊高危患者的糖尿病筛查

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240968

Kanishka Kaul

{"title":"Screening of diabetes mellitus in patients at risk in dermatology outpatient department","authors":"Kanishka Kaul","doi":"10.18203/issn.2455-4529.intjresdermatol20240968","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240968","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is a widely spread multidisciplinary condition that requires the attention of many different disciplines; yet, the involvement of dermatologists in this regard has not been recognized. The current study focused on the role of dermatologists in screening the prevalence and pattern of cutaneous manifestations in diabetic and pre-diabetic patients.\u0000Methods: A randomized study was carried out from April 2023 to October 2023 in the department of dermatology at SSB Heart and Multispecialty Hospital in Faridabad, Haryana. In the current study, patients with dermatological problems suspected of diabetes mellitus were enrolled. Dermatological problems such acanthosis nigricans, dermatophyte infections, psoriasis, endogenous eczema, chronic urticaria, generalized pruritus, lichen simplex chronicus, patients older than 40, and coexisting conditions like obesity were focused in this study.\u0000Results: This study enrolled a total of 100 patients. Only 37 patients were recognized as having a high risk of diabetes, with 67.57% having a verified history of the disease. Furthermore, 32% of T2DM patients were examined for specific skin symptoms during their initial visits, with 4 individuals being found to have generalized pruritus and dermatophyte infection.\u0000Conclusions: This study finally concluded that dermatologists may play a crucial role in fighting the T2DM epidemic by early detection of T2DM and treatment initiation which may reduce the risk of serious complications.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"23 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symmetrical acrokeratoderma: a case series 对称性角化棘皮症：一个病例系列

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240971

Swale Iftikhar, Anil Kumar Gupta, Rajkumar, Urjasweta Singh

引用次数: 0

Aleukemic leukemia cutis: a rare case report 角膜白血病：罕见病例报告

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240976

Akshara Kharabanda, Sudhir Singh

引用次数: 0

Expert opinion on the prescription practice of topical calamine lotion for chronic urticaria and other dermatologic conditions in Indian clinical settings 关于印度临床上使用炉甘石洗剂治疗慢性荨麻疹和其他皮肤病的处方做法的专家意见

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240969

M. S, K. Kumar M

{"title":"Expert opinion on the prescription practice of topical calamine lotion for chronic urticaria and other dermatologic conditions in Indian clinical settings","authors":"M. S, K. Kumar M","doi":"10.18203/issn.2455-4529.intjresdermatol20240969","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240969","url":null,"abstract":"Background: Calamine is suggested as a potentially effective treatment for skin exudation, itching, and rashes. However, there aren't many thorough analyses of the drug prescription patterns for treating urticaria in the Indian literature. This study aimed to gather expert opinions on the prescription practice of topical calamine lotion for chronic urticaria and other dermatologic conditions in Indian clinical settings.\u0000Methods: The cross-sectional questionnaire-based survey, comprising 25 questions, gathered data regarding the prescription practice of topical calamine lotion for the management of chronic urticaria and other dermatological conditions.\u0000Results: Of the 467 participants, 62% indicated that they would prescribe topical calamine lotion for pruritus management. About 39% of the participants preferred the cream formulation of the calamine lotion for treating diaper dermatitis in 11-25% of patients. About 76% of the respondents stated that they would recommend an oral antihistamine along with topical calamine lotion to treat chronic urticaria. For the treatment of pruritus, 44% of the participants preferred menthol in addition to calamine. Sixty-eight per cent of the respondents stated that approximately 5% of those with chronic urticaria need to be treated with calamine and tetrahydrocurcumin. Most specialists (69.38%) preferred using calamine lotion on 5-10% of patients with itchy skin conditions during pregnancy.\u0000Conclusions: Experts recommend the topical calamine lotion for managing various skin conditions including pruritus and chronic urticaria. Specialists recommended it as a safe option for managing itchy skin conditions during pregnancy.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"48 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140661004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of azathioprine induced anagen effluvium and plica neuropathica 一个罕见的硫唑嘌呤诱发增生性流出和神经性斑块病病例

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240973

M. Rijhwani, Meet D. Patel, Amrit Malik, M. Nijhawan

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