Yashmeen Nikhat P., Jutla V. Kumar, Chennasamudram C. Kesavulu
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Laboratory reports indicated abnormalities in hematology, blood glucose, lipid profile, hepatic and renal function. Biopsy results confirmed acanthosis, hyperkeratosis, dysplsia and granulomatous inflammation. The association of Kyrle’s disease and metabolic abnormalities, emphasizing diabetes and chronic renal failure. Potential pathways involve oxidative damage, endoplasmic stress, and vasculopathy. Treatment options include keratolytics, emollients, antihistamines. Kyrle’s disease often linked to diabetes and chronic renal failure, is a chronic condition with variable remission periods. Early detection and appropriate management are crucial for improving patients’ quality of life. Understanding the association with metabolic abnormalities guides effective therapeutic approaches for this rare dermatological condition.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"9 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A case report on Kyrle’s disease in patient with diabetes mellitus\",\"authors\":\"Yashmeen Nikhat P., Jutla V. Kumar, Chennasamudram C. Kesavulu\",\"doi\":\"10.18203/issn.2455-4529.intjresdermatol20240975\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Kyrles disease classified under acquired perforating dermatosis, is a rare skin condition predominantly affecting 30-50-year-old females. Characterized by pruritic hyperkeratotic and ulcerated nodules, the disease involves the transepidermal clearance of aberrant endogenous components, leading to inflammatory reactions and expulsion of keratin and cellular material. The etiology though not fully understood, suggests changes in dermal connective tissue may play a role. In case report, a 56-year-old male with type II diabetes mellitus presented knee pain and 3 mm papules on lower limbs. Laboratory findings revealed hematological and metabolic abnormalities, and a skin biopsy confirmed Kyrle’s disease features. Laboratory reports indicated abnormalities in hematology, blood glucose, lipid profile, hepatic and renal function. Biopsy results confirmed acanthosis, hyperkeratosis, dysplsia and granulomatous inflammation. The association of Kyrle’s disease and metabolic abnormalities, emphasizing diabetes and chronic renal failure. Potential pathways involve oxidative damage, endoplasmic stress, and vasculopathy. Treatment options include keratolytics, emollients, antihistamines. Kyrle’s disease often linked to diabetes and chronic renal failure, is a chronic condition with variable remission periods. Early detection and appropriate management are crucial for improving patients’ quality of life. 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引用次数: 0
摘要
Kyrles 病属于获得性穿孔性皮肤病,是一种罕见的皮肤病,主要影响 30-50 岁的女性。该病以瘙痒性角化过度和溃疡性结节为特征,涉及经表皮清除异常的内源性成分,导致炎症反应以及角蛋白和细胞物质的排出。虽然病因尚未完全清楚,但真皮结缔组织的变化可能是其中的一个原因。在病例报告中,一名 56 岁的 II 型糖尿病男性患者出现膝关节疼痛,下肢出现 3 毫米的丘疹。实验室检查结果显示其血液和代谢异常,皮肤活检证实了柯尔氏症的特征。实验室报告显示血液学、血糖、血脂、肝功能和肾功能异常。活检结果证实了棘皮症、角化过度、发育不良和肉芽肿性炎症。柯尔氏症与代谢异常有关,重点是糖尿病和慢性肾功能衰竭。潜在的发病途径包括氧化损伤、内质应激和血管病变。治疗方法包括角质溶解剂、润肤剂、抗组胺剂。柯尔氏症通常与糖尿病和慢性肾功能衰竭有关,是一种慢性疾病,缓解期不定。早期发现和适当治疗对改善患者的生活质量至关重要。了解这种疾病与代谢异常的关系,可以为这种罕见的皮肤病提供有效的治疗方法。
A case report on Kyrle’s disease in patient with diabetes mellitus
Kyrles disease classified under acquired perforating dermatosis, is a rare skin condition predominantly affecting 30-50-year-old females. Characterized by pruritic hyperkeratotic and ulcerated nodules, the disease involves the transepidermal clearance of aberrant endogenous components, leading to inflammatory reactions and expulsion of keratin and cellular material. The etiology though not fully understood, suggests changes in dermal connective tissue may play a role. In case report, a 56-year-old male with type II diabetes mellitus presented knee pain and 3 mm papules on lower limbs. Laboratory findings revealed hematological and metabolic abnormalities, and a skin biopsy confirmed Kyrle’s disease features. Laboratory reports indicated abnormalities in hematology, blood glucose, lipid profile, hepatic and renal function. Biopsy results confirmed acanthosis, hyperkeratosis, dysplsia and granulomatous inflammation. The association of Kyrle’s disease and metabolic abnormalities, emphasizing diabetes and chronic renal failure. Potential pathways involve oxidative damage, endoplasmic stress, and vasculopathy. Treatment options include keratolytics, emollients, antihistamines. Kyrle’s disease often linked to diabetes and chronic renal failure, is a chronic condition with variable remission periods. Early detection and appropriate management are crucial for improving patients’ quality of life. Understanding the association with metabolic abnormalities guides effective therapeutic approaches for this rare dermatological condition.