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Evaluation of Anticancer, Antioxidant and Possible Anti-microbial Properties of extracts of Momordica diocia roots 苦瓜根提取物的抗癌、抗氧化及可能的抗菌性能评价
International Journal of Pharmaceutical Chemistry Pub Date : 2017-06-01 DOI: 10.7439/IJPC.V7I5.4174
G. V. Kumar, A. Reddy, B. V. kumar
{"title":"Evaluation of Anticancer, Antioxidant and Possible Anti-microbial Properties of extracts of Momordica diocia roots","authors":"G. V. Kumar, A. Reddy, B. V. kumar","doi":"10.7439/IJPC.V7I5.4174","DOIUrl":"https://doi.org/10.7439/IJPC.V7I5.4174","url":null,"abstract":"Since many years, plants were known to possess anticancer activities against different cancer cell lines. In this paper, we report a study based on anticancer,anti-bacterial and antioxidant properties plants Momordicadioica . The roots of plant material were collected, shade dried and extracted with methanol using soxhlet extraction procedure. Anticancer activities were assayed with standard XTT colorimetric procedure against MCF-7 and Hep-G2 cell lines. From the analysis, it was found that Momordicadioica showed good cytotoxic activity on MCF-7 cell line at tested dose. Further work is in progress to evaluate the chemical constituents present in these plants","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"72 1","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82285562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A short review on sulphonamides with antimicrobial activity 磺胺类抗菌药物的研究进展
International Journal of Pharmaceutical Chemistry Pub Date : 2017-05-28 DOI: 10.7439/IJPC.V7I5.4125
Sonu, B. Parveen, S. Praveen, H. Pal
{"title":"A short review on sulphonamides with antimicrobial activity","authors":"Sonu, B. Parveen, S. Praveen, H. Pal","doi":"10.7439/IJPC.V7I5.4125","DOIUrl":"https://doi.org/10.7439/IJPC.V7I5.4125","url":null,"abstract":"Sulfonamides are one of the organosulphur compounds containing the -SO 2 NH 2 and/or -SO 2 NH- group(s). The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in micro-organisms and subsequently inhibit multiplication of bacteria but do not actively kill them. They have been used against most gram-positive and many gram-negative bacteria, some fungi, and certain protozoa. Medically important sulphonamides","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"47 1","pages":"70-73"},"PeriodicalIF":0.0,"publicationDate":"2017-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73821889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Controlled swelling and in vitro release of insulin from konkoli grafted polymethylacrylaminde hydrogel 聚甲基丙烯酰胺水凝胶移植孔枣的体外消肿及胰岛素释放
International Journal of Pharmaceutical Chemistry Pub Date : 2017-05-01 DOI: 10.7439/IJPC.V7I4.4087
I. Nkafamiya, A. Akinterinwa
{"title":"Controlled swelling and in vitro release of insulin from konkoli grafted polymethylacrylaminde hydrogel","authors":"I. Nkafamiya, A. Akinterinwa","doi":"10.7439/IJPC.V7I4.4087","DOIUrl":"https://doi.org/10.7439/IJPC.V7I4.4087","url":null,"abstract":"The extended study of konkoli grafted polymethylacrylaminde (KG-g-poly (MAAm) hydrogel synthesized in our earlier work from methacrylamide (MAAm) grafted and N,N-methylenebisacrylamide (N,N-MBAAm) crosslinked Konkoli ( Maesopsis eminni ) galactomannan (KG), is necessary to establish its potential application as an oral insulin delivery system. In this study, the kg-g-poly (MAAm) Hydrogel swelling in typical pH media show an initial rapid swelling before stabilizing. The hydrogel attains its parabolic peak swelling in distill water (pH = 7). Swelling rises from a lower pH medium (pH = 2.2), and in a medium with a slight pH above this (pH = 7.4), swelling starts dropping. Comparing the media for the insulin release studies, the cumulative release drops to its parabolic trough in the distill water medium (pH = 7). A higher cumulative release was recorded at a lower pH (pH = 2.2), and the highest cumulative release was recorded at a higher pH (pH = 7.4). The kinetics and mechanisms of these processes were presented while using the descriptive statistic of regression to fit the results from the processes to a power law. The release of insulin from kg-g-poly (MAAm) Hydrogel was also shown to increase with increase in glucose concentration in the media with an initial rapid release in all solutions, while in a typical intestinal pH media range, higher release at all concentrations was recorded at pH = 6.8.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"71 1","pages":"63-69"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89624246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Phytochemical screening (qualitative) of certain medicinal plants of Saharanpur city 萨哈兰普尔市某些药用植物的植物化学筛选(定性)
International Journal of Pharmaceutical Chemistry Pub Date : 2017-04-28 DOI: 10.7439/ijpc.v7i4.3262
A. Sharma, S. Upadhyaya, S. Chauhan, H. Sharma, Shrikant Sharma
{"title":"Phytochemical screening (qualitative) of certain medicinal plants of Saharanpur city","authors":"A. Sharma, S. Upadhyaya, S. Chauhan, H. Sharma, Shrikant Sharma","doi":"10.7439/ijpc.v7i4.3262","DOIUrl":"https://doi.org/10.7439/ijpc.v7i4.3262","url":null,"abstract":"Saharanpur city is situated close to the borders of Haryana and Uttarakhand states, the city is surrounded by a fertile agricultural region. Medicinal plants are the major source of raw materials and good resources for pharmaceutical industry. These are the good source of primary and secondary metabolites. In present study phytochemical screening of three medicinal plants of Saharanpur city i.e.  Achyranthus  aspera, Euphorbia hirta,   Parthenium  hysterophorus  were carried out by using standard methods for conducting Qualitative phytochemical analysis and  studying the presence of active compounds like Alkaloids, Tannins, Saponins, Glycosides, Phenols, Flavonoids, Anthroquinone, Terpenoids and Steroids. Achyranthus aspera showed maximum of these phytocompounds in ethanolic extract. Ethanolic extracts of all plant species revealed the presence of most of the phytochemicals","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"29 1","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85955579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
GC-MS analysis of bio-active compounds in the methanolic extract of Ghee Residue 油渣甲醇提取物中生物活性物质的GC-MS分析
International Journal of Pharmaceutical Chemistry Pub Date : 2017-04-05 DOI: 10.7439/IJPC.V7I3.4018
P. Kumar, V. Ranjith, R. Subash, A. GowriShankarB
{"title":"GC-MS analysis of bio-active compounds in the methanolic extract of Ghee Residue","authors":"P. Kumar, V. Ranjith, R. Subash, A. GowriShankarB","doi":"10.7439/IJPC.V7I3.4018","DOIUrl":"https://doi.org/10.7439/IJPC.V7I3.4018","url":null,"abstract":"Ghee residue is a disuse by-product of ghee manufacturing industry and it is arich potential source of natural antioxidants. It is used as the ingredient for the preparation of chocolates, cakes and cookies in many industries because of the presence of high protein content in it. The aim of this study is to identify and characterize the vital bioactive compounds from the methanolic extract of ghee residue by Gas chromatography and Mass spectroscopy (GC-MS). The GC-MS analysis of the methanolic extract revealed the presence of 30 bioactive compounds. Among the 30 compounds, the most predominant compounds are fatty acids like hexadecanoic acid, tetradecanoic acid, dodecanoic acid, octadecanoic acid and an amino acid N-glycyl L-threonine. This study forms a basis for the biological characterization and importance of the compounds which could be exploited for future development of drugs.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"1 1","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2017-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84328514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of Computer Spreadsheet Used to Calculate Dissolution Profiles without Media Replacement 不更换介质计算溶出曲线的计算机电子表格的开发和验证
International Journal of Pharmaceutical Chemistry Pub Date : 2017-04-01 DOI: 10.7439/IJAPA.V7I1.4082
Imad Osman Abu Reid
{"title":"Development and Validation of Computer Spreadsheet Used to Calculate Dissolution Profiles without Media Replacement","authors":"Imad Osman Abu Reid","doi":"10.7439/IJAPA.V7I1.4082","DOIUrl":"https://doi.org/10.7439/IJAPA.V7I1.4082","url":null,"abstract":"Calculations carried out to generate dissolution profile data are complicated and subject to error to be performed manually, moreover and due to the repetitive nature of the dissolution testing experiments it is necessary to create a validated spreadsheet to replace and overcome the problems associated with manual calculations. A simple, user friendly spreadsheet was written to calculate dissolution profiles for a dissolution experiment where the volume of the dissolution medium for the vessel varies with time as the removed dissolution medium is not replaced with fresh one at each time point. The calculations of the spreadsheet were validated against manual calculations using a hand-held calculator; the results of the two methods were found to be comparable. The developed spreadsheet can be easily adapted for use in regulated environment after activating the security features embedded in Microsoft Excel software such as formula hiding, cell block and password protection.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"1 1","pages":"06-09"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88282726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
H-Point Standard Additions method for the simultaneous determination of Paracetamol and Chlorzoxazone in Tablets using addition of both analytes and absorbance increment (?A) h点标准加样法同时测定片剂中对乙酰氨基酚和氯唑唑酮的含量
International Journal of Pharmaceutical Chemistry Pub Date : 2017-04-01 DOI: 10.7439/IJAPA.V7I1.4006
Mohammed Abdeen Mohammed, Imad Osman Abu Reid, Alaa E. Elawni
{"title":"H-Point Standard Additions method for the simultaneous determination of Paracetamol and Chlorzoxazone in Tablets using addition of both analytes and absorbance increment (?A)","authors":"Mohammed Abdeen Mohammed, Imad Osman Abu Reid, Alaa E. Elawni","doi":"10.7439/IJAPA.V7I1.4006","DOIUrl":"https://doi.org/10.7439/IJAPA.V7I1.4006","url":null,"abstract":"The suitability of H-point standard additions method (HPSAM) to resolve of overlapping spectra corresponding to the paracetamol and chlorzoxazone was verified. The results showed that the H-point standard additions method with simultaneous addition of both analytes utilizing absorbance increment is suitable for the simultaneous determination of paracetamol and chlorzoxazone. The results of applying the H-point standard additions method showed that the two drugs could be determined simultaneously with the concentration ratios of paracetamol to chlorzoxazone varying from 1:2 to 2:1 in the mixed samples. In addition the means of the calculated RSD (%) were 1.40 and 1.92 in synthetic mixtures with 1.29 and 1.68 in dosage form for paracetamol and chlorzoxazone, respectively.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"112 1","pages":"01-05"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78058622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Phytochemical analysis of some medicinal plants of district Saharanpur 萨哈兰普尔地区一些药用植物的植物化学分析
International Journal of Pharmaceutical Chemistry Pub Date : 2017-03-28 DOI: 10.7439/IJPC.V7I3.3261
A. Sharma, S. Upadhyaya, S. Chauhan, Shrikant Sharma
{"title":"Phytochemical analysis of some medicinal plants of district Saharanpur","authors":"A. Sharma, S. Upadhyaya, S. Chauhan, Shrikant Sharma","doi":"10.7439/IJPC.V7I3.3261","DOIUrl":"https://doi.org/10.7439/IJPC.V7I3.3261","url":null,"abstract":"District Saharanpur is a rich source of medicinal plants because of its physical features, the north and the north-east of the district is surrounded by Shivalik hills and having rich biodiversity. The objective of present study was to investigate the presence of phytochemicals in five medicinal plants such as, Tinospora cordifolia (Thunb.)Miers, Bryophyllum pinnatum (Lam.)Oken , Terminalia belerica Roxb.,  Xanthium strumarium Linn. and Oldenlandia corymbosa Linn. For the study the solvents used were water, methanol, ethanol and acetone. Soxhlet apparatus was used for the organic solvent extraction. Carbohydrates, proteins, flavonoids, tannins, saponin, and phenols were detected in these selected medicinal plants. Our analysis proved that crude aqueous and organic solvent extracts of these plants having the bioactive compounds which are medicinally important for the use in the treatment of various diseases","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"9 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2017-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84881548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fast and complete decontamination of bacteria and yeast from water by silica-supported carbon nanoparticles simple filtration 通过二氧化硅支撑的碳纳米颗粒简单过滤，快速完全去除水中的细菌和酵母菌
International Journal of Pharmaceutical Chemistry Pub Date : 2017-02-28 DOI: 10.7439/IJPC.V7I2.3887
B. Hamaoui, M. Hamzé, H. Hammud, N. Chihib, C. Jama, Y. Bakkour, Ismail Abbas, F. Omar
{"title":"Fast and complete decontamination of bacteria and yeast from water by silica-supported carbon nanoparticles simple filtration","authors":"B. Hamaoui, M. Hamzé, H. Hammud, N. Chihib, C. Jama, Y. Bakkour, Ismail Abbas, F. Omar","doi":"10.7439/IJPC.V7I2.3887","DOIUrl":"https://doi.org/10.7439/IJPC.V7I2.3887","url":null,"abstract":"The present work aim to study the adsorption of different models of bacteria and yeast by silica-supported carbon nanoparticles (SCNP). SCNP was prepared at room temperature by ultrasonication of anthracene in toluene, in presence of ferrocene as catalyst and silica as nucleation sites. The strength of bacterial removal by the resultant SCNP was studied with Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus (as bacterial models) and Candida albicans (as yeast model). The bacterial suspension was left for 10 minutes in contact with the carbon material, filtrated and we enumerated bacteria in the filtrate obtained. The bacterial adsorption results exhibited complete adsorption efficiency after short contact time with SCNP. These results demonstrate the strength of the SCNP to completely adhere the bacteria and yeast. Similar experiment was conducted on silica particles without carbon, but no bacterial adsorption was observed. This clearly indicates the effectiveness of the SCNP to easily and simply adsorb bacteria and yeast without outside interference parameters.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"85 1","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76838330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pass biological activity spectrum predictions of chromones in the enhanced open nci database browser 在增强型开放nci数据库浏览器中传递色素的生物活性谱预测
International Journal of Pharmaceutical Chemistry Pub Date : 2017-02-28 DOI: 10.7439/IJPC.V7I2.3894
V. Banewar
{"title":"Pass biological activity spectrum predictions of chromones in the enhanced open nci database browser","authors":"V. Banewar","doi":"10.7439/IJPC.V7I2.3894","DOIUrl":"https://doi.org/10.7439/IJPC.V7I2.3894","url":null,"abstract":"Chromone nucleus containing drugs have its own importance in drug chemistry. Chromones and its substituted compounds possess various pharmacological activities and acts as HIV 1 Protease inhibitors. The concept of Biological Activity Spectrum served as a basis for developing PASS (Prediction of Activity Spectra for Substances) software products. Evaluation of the general biological potential of molecule is possible using computer based program PASS that predicts more than 780 pharmacological effects on the basis of structural formula of compounds. The result of PASS studies shows that substituted and unsubstituted Chromone show many important biological activities. PASS also predicts some unwanted activities of Chromone, providing medicinal chemists with the means to increase the efficiency of projects.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"21 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74448433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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