评估强力霉素和三氮茚联合治疗中重度寻常型痤疮的疗效:一项在三级医院开展的研究

M. K. Uddin, Sanjida Yesmin
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引用次数: 0

摘要

背景:寻常型痤疮(AV)影响着不同的皮肤类型,因此需要采用统一的治疗方法,从局部治疗到全身治疗,不一而足。作为第四代外用维甲酸类药物,三苯氧胺可针对皮肤的具体情况提供精确的疗效,尤其是在面部和躯干痤疮治疗方面。该研究旨在评估强力霉素和曲法洛汀联合治疗中重度痤疮的效果:方法:该研究从 2023 年 1 月至 6 月,在迈门辛医学院附属医院招募了 100 名患者,以评估一种治疗中度 AV 的新疗法。治疗方法包括口服多西环素(100 毫克)和外用三碳砷(0.005% w/w),为期 2 个月,采用分层随机分配程序。评估标准包括临床评分、皮损计数和安全性参数,并使用 SPSS v20 进行分析:结果:多西环素和三羟甲基丙烷治疗中重度痤疮的研究结果令人鼓舞。参与者的年龄主要在 15-25 岁之间,他们的人口统计学特征各不相同,性别比例均衡。研究者总体评估(IGA)量表显示,35%的患者在9-10周时症状明显改善,痤疮丙酸杆菌生长减少,患者反馈积极,36%的患者反应 "良好":多西环素和曲安奈德治疗中度痤疮的研究采用了可靠的方法,坚持了既定的实践和分层随机化。通过IGA评估的结果表明,该疗法具有良好的疗效和安全性,为不同皮肤类型的痤疮治疗提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the effectiveness of the combination of doxycycline and trifarotene for managing acne vulgaris of moderate to severe severity: a study in a tertiary care hospital
Background: Acne vulgaris (AV), affecting diverse skin types, prompts a uniform therapeutic approach, with options ranging from topical to systemic treatments. Trifarotene, a fourth-generation topical retinoid, offers precise skin-specific effects, especially in facial and truncal acne treatment. The study aimed to evaluate the effectiveness of the combination of doxycycline and trifarotene for managing AV of moderate to severe severity. Methods: At Mymensingh medical college hospital, the study enrolled 100 individuals to evaluate a new treatment for moderate AV from Jan-Jun 2023. Treatment comprised oral doxycycline (100 mg) and topical trifarotene (0.005% w/w) over 2 months, following a stratified randomization process. Evaluation criteria included clinical scores, lesion counts, and safety parameters, analyzed using SPSS v20. Results: Study on doxycycline and trifarotene for moderate to severe acne shows promising results. Participants, mainly aged 15-25 exhibit diverse demographics and balanced gender ratio. Significant improvement on investigator's global assessment (IGA) scale is noted, with 35% experiencing notable progress at 9-10 weeks, alongside reduction in Propionibacterium acnes growth and positive patient feedback with 36% reporting 'good' response. Conclusions: The study on doxycycline and trifarotene for moderate acne exhibits robust methodology with adherence to established practices and stratified randomization. Results, assessed via IGA, demonstrate promising efficacy and safety, providing insights for diverse skin types' acne management enhancement.
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