用杜匹单抗治疗一例良性家族性丘疹性荨麻疹

Kyle T. Machynia
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引用次数: 0

摘要

海利-海利病(Hailey-Hailey disease,HHD)是一种不常见的常染色体显性遗传性皮肤病,其特点是反复发生水疱性糜烂,主要影响三叉神经间区域,导致皮肤褶皱内形成糜烂性红斑。由于感染频发,这种疾病严重影响了患者的生活质量,而目前针对 HHD 的治疗方案有限且往往效果不佳,更加剧了这种疾病的恶化。在本报告中,我们介绍了一例成功使用杜匹单抗治疗 HHD 的病例,该病例在开始使用这种新型治疗药物治疗的短短两周内就得到了显著改善。这一令人鼓舞的结果凸显了双鲁单抗在治疗具有挑战性的 HHD 病例方面的潜力,值得在更大规模的临床试验中进一步探索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dupilumab as a treatment for a case of benign familial pemphigus
Hailey-Hailey disease (HHD) is an uncommon autosomal dominant genodermatosis characterized by recurrent blistering eruptions primarily affecting intertriginous areas, leading to the formation of eroded, erythematous plaques within flexural skin folds. The condition significantly impairs quality of life due to the frequency of infections, exacerbated by the limited and often ineffective therapeutic options currently available for HHD. In this report, we present a compelling case of HHD successfully treated with dupilumab, highlighting remarkable improvement observed within just two weeks of initiating treatment with this novel therapeutic agent. This promising outcome underscores the potential of dupilumab in managing challenging cases of HHD and warrants further exploration in larger clinical trials.
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