International Journal of Research in Dermatology最新文献_第2页

Extensive extra genital Csillag’s disease: a rare case report 大范围生殖器外奇拉格氏病：罕见病例报告

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240972

Rajesh Rajagopalan

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Navigating the complexities: a case report on the varied presentation of lupus vulgaris 驾驭复杂情况：关于寻常狼疮各种表现的病例报告

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240974

Ashima R. Chandran

引用次数: 0

A comparison of the effectiveness of intralesional tranexamic acid against platelet-rich plasma in the treatment of melasma 穴内注射氨甲环酸与富血小板血浆治疗黄褐斑的效果比较

International Journal of Research in Dermatology Pub Date : 2024-04-24 DOI: 10.18203/issn.2455-4529.intjresdermatol20240970

Manasha Karthikeyan, Govardhan Jagadeesh Kumar, Indradevi Radhakrishnan

{"title":"A comparison of the effectiveness of intralesional tranexamic acid against platelet-rich plasma in the treatment of melasma","authors":"Manasha Karthikeyan, Govardhan Jagadeesh Kumar, Indradevi Radhakrishnan","doi":"10.18203/issn.2455-4529.intjresdermatol20240970","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240970","url":null,"abstract":"Background: Melasma, derived from the Greek word \"melas\" meaning \"black\", manifests as an acquired, more or less symmetrical hypermelanosis of sun-exposed skin. This study aimed to compare and evaluate the efficacy and safety of intradermal injection of tranexamic acid and platelet-rich plasma in treating various types of melasma.\u0000Methods: Conducted from June 2022 to December 2023 at the outpatient department of dermatology, Sri Lakshmi Narayana institute of medical sciences, Puducherry, this split-face prospective study involved 40 melasma cases. Tranexamic acid (4 mg/ml) was intradermally injected into the right side of the face, while PRP was injected into the left side. Improvement was assessed using the modified Melasma area severity index (MASI) grading system and dermoscopy, measuring disease severity and percentage of improvement before and after therapy on both sides of the face.\u0000Results: The study comprised predominantly females (80%) aged 20 to 30 years (50%), followed by those aged 30 to 40 years (35%). Most cases (93%) exhibited a gradual onset, with centrofacial (52.5%) and malar (37.5%) patterns being predominant. Mixed pattern (67.5%) was common. Pre-treatment mean MASI scores for tranexamic acid and PRP sides were 7.54 and 6.92, respectively, with post-treatment scores of 4.6 and 2.83, respectively.\u0000Conclusions: Intradermal PRP demonstrated significantly superior efficacy over intradermal tranexamic acid in managing melasma, particularly in the longer term. Thus, PRP, coupled with good compliance, may substantially reduce the disease burden compared to conventional tranexamic acid treatment.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"57 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-phospholipid antibody syndrome with skin as a primary involved organ: an interesting case report 以皮肤为主要受累器官的抗磷脂抗体综合征：一份有趣的病例报告

International Journal of Research in Dermatology Pub Date : 2024-03-16 DOI: 10.18203/issn.2455-4529.intjresdermatol20240686

Aum N. Soni, Harshad V. Parmar, Hinal J. Prajapati

引用次数: 0

Expert dialogue on topical minocycline gel in acne vulgaris: minologue India 关于米诺环素外用凝胶治疗寻常痤疮的专家对话：印度小型研讨会

International Journal of Research in Dermatology Pub Date : 2024-03-16 DOI: 10.18203/issn.2455-4529.intjresdermatol20240685

Malavika Kohli, P. Sangolli, Sanjeev Aurangabadkar, Rajetha Damisetty, D. A. Satish, Shrichand G. Parasramani, Anil Ganjoo, Deepak Jakhar, Anand Nott, Miti Gandhi, D. Dhoot, Kruttika R Chitnis, Hanmant Barkate

{"title":"Expert dialogue on topical minocycline gel in acne vulgaris: minologue India","authors":"Malavika Kohli, P. Sangolli, Sanjeev Aurangabadkar, Rajetha Damisetty, D. A. Satish, Shrichand G. Parasramani, Anil Ganjoo, Deepak Jakhar, Anand Nott, Miti Gandhi, D. Dhoot, Kruttika R Chitnis, Hanmant Barkate","doi":"10.18203/issn.2455-4529.intjresdermatol20240685","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240685","url":null,"abstract":"Acne vulgaris is a common skin disorder with a global prevalence of about 9.4%. Oral antibacterials are recommended but they are associated with potential systemic side effects. Topical minocycline 4% has been recently approved by the United States Food and Drug Administration (US-FDA) for the management of moderate to severe acne. Although efficacy and safety are established, little is known of its real word usage. To review and appraise existing literature and make recommendations on the real world usage and positioning of topical minocycline 4% in acne management. The minocycline 4% consensus was developed by nine acne experts and was evidence-based on a review of recent topical minocycline 4% literature. A total of 11 questions were discussed regarding different domains like positioning of topical minocycline in acne management as monotherapy and combination therapy, safety and use in special population. Several recommendations were given regarding topical minocycline use like: no monotherapy use; consider use in combination with other anti-acne treatments like isotretinoin, adapalene and benzoyl peroxide; not recommended to be combined with systemic antibiotics; low chances for hyperpigmentation; use of sun protection measures; consider risk benefit ratio in pregnancy; use in lactation not recommended; and can be used only in children >9 years of age. This consensus has discussed and answered many real world usage questions and place in therapy for topical minocycline in acne management and finds it a useful addition to the existing armamentarium.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"100 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic epidermal necrolysis in a 37-year-old man with pneumonia: a case report 一名患有肺炎的 37 岁男子的中毒性表皮坏死症：病例报告

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240398

Wiryanti Ambarita, Sri Lestari, Anwar Fuadi, A. Raza

{"title":"Toxic epidermal necrolysis in a 37-year-old man with pneumonia: a case report","authors":"Wiryanti Ambarita, Sri Lestari, Anwar Fuadi, A. Raza","doi":"10.18203/issn.2455-4529.intjresdermatol20240398","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240398","url":null,"abstract":"Apart from allergy, TEN can be caused by infection, such as M. pneumoniae infection. Aim of this case report is to present clinical manifestations of TEN with pneumonia. A 37-year-old man, came to the emergency room with cough and fever since 5 days before hospitalized. The patient received intravenous ceftriaxone (with negative skin test), paracetamol, and n-acetylcysteine. Three days earlier, the patient had gone to primary health center and got paracetamol and n-acetylcysteine. On the first day of treatment, erythematous macules were seen on the anterior and posterior thoracic region, also the patient had sore throat and dysphagia, treated with intravenous dipenhydramine, mefenamic acid, and cetirizine. On the following day, the lesions expanded with multiple bullae on the anterior and posterior thoracic region, and erosion on the labia (BSA 28%). Intravenous methylprednisolone was administered, also Kloderma® and Ikagen® cream, and Kenalog®. Mefenamic acid and paracetamol were discontinued. On the third day of treatment, the lesions expanded (BSA 38%) and the next day, BSA reached 91.5%. The SCORTEN was 1. The patient was referred for treatment at the burn center and IVIg therapy. After the eleventh day of treatment at the referral hospital, the patient was fully recovered. The managements of TEN are stop suspected drugs, wound care, fluid therapy, systemic corticosteroids, and IVIg therapy. Appropriate management of TEN gives complete recovery to patient.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"32 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140437324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicomorphological patterns in an outbreak of paederus dermatitis in patients attending rural tertiary care hospital 在农村三级医院就诊的患者中爆发的脓疱疮皮炎的临床形态学模式

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240396

Bandi Niharika Reddy, Duttala Indira Reddy, B. Udaya Kumar, N. H. K. Reddy

{"title":"Clinicomorphological patterns in an outbreak of paederus dermatitis in patients attending rural tertiary care hospital","authors":"Bandi Niharika Reddy, Duttala Indira Reddy, B. Udaya Kumar, N. H. K. Reddy","doi":"10.18203/issn.2455-4529.intjresdermatol20240396","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240396","url":null,"abstract":"Background: Paederus dermatitis (PD) is an acute irritant contact dermatitis caused by beetles belonging to the genus ‘Paederus’. The study aims to describe the clinical and morphological patterns and epidemiology of PD.\u0000Methods: A descriptive study was done on 80 patients with PD attending DVL OPD in a tertiary care hospital for 6 months i.e.; from March to August 2023. A detailed clinical history was taken and local and systemic examinations were done.\u0000Results: The mean age of the patients was 24.8 years. The percentage of females affected was 61.25% and males was 38.75%. Peak cases were noted during May (32.5%) followed by August (17.5%). Out of 80 patients, 61 had erythematous plaques (76.25%) along with other types of lesions (mixed lesions), 8 had post-inflammatory hyperpigmentation (10%), 5 had bullae (6.25%), 6 had erosions alone (7.5%). Out of 61 patients with erythematous plaques, 16 had vesicles and 15 had pustules. Common sites involved were face and neck (42.5%), trunk (35%), and upper extremity (30%), 51.2% of patients were sleeping with windows open, 73.7 % of patients complained of itching, 80% of patients were residing in areas with nearby vegetations. 60% of the patients affected were students residing at college hostels in rural areas with surrounding vegetation.\u0000Conclusions: PD can present in various forms and should be promptly differentiated from other conditions. Proper education of the general population and awareness about the paederus beetles should be given.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"12 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139957502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effectiveness of the combination of doxycycline and trifarotene for managing acne vulgaris of moderate to severe severity: a study in a tertiary care hospital 评估强力霉素和三氮茚联合治疗中重度寻常型痤疮的疗效：一项在三级医院开展的研究

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240392

M. K. Uddin, Sanjida Yesmin

{"title":"Evaluation of the effectiveness of the combination of doxycycline and trifarotene for managing acne vulgaris of moderate to severe severity: a study in a tertiary care hospital","authors":"M. K. Uddin, Sanjida Yesmin","doi":"10.18203/issn.2455-4529.intjresdermatol20240392","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240392","url":null,"abstract":"Background: Acne vulgaris (AV), affecting diverse skin types, prompts a uniform therapeutic approach, with options ranging from topical to systemic treatments. Trifarotene, a fourth-generation topical retinoid, offers precise skin-specific effects, especially in facial and truncal acne treatment. The study aimed to evaluate the effectiveness of the combination of doxycycline and trifarotene for managing AV of moderate to severe severity.\u0000Methods: At Mymensingh medical college hospital, the study enrolled 100 individuals to evaluate a new treatment for moderate AV from Jan-Jun 2023. Treatment comprised oral doxycycline (100 mg) and topical trifarotene (0.005% w/w) over 2 months, following a stratified randomization process. Evaluation criteria included clinical scores, lesion counts, and safety parameters, analyzed using SPSS v20.\u0000Results: Study on doxycycline and trifarotene for moderate to severe acne shows promising results. Participants, mainly aged 15-25 exhibit diverse demographics and balanced gender ratio. Significant improvement on investigator's global assessment (IGA) scale is noted, with 35% experiencing notable progress at 9-10 weeks, alongside reduction in Propionibacterium acnes growth and positive patient feedback with 36% reporting 'good' response.\u0000Conclusions: The study on doxycycline and trifarotene for moderate acne exhibits robust methodology with adherence to established practices and stratified randomization. Results, assessed via IGA, demonstrate promising efficacy and safety, providing insights for diverse skin types' acne management enhancement.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139957551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic parameters in acne vulgaris: a case control study investigating fasting blood glucose and insulin levels in acne vulgaris 寻常型痤疮的代谢参数：调查寻常型痤疮患者空腹血糖和胰岛素水平的病例对照研究

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240395

Saranya Palaniswami, Bhanu Prakash, Praveen Vasanthi Saminathan

{"title":"Metabolic parameters in acne vulgaris: a case control study investigating fasting blood glucose and insulin levels in acne vulgaris","authors":"Saranya Palaniswami, Bhanu Prakash, Praveen Vasanthi Saminathan","doi":"10.18203/issn.2455-4529.intjresdermatol20240395","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240395","url":null,"abstract":"Background: Influence of diet and lifestyle on acne among Indian population. Objectives were to identify the clinico-epidemiological profile of patients with Acne vulgaris and to assess the fasting plasma glucose and serum insulin levels in Acne vulgaris patients and the controls and correlate them.\u0000Methods: This was a hospital-based case-control study conducted in the Department of Dermatology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore. Study included 60 cases of acne and 60 controls (age and sex matched), attending the outpatient department. After complete history, general physical, systemic and cutaneous examination, all cases were subjected to following investigation: fasting blood sugar and serum insulin levels.\u0000Results: Acne was common in the age group 18-24 yrs (70%). In almost half the patients the age of onset was between 12-18 yrs. Commonly observed site for acne was cheeks (83.3%), forehead (66.7%), nose (55%) and chin (41.7%). The risk of developing acne was 3.5 times more among smokers than non-smokers. The mean fasting blood sugar values of cases and controls when compared showed a statistically significant difference (p<0.05). Our study did not find any statistically significant difference in fasting insulin levels between cases and controls.\u0000Conclusions: There was only significant difference in the Mean fasting blood glucose in cases as compared to controls. Mean fasting serum insulin level though found to be raised in cases compared to controls, does not prove statistical significance. Fasting plasma glucose was significantly raised in grade III acne as compared to other grades.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"3 7‐8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140437514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and safety of alcohol-free minoxidil in the management of treatment-naive patients with androgenetic alopecia 无酒精米诺地尔治疗雄激素性脱发患者的有效性和安全性

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240394

Narendra G. Patwardhan, Dhanashree Bhide, Sonal Shendkar

{"title":"Effectiveness and safety of alcohol-free minoxidil in the management of treatment-naive patients with androgenetic alopecia","authors":"Narendra G. Patwardhan, Dhanashree Bhide, Sonal Shendkar","doi":"10.18203/issn.2455-4529.intjresdermatol20240394","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240394","url":null,"abstract":"Background: Androgenetic alopecia (AGA) is a common dermatological condition in India, with potentially adverse psychosocial consequences. Here, we assess the effectiveness and safety of an alcohol-free, procapil-based formulation of minoxidil 5% in patients with AGA.\u0000Methods: Treatment-naïve, male patients (aged 18 to ≤45 years) with AGA were enrolled in this open-label, single-arm, non-comparative, investigator-initiated study. The change in anagen/telogen ratio (ATR), hair density, and hair shaft thickness from baseline to days 45, 90, 135 and 180, investigator and patients’ global assessment for effectiveness and tolerability, and safety were assessed. A total of 53 men were enrolled.\u0000Results: The mean (standard deviation [SD]) age of the study population was 28.3 (6.0) years. The mean (SD) ATR improvement post-treatment with minoxidil 5% was seen from day 90 (mean change: 0.4; p=0.009; 95% confidence interval [CI]: 0.1-0.7) till Day 180 (mean change: 0.4; p=0.011; 95% CI: 0.1-0.6). Improvement in hair density (p<0.01) and hair shaft thickness (p<0.01) across frontal, temporal, and occipital regions was also evident. The investigator assessment for effectiveness was ‘excellent’/’good’/’satisfactory’ for 90% of patients, which corroborated with patients’ assessment (90%) at day 180. All the investigators and patients indicated that minoxidil had ‘good’ tolerability for all patients. No adverse events were reported during the study.\u0000Conclusions: Alcohol-free minoxidil 5% was found to have a good safety profile and was efficacious in Indian male patients with AGA, with a high level of patient acceptance.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0