International Journal of Research in Dermatology最新文献_第3页

Study on clinical, histopathological and dermoscopic features of palmoplantar pustulosis and palmoplantar psoriasis with pustules 掌跖脓疱病和掌跖脓疱型银屑病的临床、组织病理学和皮肤镜特征研究

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240393

Neethu M. George, P. Sangolli, Rosamma Thomas, Jerry R. John

{"title":"Study on clinical, histopathological and dermoscopic features of palmoplantar pustulosis and palmoplantar psoriasis with pustules","authors":"Neethu M. George, P. Sangolli, Rosamma Thomas, Jerry R. John","doi":"10.18203/issn.2455-4529.intjresdermatol20240393","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240393","url":null,"abstract":"Background: Palmo-plantar pustulosis (PPP) and palmoplantar psoriasis with pustules (PPso)/Palmoplantar pustular psoriasis are entities that present with chronic cyclical eruptions of vesicles and pustules of palms and soles, which were initially considered to be similar but was defined as separate entities by the international psoriasis council in 2007. Individuals with PPP are at increased risk of psoriasis vulgaris, psoriatic arthritis, autoimmune thyroid disease and 90% of pustulosis patients can have psoriasis-like rash at some stage of the disease. Aim was to assess the clinical, histopathological and dermoscopic features of PPP and palmoplantar psoriasis with pustules.\u0000Methods: A cross sectional analysis of all patients who presented to us over 1 year with vesicles and/or pustules of hands and/or feet and were diagnosed with PPP and palmoplantar psoriasis with pustules/palmoplantar pustular psoriasis, both clinically and histologically, were done. The severity was analysed using palmoplantar pustulosis area severity index (PPPASI) and the clinical, histological and dermoscopic features were noted.\u0000Results: Twenty-four patients were categorized into 2 groups of 12 each, with a male predominance in both the groups. Majority (66.6%) of PPP belonged to the age group of 20-40 years whereas 83% of PPso belonged to >40 years of age. Dermoscopic findings noted in both groups were translucent yellow areas, yellow/red-brown globules, dotted regularly arranged vessels, yellow crust and globules following dermatoglyphics.\u0000Conclusions: The study, though with limited sample size, highlights few clinical, histopathological and dermoscopic features which helps in differentiating the two groups.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"25 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaposi sarcoma in an immunocompetent patient: a case report 免疫功能正常患者的卡波西肉瘤：病例报告

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240399

Anjana B., Ranjeeta Sapam, Gurumayum Chitralekha Devi

引用次数: 0

Bowens disease: clinico pathological correlation with review of literature 鲍温斯病：临床病理相关性及文献综述

International Journal of Research in Dermatology Pub Date : 2024-02-23 DOI: 10.18203/issn.2455-4529.intjresdermatol20240397

Rohini A., Leena Dennis Joseph, A. Priyadarshini

{"title":"Bowens disease: clinico pathological correlation with review of literature","authors":"Rohini A., Leena Dennis Joseph, A. Priyadarshini","doi":"10.18203/issn.2455-4529.intjresdermatol20240397","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240397","url":null,"abstract":"Bowen’s disease is a type of squamous cell carcinoma in situ. It is most frequently diagnosed in the sixth to eighth decade of life. However, there have also been a few reports of pigmented Bowen’s disease. A single or multiple erythematous, round to irregular, scaly, keratotic, nodular, pigmented patches/plaques are first signs of the lesion. All cases of Bowen’s disease presented at a tertiary care centre over a period of seven years were included in this study. The patient details and clinical history were obtained from medical records. Histopathological slides of these cases were reviewed and analyzed. There were fourteen cases of Bowen’s disease with most patients belonging to 5-6th decade of life (80%). Males were more commonly affected (60%). Duration of the lesion ranged between 3-5 years in 60% of the patients. Most common site involved was lower back (80%). Most common presenting feature was hyperpigmented, erythematous plaques with scaling seen in 90% of the patients. Epidermal changes such as marked acanthosis with full thickness atypia were noted in 90 % and hyperkeratosis, parakeratosis was noted in 70% of the patients. Lichenoid infiltrates at dermo-epidermal junction was noted in 70% cases. The correct identification helps in appropriate diagnosis and treatment after biopsy confirmation. Adequate resection helps in preventing risk of invasive malignancy in these conditions.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"11 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140437459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of thyroid function test abnormalities and serum thyroid autoantibodies in vitiligo and alopecia areata patients in Saudi Arabian population 沙特阿拉伯人群中白癜风和斑秃患者甲状腺功能检测异常和血清甲状腺自身抗体的患病率

International Journal of Research in Dermatology Pub Date : 2024-02-14 DOI: 10.18203/issn.2455-4529.intjresdermatol20240323

Renad Alnemari, Awadh Alamri

{"title":"The prevalence of thyroid function test abnormalities and serum thyroid autoantibodies in vitiligo and alopecia areata patients in Saudi Arabian population","authors":"Renad Alnemari, Awadh Alamri","doi":"10.18203/issn.2455-4529.intjresdermatol20240323","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240323","url":null,"abstract":"Background: Alopecia areata (AA) and vitiligo are immune-mediated inflammatory diseases characterized by hair loss and depigmented macules, respectively. It is often associated with other autoimmune conditions especially with autoimmune thyroid disorders indicating a potential role of autoimmunity in its development.\u0000Methods: A 222 patients, 113 AA and 109 vitiligo diagnosed, were retrospectively reviewed. We analyzed TG-Ab, TPO-Ab, Thyroid function tests (free T3, free T4, and TSH) in all patients.\u0000Results: In vitiligo patients, 11% (n=12) had elevated levels of anti-TG levels and 26.6% (n=29) had elevated levels of anti-TPO, Thyroid hormonal abnormalities were found in 15.6% (n=17) of vitiligo patients, and fT4 was elevated in 1.83% (n=2) patients. Within AA patients, 15.9% (n=18) had anti-TG elevation and 23.9% (n=27) had anti-TPO elevation, thyroid hormonal abnormalities were found in 16.8% (n=19), and fT4 was high in 0.88% (n=1) patient. No significant difference was found between the two groups for all measured parameters. No statistically significant correlation between the gender of the patients and the diagnosis, thyroid hormonal test, and thyroid autoantibody levels could be detected (p>0.05)\u0000Conclusions: In our study, impaired thyroid functions and thyroid autoantibodies in vitiligo and AA patients were identified at similar rates of the previous studies. Moreover, we could not find differences in comparison to other ethnicities.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"124 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139838070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of thyroid function test abnormalities and serum thyroid autoantibodies in vitiligo and alopecia areata patients in Saudi Arabian population 沙特阿拉伯人群中白癜风和斑秃患者甲状腺功能检测异常和血清甲状腺自身抗体的患病率

International Journal of Research in Dermatology Pub Date : 2024-02-14 DOI: 10.18203/issn.2455-4529.intjresdermatol20240323

Renad Alnemari, Awadh Alamri

{"title":"The prevalence of thyroid function test abnormalities and serum thyroid autoantibodies in vitiligo and alopecia areata patients in Saudi Arabian population","authors":"Renad Alnemari, Awadh Alamri","doi":"10.18203/issn.2455-4529.intjresdermatol20240323","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240323","url":null,"abstract":"Background: Alopecia areata (AA) and vitiligo are immune-mediated inflammatory diseases characterized by hair loss and depigmented macules, respectively. It is often associated with other autoimmune conditions especially with autoimmune thyroid disorders indicating a potential role of autoimmunity in its development.\u0000Methods: A 222 patients, 113 AA and 109 vitiligo diagnosed, were retrospectively reviewed. We analyzed TG-Ab, TPO-Ab, Thyroid function tests (free T3, free T4, and TSH) in all patients.\u0000Results: In vitiligo patients, 11% (n=12) had elevated levels of anti-TG levels and 26.6% (n=29) had elevated levels of anti-TPO, Thyroid hormonal abnormalities were found in 15.6% (n=17) of vitiligo patients, and fT4 was elevated in 1.83% (n=2) patients. Within AA patients, 15.9% (n=18) had anti-TG elevation and 23.9% (n=27) had anti-TPO elevation, thyroid hormonal abnormalities were found in 16.8% (n=19), and fT4 was high in 0.88% (n=1) patient. No significant difference was found between the two groups for all measured parameters. No statistically significant correlation between the gender of the patients and the diagnosis, thyroid hormonal test, and thyroid autoantibody levels could be detected (p>0.05)\u0000Conclusions: In our study, impaired thyroid functions and thyroid autoantibodies in vitiligo and AA patients were identified at similar rates of the previous studies. Moreover, we could not find differences in comparison to other ethnicities.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"33 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139778458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perianal warty dyskeratoma 肛周疣状角化不良瘤

International Journal of Research in Dermatology Pub Date : 2024-02-01 DOI: 10.18203/issn.2455-4529.intjresdermatol20240302

Otarid B. Mohammed, Waad I. Kadori, Ebrahim Ebrahim, Ahmed Gwea, Hussam Telfah, M. Z. Karzoun

{"title":"Perianal warty dyskeratoma","authors":"Otarid B. Mohammed, Waad I. Kadori, Ebrahim Ebrahim, Ahmed Gwea, Hussam Telfah, M. Z. Karzoun","doi":"10.18203/issn.2455-4529.intjresdermatol20240302","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240302","url":null,"abstract":"Warty dyskeratoma is a rare keratinization disorder marked by acantholytic dyskeratosis and belongs to the spectrum of acantholytic dyskeratosis in dermatology. It was first documented in 1954 and typically manifests in the head, neck, oral mucosa, and trunk, with several cases reported since its discovery. A 35-year-old unmarried gentleman presented in April 2022 with a 5-year history of perineal itching and discomfort. His physical examination revealed a 7-8 centimeter perianal grouped papular plaque. His medical history was unremarkable, and he has no family history of similar conditions or other dermatological disorders. Lab results showed non-reactive rapid plasma reagin and human immunodeficiency antigen/antibody combo. Liver and renal function tests were within normal range as well. The microscopic findings revealed features including prominent hyperkeratosis, invagination filled with keratin, and the surrounding area exhibiting acantholysis and intercellular edema. In conjunction with the patient’s clinical presentation, this histological profile led to the diagnosis of warty dyskeratoma. After treatment with calcipotriene and other topical agents, the last presentation showed very good improvement; the physical examination indicated remarkable thin, flat, soft, grayish plaque in the perianal area. This case report presents a unique instance of warty dyskeratoma affecting the perianal area, shedding light on differential diagnosis and clinical management in this atypical context, which significantly broadens the understanding and emphasizing that the Warty dyskeratoma can manifest in diverse body regions, urging its consideration in the differential diagnosis of perianal papular lesions.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"37 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perianal warty dyskeratoma 肛周疣状角化不良瘤

International Journal of Research in Dermatology Pub Date : 2024-02-01 DOI: 10.18203/issn.2455-4529.intjresdermatol20240302

Otarid B. Mohammed, Waad I. Kadori, Ebrahim Ebrahim, Ahmed Gwea, Hussam Telfah, M. Z. Karzoun

{"title":"Perianal warty dyskeratoma","authors":"Otarid B. Mohammed, Waad I. Kadori, Ebrahim Ebrahim, Ahmed Gwea, Hussam Telfah, M. Z. Karzoun","doi":"10.18203/issn.2455-4529.intjresdermatol20240302","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240302","url":null,"abstract":"Warty dyskeratoma is a rare keratinization disorder marked by acantholytic dyskeratosis and belongs to the spectrum of acantholytic dyskeratosis in dermatology. It was first documented in 1954 and typically manifests in the head, neck, oral mucosa, and trunk, with several cases reported since its discovery. A 35-year-old unmarried gentleman presented in April 2022 with a 5-year history of perineal itching and discomfort. His physical examination revealed a 7-8 centimeter perianal grouped papular plaque. His medical history was unremarkable, and he has no family history of similar conditions or other dermatological disorders. Lab results showed non-reactive rapid plasma reagin and human immunodeficiency antigen/antibody combo. Liver and renal function tests were within normal range as well. The microscopic findings revealed features including prominent hyperkeratosis, invagination filled with keratin, and the surrounding area exhibiting acantholysis and intercellular edema. In conjunction with the patient’s clinical presentation, this histological profile led to the diagnosis of warty dyskeratoma. After treatment with calcipotriene and other topical agents, the last presentation showed very good improvement; the physical examination indicated remarkable thin, flat, soft, grayish plaque in the perianal area. This case report presents a unique instance of warty dyskeratoma affecting the perianal area, shedding light on differential diagnosis and clinical management in this atypical context, which significantly broadens the understanding and emphasizing that the Warty dyskeratoma can manifest in diverse body regions, urging its consideration in the differential diagnosis of perianal papular lesions.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"24 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139823705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin C in dermatology and cosmetology: a review 皮肤病学和美容学中的维生素 C：综述

International Journal of Research in Dermatology Pub Date : 2024-01-16 DOI: 10.18203/issn.2455-4529.intjresdermatol20240023

S. Mohan, Neelu Singh, Lalit Mohan

{"title":"Vitamin C in dermatology and cosmetology: a review","authors":"S. Mohan, Neelu Singh, Lalit Mohan","doi":"10.18203/issn.2455-4529.intjresdermatol20240023","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240023","url":null,"abstract":"Vitamin C is a very powerful water-soluble antioxidant with various potential benefits for patients with skin diseases. The chemically active form of vitamin C is L-ascorbic acid (LAA) and thus is used extensively in medical practices. Due to an active transport mechanism, the absorption of vitamin C in the gut is limited, thereby reducing the amount of drug absorbed orally despite a high dosage, which in turn reduces the bioavailability of vitamin C in the skin. Therefore, topical use of vitamin C is usually preferred in dermatology practice. The function of vitamin C is mostly linked to its electron-donating property. Several processes such as reduction of iron in the gastrointestinal tract, synthesis of carnitine, gene transcription, protection against reactive oxygen species (ROS), demethylation of DNA, Hydroxylation of transcription factors, tRNA, and ribosomal proteins, collagen, and hormonal synthesis are carried out due to the active participation of vitamin C in the body. Scurvy usually occurs due to inadequate consumption of vitamin C through a regular diet or inability to absorb the vitamin C in the body. 90% of ascorbic acid comes from fresh fruits and vegetable consumption, failure of which can lead to scurvy.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139620234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the surface: confronting the impact of topical steroids on facial skin 超越表面：正视局部类固醇对面部皮肤的影响

International Journal of Research in Dermatology Pub Date : 2024-01-08 DOI: 10.18203/issn.2455-4529.intjresdermatol20240010

Krut J. Patel, Som J. Lakhani, Shreya D. Patel

{"title":"Beyond the surface: confronting the impact of topical steroids on facial skin","authors":"Krut J. Patel, Som J. Lakhani, Shreya D. Patel","doi":"10.18203/issn.2455-4529.intjresdermatol20240010","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240010","url":null,"abstract":"Background: Topical steroids have become the primary therapeutic approach among dermatologists. The clinical outcomes are attributed to their anti-inflammatory, antiproliferative, and immunosuppressive effects. However, this miraculous remedy can lead to significant trouble when used improperly, especially on the face where it can lead to topical steroid damaged faces (TSDF).\u0000Methods: study was conducted for 9 months among 30 patients presenting with chief complaints due to topical steroid abuse over face and data was collected and analysed after using self-designed open ended questionnaire.\u0000Results: Out of 30 patients, preponderance were seen in females (M:F=1:2.3) The most common age group was 18-28 years (50%). Majority of them (36.6%) used class-3 of highly potent steroid which is betamethasone valerate 0.1%. Most common indication for application was as fairness cream (46.7%). In majority of the patients (70%), suggestion for application was given by pharmacist. 73.3% of patients, purchase medication over the counter (OTC) without prescription. Duration of usage was more than 6 months in 10% patients. Dyspigmentation (32.1%) followed by erythema (28.6%) were the most common adverse effects.\u0000Conclusions: Using too many topical corticosteroids may benefit manufacturers and sellers, but it harms unsuspecting people. It's crucial to evaluate and advise patients, as well as inform doctors about avoiding excessive use of these products on the face. This is an important step that needs attention now.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"12 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypopyon sign: a half full or half empty scenario Hypopyon 信号：半满或半空的情景

International Journal of Research in Dermatology Pub Date : 2023-12-22 DOI: 10.18203/issn.2455-4529.intjresdermatol20233879

K. Manoharan, V. N. R., Sukanya G., Ashna Jaffrey

引用次数: 0